Skip to content
Home
Glynis A. Scott, M.D.

Glynis A. Scott, M.D.

About Me

Faculty Appointments

Professor - Department of Dermatology (SMD)

Credentials

Post-doctoral Training & Residency

Fellowship, Dermatopathology, Yale University School of Medicine. 1987 - 1988

Residency, Pathology - Anatomic, Yale University School of Medicine. 1984 - 1987

Internship, Internal Medicine, Albany Medical Center Hospital. 1983 - 1984

Education

MD | Albany Medical College. 1983

Research

There are two major projects on going in my laboratory--the first is the investigation into signaling pathways of prostaglandins in human melanocytes and melanoma, and the second is the role of Plexin receptors in melanocyte and melanoma biology.
Melanocytes are pigment producing cells within th...
There are two major projects on going in my laboratory--the first is the investigation into signaling pathways of prostaglandins in human melanocytes and melanoma, and the second is the role of Plexin receptors in melanocyte and melanoma biology.
Melanocytes are pigment producing cells within the epidermis that are progenitor cells for a deadly cancer, melanoma. The production of melanin by melanocytes is a key function of melanocytes and provides photoprotection to the skin. Prostaglandins (PG) are lipid signaling molecules released by keratinocytes and melanocytes in response to ultraviolet irradiation. Our research focus is on defining signaling intermediates that mediate the effect of the two primary PG in the skin, PGE2 & PGF2?? on melanocyte dendrite extension, growth and pigment production. Our laboratory is also investigating the role of semaphorins and their receptors on melanocyte growth, differentiation, and progression to melanoma. Semaphorins are membrane bound and secreted proteins involved in neuronal pathfinding, that we have recently shown to be involved in melanocyte adhesion and dendrite formation. Our particular focus is on Semaphorin 7A and Semaphorin 4D, and their cognate receptors Plexin C1 and Plexin B1, which are lost during progression of melanocytes to melanoma. Integration of signaling intermediates with biologic functions such as proliferation, apoptosis and migration, allow us to dissect the function of PG and semaphorins in melanocyte, and to link signaling by specific receptors to downstream biologic targets important for skin pigmentation and melanoma progression.

Patents

Small Molecule Modulators of Melanin Expression

Issue date: October 20, 2015

Patent #: 9,162,984

Country: United States

Inventors: Peter Gareiss, Brian R McNaughton, Benjamin Locke Miller, Glynis A Scott

Publications

Journal Articles

A case of concurrent systemic sclerosis and scleredema.

Mitchell DC, Agnihothri R, Scott GA, Korman B, Richardson CT

JAAD case reports.. 2019 November 5 (11):940-942. Epub 10/24/2019.

An atypical clinical presentation of alopecia in 2 patients with systemic lupus erythematosus.

Lerman I, Agnihothri R, Scott GA, Richardson CT

JAAD case reports.. 2019 November 5 (11):953-956. Epub 10/24/2019.

Pigmented epithelioid melanocytoma (animal-type melanoma): An institutional experience.

Bax MJ, Brown MD, Rothberg PG, Laughlin TS, Scott GA

Journal of the American Academy of Dermatology.. 2017 August 77 (2):328-332. Epub 04/14/2017.

Isolating Fc-Tagged SEMA4D Recombinant Protein from 293FT Cells.

Soong J, Scott GA

Methods in molecular biology.. 2017 1493 :29-40. Epub 1900 01 01.

Metastatic rectal adenocarcinoma and anal squamous cell carcinoma masquerading as vulvar lymphangioma circumscriptum.

Soh JM, Scott GA, Pavlovitz BT, Mercurio MG

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.. 2016 October 36 (7):876-878. Epub 09/10/2016.

Cutaneous mucinosis of infancy.

Reddy SC, Baman JR, Morrison CS, Scott GA

JAAD case reports.. 2016 May 2 (3):250-2. Epub 06/27/2016.

Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature.

Barrett MM, Strikwerda AM, Somers K, Beck LA, Scott GA

Pediatric dermatology.. 2016 33 (2):e52-6. Epub 01/14/2016.

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma.

Scott GA, Laughlin TS, Rothberg PG

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2014 April 27 (4):516-23. Epub 09/13/2013.

Outbreak of Mycobacterium chelonae infection associated with tattoo ink.

Kennedy BS, Bedard B, Younge M, Tuttle D, Ammerman E, Ricci J, Doniger AS, Escuyer VE, Mitchell K, Noble-Wang JA, O'Connell HA, Lanier WA, Katz LM, Betts RF, Mercurio MG, Scott GA, Lewis MA, Goldgeier MH

The New England journal of medicine.. 2012 September 13367 (11):1020-4. Epub 08/22/2012.

Sema4D, the ligand for Plexin B1, suppresses c-Met activation and migration and promotes melanocyte survival and growth.

Soong J, Chen Y, Shustef EM, Scott GA

The Journal of investigative dermatology.. 2012 April 132 (4):1230-8. Epub 12/22/2011.

Primary cutaneous Nocardia brasiliensis infection isolated in an immunosuppressed patient: a case report.

Lai KW, Brodell LA, Lambert E, Menegus M, Scott GA, Tu JH

Cutis.. 2012 February 89 (2):75-7. Epub 1900 01 01.

Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor.

Pryor JG, Brown-Kipphut BA, Iqbal A, Scott GA

The American Journal of dermatopathology.. 2011 December 33 (8):780-5. Epub 1900 01 01.

Diagnostic utility of IMP3 in segregating metastatic melanoma from benign nevi in lymph nodes.

Mentrikoski MJ, Ma L, Pryor JG, McMahon LA, Yang Q, Spaulding BO, Scott GA, Wang HL, Xu H

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2009 December 22 (12):1582-7. Epub 09/04/2009.

A potent activator of melanogenesis identified from small-molecule screening.

McNaughton BR, Gareiss PC, Jacobs SE, Fricke AF, Scott GA, Miller BL

ChemMedChem.. 2009 October 4 (10):1583-9. Epub 1900 01 01.

Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression.

Scott GA, McClelland LA, Fricke AF, Fender A

The Journal of investigative dermatology.. 2009 April 129 (4):954-63. Epub 11/06/2008.

Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas.

Pryor JG, Simon RA, Bourne PA, Spaulding BO, Scott GA, Xu H

Human pathology.. 2009 February 40 (2):238-43. Epub 10/05/2008.

Glioblastoma multiforme in skin: a report of 2 cases and review of the literature.

Mentrikoski M, Johnson MD, Korones DN, Scott GA

The American Journal of dermatopathology.. 2008 August 30 (4):381-4. Epub 1900 01 01.

IMP-3 is a novel progression marker in malignant melanoma.

Pryor JG, Bourne PA, Yang Q, Spaulding BO, Scott GA, Xu H

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2008 April 21 (4):431-7. Epub 01/18/2008.

Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins.

Scott GA, McClelland LA, Fricke AF

The Journal of investigative dermatology.. 2008 January 128 (1):151-61. Epub 08/02/2007.

Congenital leukemia cutis.

Fender AB, Gust A, Wang N, Scott GA, Mercurio MG

Pediatric dermatology.. 2008 25 (1):34-7. Epub 1900 01 01.

Nephrogenic systemic fibrosis: a clinicopathologic study of six cases.

Pryor JG, Poggioli G, Galaria N, Gust A, Robison J, Samie F, Hanjani NM, Scott GA

Journal of the American Academy of Dermatology.. 2007 July 57 (1):105-11. Epub 04/06/2007.

Lysophosphatidylcholine mediates melanocyte dendricity through PKCzeta activation.

Scott GA, Arioka M, Jacobs SE

The Journal of investigative dermatology.. 2007 March 127 (3):668-75. Epub 10/05/2006.

sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanism.

Scott GA, Jacobs SE, Pentland AP

The Journal of investigative dermatology.. 2006 April 126 (4):855-61. Epub 1900 01 01.

Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five cases.

Cooper JZ, Newman SR, Scott GA, Brown MD

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].. 2005 February 31 (2):221-5; discussion 225. Epub 1900 01 01.

Leukemia cutis at the site of trauma in a patient with Burkitt leukemia.

Burns CA, Scott GA, Miller CC

Cutis.. 2005 January 75 (1):54-6. Epub 1900 01 01.

Self-healing juvenile cutaneous mucinosis.

Cowen EW, Scott GA, Mercurio MG

Journal of the American Academy of Dermatology.. 2004 May 50 (5 Suppl):S97-100. Epub 1900 01 01.

Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.

Nieves DS, Phipps RP, Pollock SJ, Ochs HD, Zhu Q, Scott GA, Ryan CK, Kobayashi I, Rossi TM, Goldsmith LA

Archives of dermatology.. 2004 April 140 (4):466-72. Epub 1900 01 01.

Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition.

Pentland AP, Schoggins JW, Scott GA, Khan KN, Han R

Carcinogenesis.. 1999 October 20 (10):1939-44. Epub 1900 01 01.

Melanocytes adhere to and synthesize laminin-5 in vitro.

Scott GA, Cassidy L, Tran H, Rao SK, Marinkovich MP

Experimental dermatology.. 1999 June 8 (3):212-21. Epub 1900 01 01.

Rac1 mediates dendrite formation in response to melanocyte stimulating hormone and ultraviolet light in a murine melanoma model.

Scott GA, Cassidy L

The Journal of investigative dermatology.. 1998 August 111 (2):243-50. Epub 1900 01 01.

Malignant fibrous tumors.

Stadler FJ, Scott GA, Brown MD

Seminars in cutaneous medicine and surgery.. 1998 June 17 (2):141-52. Epub 1900 01 01.

Multiple chemical sensitivities, including iatrogenic allergic contact dermatitis, in a patient with chronic actinic dermatitis: implications for management.

Stitt WZ, Scott GA, Martin RE, Gaspari AA

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.. 1996 September 7 (3):166-70. Epub 1900 01 01.

Developmental regulation of focal contact protein expression in human melanocytes.

Scott GA, Liang H, Cassidy LL

Pigment cell research. 1995 August 8 (4):221-8. Epub 1900 01 01.

Picture of the month. Monilethrix.

Zalka AD, Goldsmith LA, Scott GA, Tunnessen WW

Archives of pediatrics & adolescent medicine.. 1995 May 149 (5):549-50. Epub 1900 01 01.

Report of three cases of cutaneous reactions to granulocyte macrophage-colony-stimulating factor and a review of the literature.

Scott GA

The American Journal of dermatopathology.. 1995 April 17 (2):107-14. Epub 1900 01 01.

Homeobox genes and skin development: a review.

Scott GA, Goldsmith LA

The Journal of investigative dermatology.. 1993 July 101 (1):3-8. Epub 1900 01 01.

Clear cell sarcoma of tendons and aponeuroses and malignant blue nevus arising in prepubescent children. Report of two cases and review of the literature.

Scott GA, Trepeta R

The American Journal of dermatopathology.. 1993 April 15 (2):139-45. Epub 1900 01 01.

Keratinocytes regulate melanocyte number in human fetal and neonatal skin equivalents.

Scott GA, Haake AR

The Journal of investigative dermatology.. 1991 November 97 (5):776-81. Epub 1900 01 01.

Diagnosis of cutaneous cytomegalovirus infection: a review and report of a case.

Toome BK, Bowers KE, Scott GA

Journal of the American Academy of Dermatology.. 1991 May 24 (5 Pt 2):860-7. Epub 1900 01 01.

Physiologic distribution and differentiation of melanocytes in human fetal and neonatal skin equivalents.

Haake AR, Scott GA

The Journal of investigative dermatology.. 1991 January 96 (1):71-7. Epub 1900 01 01.

Development of human fetal skin transplanted to the nude mouse.

Lane AT, Scott GA, Day KH

The Journal of investigative dermatology.. 1989 December 93 (6):787-91. Epub 1900 01 01.

Locations

400 Red Creek Drive, Suite 200
Rochester, NY 14623