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Pediatrics / Critical Care Division / Current Research


Research Test TubesOur research activities center largely on clinical questions related to children with critical illness. Major current foci include, assessing alterations in hemostatic function in critically ill children, and assessing new devices for measuring hemodynamic function in a critical care setting.

Current Studies

  • ABC-Trial, “Age of Blood Cell Transfusions in Children” An international study examining the impact of the age of blood cells in pediatric critically ill patients.” 
    (PALISI Network) PI: Phillip Spinella; Marissa Tucci; Jacques Lacroix. University of Rochester Site PI: Jill M. Cholette, MD, Co-Investigator: L. Eugene Daugherty, MD.
  • “Genetic Epidemiology of Life Threatening Influenza in Children.”
    PI: Adrienne Randolph, MD, Children's Hospital Boston. Co-Investigator: Kate Ackerman, MD, Sub-Investigators: L. Eugene Daugherty, MD and Jill M. Cholette, MD.
  • "Iron Treatment for Insomnia in Children with Autism Spectrum Disorders." A multi-site, collaborative trial with University of Colorado. PI: Ann Reynolds, MD. University of Rochester Site PI: Heidi V. Connolly, MD.
  • "Prevention of Central Venous Catheter-Associated Thrombosis in Critically Ill Children: A Multicenter Phase 2b Trial"
    Yale (Vince Faustino PI). Site PI: Jill M. Cholette, MD.
  • "Enoxaparin Prophylaxis for High Risk Pediatric Cardiac Surgery Patients"
    PI: Jill Cholette, MD.
  • "Transfusion of Cell Saver Blood for 24 Hours After its Collection: Impact on Infection and Outcomes."
    PI: Elizabeth Nocera. Senior Investigator: Jill M. Cholette, MD.
  • "Use of Neural Networking to Create Smarter PICU Alarm Parameters."
    PI: Heather Reyes. Senior Investigator: Jeffrey  Rubenstein, MD, MBA.
  • "Cell-Free DNA (cfDNA) as a Marker for Clinical Outcomes After Neonatal Cardiovascular Surgery."
    PI: Melissa Cullimore. Senior Investigator: Kate Ackerman, MD.
  • "Pediatric Acute Respiratory Distress Incidence and Epidemiology (PARDIE)."
    PALISI Network. Site PI: Kate Ackerman, MD.
  • "Patient Driven Gene Discovery in Children with Critical Illness."
    Yale (Saquib Lakhani). Site PI: Kate Ackerman, MD.
  • "Epigenetics of Transition from Fetal to Adult Circulation."
    PI: Kate Ackerman, MD.

Investigators' Research Interests

Jill Cholette, M.D.

  • Blood cell utilization, modification and impact on inflammation and immune modulation
  • Clinical outcomes after blood transfusions in children with congenital heart disease status post cardiac surgery
  • Venous thrombosis prevention, as well as management, particularly in pediatric cardiac surgery and in association with central venous lines

Elise van der Jagt, M.D.

  • Multi-center control trials studying the morbidity and mortality of cooling pediatric patients status post cardiac arrest
  • Effectiveness of medical simulation as both a teaching tool and assessment tool in the Pediatric Intensive Care Unit

Research Networks

Our participation in Pediatric Critical Care research networks allows our faculty to collaborate with teams of investigators in multi-center studies on a national and an international level.

PALISI Network - Pediatric Acute Lung Injury and Sepsis Investigators

This network of PICU researchers identifies optimal supportive, preventive and therapeutic strategies for acute lung injury, sepsis, multi-organ failure, and life-threatening pulmonary or systemic inflammatory syndromes that affect critically ill infants and children.

Blood Net - Pediatric Critical Care Blood Research Network 

Blood Net is an international multi-disciplinary group of investigators who focus on transfusion medicine, blood conservation and hemostasis to improve outcomes in critically ill children.

Autism Treatment Network

ATN is a collaboration of medical centers dedicated to providing high-quality, multi-disciplinary, coordinated medical care for children and adolescents with autism and associated conditions.

Fellowship Research

View research projects of current and past fellows.