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Brendan F. Boyce, M.B.Ch.B.

Brendan F. Boyce, M.B.Ch.B.

UR Medicine Labs

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Contact

Appointment (585) 275-3202
Office (585) 275-5837
Fax (585) 276-2832
Administrative (585) 275-5892

About Me

Professor, Pathology & Laboratory Medicine. An internationally recognized expert in bone biology, osteoporosis, and metabolic bone disease, Dr. Boyce is also a diagnostic surgical pathologist with a sub-specialty interest in bone and soft tissue pathology. He served as Director of Surgical Pathology...
Professor, Pathology & Laboratory Medicine. An internationally recognized expert in bone biology, osteoporosis, and metabolic bone disease, Dr. Boyce is also a diagnostic surgical pathologist with a sub-specialty interest in bone and soft tissue pathology. He served as Director of Surgical Pathology from 1999-2007, Director of Anatomic Pathology from 2007-13 and Vice Chair for Anatomic Pathology 2013-2016. His research laboratory studies regulatory mechanisms controlling osteoblast and osteoclast formation and function, in particular where there is the potential for development of new therapeutics for preventing or treating osteoporosis. He was the first to report osteoclast apoptosis in 1996, and has been funded continuously since then by the NIH to study the mechanisms that regulate the formation and activation of osteoclasts, which are essential for bone modeling and remodeling and mediate bone loss in common bone diseases, including rheumatoid arthritis and postmenopausal and age-related osteoporosis.

Faculty Appointments

Professor (Part-Time) - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Residency & Fellowship

Fellowship, Pathology, Glasgow Royal Infirmary (United Kingdom). 1979 - 1982

Internship, Surgery (General Surgery), Glasgow Royal Infirmary (United Kingdom). 1973 - 1973

Residency, Pathology, Glasgow Royal Infirmary (United Kingdom). 1973 - 1979

Internship, Internal Medicine, Western Infirmary (Scotland). 1972 - 1973

Education

MBBCH | University of Glasgow (United Kingdom). 1972

Awards

Secretary/Treasurer, American Society for Bone & Mineral Research. 2011 - 2013

Treasurer, United States Biological Stain Commission. 2010

Member, Executive Committee, American Society for Bone & Mineral Research. 2010 - 2013

Secretary/Treasurer-Elect, American Society for Bone & Mineral Research. 2010 - 2011

Chair, Gordon Research Conference on Bones and Teeth. 2009

Treasurer, International Society of Bone Morphometry. 2009 - 2012

Vice Chair, Gordon Research Conference on Bone and Teeth. 2007

Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab). 2007

Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Qian Zhang (post-doc fellow in my lab). 2005

Young Investigator of Year Award from International Society of Bone Morphometry to Dr. Zhenqiang Yao (post-doc fellow in my lab). 2005

Secretary/Treasurer, Association of Osteobiology. 2003 - 2006

President International Society of Bone Morphometry. 2002 - 2006

Council Member Association of Osteobiology. 2001 - 2007

Travel Award From American Society for Bone and Mineral Research to Dr. Lianping Xing from my lab. 2000

Member, Board of Directors International Society of Bone Morphometry. 1999

New Investigator Award From Orthopaedic Research Society to Dr. Lianping Xing (post-doctoral fellow in my lab). 1999

Travel Award From American Society for Bone and Mineral Research to Dr. Sheela Rani (post-doctoral fellow in my lab). 1998

Most Outstanding Abstract of Mtg President's Award fr. Amer. Soc Bone & Min Res Drs L Xing, G Franzoso, U Siebenlist & BF Boyce. 1997

Young Investigator of Year Award fr Amer. Society for Bone & Mineral Research to Dr. Lianping Xing (post-doc fellow in my lab). 1996

Young Investigator of Year Award from Amer. Society for Bone & Mineral Research to Dr. Hong Chen (post-doc fellow in my lab). 1993

Peel International Research Fellowship (London, England). 1986 - 1987

Pathological Society Travel Award (London, England). 1986 - 1987

McCunn Trust Traveling Fellowship (Glasgow, Scotland). 1986 - 1987

Jean Mackintosh Traveling Research Fellowship (Glasgow, Scotland). 1977

Research

The major focus of research in my lab is study of the role of NF-kappaB signaling in the regulation of formation, activation and survival of osteoclasts, the cells that resorb bone, and in the formation of osteoblasts, the cells that make new bone matrix. In the past 26 years since we discovered wit...
The major focus of research in my lab is study of the role of NF-kappaB signaling in the regulation of formation, activation and survival of osteoclasts, the cells that resorb bone, and in the formation of osteoblasts, the cells that make new bone matrix. In the past 26 years since we discovered with colleagues at the NIH that NF-kappaB signaling is essential for osteoclast formation, many genes have been identified as regulators of these aspects of osteoclast function. Our studies presently are focused on the roles of NF-kappaB signaling in age-related bone loss. My colleagues, Dr. Lianping Xing and Zhenqiang Yao, and I, along with members of the Center for Musculoskeletal Research at the University Medical Center, are studying how increased NF-kappaB signaling mediates the increased bone resorption and decreased bone formation that characterize a number of bone diseases, including postmenopausal and age-related osteoporosis, inflammatory joint disease, and metastatic bone disease. We are also studying how to repurpose a number of FDA-approved drugs and small molecules that we have shown can interfere with aberrantly enhanced NF-kappaB signaling to prevent bone resorption and stimulate bone formation, using a number of models of human bone diseases. We acknowledge funding from the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute on Aging at the National Institutes of Health and New York State for support of our studies.

Patents

Methods and Compositions for Treating Inflammatory Conditions

Issue date: November 12, 2013

Patent #: 8,580,755

Country: United States

Inventors: Brendan Boyce, Edward Michael Schwarz, Lianping Xing

Phosphonate-Chloroquine Conjugates and Methods Using Same

Issue date: May 26, 2020

Patent #: 10,660,884

Country: United States

Inventors: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Zhenqiang Yao

Bortezomib Conjugates and Methods Using Same

Issue date: February 26, 2020

Patent #: 3371203

Country: Europe

Inventors: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Bortezomib Conjugates and Methods Using Same

Issue date: February 26, 2020

Patent #: FR3371203

Country: France

Inventors: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Bortezomib Conjugates and Methods Using Same

Issue date: February 26, 2020

Patent #: DE3371203

Country: Germany

Inventors: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Bortezomib Conjugates and Methods Using Same

Issue date: February 26, 2020

Patent #: GB3371203

Country: United Kingdom

Inventors: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Publications

Journal Articles

Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis.

Faust HJ, Cheng TY, Korsunsky I, Watts GFM, Gal-Oz ST, Trim WV, Kongthong S, Jonsson AH, Simmons DP, Zhang F, Padera R, Chubinskaya S, , Wei K, Raychaudhuri S, Lynch L, Moody DB, Brenner MB

Nature communications.. 2024 November 1415 (1):9859. Epub 11/14/2024.

A Novel Rat Model to Simulate Positive Margins in the Wound Bed of a Resected Sarcoma.

Singh G, Kaymakcalan O, Hays TR, Abbas A, Sridevan S, Kaur J, Rathi S, Marquez J, Ghazizadeh S, Tavernier F, Boyce BF, Khan SU, Khan FA, Bui DT, Dagum AB

Plastic and reconstructive surgery. Global open.. 2024 November 12 (11):e6317. Epub 11/27/2024.

Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects.

Yao Z, Ayoub A, Srinivasan V, Wu J, Tang C, Duan R, Milosavljevic A, Xing L, Ebetino FH, Frontier AJ, Boyce BF

Bone research.. 2024 September 512 (1):52. Epub 09/05/2024.

Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue.

Bell RD, Brendel M, Konnaris MA, Xiang J, Otero M, Fontana MA, Bai Z, , Krenitsky DM, Meednu N, Rangel-Moreno J, Scheel-Toellner D, Carr H, Nayar S, McMurray J, DiCarlo E, Anolik JH, Donlin LT, Orange DE, Kenney HM, Schwarz EM, Filer A, Ivashkiv LB, Wang F

Nature communications.. 2024 August 2915 (1):7503. Epub 08/29/2024.

Chimeric antigen receptor dendritic cells targeted delivery of a single tumoricidal factor for cancer immunotherapy.

Duan R, Milton P, Sittplangkoon C, Liu X, Sui Z, Boyce BF, Yao Z

Cancer immunology, immunotherapy : CII.. 2024 August 673 (10):203. Epub 08/06/2024.

Publisher Correction: Interferon subverts an AHR-JUN axis to promote CXCL13 T cells in lupus.

Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S, Skidanova V, Li Z, Adejoorin I, Dillon E, Benque IJ, Nunez DP, Simmons DP, Keegan J, Chen L, Baker T, Brohawn PZ, Al-Mossawi H, Hao LY, Jones B, Rao N, Qu Y, Alves SE, , Jonsson AH, Shaw KS, Vleugels RA, Massarotti E, Costenbader KH, Brenner MB, Lederer JA, Hultquist JF, Choi J, Rao DA

Nature.. 2024 August 632 (8025):E6. Epub 1900 01 01.

Celebrating 50-years: the history and future of the International Society of Bone Morphometry.

Scheller EL, McDonald M, Andersen TL, Sumner DR, Noda M, Erben RG, Boyce BF, Compston JE, Dempster DW, Takahashi HE, Malluche HH, Wronski TJ

JBMR plus.. 2024 July 8 (7):ziae070. Epub 06/12/2024.

Interferon subverts an AHR-JUN axis to promote CXCL13 T cells in lupus.

Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S, Skidanova V, Li Z, Adejoorin I, Dillon E, Benque IJ, Nunez DP, Simmons DP, Keegan J, Chen L, Baker T, Brohawn PZ, Al-Mossawi H, Hao LY, Jones B, Rao N, Qu Y, Alves SE, , Jonsson AH, Shaw KS, Vleugels RA, Massarotti E, Costenbader KH, Brenner MB, Lederer JA, Hultquist JF, Choi J, Rao DA

Nature.. 2024 July 631 (8022):857-866. Epub 07/10/2024.

Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.

Dunlap G, Wagner A, Meednu N, Wang R, Zhang F, Ekabe JC, Jonsson AH, Wei K, Sakaue S, Nathan A, , Bykerk VP, Donlin LT, Goodman SM, Firestein GS, Boyle DL, Holers VM, Moreland LW, Tabechian D, Pitzalis C, Filer A, Raychaudhuri S, Brenner MB, Thakar J, McDavid A, Rao DA, Anolik JH

Nature communications.. 2024 June 1115 (1):4991. Epub 06/11/2024.

The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis.

Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Al Suqri M, Zhu Z, , Rao DA, Anolik JH, Brenner MB, Donlin LT, Wei K, Raychaudhuri S

Nature communications.. 2024 May 3115 (1):4650. Epub 05/31/2024.

Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.

Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E, DiCarlo E, Gravallese EM, Smith MH, , Frank MO, Jiang CS, Zhang H, Pyrgaki C, Lewis MJ, Sikandar S, Pitzalis C, Lesnak JB, Mazhar K, Price TJ, Malfait AM, Miller RE, Zhang F, Goodman S, Darnell RB, Wang F, Orange DE

Science translational medicine.. 2024 April 1016 (742):eadk3506. Epub 04/10/2024.

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.

Sakaue S, Weinand K, Isaac S, Dey KK, Jagadeesh K, Kanai M, Watts GFM, Zhu Z, , Brenner MB, McDavid A, Donlin LT, Wei K, Price AL, Raychaudhuri S

Nature genetics.. 2024 April 56 (4):615-626. Epub 04/09/2024.

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.

Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W, Watts GFM, Weisenfeld D, Nayar S, Rangel-Moreno J, Meednu N, Marks KE, Mantel I, Kang JB, Rumker L, Mears J, Slowikowski K, Weinand K, Orange DE, Geraldino-Pardilla L, Deane KD, Tabechian D, Ceponis A, Firestein GS, Maybury M, Sahbudin I, Ben-Artzi A, Mandelin AM, Nerviani A, Lewis MJ, Rivellese F, Pitzalis C, Hughes LB, Horowitz D, DiCarlo E, Gravallese EM, Boyce BF, , Moreland LW, Goodman SM, Perlman H, Holers VM, Liao KP, Filer A, Bykerk VP, Wei K, Rao DA, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S

Nature.. 2023 November 623 (7987):616-624. Epub 11/08/2023.

TGF?1CCR5 neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice.

Li J, Yao Z, Liu X, Duan R, Yi X, Ayoub A, Sanders JO, Mesfin A, Xing L, Boyce BF

Nature communications.. 2023 January 1114 (1):159. Epub 01/11/2023.

TGF? priming promotes TNF-induced bone erosion: a promising new target in RA?

Yao Z, Boyce BF

Nature reviews. Rheumatology.. 2022 November 18 (11):617-618. Epub 1900 01 01.

HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia.

Dong Q, Xiu Y, Wang Y, Hodgson C, Borcherding N, Jordan C, Buchanan J, Taylor E, Wagner B, Leidinger M, Holman C, Thiele DJ, O'Brien S, Xue HH, Zhao J, Li Q, Meyerson H, Boyce BF, Zhao C

Nature communications.. 2022 October 1613 (1):6107. Epub 10/16/2022.

Glomus Tumor of the Lower Extremity Previously Misdiagnosed as Complex Regional Pain Syndrome in Close Proximity to a Myxofibrosarcoma: A Case Report.

Nazemi AK, Grossi J, Tavernier FB, Boyce BF, Komatsu DE, Khan FA

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews.. 2022 July 16 (7)Epub 07/06/2022.

Age-associated callus senescent cells produce TGF-?1 that inhibits fracture healing in aged mice.

Liu J, Zhang J, Lin X, Boyce BF, Zhang H, Xing L

The Journal of clinical investigation.. 2022 April 15132 (8)Epub 1900 01 01.

Bone-Targeted Bortezomib Inhibits Bortezomib-Resistant Multiple Myeloma in Mice by Providing Higher Levels of Bortezomib in Bone.

Tao J, Srinivasan V, Yi X, Zhao Y, Zhang H, Lin X, Zhou X, Boyce BF, Villalta PW, Ebetino FH, Ho KK, Boeckman RK, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2022 April 37 (4):629-642. Epub 01/22/2022.

Aged Callus Skeletal Stem/Progenitor Cells Contain an Inflammatory Osteogenic Population With Increased IRF and NF-?B Pathways and Reduced Osteogenic Potential.

Lin X, Zhang H, Liu J, Wu CL, McDavid A, Boyce BF, Xing L

Frontiers in molecular biosciences.. 2022 9 :806528. Epub 06/09/2022.

Intraligamentous synovial osteochondroma of the ligamentum teres: a series of 14 cases.

Ajabnoor RM, Quinzi DA, Carmody E, Boyce BF

International journal of clinical and experimental pathology.. 2022 15 (7):282-288. Epub 07/15/2022.

TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9.

Zhao J, Xiu Y, Fu L, Dong Q, Borcherding N, Wang Y, Li Q, De Silva NS, Klein U, Boyce BF, Zhao C

iScience.. 2021 December 1724 (12):103425. Epub 11/12/2021.

IKK?-NF-?B signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice.

Catheline SE, Bell RD, Oluoch LS, James MN, Escalera-Rivera K, Maynard RD, Chang ME, Dean C, Botto E, Ketz JP, Boyce BF, Zuscik MJ, Jonason JH

Science signaling.. 2021 September 2114 (701):eabf3535. Epub 09/21/2021.

The E3 ubiquitin ligase Itch limits the progression of post-traumatic osteoarthritis in mice by inhibiting macrophage polarization.

Lin X, Wang W, McDavid A, Xu H, Boyce BF, Xing L

Osteoarthritis and cartilage. 2021 August 29 (8):1225-1236. Epub 04/30/2021.

Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting.

Cole CL, Bachman JF, Ye J, Murphy J, Gerber SA, Beck CA, Boyce BF, Muthukrishnan G, Chakkalakal JV, Schwarz EM, Linehan D

Journal of cachexia, sarcopenia and muscle.. 2021 June 12 (3):731-745. Epub 05/07/2021.

Bisphosphonates for delivering drugs to bone.

Sun S, Tao J, Sedghizadeh PP, Cherian P, Junka AF, Sodagar E, Xing L, Boeckman RK, Srinivasan V, Yao Z, Boyce BF, Lipe B, Neighbors JD, Russell G, McKenna CE, Ebetino FH

British journal of pharmacology.. 2021 May 178 (9):2008-2025. Epub 04/10/2021.

Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant-associated bone infection in mice.

Masters EA, Hao SP, Mark Kenney H, Morita Y, Galloway CA, de Mesy Bentley KL, Ricciardi BF, Boyce BF, Schwarz EM, Oh I

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2021 February 39 (2):389-401. Epub 12/29/2020.

Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons.

Nat Neurosci. 2021; 21 ;24(5): :667-676.doi: 10.1038/s41593-021-00814-8. Epub 2021 Mar 15. Erra.

RANKL-Based Osteoclastogenic Assay from Murine Bone Marrow Cells.

Yao Z, Xing L, Boyce BF

Methods in molecular biology.. 2021 2230 :457-465. Epub 1900 01 01.

Classification of Soft Tissue Sarcoma Specimens with Raman Spectroscopy as Smart Sensing Technology.

Li L, Mustahsan VM, He G, Tavernier FB, Singh G, Boyce BF, Khan F, Kao I

Cyborg and bionic systems.. 2021 2021 :9816913. Epub 12/06/2021.

CLL dedifferentiation to clonally related myeloid cells.

Dong Q, Xiu Y, Bossler A, Syrbu S, Wang H, Xue W, Zhao J, Li Q, Jin M, Wang L, Boyce B, Sakr H, Ansari MQ, Zhao C

Blood advances.. 2020 December 224 (24):6169-6174. Epub 1900 01 01.

Targeting anti-cancer agents to bone using bisphosphonates.

Xing L, Ebetino FH, Boeckman RK, Srinivasan V, Tao J, Sawyer TK, Li J, Yao Z, Boyce BF

Bone.. 2020 September 138 :115492. Epub 06/23/2020.

Ubiquitination of interleukin-1? is associated with increased pro-inflammatory polarization of murine macrophages deficient in the E3 ligase ITCH.

Lin X, Zhang H, Boyce BF, Xing L

The Journal of biological chemistry.. 2020 August 14295 (33):11764-11775. Epub 06/25/2020.

IFN- and TNF- drive a + + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation.

Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A, , Donlin LT, Raychaudhuri S

bioRxiv : the preprint server for biology.. 2020 August 5 Epub 08/05/2020.

TNF Receptor-Associated Factor 6 Mediates TNF?-Induced Skeletal Muscle Atrophy in Mice During Aging.

Li J, Yi X, Yao Z, Chakkalakal JV, Xing L, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 August 35 (8):1535-1548. Epub 04/27/2020.

Surgical management of aggressive hemangiomas of the spine.

Qiu B, Joo P, Ajabnoor R, Boyce B, Mesfin A

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.. 2020 August 78 :67-72. Epub 07/01/2020.

Notch signalling drives synovial fibroblast identity and arthritis pathology.

Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB

Nature.. 2020 June 582 (7811):259-264. Epub 04/22/2020.

The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice.

Lei W, Duan R, Li J, Liu X, Huston A, Boyce BF, Yao Z

Scientific reports.. 2020 April 2410 (1):7004. Epub 04/24/2020.

Targeting Bortezomib to Bone Increases Its Bone Anabolic Activity and Reduces Systemic Adverse Effects in Mice.

Wang H, Zhang H, Srinivasan V, Tao J, Sun W, Lin X, Wu T, Boyce BF, Ebetino FH, Boeckman RK, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 February 35 (2):343-356. Epub 11/19/2019.

Coactivation of NF-?B and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion.

Xiu Y, Dong Q, Fu L, Bossler A, Tang X, Boyce B, Borcherding N, Leidinger M, Sardina JL, Xue HH, Li Q, Feldman A, Aifantis I, Boccalatte F, Wang L, Jin M, Khoury J, Wang W, Hu S, Yuan Y, Wang E, Yuan J, Janz S, Colgan J, Habelhah H, Waldschmidt T, Müschen M, Bagg A, Darbro B, Zhao C

Blood.. 2020 January 9135 (2):108-120. Epub 1900 01 01.

Avian Reticuloendotheliosis Viral Oncogene Related B Regulates Lymphatic Endothelial Cells during Vessel Maturation and Is Required for Lymphatic Vessel Function in Adult Mice.

Liang Q, Zhang L, Wood RW, Ji RC, Boyce BF, Schwarz EM, Wang Y, Xing L

The American journal of pathology.. 2019 December 189 (12):2516-2530. Epub 09/17/2019.

Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice.

Wang W, Wang H, Zhou X, Li X, Sun W, Dellinger M, Boyce BF, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2019 November 34 (11):2162. Epub 08/02/2019.

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM, Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S

Nature immunology.. 2019 July 20 (7):928-942. Epub 05/06/2019.

TGF?-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.

Li J, Ayoub A, Xiu Y, Yin X, Sanders JO, Mesfin A, Xing L, Yao Z, Boyce BF

Nature communications.. 2019 June 2610 (1):2795. Epub 06/26/2019.

Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy".

Masters EA, Trombetta RP, de Mesy Bentley KL, Boyce BF, Gill AL, Gill SR, Nishitani K, Ishikawa M, Morita Y, Ito H, Bello-Irizarry SN, Ninomiya M, Brodell JD, Lee CC, Hao SP, Oh I, Xie C, Awad HA, Daiss JL, Owen JR, Kates SL, Schwarz EM, Muthukrishnan G

Bone research.. 2019 7 :20. Epub 07/15/2019.

B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation.

Sun W, Meednu N, Rosenberg A, Rangel-Moreno J, Wang V, Glanzman J, Owen T, Zhou X, Zhang H, Boyce BF, Anolik JH, Xing L

Nature communications.. 2018 December 39 (1):5127. Epub 12/03/2018.

Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice.

Wang H, Xiao L, Tao J, Srinivasan V, Boyce BF, Ebetino FH, Oyajobi BO, Boeckman RK, Xing L

Pharmaceutics.. 2018 September 1010 (3)Epub 09/10/2018.

Chordoma of the mobile spine and sacrum: clinical management and prognosis.

D'Amore T, Boyce B, Mesfin A

Journal of spine surgery.. 2018 September 4 (3):546-552. Epub 1900 01 01.

Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue.

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A, , Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH

Arthritis research & therapy.. 2018 July 1120 (1):139. Epub 07/11/2018.

Stabilization of NF-?B-Inducing Kinase Suppresses MLL-AF9-Induced Acute Myeloid Leukemia.

Xiu Y, Dong Q, Li Q, Li F, Borcherding N, Zhang W, Boyce B, Xue HH, Zhao C

Cell reports.. 2018 January 922 (2):350-358. Epub 1900 01 01.

Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption.

Boyce BF, Li J, Xing L, Yao Z

Frontiers in immunology.. 2018 9 :2263. Epub 09/28/2018.

Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis.

Sun W, Zhang H, Wang H, Chiu YG, Ritchlin CT, Kiernan A, Boyce BF, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 July 32 (7):1469-1480. Epub 04/10/2017.

RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors.

Yao Z, Lei W, Duan R, Li Y, Luo L, Boyce BF

The Journal of biological chemistry.. 2017 June 16292 (24):10169-10179. Epub 04/24/2017.

Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice.

Wang W, Wang H, Zhou X, Li X, Sun W, Dellinger M, Boyce BF, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 May 32 (5):939-950. Epub 01/31/2017.

Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid.

Li X, Sun W, Li J, Wang M, Zhang H, Pei L, Boyce BF, Wang Z, Xing L

Scientific reports.. 2017 February 17 :41358. Epub 02/01/2017.

An update on the validation of whole slide imaging systems following FDA approval of a system for a routine pathology diagnostic service in the United States.

Boyce BF

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2017 92 (6):381-389. Epub 08/24/2017.

Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation.

Zhang H, Sun W, Li X, Wang M, Boyce BF, Hilton MJ, Xing L

Bone.. 2016 September 90 :80-9. Epub 06/04/2016.

Chronic tenosynovitis of the hand caused by Mycobacterium heraklionense.

Aburjania N, Hammert WC, Bansal M, Boyce BF, Munsiff SS

International journal of mycobacteriology.. 2016 September 5 (3):273-275. Epub 06/16/2016.

Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice.

Liang Q, Ju Y, Chen Y, Wang W, Li J, Zhang L, Xu H, Wood RW, Schwarz EM, Boyce BF, Wang Y, Xing L

Arthritis research & therapy.. 2016 March 1218 :62. Epub 03/12/2016.

Increased bone density in mice lacking the proton receptor OGR1.

Krieger NS, Yao Z, Kyker-Snowman K, Kim MH, Boyce BF, Bushinsky DA

Kidney international.. 2016 March 89 (3):565-73. Epub 01/06/2016.

Chronic tenosynovitis of the hand caused by Mycobacterium heraklionense.

Aburjania N; Hammert WC; Bansal M; Boyce BF; Munsiff SS.

Int J Mycobacteriol. 2016; : 5(3):273-275 doi.

Analysis of new bone, cartilage, and fibrosis tissue in healing murine allografts using whole slide imaging and a new automated histomorphometric algorithm.

Zhang L, Chang M, Beck CA, Schwarz EM, Boyce BF

Bone research.. 2016 4 :15037. Epub 01/19/2016.

Whole slide imaging: uses and limitations for surgical pathology and teaching.

Boyce BF

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2015 July 90 (5):321-30. Epub 04/22/2015.

High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment.

Shu L, Beier E, Sheu T, Zhang H, Zuscik MJ, Puzas EJ, Boyce BF, Mooney RA, Xing L

Calcified tissue international.. 2015 April 96 (4):313-23. Epub 02/13/2015.

NF-?B-Mediated Regulation of Osteoclastogenesis.

Boyce BF, Xiu Y, Li J, Xing L, Yao Z

Endocrinology and metabolism.. 2015 March 2730 (1):35-44. Epub 1900 01 01.

RelB/p50 complexes regulate cytokine-induced YKL-40 expression.

Bhardwaj R, Yester JW, Singh SK, Biswas DD, Surace MJ, Waters MR, Hauser KF, Yao Z, Boyce BF, Kordula T

The Journal of immunology : official journal of the American Association of Immunologists.. 2015 March 15194 (6):2862-70. Epub 02/13/2015.

TNF Induction of NF-?B RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression.

Zhao Z, Hou X, Yin X, Li Y, Duan R, Boyce BF, Yao Z

PloS one.. 2015 10 (8):e0135728. Epub 08/19/2015.

NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-?B.

Zhang H, Hilton MJ, Anolik JH, Welle SL, Zhao C, Yao Z, Li X, Wang Z, Boyce BF, Xing L

The Journal of clinical investigation.. 2014 July 124 (7):3200-14. Epub 06/02/2014.

NF-?B RelB negatively regulates osteoblast differentiation and bone formation.

Yao Z, Li Y, Yin X, Dong Y, Xing L, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2014 April 29 (4):866-77. Epub 1900 01 01.

Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.

Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS

Bone.. 2014 March 60 :148-61. Epub 12/04/2013.

Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice.

Shi J, Liang Q, Zuscik M, Shen J, Chen D, Xu H, Wang YJ, Chen Y, Wood RW, Li J, Boyce BF, Xing L

Arthritis & rheumatology.. 2014 March 66 (3):657-66. Epub 1900 01 01.

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation.

Xiu Y, Xu H, Zhao C, Li J, Morita Y, Yao Z, Xing L, Boyce BF

The Journal of clinical investigation.. 2014 January 124 (1):297-310. Epub 12/09/2013.

Chondrocyte ?-catenin signaling regulates postnatal bone remodeling through modulation of osteoclast formation in a murine model.

Wang B, Jin H, Zhu M, Li J, Zhao L, Zhang Y, Tang D, Xiao G, Xing L, Boyce BF, Chen D

Arthritis & rheumatology.. 2014 January 66 (1):107-20. Epub 1900 01 01.

The murine femoral bone graft model and a semiautomated histomorphometric analysis tool.

Dhillon RS, Zhang L, Schwarz EM, Boyce BF, Xie C

Methods in molecular biology.. 2014 1130 :45-59. Epub 1900 01 01.

RANKL-based osteoclastogenic assays from murine bone marrow cells.

Xing L, Boyce BF

Methods in molecular biology.. 2014 1130 :307-313. Epub 1900 01 01.

Use of a whole-slide imaging system to assess the presence and alteration of lymphatic vessels in joint sections of arthritic mice.

Shi J, Liang Q, Wang Y, Mooney R, Boyce B, Xing L

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2013 November 88 (8):428-39. Epub 11/23/2012.

Advances in the regulation of osteoclasts and osteoclast functions.

Boyce BF

Journal of dental research.. 2013 October 92 (10):860-7. Epub 08/01/2013.

Ubiquitin E3 ligase Wwp1 negatively regulates osteoblast function by inhibiting osteoblast differentiation and migration.

Shu L, Zhang H, Boyce B, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2013 September 28 (9):1925-35. Epub 1900 01 01.

Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6.

Zhang H, Wu C, Matesic LE, Li X, Wang Z, Boyce BF, Xing L

The Journal of biological chemistry.. 2013 August 2288 (31):22359-68. Epub 06/19/2013.

Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts.

Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2013 April 28 (4):711-22. Epub 1900 01 01.

Mice deficient in NF-kB p50 and p52 ro RANK have defective growth plate formation and post-natal dwarfism.

Xing L, Chen D, Boyce BF.

Bone Res. 2013; 1(4): 336-345.

Osteoclast fusion and regulation by RANKL-dependent and independent factors.

Xing L, Xiu Y, Boyce BF

World journal of orthopedics.. 2012 December 183 (12):212-22. Epub 1900 01 01.

The osteoclast, bone remodelling and treatment of metabolic bone disease.

Boyce BF, Rosenberg E, de Papp AE, Duong LT

European journal of clinical investigation.. 2012 December 42 (12):1332-41. Epub 09/23/2012.

Noncanonical NF-?B signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions.

Zhao C, Xiu Y, Ashton J, Xing L, Morita Y, Jordan CT, Boyce BF

Stem cells.. 2012 April 30 (4):709-18. Epub 1900 01 01.

The challenge and importance of standardizing pre-analytical variables in surgical pathology specimens for clinical care and translational research.

Hicks D, Boyce B

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2012 January 87 (1):14-7. Epub 07/06/2011.

Optimizing the use and applications of special stains: clinical and experimental approaches.

Boyce BF

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2012 January 87 (1):1-2. Epub 07/06/2011.

The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis.

Subik K, Shu L, Wu C, Liang Q, Hicks D, Boyce B, Schiffhauer L, Chen D, Chen C, Tang P, Xing L.

Bone. 2012; 50(4): 813-823.

Polymicrobial periodontal pathogen transcriptomes in calvarial bone and soft tissue.

Bakthavatchalu V, Meka A, Mans JJ, Sathishkumar S, Lopez MC, Bhattacharyya I, Boyce BF, Baker HV, Lamont RJ, Ebersole JL, Kesavalu L

Molecular oral microbiology.. 2011 October 26 (5):303-20. Epub 07/19/2011.

Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice.

Zhou Q, Guo R, Wood R, Boyce BF, Liang Q, Wang YJ, Schwarz EM, Xing L

Arthritis and rheumatism.. 2011 August 63 (8):2318-28. Epub 1900 01 01.

Metabolic bone diseases.

Horvai AE, Boyce BF

Seminars in diagnostic pathology.. 2011 February 28 (1):13-25. Epub 1900 01 01.

Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data.

Boyce B, Xing L.

Clin Investig (Lond). 2011; 1(12): 1695-1706.

Metastasis and bone loss: advancing treatment and prevention.

Coleman RE, Lipton A, Roodman GD, Guise TA, Boyce BF, Brufsky AM, Clézardin P, Croucher PI, Gralow JR, Hadji P, Holen I, Mundy GR, Smith MR, Suva LJ

Cancer treatment reviews.. 2010 December 36 (8):615-20. Epub 05/15/2010.

Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles.

Bakthavatchalu V, Meka A, Sathishkumar S, Lopez MC, Bhattacharyya I, Boyce BF, Mans JJ, Lamont RJ, Baker HV, Ebersole JL, Kesavalu L

Molecular oral microbiology.. 2010 October 25 (5):317-30. Epub 1900 01 01.

Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles.

Bakthavatchalu V, Meka A, Sathishkumar S, Lopez MC, Verma RK, Wallet SM, Bhattacharyya I, Boyce BF, Mans JJ, Lamont RJ, Baker HV, Ebersole JL, Kesavalu L

Molecular oral microbiology.. 2010 August 25 (4):260-74. Epub 1900 01 01.

Dominant TRPV4 mutations in nonlethal and lethal metatropic dysplasia.

Camacho N, Krakow D, Johnykutty S, Katzman PJ, Pepkowitz S, Vriens J, Nilius B, Boyce BF, Cohn DH

American journal of medical genetics. Part A.. 2010 May 152A (5):1169-77. Epub 1900 01 01.

Functions of nuclear factor kappaB in bone.

Boyce BF, Yao Z, Xing L

Annals of the New York Academy of Sciences.. 2010 March 1192 :367-75. Epub 1900 01 01.

Porphyromonas gingivalis infection-induced tissue and bone transcriptional profiles.

Meka A, Bakthavatchalu V, Sathishkumar S, Lopez MC, Verma RK, Wallet SM, Bhattacharyya I, Boyce BF, Handfield M, Lamont RJ, Baker HV, Ebersole JL, Kesavalu L

Molecular oral microbiology.. 2010 February 25 (1):61-74. Epub 1900 01 01.

The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis.

Schwarz EM, Proulx ST, Ritchlin CT, Boyce BF, Xing L

Advances in experimental medicine and biology.. 2010 658 :1-10. Epub 1900 01 01.

Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice.

Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, Chen D

Journal of cell science.. 2009 October 1122 (Pt 19):3566-78. Epub 09/08/2009.

NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism.

Yao Z, Xing L, Boyce BF

The Journal of clinical investigation.. 2009 October 119 (10):3024-34. Epub 09/21/2009.

Stomaching calcium for bone health.

Boyce BF

Nature medicine.. 2009 June 15 (6):610-2. Epub 1900 01 01.

Sphingosine-1 phosphate: a new player in osteoimmunology.

Boyce BF

Developmental cell.. 2009 March 16 (3):323-4. Epub 1900 01 01.

Disruption of Rankl/Rank Signaling Reduces TNF-Induced Joint Inflammation in Vivo.

Yao Z, Li P, Zhang Q, Guo R, Schwarz EM, Boyce BF, Xing L.

Open Arthritis Journal. 2009; 2: 7-13.

Reduced COX-2 expression in aged mice is associated with impaired fracture healing.

Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ.

J Bone Miner Res. 2009; 24(2): 251-264.

Osteoclasts have multiple roles in bone in addition to bone resorption.

Boyce BF, Yao Z, Xing L

Critical reviews in eukaryotic gene expression.. 2009 19 (3):171-80. Epub 1900 01 01.

Advancing treatment for metastatic bone cancer: consensus recommendations from the Second Cambridge Conference.

Coleman RE, Guise TA, Lipton A, Roodman GD, Berenson JR, Body JJ, Boyce BF, Calvi LM, Hadji P, McCloskey EV, Saad F, Smith MR, Suva LJ, Taichman RS, Vessella RL, Weilbaecher KN

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2008 October 1514 (20):6387-95. Epub 1900 01 01.

Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.

Guo R, Yamashita M, Zhang Q, Zhou Q, Chen D, Reynolds DG, Awad HA, Yanoso L, Zhao L, Schwarz EM, Zhang YE, Boyce BF, Xing L

The Journal of biological chemistry.. 2008 August 22283 (34):23084-92. Epub 06/19/2008.

Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging.

Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Calvi LM, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM

Arthritis and rheumatism.. 2008 July 58 (7):2019-29. Epub 1900 01 01.

Functions of RANKL/RANK/OPG in bone modeling and remodeling.

Boyce BF, Xing L

Archives of biochemistry and biophysics.. 2008 May 15473 (2):139-46. Epub 03/25/2008.

VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism.

Zhang Q, Guo R, Lu Y, Zhao L, Zhou Q, Schwarz EM, Huang J, Chen D, Jin ZG, Boyce BF, Xing L

The Journal of biological chemistry.. 2008 May 9283 (19):13491-9. Epub 03/20/2008.

Inhibition of beta-catenin signaling causes defects in postnatal cartilage development.

Chen M, Zhu M, Awad H, Li TF, Sheu TJ, Boyce BF, Chen D, O'Keefe RJ

Journal of cell science.. 2008 May 1121 (Pt 9):1455-65. Epub 04/08/2008.

Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism.

Yao Z, Xing L, Qin C, Schwarz EM, Boyce BF

The Journal of biological chemistry.. 2008 April 11283 (15):9917-24. Epub 02/04/2008.

Bruton and Tec: new links in osteoimmunology.

Boyce BF, Xing L

Cell metabolism.. 2008 April 7 (4):283-5. Epub 1900 01 01.

Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2.

Usui M, Xing L, Drissi H, Zuscik M, O'Keefe R, Chen D, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2008 March 23 (3):314-25. Epub 1900 01 01.

Dimorphic effects of Notch signaling in bone homeostasis.

Engin F, Yao Z, Yang T, Zhou G, Bertin T, Jiang MM, Chen Y, Wang L, Zheng H, Sutton RE, Boyce BF, Lee B

Nature medicine.. 2008 March 14 (3):299-305. Epub 02/24/2008.

SAR of carbon-linked, 2-substituted purines: synthesis and characterization of AP23451 as a novel bone-targeted inhibitor of Src tyrosine kinase with in vivo anti-resorptive activity.

Shakespeare WC, Wang Y, Bohacek R, Keenan T, Sundaramoorthi R, Metcalf C, Dilauro A, Roeloffzen S, Liu S, Saltmarsh J, Paramanathan G, Dalgarno D, Narula S, Pradeepan S, van Schravendijk MR, Keats J, Ram M, Liou S, Adams S, Wardwell S, Bogus J, Iuliucci J, Weigele M, Xing L, Boyce B, Sawyer TK

Chemical biology & drug design.. 2008 February 71 (2):97-105. Epub 01/03/2008.

TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood.

Zhang Q, Guo R, Schwarz EM, Boyce BF, Xing L

Arthritis research & therapy.. 2008 10 (2):R37. Epub 03/27/2008.

Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography.

Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM

Arthritis and rheumatism.. 2007 December 56 (12):4024-37. Epub 1900 01 01.

MRI and quantification of draining lymph node function in inflammatory arthritis.

Proulx ST, Kwok E, You Z, Beck CA, Shealy DJ, Ritchlin CT, Boyce BF, Xing L, Schwarz EM

Annals of the New York Academy of Sciences.. 2007 November 1117 :106-23. Epub 07/23/2007.

New roles for osteoclasts in bone.

Boyce BF, Yao Z, Zhang Q, Guo R, Lu Y, Schwarz EM, Xing L

Annals of the New York Academy of Sciences.. 2007 November 1116 :245-54. Epub 1900 01 01.

The RANKL/RANK/OPG pathway.

Boyce BF, Xing L

Current osteoporosis reports.. 2007 September 5 (3):98-104. Epub 1900 01 01.

NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1.

Yamashita T, Yao Z, Li F, Zhang Q, Badell IR, Schwarz EM, Takeshita S, Wagner EF, Noda M, Matsuo K, Xing L, Boyce BF

The Journal of biological chemistry.. 2007 June 22282 (25):18245-18253. Epub 05/07/2007.

Pseudoaneurysm of a genicular branch of the popliteal artery and deep venous thrombosis: an unusual presentation of an osteochondroma.

Saad NE, Briones AJ, Rhodes J, Waldman DL, Boyce B, Davies MG

Journal of vascular and interventional radiology : JVIR.. 2007 April 18 (4):581-3. Epub 1900 01 01.

Biology of RANK, RANKL, and osteoprotegerin.

Boyce BF, Xing L

Arthritis research & therapy.. 2007 9 Suppl 1 (Suppl 1):S1. Epub 1900 01 01.

Increased lymphangiogenesis in joints of mice with inflammatory arthritis.

Zhang Q, Lu Y, Proulx ST, Guo R, Yao Z, Schwarz EM, Boyce BF, Xing L

Arthritis research & therapy.. 2007 9 (6):R118. Epub 1900 01 01.

Osteoclasts, no longer osteoblast slaves.

Boyce BF, Xing L

Nature medicine.. 2006 December 12 (12):1356-8. Epub 1900 01 01.

CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta.

Morello R, Bertin TK, Chen Y, Hicks J, Tonachini L, Monticone M, Castagnola P, Rauch F, Glorieux FH, Vranka J, Bächinger HP, Pace JM, Schwarze U, Byers PH, Weis M, Fernandes RJ, Eyre DR, Yao Z, Boyce BF, Lee B

Cell.. 2006 October 20127 (2):291-304. Epub 1900 01 01.

Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference.

Lipton A, Berenson JR, Body JJ, Boyce BF, Bruland OS, Carducci MA, Cleeland CS, Clohisy DR, Coleman RE, Cook RJ, Guise TA, Pearse RN, Powles TJ, Rogers MJ, Roodman GD, Smith MR, Suva LJ, Vessella RL, Weilbaecher KN, King L

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2006 October 1512 (20 Pt 2):6209s-6212s. Epub 1900 01 01.

SRC inhibitors in metastatic bone disease.

Boyce BF, Xing L, Yao Z, Yamashita T, Shakespeare WC, Wang Y, Metcalf CA, Sundaramoorthi R, Dalgarno DC, Iuliucci JD, Sawyer TK

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2006 October 1512 (20 Pt 2):6291s-6295s. Epub 1900 01 01.

Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease.

Boyce BF, Schwarz EM, Xing L

Current opinion in rheumatology.. 2006 July 18 (4):427-32. Epub 1900 01 01.

Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression.

Yao Z, Li P, Zhang Q, Schwarz EM, Keng P, Arbini A, Boyce BF, Xing L

The Journal of biological chemistry.. 2006 April 28281 (17):11846-55. Epub 02/06/2006.

Autoimmunity and bone.

Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT

Annals of the New York Academy of Sciences.. 2006 April 1068 :275-83. Epub 1900 01 01.

Future anti-catabolic therapeutic targets in bone disease.

Boyce BF, Xing L, Yao Z, Shakespeare WC, Wang Y, Metcalf CA, Sundaramoorthi R, Dalgarno DC, Iuliucci JD, Sawyer TK

Annals of the New York Academy of Sciences.. 2006 April 1068 :447-57. Epub 1900 01 01.

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

Kaneki H, Guo R, Chen D, Yao Z, Schwarz EM, Zhang YE, Boyce BF, Xing L

The Journal of biological chemistry.. 2006 February 17281 (7):4326-33. Epub 12/22/2005.

Osteoclast precursors, RANKL/RANK, and immunology.

Xing L, Schwarz EM, Boyce BF

Immunological reviews.. 2005 December 208 :19-29. Epub 1900 01 01.

Osteoprotegerin, the bone protector, is a surprising target for beta-catenin signaling.

Boyce BF, Xing L, Chen D

Cell metabolism.. 2005 December 2 (6):344-5. Epub 1900 01 01.

Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2.

Zhang Q, Badell IR, Schwarz EM, Boulukos KE, Yao Z, Boyce BF, Xing L

Arthritis and rheumatism.. 2005 September 52 (9):2708-18. Epub 1900 01 01.

TNF-alpha and pathologic bone resorption.

Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, O'Keefe RJ, Xing L

The Keio journal of medicine.. 2005 September 54 (3):127-31. Epub 1900 01 01.

Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency.

Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM

Environmental health perspectives.. 2005 June 113 (6):749-55. Epub 1900 01 01.

Regulation of apoptosis in osteoclasts and osteoblastic cells.

Xing L, Boyce BF

Biochemical and biophysical research communications.. 2005 March 18328 (3):709-20. Epub 1900 01 01.

Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.

Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM

Nature medicine.. 2005 March 11 (3):291-7. Epub 02/13/2005.

Roles for NF-kappaB and c-Fos in osteoclasts.

Boyce BF, Yamashita T, Yao Z, Zhang Q, Li F, Xing L

Journal of bone and mineral metabolism.. 2005 23 Suppl :11-5. Epub 1900 01 01.

Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank.

Kapur RP, Yao Z, Iida MH, Clarke CM, Doggett B, Xing L, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2004 October 19 (10):1689-97. Epub 07/21/2004.

RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis.

Li P, Schwarz EM, O'Keefe RJ, Ma L, Boyce BF, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2004 February 19 (2):207-13. Epub 1900 01 01.

Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice.

Li P, Schwarz EM, O'Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L

Arthritis and rheumatism.. 2004 January 50 (1):265-76. Epub 1900 01 01.

NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro.

Feng JQ, Xing L, Zhang JH, Zhao M, Horn D, Chan J, Boyce BF, Harris SE, Mundy GR, Chen D

The Journal of biological chemistry.. 2003 August 1278 (31):29130-5. Epub 05/20/2003.

Regulation of bone remodeling and emerging breakthrough drugs for osteoporosis and osteolytic bone metastases.

Boyce BF, Xing L, Shakespeare W, Wang Y, Dalgarno D, Iuliucci J, Sawyer T

Kidney international. Supplement.. 2003 June (85):S2-5. Epub 1900 01 01.

Bad bones, grey hair, one mutation.

Boyce BF

Nature medicine.. 2003 April 9 (4):395-6. Epub 1900 01 01.

Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption.

Xing L, Carlson L, Story B, Tai Z, Keng P, Siebenlist U, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2003 February 18 (2):260-9. Epub 1900 01 01.

Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues.

Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X, Xing L, Boyce BF, Hung MC, Zhang S, Gan L, Chang C, Hung MC

Proceedings of the National Academy of Sciences of the United States of America.. 2002 October 1599 (21):13498-503. Epub 10/07/2002.

NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis.

Xing L, Bushnell TP, Carlson L, Tai Z, Tondravi M, Siebenlist U, Young F, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 July 17 (7):1200-10. Epub 1900 01 01.

In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis.

Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 February 17 (2):192-9. Epub 1900 01 01.

Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development.

Choi JY, Pratap J, Javed A, Zaidi SK, Xing L, Balint E, Dalamangas S, Boyce B, van Wijnen AJ, Lian JB, Stein JL, Jones SN, Stein GS

Proceedings of the National Academy of Sciences of the United States of America.. 2001 July 1798 (15):8650-5. Epub 07/03/2001.

Src inhibitors: genomics to therapeutics.

Sawyer T, Boyce B, Dalgarno D, Iuliucci J

Expert opinion on investigational drugs.. 2001 July 10 (7):1327-44. Epub 1900 01 01.

Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis.

Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 April 16 (4):660-70. Epub 1900 01 01.

Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival.

Xing L, Venegas AM, Chen A, Garrett-Beal L, Boyce BF, Varmus HE, Schwartzberg PL

Genes & development.. 2001 January 1515 (2):241-53. Epub 1900 01 01.

Decreased c-Src expression enhances osteoblast differentiation and bone formation.

Marzia M, Sims NA, Voit S, Migliaccio S, Taranta A, Bernardini S, Faraggiana T, Yoneda T, Mundy GR, Boyce BF, Baron R, Teti A

The Journal of cell biology.. 2000 October 16151 (2):311-20. Epub 1900 01 01.

A murine model of inflammatory bone disease.

Hentunen TA, Choi SJ, Boyce BF, Dallas MR, Dallas SL, Shen-Ong GL, Roodman GD

Bone.. 2000 February 26 (2):183-8. Epub 1900 01 01.

Bone metastasis: an update on mechanisms of bone resorption and therapeutic strategies.

O'Keefe, RJ; Schwarz, EM; Boyce, BF.

Curr. Opin. Ortho. 2000; 11(5): 353-359.

Stimulation of bone formation in vitro and in rodents by statins.

Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G

Science.. 1999 December 3286 (5446):1946-9. Epub 1900 01 01.

Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption.

Choi SJ, Reddy SV, Devlin RD, Menaa C, Chung H, Boyce BF, Roodman GD

The Journal of biological chemistry.. 1999 September 24274 (39):27747-53. Epub 1900 01 01.

Factors regulating the growth of metastatic cancer in bone.

Boyce BF, Yoneda T, Guise TA

Endocrine-related cancer.. 1999 September 6 (3):333-47. Epub 1900 01 01.

Dental abnormalities associated with failure of tooth eruption in src knockout and op/op mice.

Tiffee JC, Xing L, Nilsson S, Boyce BF

Calcified tissue international.. 1999 July 65 (1):53-8. Epub 1900 01 01.

Required and nonessential functions of nuclear factor-kappa B in bone cells.

Boyce BF, Xing L, Franzoso G, Siebenlist U

Bone.. 1999 July 25 (1):137-9. Epub 1900 01 01.

Systemic administration of acidic fibroblast growth factor (FGF-1) prevents bone loss and increases new bone formation in ovariectomized rats.

Dunstan CR, Boyce R, Boyce BF, Garrett IR, Izbicka E, Burgess WH, Mundy GR

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1999 June 14 (6):953-9. Epub 1900 01 01.

Ibandronate reduces osteolytic lesions but not tumor burden in a murine model of myeloma bone disease.

Dallas SL, Garrett IR, Oyajobi BO, Dallas MR, Boyce BF, Bauss F, Radl J, Mundy GR

Blood.. 1999 March 193 (5):1697-706. Epub 1900 01 01.

Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice.

Zhao W, Byrne MH, Boyce BF, Krane SM

The Journal of clinical investigation.. 1999 February 103 (4):517-24. Epub 1900 01 01.

Recent advances in bone biology provide insight into the pathogenesis of bone diseases.

Boyce BF, Hughes DE, Wright KR, Xing L, Dai A

Laboratory investigation; a journal of technical methods and pathology.. 1999 February 79 (2):83-94. Epub 1900 01 01.

Bone resorption caused by three periodontal pathogens in vivo in mice is mediated in part by prostaglandin.

Zubery Y, Dunstan CR, Story BM, Kesavalu L, Ebersole JL, Holt SC, Boyce BF

Infection and immunity.. 1998 September 66 (9):4158-62. Epub 1900 01 01.

Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice.

Hentunen TA, Reddy SV, Boyce BF, Devlin R, Park HR, Chung H, Selander KS, Dallas M, Kurihara N, Galson DL, Goldring SR, Koop BA, Windle JJ, Roodman GD

The Journal of clinical investigation.. 1998 July 1102 (1):88-97. Epub 1900 01 01.

Estrogen, transforming growth factors-beta and the regulation of bone metabolism in health and disease.

Hughes, DE; Boyce, BF.

Endocrinologist. 1998; 8: 55-61.

Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage.

Taguchi Y, Yamamoto M, Yamate T, Lin SC, Mocharla H, DeTogni P, Nakayama N, Boyce BF, Abe E, Manolagas SC

Proceedings of the Association of American Physicians. 1998 110 (6):559-74. Epub 1900 01 01.

Requirement for NF-kappaB in osteoclast and B-cell development.

Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, Leonardi A, Tran T, Boyce BF, Siebenlist U

Genes & development.. 1997 December 1511 (24):3482-96. Epub 1900 01 01.

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.

Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE

Genes & development.. 1997 November 111 (21):2835-44. Epub 1900 01 01.

Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo.

Uy HL, Mundy GR, Boyce BF, Story BM, Dunstan CR, Yin JJ, Roodman GD, Guise TA

Cancer research.. 1997 August 157 (15):3194-9. Epub 1900 01 01.

Apoptosis in bone physiology and disease.

Hughes DE, Boyce BF

Molecular pathology : MP. 1997 June 50 (3):132-7. Epub 1900 01 01.

Mice lacking 5-lipoxygenase have increased cortical bone thickness.

Bonewald LF, Flynn M, Qiao M, Dallas MR, Mundy GR, Boyce BF

Advances in experimental medicine and biology.. 1997 433 :299-302. Epub 1900 01 01.

Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo.

Garcia C, Boyce BF, Gilles J, Dallas M, Qiao M, Mundy GR, Bonewald LF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1996 November 11 (11):1619-27. Epub 1900 01 01.

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.

Guise TA, Yin JJ, Taylor SD, Kumagai Y, Dallas M, Boyce BF, Yoneda T, Mundy GR

The Journal of clinical investigation.. 1996 October 198 (7):1544-9. Epub 1900 01 01.

Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta.

Hughes DE, Dai A, Tiffee JC, Li HH, Mundy GR, Boyce BF

Nature medicine.. 1996 October 2 (10):1132-6. Epub 1900 01 01.

Metastatic prostate cancer in a transgenic mouse.

Gingrich JR, Barrios RJ, Morton RA, Boyce BF, DeMayo FJ, Finegold MJ, Angelopoulou R, Rosen JM, Greenberg NM

Cancer research.. 1996 September 1556 (18):4096-102. Epub 1900 01 01.

Increased bone formation in osteocalcin-deficient mice.

Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty G

Nature.. 1996 August 1382 (6590):448-52. Epub 1900 01 01.

Development of an in vivo model of human multiple myeloma bone disease.

Alsina M, Boyce B, Devlin RD, Anderson JL, Craig F, Mundy GR, Roodman GD

Blood.. 1996 February 1587 (4):1495-501. Epub 1900 01 01.

A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates.

Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1996 February 11 (2):150-9. Epub 1900 01 01.

Targeting simian virus 40 T antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts.

Boyce BF, Wright K, Reddy SV, Koop BA, Story B, Devlin R, Leach RJ, Roodman GD, Windle JJ

Endocrinology.. 1995 December 136 (12):5751-9. Epub 1900 01 01.

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo.

Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1995 October 10 (10):1478-87. Epub 1900 01 01.

Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.

Sasaki A, Boyce BF, Story B, Wright KR, Chapman M, Boyce R, Mundy GR, Yoneda T

Cancer research.. 1995 August 1555 (16):3551-7. Epub 1900 01 01.

Effects of parathyroid hormone (PTH)-related protein and PTH on osteoclasts and osteoclast precursors in vivo.

Uy HL, Guise TA, De La Mata J, Taylor SD, Story BM, Dallas MR, Boyce BF, Mundy GR, Roodman GD

Endocrinology.. 1995 August 136 (8):3207-12. Epub 1900 01 01.

An in vivo model of human multiple myeloma bone disease.

Alsina M, Boyce BF, Mundy GR, Roodman GD

Stem cells.. 1995 August 13 Suppl 2 :48-50. Epub 1900 01 01.

The effects of cytokines and growth factors on osteoblastic cells.

Mundy GR, Boyce B, Hughes D, Wright K, Bonewald L, Dallas S, Harris S, Ghosh-Choudhury N, Chen D, Dunstan C

Bone.. 1995 August 17 (2 Suppl):71S-75S. Epub 1900 01 01.

The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow.

Mbalaviele G, Chen H, Boyce BF, Mundy GR, Yoneda T

The Journal of clinical investigation.. 1995 June 95 (6):2757-65. Epub 1900 01 01.

Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo.

de la Mata J, Uy HL, Guise TA, Story B, Boyce BF, Mundy GR, Roodman GD

The Journal of clinical investigation.. 1995 June 95 (6):2846-52. Epub 1900 01 01.

Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.

Bellido T, Jilka RL, Boyce BF, Girasole G, Broxmeyer H, Dalrymple SA, Murray R, Manolagas SC

The Journal of clinical investigation.. 1995 June 95 (6):2886-95. Epub 1900 01 01.

Suramin suppresses hypercalcemia and osteoclastic bone resorption in nude mice bearing a human squamous cancer.

Yoneda T, Williams P, Rhine C, Boyce BF, Dunstan C, Mundy GR

Cancer research.. 1995 May 155 (9):1989-93. Epub 1900 01 01.

Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage.

Uy HL, Dallas M, Calland JW, Boyce BF, Mundy GR, Roodman GD

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1995 February 10 (2):295-301. Epub 1900 01 01.

Osteoblastic cell lines from a transgenic mouse containing the osteocalcin promoter T-antigen gene capable of extensive differentiation.

Chen D, Chen H, Feng JQ, Windle JJ, Harris M, Bonewald LF, Boyce BF, Wozney JM, Mundy GR, Harris SE.

Molecular Cell Different. 1995; 3: 193-212.

Extracts of porcine pancreas prevent progression of hypercalcemia and cachexia and prolong survival in nude mice bearing a human squamous carcinoma.

Yoneda T, Takaoka Y, Boyce BF, Scott L, Mundy GR

Cancer research.. 1994 May 154 (9):2509-13. Epub 1900 01 01.

pp60 c-src expression and activity in MG-63 osteoblastic cells modulated by PTH but not required for PTH-mediated adenylate cyclase response.

Izbicka E, Niewolna M, Yoneda T, Lowe C, Boyce B, Mundy G

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1994 January 9 (1):127-32. Epub 1900 01 01.

Mineralisation defects with pamidronate therapy for Paget's disease.

Adamson BB, Gallacher SJ, Byars J, Ralston SH, Boyle IT, Boyce BF

Lancet.. 1993 December 11342 (8885):1459-60. Epub 1900 01 01.

Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.

Lowe C, Yoneda T, Boyce BF, Chen H, Mundy GR, Soriano P

Proceedings of the National Academy of Sciences of the United States of America.. 1993 May 1590 (10):4485-9. Epub 1900 01 01.

Histomorphometric and immunocytochemical studies of src-related osteopetrosis.

Boyce BF, Chen H, Soriano P, Mundy GR

Bone.. 1993 14 (3):335-40. Epub 1900 01 01.

A synthetic antagonist to laminin inhibits the formation of osteolytic metastases by human melanoma cells in nude mice.

Nakai M, Mundy GR, Williams PJ, Boyce B, Yoneda T

Cancer research.. 1992 October 152 (19):5395-9. Epub 1900 01 01.

Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

Boyce BF, Yoneda T, Lowe C, Soriano P, Mundy GR

The Journal of clinical investigation.. 1992 October 90 (4):1622-7. Epub 1900 01 01.

Chinese hamster ovarian cells transfected with human parathyroid hormone-related protein cDNA cause hypercalcemia in nude mice.

Guise TA, Chirgwin JM, Favarato G, Boyce BF, Mundy GR

Laboratory investigation; a journal of technical methods and pathology.. 1992 October 67 (4):477-85. Epub 1900 01 01.

Increased osteoclast development after estrogen loss: mediation by interleukin-6.

Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC

Science.. 1992 July 3257 (5066):88-91. Epub 1900 01 01.

Expression of human transforming growth factor alpha by Chinese hamster ovarian tumors in nude mice causes hypercalcemia and increased osteoclastic bone resorption.

Yates AJ, Boyce BF, Favarato G, Aufdemorte TB, Marcelli C, Kester MB, Walker R, Langton BC, Bonewald LF, Mundy GR

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1992 July 7 (7):847-53. Epub 1900 01 01.

Histological and electron microprobe studies of mineralisation in aluminium-related osteomalacia.

Boyce BF, Byars J, McWilliams S, Mocan MZ, Elder HY, Boyle IT, Junor BJ

Journal of clinical pathology.. 1992 June 45 (6):502-8. Epub 1900 01 01.

Autonomous hyperparathyroidism not associated with increased aluminum absorption.

Mocan MZ, Mocan H, Fell GS, Junor BJ, Boyce BF

Israel journal of medical sciences.. 1992 January 28 (1):24-6. Epub 1900 01 01.

Clinical experience with pamidronate in the treatment of Paget's disease of bone.

Gallacher SJ, Boyce BF, Patel U, Jenkins A, Ralston SH, Boyle IT

Annals of the rheumatic diseases.. 1991 December 50 (12):930-3. Epub 1900 01 01.

Immobilization-related hypercalcaemia--a possible novel mechanism and response to pamidronate.

Gallacher SJ, Ralston SH, Dryburgh FJ, Logue FC, Allam BF, Boyce BF, Boyle IT

Postgraduate medical journal.. 1990 November 66 (781):918-22. Epub 1900 01 01.

Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR

The Journal of clinical investigation.. 1990 March 85 (3):632-9. Epub 1900 01 01.

Bolus injections of recombinant human interleukin-1 cause transient hypocalcemia in normal mice.

Boyce BF, Yates AJ, Mundy GR

Endocrinology.. 1989 November 125 (5):2780-3. Epub 1900 01 01.

Effects of interleukin-1 on bone turnover in normal mice.

Boyce BF, Aufdemorte TB, Garrett IR, Yates AJ, Mundy GR

Endocrinology.. 1989 September 125 (3):1142-50. Epub 1900 01 01.

Tumors producing human tumor necrosis factor induced hypercalcemia and osteoclastic bone resorption in nude mice.

Johnson RA, Boyce BF, Mundy GR, Roodman GD

Endocrinology.. 1989 March 124 (3):1424-7. Epub 1900 01 01.

Contrasting mechanisms of hypercalcemia in patients with early and advanced humoral hypercalcemia of malignancy.

Ralston SH, Boyce BF, Cowan RA, Gardner MD, Fraser WD, Boyle IT

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1989 February 4 (1):103-11. Epub 1900 01 01.

What are the most common errors in the management of renal osteodystrophy?

Boyce, BF; Mocan, MZ; Junor, BJR;.

Sem Dialysis. 1989; 2: 154-156.

Microcytic anemia does not predict aluminium bone disease in chronic renal failure.

Mocan, MZ; Mocan, H; Ozbay, G; Boyce, BF;.

Hacettepe Medical Journal. 1989; 22: 33-38.

Infusions of recombinant human interleukins 1 alpha and 1 beta cause hypercalcemia in normal mice.

Sabatini M, Boyce B, Aufdemorte T, Bonewald L, Mundy GR

Proceedings of the National Academy of Sciences of the United States of America.. 1988 July 85 (14):5235-9. Epub 1900 01 01.

Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents.

Yates AJ, Gutierrez GE, Smolens P, Travis PS, Katz MS, Aufdemorte TB, Boyce BF, Hymer TK, Poser JW, Mundy GR

The Journal of clinical investigation.. 1988 March 81 (3):932-8. Epub 1900 01 01.

Aluminium bone disease in patients receiving plasma exchange with contaminated albumin.

Maharaj D, Fell GS, Boyce BF, Ng JP, Smith GD, Boulton-Jones JM, Cumming RL, Davidson JF

British medical journal.. 1987 September 19295 (6600):693-6. Epub 1900 01 01.

An outbreak of 'slapped cheek' parvovirus infection (erythema infectiosum) in a Scottish street.

Boyce BF, Forgie I

Scottish medical journal.. 1987 June 32 (3):70-1. Epub 1900 01 01.

The effect of 1 alpha-hydroxyvitamin D3 on the mineralization defect in disodium etidronate-treated Paget's disease--a double-blind randomized clinical study.

Ralston SH, Boyce BF, Cowan RA, Fogelman I, Smith ML, Jenkins A, Boyle IT

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1987 February 2 (1):5-12. Epub 1900 01 01.

Humoral hypercalcaemia of malignancy: metabolic and histomorphometric studies during surgical management of the primary tumour.

Ralston SH, Boyce BF, Cowan RA, Gardner MD, Dryburgh FJ, Boyle IT

The Quarterly journal of medicine.. 1986 March 58 (227):325-35. Epub 1900 01 01.

Does osteomalacia contribute to development of oral complications of oxalosis?

Boyce BF, Prime SS, Halls D, Johnston E, Critchlow H, MacDonald DG, Junor BJ

Oral surgery, oral medicine, and oral pathology.. 1986 March 61 (3):272-7. Epub 1900 01 01.

Malignant histiocytosis complicating rheumatoid arthritis: report of four cases.

Jack AS, Boyce BF, Lee FD

Journal of clinical pathology.. 1986 January 39 (1):16-21. Epub 1900 01 01.

Bone response in patients with aluminium-related osteomalacia after desferrioxamine therapy and adequate water treatment

Boyce, BF; Mocan, MZ; Byars, J; Halls, DJ; Leung, ACT; Burgoyne, M; Junor, BJR;.

Nefrologia. 1986; 6: 109-113.

Toxic effects of aluminium and other substances on bone turnover

Boyce, BF; Mocan, MZ; Junor, BJR;.

Nefrologia. 1986; 6: 103-108.

The physiology and pathology of bone formation and turnover

Boyle, IT; Boyce, BF;.

Nefrologia. 1986; 6: 97-101.

Bone disease following renal transplantation

Junor, BJR; Boyce, BF; Briggs, JD; Forwell, MA; Mocan, MZ; Tsakiris, D;.

Nefrologia. 1986; 6: 119-122.

Aluminum absorption in chronic renal failure.

Mocan MZ; Boyce BF; Briggs JD; Briggs JD; Forwell MA; Halls DJ; Forwell M.A.; Halls DJ; Junor BJR.

Nefrologia. 1986; 6:: 87-90.

Bone scan appearances following biopsy of bone and bone marrow.

McKillop JH, Maharaj D, Boyce BF, Fogelman I

Radiology.. 1984 October 153 (1):241-2. Epub 1900 01 01.

Focal osteomalacia due to low-dose diphosphonate therapy in Paget's disease.

Boyce BF, Smith L, Fogelman I, Johnston E, Ralston S, Boyle IT

Lancet.. 1984 April 141 (8381):821-4. Epub 1900 01 01.

4th International Workshop on Bone Histomorphometry, (Review)

Boyce BF.

Bone. 1984; 1: 33.

Correlation of skeletal uptake of 99mTc-diphosphonate and alkaline phosphatase before and after oral diphosphonate therapy in Paget's disease.

Smith ML, Fogelman I, Ralston S, Boyce BF, Boyle IT

Metabolic bone disease & related research. 1984 5 (4):167-70. Epub 1900 01 01.

Pre-operative localisation of parathyroid tumours using neck vein catheterisation and radioimmunoassay for parathyroid hormone: the Glasgow experience.

Beastall GH, McKellar N, Boyle IT, Joffe SN, Hutchison JS, Boyce BF, Gardner MD, Bell MA, Cowan RA, Fogelman I, Smith L

Scottish medical journal.. 1983 April 28 (2):146-52. Epub 1900 01 01.

Hypercalcaemic osteomalacia due to aluminium toxicity.

Boyce BF, Fell GS, Elder HY, Junor BJ, Elliot HL, Beastall G, Fogelman I, Boyle IT

Lancet.. 1982 November 62 (8306):1009-13. Epub 1900 01 01.

Hyperplastic parathyroiditis--a new autoimmune disease?

Boyce BF, Doherty VR, Mortimer G

Journal of clinical pathology.. 1982 August 35 (8):812-4. Epub 1900 01 01.

Do anticonvulsant drugs commonly induce osteomalacia?

Fogelman I, Gray JM, Gardner MD, Beastall GH, McIntosh WB, Allam BF, Boyce BF, Boyle IT, Lawson DH

Scottish medical journal.. 1982 April 27 (2):136-42. Epub 1900 01 01.

Scoring technique for diagnosis of ventricular hypertrophy from three orthogonal lead electrocardiogram.

Macfarlane PW, Chen CY, Boyce B, Fraser RS

British heart journal.. 1981 April 45 (4):402-10. Epub 1900 01 01.

Quantitation and localization of aluminium in human cancellous bone in renal osteodystrophy.

Boyce, BF; Elder, HY; Fell, GS; Nicholson, WAP; Smith, GD; Dempster, DW; Gray, CC; Boyle, IT.

Scanning Electron Microscopy Inc. 1981; III: 329-337.

Rickets in a white adolescent.

Fogelman I, Boyce B, Boyle IT

Postgraduate medical journal.. 1979 November 55 (649):808-9. Epub 1900 01 01.

1-Alpha-hydroxy vitamin D3 in primary hyperparathyroidism.

Boyle IT, Fogelman I, Beastall GH, Joffe S, Boyce B

British medical journal.. 1979 March 241 (6166):822-3. Epub 1900 01 01.

Amount of bone in osteoporosis and physiological senile osteopenia: Comparison of two histomorphometric parameters

Boyce, BF; Courpron, P; Meunier, PJ;.

Metab Bone Dis Rel Res. 1978; 1(1): 35-38.

1alpha-hydroxyvitamin D3 in primary hyperparathyroidism.

Boyle IT, Fogelman I, Boyce B, Thomson JE, Beastall GH, McIntosh WB, McLennan I

Clinical endocrinology.. 1977 December 7 Suppl :215s-222s. Epub 1900 01 01.

Bone scan findings in hypervitaminosis D: case report.

Fogelman I, McKillop JH, Cowden EA, Fine A, Boyce B, Boyle IT, Greig WR

Journal of nuclear medicine : official publication, Society of Nuclear Medicine.. 1977 December 18 (12):1205-7. Epub 1900 01 01.

1-alpha-hydroxyvitamin D3 in primary hyperparathyroidism

Boyle, IT; Fogelman, I; Boyce, BF; Thomson, JE; Beastall, GH; McIntosh, WB; McLellan, I;.

Clin Endocrinol. 1977; 7(7): 215s-222s.

Author Correction:. "Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons."

Kronman, H., et al. (2021).

Nat Neurosci. 24(5):: 753-754.

Books

Genetics of Bone Biology and Skeletal Disease (2018)

Chapter: Biology of Bone and Cartilage

Authors: Boyce BF, Zuscik MJ, Xing L

Publisher: Elsevier. 2018

Skeletal Development and Repair: Methods and Protocols (2014)

Chapter: RANKL-based osteoclastogenic assay from murine bone marrow cells.

Authors: Xing L, Boyce BF.

Publisher: Springer Link, Humana Press 2014

Primer on the Metabolic Bone Diseases and Disorder of Mineral Metabolism (2013)

Chapter: Bone and Immune Cell Interactions

Authors: Boyce BF

Publisher: Wiley-Blackwell 2013

Genetics of Bone Biology and Skeletal Disease (2012)

Chapter: Biology of Bone and Cartilage

Authors: Boyce BF, Zuscik MJ, Xing L.

Publisher: Elsevier 2012

Osteoimmunology: Interactions of the Immune and Skeletal Systems (2011)

Chapter: The role of the immune system and bone cells in acute and chronic osteomyelitis

Authors: Boyce BF, Xing L, Schwarz EM

Publisher: Elsevier Inc. 2011

Handbook of Cancer-Related Bone Disease. (2010)

Chapter: Bone biology and pathology.

Authors: Boyce BF

Publisher: BioScientifica 2010

Proc. N.Y. Acad. Sci. (2006)

Chapter: Autoimmunity and bone.

Authors: Schwarz EM, Looney J, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT.

Publisher: Proc. N.Y. Acad. Sci 2006

Proc. N.Y. Acad. Sci. (2006)

Chapter: Future anti-catabolic therapeutic targets in bone disease.

Authors: Boyce BF, Xing L, Yao Z, Yamashita T, Wang Y, Shakespeare W, Metcalf CA, Sundaramoorthi R, Dalgarno DC, Iuliucci JD, Sawyer TK.

Publisher: Proc. N.Y. Acad. Sci. 2006

Principles of Bone Biology (2002)

Chapter: Apoptosis in bone cells

Authors: Boyce BF, Xing L, Jilka RL, Bellido T, Weinstein RS, Parfitt AM, Manolagos SC

Publisher: Academic Press, San Diego, CA 2002

Bone (2001)

Authors: Boyce BF, Xing L

Publisher: McGraw-Hill Yearbook of Science & Technology 2001

Methods in bone biology (1998)

Chapter: Animal models for investigation of the action of factors on bone

Authors: Dunstan CR, Boyce BF,

Publisher: Chapman and Hall, London, England 1998

Molecular and Cellular Biology of Bone (1998)

Chapter: Bone disease in malignancy

Authors: Boyce BF, Yoneda T, Guise TA

Publisher: JAI Press Inc., Stamford, CT 1998

Novel Approaches to Treatment of Osteoporosis (1998)

Chapter: Apoptosis in Bone Cells

Authors: Boyce BF, Hughes DE, Wright KR, Xing L, Dai A

Publisher: Springer-Verlag, Berlin, New York 1998

Methods in bone biology (1997)

Chapter: Methods for studying cell death in bone

Authors: Boyce BF, Hughes DE, Wright KR

Publisher: Chapman and Hall, London, England 1997

Principles of Bone Biology (1996)

Chapter: Role of apoptosis in local regulation

Authors: Boyce BF

Publisher: Academic Press, San Diego, CA 1996

Osteoporosis (1996)

Chapter: Cytokines and bone remodeling

Authors: Mundy GR, Boyce BF, Yoneda T, Bonewald, LF, Roodman GD

Publisher: Academic Press, New York 1996

Metastatic Bone Disease (1994)

Chapter: Mechanisms of osteolytic bone destruction

Authors: Mundy GR, Boyce BF, Yoneda T

Publisher: Springer-Verlag, Heidelberg, Germany 1994

Histology of Ancient Human Bone: Methods and Diagnosis (1993)

Chapter: Pathology of metabolic bone and joint disease

Authors: Boyce BF

Publisher: Springer-Verlag, Berlin 1993

Bone Metastasis (1993)

Chapter: Normal bone remodeling and metastatic bone disease

Authors: Boyce BF, Chen H

Publisher: Springer-Verlag, Heidelberg, Germany 1993

Actualizacione en metabolismo oeso (1992)

Chapter: Histologia osea: aplication actual y Futuro

Authors: Boyce BF

Publisher: Jarpyo Editores, Madrid 1992

Actualizaciones en metabolismo oseo (1992)

Chapter: Efecto de los corticoides sobre el hueso

Authors: Boyce BF, Adamson B, Gallacher S, Byars J, Boyle IT

Publisher: Jarpyo Editores, Madrid 1992

Methods in Enzymology: Peptide Growth Factors, Part C, Section VII (1991)

Chapter: Assays for bone formation and bone resorption

Authors: Mundy GR, Roodman GD, Bonewald LF, Oreffo ROC, Boyce BF

Publisher: Academic Press, New York 1991

Bone Metastases-Diagnosis and Treatment (1991)

Chapter: Normal bone remodeling and its disruption in metastatic bone disease.

Authors: Boyce BF

Publisher: Springer-Verlag, London 1991

Aluminum and Renal Failure (1990)

Chapter: Cellular and subcellular localization of aluminum

Authors: Boyce BF

Publisher: Kluwer Academic, Dordrecht the Netherlands 1990

New Techniques in Metabolic Bone Disease (1990)

Chapter: Bone biopsy and histomorphometry in metabolic bone disease

Authors: Boyce BF

Publisher: Butterworths, London 1990

International Congress of Bone Histomorphometry (1990)

Chapter: A novel orthopaedic implant to repeatedly sample cancellous bone for histomorphometric analysis

Authors: Aufdemorte T, Fox C, Boyce BF, Triplet G, Poser J, Moore G, Holt R

Publisher: Nishimura, Japan 1990

Clinical Disorders of Bone and Mineral Metabolism (1989)

Chapter: Current problems in renal osteodystrophy

Authors: Boyce BF, Mocan Z, Halls DJ, Junor BJR

Publisher: Mary Ann Liebert, New York 1989

Contributions to Nephrology (1988)

Chapter: Histological healing and treatment of aluminum-related osteomalacia

Authors: Boyce BF, Mocan MZ, Byars J, Junor BJR

Publisher: Basel, Karger 1988

Bailliere's Clinical Endocrinology and Metabolism (1988)

Chapter: Uses and limitations of bone biopsy in management of metabolic bone disease

Authors: Boyce BF

Publisher: Bailliere Tindall, London 1988

Osteoporosis (1987)

Chapter: The value of calcium supplements in the management of patients with spinal osteoporosis: Microcrystalline hydroxyapatite compound versus calcium lactate gluconate versus controls.

Authors: Boyle IT, Davis BS, Boyce BF, Ralston SH, Cowan R, Byars J, Bessent R, Jenkins A

Publisher: Christiansen C, Johansen JS, Riis BJ (eds.), Denmark 1987

Aluminum and other trace elements in renal disease (1986)

Chapter: Aluminum-related osteomalacia due to oral aluminum: Can patients at risk be identified by an aluminum absorption test?

Authors: Boyce BF, Mocan MZ, Halls DJ, Cowan RA, Forwell M, Junor BJR

Publisher: Bailliere Tindall, London 1986

Osteoporosis (1982)

Chapter: Iliac bone histomorphometry in patients with femoral neck fracture

Authors: Boyce BF, Scullion JC, Beastall G, Ferguson A, Cowan R, Fogelman I, Boyle IT

Publisher: Chichester, John Wiley & Sons 1982

Hungarian Academy of Science (1978)

Chapter: New three orthogonal lead ECG criteria for ventricular hypertrophy

Authors: MacFarlane PW, Fraser RS, Boyce BF, Lawrie TVD

Publisher: Hungarian Academy of Science 1978

Osteoporosis (1977)

Chapter: Bone histomorphometry is osteoporotic states

Authors: Meunier PJ, Courpron P, Edouard C, Alexandre C, Bressot D, Lips P, Boyce BF.

Publisher: Grune and Stratton, New York 1977

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