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Majed A. Refaai, M.D.

Majed A. Refaai, M.D.

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UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
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Contact

Office (585) 275-2251

About Me

Dr. Refaai's clinical service is in Transfusion Medicine with subspecialty involvement in laboratory coagulation/thrombosis testing.
Dr. Refaai's clinical service is in Transfusion Medicine with subspecialty involvement in laboratory coagulation/thrombosis testing.

Faculty Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Residency & Fellowship

Fellowship, Fellow, University of Texas Southwestern Medical Center. 2006 - 2007

Residency, Pathology, Washington University in St. Louis. 2003 - 2006

Fellowship, Fellow, Massachusetts General Hospital. 1997 - 2003

Fellowship, Research, Massachusetts General Hospital. 1997 - 2003

Education

MD | Aleppo University (Syria). 1993

Awards

Recognized Volunteer Item Writer for ABPath CertLink (ABPCL). 2023

Patient Blood Management and Stewardship of Resources During Inventory Crisis. 2022

Eric A. Schenk Award for Excellence in Teaching. 2019

Quality and Safety Recognition for the Patient Blood Management Program; Directorship Award. 2016

Quality and Safety Recognition for the Patient Blood Management Program; Blood Bank Team Award. 2016

Health Care Team Award for our URMC Patient Blood Management Program (PBM). 2016

Certificate of Appreciation from Spencerport Service Learning Program for being a valued participant. 2013

Teaching Grant for the bi-monthly Thrombosis and Hemostasis conference. 2007

"Employee-of-The Year" Special Coagulation Laboratory. 2003

"Team-of-The Year" Special Coagulation Laboratory (Best laboratory team of the year 2003). 2003

Research

Dr. Refaai's recent studies have included: The in-vitro effect of ABO anti-bodies on platelet function; The correlation between cancer and tissue factor (TF) plasma concentrations and its role in developing DVT; The relationship between the circulating TF and the cancer tissue concentrations of TF i...
Dr. Refaai's recent studies have included: The in-vitro effect of ABO anti-bodies on platelet function; The correlation between cancer and tissue factor (TF) plasma concentrations and its role in developing DVT; The relationship between the circulating TF and the cancer tissue concentrations of TF in different types of mouse models; Beriplex phase IIIb drug study for bleeding patients with Warfarin overdose; Beriplex phase IIIb drug study for surgical patients who require a quick reversal of Warfarin; The effect of ABO non-identical blood products transfusion on platelet function (in-vivo); Platelet transfusion in patients with positive heparin-induced thrombocytopenia; Comparison of tissue factor pathway inhibitor (TFPI) concentration and activity in mononuclear cells from normal individuals versus patients with Paroxysmal Nocturnal Hemoglobinuria; Comparison of TFPI concentrations in normal mouse plasma and endothelial cells versus a diabetic mouse model; Analysis of fatty acid ethyl ester (FAEE) concentrations in binge drinking, chronic alcoholics, and postmortem biopsies.

Patents

Systemic and Topical Application of Platelet Microparticles to Treat Bleeding in Trauma Patients

Issue date: March 19, 2021

Patent #: ZL 201680012653.9

Country: China, People's Republic of

Inventors: Majed A Refaai

Systemic and Topical Application of Platelet Microparticles to Treat Bleeding in Trauma Patients

Issue date: June 02, 2021

Patent #: 3265116

Country: Europe

Inventors: Majed A Refaai

Systemic and Topical Application of Platelet Microparticles to Treat Bleeding in Trauma Patients

Issue date: July 28, 2020

Patent #: 10,722,608

Country: United States

Inventors: Majed A Refaai

Systemic and Topical Application of Platelet Microparticles to Treat Bleeding in Trauma Patients

Issue date: June 02, 2021

Patent #: FR3265116

Country: France

Inventors: Majed A Refaai

Systemic and Topical Application of Platelet Microparticles to Treat Bleeding in Trauma Patients

Issue date: June 02, 2021

Patent #: DE3265116

Country: Germany

Inventors: Majed A Refaai

Systemic and Topical Application of Platelet Microparticles to Treat Bleeding in Trauma Patients

Issue date: June 02, 2021

Patent #: GB3265116

Country: United Kingdom

Inventors: Majed A Refaai

Publications

Journal Articles

Eliminating leukocyte reduction for whole blood: Is it premature to consider this paradigm-changing practice?

Adkins BD, Booth GS, Fasano RM, Gehrie EA, Gestring ML, Masel D, Nguyen PT, Refaai MA, Jacobs JW, Raza S, Vella MA, Tormey CA, Blumberg N

Transfusion.. 2025 February 65 (2):375-378. Epub 12/22/2024.

Platelet Transfusions, Mortality, and ABO Identicality in Premature Newborns.

Asante A, Nguyen P, Henrichs K, Masel D, Refaai M, Blumberg N

American journal of perinatology.. 2024 August 41 (11):1592-1593. Epub 10/20/2023.

Acute pulmonary injury in hematology patients supported with pathogen-reduced and conventional platelet components.

Wheeler AP, Snyder EL, Refaai MA, Cohn CS, Poisson J, Fontaine MJ, Sehl M, Nooka AK, Uhl L, Spinella PC, Fenelus M, Liles DK, Coyle T, Becker J, Jeng MR, Gehrie EA, Spencer BR, Young PP, Johnson AD, O'Brien J, Schiller GJ, Roback JD, Malynn E, Jackups R, Avecilla S, Liu K, Bentow S, Varrone J, Benjamin RJ, Corash L

Blood advances.. 2024 May 148 (9):2290-2299. Epub 1900 01 01.

In response: ABO nonidentical platelet transfusions and mortality.

Blumberg N, Nguyen PL, Asante A, Masel D, Henrichs K, Refaai M, Heal J, Love T

Transfusion.. 2024 May 64 (5):954-956. Epub 1900 01 01.

ABO blood group, ABO mismatched transfusions and leukoreduction of transfusions in hemostatic resuscitation studies.

Nguyen PL, Asante A, Refaai M, Blumberg N

Frontiers in bioengineering and biotechnology.. 2024 12 :1437471. Epub 09/16/2024.

Acquired bleeding disorders secondary to immune checkpoint inhibitors: a case report and systematic literature review.

Archibald WJ, Kouides PA, Refaai MA, Lachant NA

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.. 2023 October 134 (7):427-431. Epub 09/08/2023.

Reduction of anti-A and anti-B isoagglutinin titers of group O whole blood units employing an ABO antibody immune adsorption column.

Gupta GK, Henrichs K, Nilsson K, Wagner S, Brown B, Masel D, Gestring ML, Vella MA, Refaai MA, Blumberg N

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.. 2023 June 62 (3):103686. Epub 03/05/2023.

INR and vitamin K-dependent factor levels after vitamin K antagonist reversal with 4F-PCC or plasma.

Hood C, Goldstein JN, Milling TJ, Refaai MA, Bajcic P, Goldstein B, Sarode R

Blood advances.. 2023 May 237 (10):2206-2213. Epub 1900 01 01.

Determination of Unnecessary Blood Transfusion by Comprehensive 15-Hospital Record Review.

Jadwin DF, Fenderson PG, Friedman MT, Jenkins I, Shander A, Waters JH, Friedman A, Tesoriero E, Refaai MA, Shih AW, Awan T, Ngo AL, Perez JA, Reynolds JD

Joint Commission journal on quality and patient safety. 2023 January 49 (1):42-52. Epub 11/08/2022.

Reduced Time to Procedure for Gastrointestinal Bleeding After Warfarin Reversal With Four-Factor Complex Concentrate as Compared to Plasma.

Spector H, McRae HL, Love T, Northam K, Refaai K, Rollins-Raval MA, Refaai MA

Journal of clinical medicine research.. 2023 January 15 (1):51-57. Epub 01/24/2023.

Retrospective Analysis of the Real-World Utilization of 4-Factor Prothrombin Complex Concentrate and Plasma in Oral Anticoagulant-Associated Bleeding in US Hospitals.

Refaai MA, Bajcic P, McNeill R, Hood C, Milling TJ

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.. 2023 29 :10760296231179682. Epub 1900 01 01.

Evaluation of a Newly Implemented Critical Thromboelastography (TEG) Value Callback System.

Yang S, McRae HL, Terry T, Cahill CM, Refaai MA

American journal of clinical pathology.. 2022 December 1158 (6):667-671. Epub 1900 01 01.

Comparative risk of pulmonary adverse events with transfusion of pathogen reduced and conventional platelet components.

Snyder EL, Wheeler AP, Refaai M, Cohn CS, Poisson J, Fontaine M, Sehl M, Nooka AK, Uhl L, Spinella P, Fenelus M, Liles D, Coyle T, Becker J, Jeng M, Gehrie EA, Spencer BR, Young P, Johnson A, O'Brien JJ, Schiller GJ, Roback JD, Malynn E, Jackups R, Avecilla ST, Lin JS, Liu K, Bentow S, Peng HL, Varrone J, Benjamin RJ, Corash LM

Transfusion.. 2022 July 62 (7):1365-1376. Epub 06/24/2022.

Impact of electronic medical record-based calculation of 4Ts on heparin-induced thrombocytopenia (HIT) testing: A single center experience.

Obadina M, McRae HL, Lawal R, Refaai MA, Akwaa F

International journal of laboratory hematology.. 2022 April 44 (2):e60-e63. Epub 09/24/2021.

A rare case of catastrophic antiphospholipid syndrome triggered by estrogen-containing oral contraceptives in a patient with double heterozygous factor V Leiden and prothrombin G20210A mutations.

McRae HL, Yang AH, Kruzer K, Scott GA, Refaai MA

American journal of hematology.. 2022 February 197 (2):239-242. Epub 03/20/2021.

Evaluation of solvent/detergent-treated plasma safety and efficacy in orthotopic liver transplant and thrombotic thrombocytopenic purpura patients: A single center experience.

McRae HL, Milito C, Klapheke CA, Refaai MA

Transfusion.. 2022 February 62 (2):429-438. Epub 12/27/2021.

Platelet Recruitment in COVID-19.

Cardillo A, Refaai M

American journal of clinical pathology.. 2022 January 6157 (1):153. Epub 1900 01 01.

Essential Role of Rho-Associated Kinase in ABO Immune Complex-Mediated Endothelial Barrier Disruption.

McRae HL, Millar MW, Slavin SA, Blumberg N, Rahman A, Refaai MA

Biomedicines.. 2021 December 79 (12)Epub 12/07/2021.

Anticoagulant Reversal in Gastrointestinal Bleeding: Review of Treatment Guidelines.

Milling TJ, Refaai MA, Sengupta N

Digestive diseases and sciences.. 2021 November 66 (11):3698-3714. Epub 01/06/2021.

Performance of the microINR Point-of-Care System Used by Self-Testing Patients: A Multicenter Clinical Trial.

Refaai MA, Jacobson AK, Rosenfeld JC, Orr RR

TH open : companion journal to thrombosis and haemostasis.. 2021 October 5 (4):e577-e584. Epub 12/30/2021.

Preoperative anemia management program reduces blood transfusion in elective cardiac surgical patients, improving outcomes and decreasing hospital length of stay.

Cahill CM, Alhasson B, Blumberg N, Melvin A, Knight P, Gloff M, Robinson R, Akwaa F, Refaai MA

Transfusion.. 2021 September 61 (9):2629-2636. Epub 07/15/2021.

In Vitro and In Vivo Comparison of Hemoglobin and Electrolytes Following the Collection of Cell Saver Blood Washed with Either Normal Saline or Plasma-Lyte A.

Cholette JM, McRae HL, Angona R, Cahill C, Swartz MF, Alfieris GM, Refaai MA

The journal of extra-corporeal technology.. 2021 September 53 (3):214-219. Epub 1900 01 01.

False-positive heparin-PF4 latex immunoturbidimetric assay due to lupus anti-coagulant interference: a case report.

McRae HL, Moore JW, Ifthikharuddin JJ, Refaai MA

British journal of haematology.. 2021 July 194 (1):211-213. Epub 04/20/2021.

Reducing the Need for HLA-Matched Platelet Transfusion.

Cardillo A, Heal JM, Henrichs K, Masel D, Fountaine T, Liesveld J, Noronha S, Cahill C, Ngo A, Gupta GK, Refaai MA, Blumberg N

The New England journal of medicine.. 2021 June 24384 (25):2451-2452. Epub 1900 01 01.

Impact of RBC Transfusion on Peripheral Capillary Oxygen Saturation and Partial Pressure of Arterial Oxygen.

Turgeman A, McRae HL, Cahill C, Blumberg N, Refaai MA

American journal of clinical pathology.. 2021 June 17156 (1):149-154. Epub 1900 01 01.

Efficacy of viscoelastic hemostatic assay testing in patients with sepsis-induced disseminated intravascular coagulation.

Hu YL, McRae HL, Refaai MA

European journal of haematology.. 2021 June 106 (6):873-875. Epub 03/25/2021.

Updates in Anticoagulation Therapy Monitoring.

McRae HL, Militello L, Refaai MA

Biomedicines.. 2021 March 69 (3)Epub 03/06/2021.

Whole blood haemostatic function throughout a 28-day cold storage period: an in vitro study.

McRae HL, Kara F, Milito C, Cahill C, Blumberg N, Refaai MA

Vox sanguinis.. 2021 February 116 (2):190-196. Epub 09/23/2020.

Blood Banking and Transfusion Medicine Challenges During the COVID-19 Pandemic.

Ngo A, Masel D, Cahill C, Blumberg N, Refaai MA

Clinics in laboratory medicine.. 2020 December 40 (4):587-601. Epub 08/08/2020.

Severe Platelet Transfusion Refractoriness in Association with Antibodies Against CD36.

Schmidt AE, Sahai T, Refaai MA, Sullivan M, Curtis BR

Laboratory medicine.. 2020 September 151 (5):540-544. Epub 1900 01 01.

Evaluation of the procoagulant properties of a newly developed platelet modified lysate product.

Refaai MA, Conley GW, Hudson CA, Spinelli SL, Phipps RP, Morrell CN, Blumberg N, McRae HL

Transfusion.. 2020 July 60 (7):1579-1589. Epub 05/15/2020.

Performance of the microINR Point-of-Care System: A Multicenter Clinical Trial.

Refaai MA, Shah V, Fernando R

Thrombosis and haemostasis.. 2020 April 120 (4):687-691. Epub 04/16/2020.

Persistent Rivaroxaban Effect Due to Impaired Renal Clearance and Medication Effects.

Milito C, McRae H, Victor A, Refaai MA, Schmidt AE

Laboratory medicine.. 2020 March 1051 (2):211-216. Epub 1900 01 01.

Why do patients with immune thrombocytopenia (ITP) experience lower bleeding events despite thrombocytopenia?

Boulware R, Refaai MA

Thrombosis research.. 2020 March 187 :154-158. Epub 01/15/2020.

Post-Transfusion Purpura Mimicking Idiopathic Thrombocytopenic Purpura: A Case Report.

Milito C, Masel D, Henrichs K, Schmidt AE, Kirkley S, Aljitawi O, Becker M, Blumberg N, Refaai MA

Laboratory medicine.. 2019 October 1050 (4):396-400. Epub 1900 01 01.

Transfusion medicine: A research agenda for the coming years.

Blumberg N, Cholette JM, Cahill C, Pietropaoli AP, Winters S, Phipps R, Noronha SA, Heal JM, Kirkley SA, Fountaine TJ, Henrichs K, Masel D, Refaai MA

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.. 2019 October 58 (5):698-700. Epub 08/06/2019.

The Utility of Thromboelastography to Guide Blood Product Transfusion.

Schmidt AE, Israel AK, Refaai MA

American journal of clinical pathology.. 2019 September 9152 (4):407-422. Epub 1900 01 01.

Evaluation of a rapid and automated heparin-induced thrombocytopenia immunoassay.

Refaai MA, Conley G, Ortel TL, Francis JL

International journal of laboratory hematology.. 2019 August 41 (4):478-484. Epub 04/15/2019.

Total plasma heme concentration increases after red blood cell transfusion and predicts mortality in critically ill medical patients.

Pietropaoli AP, Henrichs KF, Cholette JM, Spinelli SL, Phipps RP, Refaai MA, Blumberg N

Transfusion.. 2019 June 59 (6):2007-2015. Epub 02/27/2019.

Sickle red blood cells are more susceptible to in vitro haemolysis when exposed to normal saline versus Plasma-Lyte A.

Blumberg N, Henrichs K, Cholette J, Pietropaoli A, Spinelli S, Noronha S, Phipps R, Refaai MA

Vox sanguinis.. 2019 May 114 (4):325-329. Epub 04/02/2019.

Effect of vitamin K administration on rate of warfarin reversal.

Polito NB, Kanouse E, Jones CMC, McCann M, Refaai MA, Acquisto NM

Transfusion.. 2019 April 59 (4):1202-1208. Epub 02/04/2019.

HLA-Mediated Platelet Refractoriness.

Schmidt AE, Refaai MA, Coppage M

American journal of clinical pathology.. 2019 March 1151 (4):353-363. Epub 1900 01 01.

Placental Chorionic Cyst Fluid Has Prothrombotic Properties and Differs From Amniotic Fluid.

Stolla M, Refaai MA, Conley G, Spinelli S, Casey A, Katerji H, McRae HL, Blumberg N, Phipps R, Metlay LA, Katzman PJ

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.. 2019 22 (4):304-314. Epub 01/02/2019.

The Clinical Significance of Fibrin Monomers.

Refaai MA, Riley P, Mardovina T, Bell PD

Thrombosis and haemostasis.. 2018 November 118 (11):1856-1866. Epub 10/12/2018.

Transfusion-Associated Circulatory Overload as a Result of Plasma Transfusion to Correct International Normalized Ratio Before an Invasive Procedure: A Case Report.

Cahill CM, Blumberg N, Refaai MA

A&A practice.. 2018 July 1511 (2):49-51. Epub 1900 01 01.

Decreased Hemolysis and Improved Platelet Function in Blood Components Washed With Plasma-Lyte A Compared to 0.9% Sodium Chloride.

Refaai MA, Conley GW, Henrichs KF, McRae H, Schmidt AE, Phipps RP, Spinelli SL, Masel D, Cholette JM, Pietropaoli A, Eaton MP, Blumberg N

American journal of clinical pathology.. 2018 July 3150 (2):146-153. Epub 1900 01 01.

Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients.

Cholette JM, Pietropaoli AP, Henrichs KF, Alfieris GM, Powers KS, Gensini F, Rubenstein JS, Sweeney D, Phipps R, Spinelli SL, Refaai MA, Eaton MP, Blumberg N

Transfusion.. 2018 July 58 (7):1631-1639. Epub 03/30/2018.

Is It Time to Reconsider the Concepts of "Universal Donor" and "ABO Compatible" Transfusions?

Refaai MA, Cahill C, Masel D, Schmidt AE, Heal JM, Kirkley SA, Blumberg N

Anesthesia and analgesia.. 2018 June 126 (6):2135-2138. Epub 1900 01 01.

Prospective analysis of bleeding events in left ventricular assist device patients.

Sherazi S, Kouides P, Francis C, Lowenstein CJ, Refaai M, Conley G, Johnson BA, Muchnik E, Lien S, Massey HT, Alexis JD

The International journal of artificial organs.. 2018 May 41 (5):269-276. Epub 03/22/2018.

Implementation of a Standardized Transfusion Protocol for Cardiac Patients Treated With Venoarterial Extracorporeal Membrane Oxygenation Is Associated With Decreased Blood Component Utilization and May Improve Clinical Outcome.

Cahill CM, Blumberg N, Schmidt AE, Knight PA, Melvin AL, Massey HT, Delehanty JM, Zebrak SB, Refaai MA

Anesthesia and analgesia.. 2018 April 126 (4):1262-1267. Epub 1900 01 01.

The precautionary principle and use of Group A plasma in recipients of unknown ABO blood group.

Blumberg N, Heal JM, Masel D, Refaai MA

Transfusion.. 2018 March 58 (3):829-831. Epub 1900 01 01.

Oxidation Reduction Potential (ORP) is Predictive of Complications Following Pediatric Cardiac Surgery.

Schmidt AE, Gore E, Henrichs KF, Conley G, Dorsey C, Bjugstad KB, Refaai MA, Blumberg N, Cholette JM

Pediatric cardiology.. 2018 February 39 (2):299-306. Epub 10/31/2017.

0.9% NaCl (Normal Saline) - Perhaps not so normal after all?

Blumberg N, Cholette JM, Pietropaoli AP, Phipps R, Spinelli SL, Eaton MP, Noronha SA, Seghatchian J, Heal JM, Refaai MA

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.. 2018 February 57 (1):127-131. Epub 02/21/2018.

Prophylactic Preprocedure Platelet Transfusion Is Associated With Increased Risk of Thrombosis and Mortality.

Schmidt AE, Henrichs KF, Kirkley SA, Refaai MA, Blumberg N

American journal of clinical pathology.. 2017 December 20149 (1):87-94. Epub 1900 01 01.

ABO identical and washed blood transfusions as candidate strategies to reduce early mortality in acute promyelocytic leukemia.

Sahai T, Henrichs K, Refaai M, Heal JM, Kirkley SA, Schmidt AE, Mendler JH, Masel D, Liesveld J, Aquina C, Blumberg N

Leukemia research.. 2017 November 62 :1-3. Epub 09/23/2017.

Management of Platelet Disorders and Platelet Transfusions in ICU Patients.

Blumberg N, Cholette JM, Schmidt AE, Phipps RP, Spinelli SL, Heal JM, Pietropaoli AP, Refaai MA, Sime PJ

Transfusion medicine reviews.. 2017 October 31 (4):252-257. Epub 05/04/2017.

Adaptive Upregulation of Clumping Factor A (ClfA) by Staphylococcus aureus in the Obese, Type 2 Diabetic Host Mediates Increased Virulence.

Farnsworth CW, Schott EM, Jensen SE, Zukoski J, Benvie AM, Refaai MA, Kates SL, Schwarz EM, Zuscik MJ, Gill SR, Mooney RA

Infection and immunity.. 2017 June 85 (6)Epub 05/23/2017.

Management of concomitant factor VII deficiency and Factor V Leiden mutation.

Agostini-Vulaj D, Francis CW, Refaai MA

International journal of laboratory hematology.. 2017 February 39 (1):e10-e13. Epub 1900 01 01.

Improved outcomes in acute myeloid leukemia patients treated with washed transfusions.

Greener D, Henrichs KF, Liesveld JL, Heal JM, Aquina CT, Phillips GL, Kirkley SA, Milner LA, Refaai MA, Mendler JH, Szydlowski J, Masel D, Schmidt A, Boscoe FP, Schymura MJ, Blumberg N

American journal of hematology.. 2017 January 92 (1):E8-E9. Epub 1900 01 01.

Four-Factor Prothrombin Complex Concentrate Reduces Time to Procedure in Vitamin K Antagonist-Treated Patients Experiencing Gastrointestinal Bleeding: A Post Hoc Analysis of Two Randomized Controlled Trials.

Refaai MA, Kothari TH, Straub S, Falcon J, Sarode R, Goldstein JN, Brainsky A, Omert L, Lee ML, Milling TJ

Emergency medicine international.. 2017 2017 :8024356. Epub 09/19/2017.

Looking Beyond INR of 1.5 and Fresh Frozen Plasma in Liver Disease.

Sharma AK, Sharma M, Refaai MA

Cardiovascular and interventional radiology.. 2016 December 39 (12):1795-1796. Epub 06/03/2016.

ABO-immune complex formation and impact on platelet function, red cell structural integrity and haemostasis: an in vitro model of ABO non-identical transfusion.

Zaffuto BJ, Conley GW, Connolly GC, Henrichs KF, Francis CW, Heal JM, Blumberg N, Refaai MA

Vox sanguinis.. 2016 April 110 (3):219-26. Epub 11/03/2015.

Safety of a Four-factor Prothrombin Complex Concentrate Versus Plasma for Vitamin K Antagonist Reversal: An Integrated Analysis of Two Phase IIIb Clinical Trials.

Milling TJ, Refaai MA, Sarode R, Lewis B, Mangione A, Durn BL, Harman A, Lee ML, Goldstein JN

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.. 2016 April 23 (4):466-75. Epub 03/21/2016.

Resveratrol preserves the function of human platelets stored for transfusion.

Lannan KL, Refaai MA, Ture SK, Morrell CN, Blumberg N, Phipps RP, Spinelli SL

British journal of haematology.. 2016 March 172 (5):794-806. Epub 12/18/2015.

Platelet Transfusion and Thrombosis: More Questions than Answers.

Schmidt AE, Refaai MA, Blumberg N

Seminars in thrombosis and hemostasis.. 2016 March 42 (2):118-24. Epub 12/30/2015.

Thromboembolic Events After Vitamin K Antagonist Reversal With 4-Factor Prothrombin Complex Concentrate: Exploratory Analyses of Two Randomized, Plasma-Controlled Studies.

Milling TJ, Refaai MA, Goldstein JN, Schneider A, Omert L, Harman A, Lee ML, Sarode R

Annals of emergency medicine.. 2016 January 67 (1):96-105.e5. Epub 06/17/2015.

Past, present and forecast of transfusion medicine: What has changed and what is expected to change?

Schmidt AE, Refaai MA, Blumberg N

La Presse me?dicale.. 2016 45 (7-8 Pt 2):e253-72. Epub 07/26/2016.

Increased risk of volume overload with plasma compared with four-factor prothrombin complex concentrate for urgent vitamin K antagonist reversal.

Refaai MA, Goldstein JN, Lee ML, Durn BL, Milling TJ, Sarode R

Transfusion.. 2015 November 55 (11):2722-9. Epub 07/01/2015.

An alternative method to dithiothreitol treatment for antibody screening in patients receiving daratumumab.

Schmidt AE, Kirkley S, Patel N, Masel D, Bowen R, Blumberg N, Refaai MA

Transfusion.. 2015 September 55 (9):2292-3. Epub 1900 01 01.

ABO matching of platelet transfusions - "Start Making Sense". "As we get older, and stop making sense…" - The Talking Heads (1984).

Blumberg N, Refaai M, Heal J

Blood transfusion = Trasfusione del sangue.. 2015 July 13 (3):347-50. Epub 02/02/2015.

Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial.

Goldstein JN, Refaai MA, Milling TJ, Lewis B, Goldberg-Alberts R, Hug BA, Sarode R

Lancet.. 2015 May 23385 (9982):2077-87. Epub 02/27/2015.

Quality of factor XI activity testing in North American Specialized Coagulation Laboratories.

Zantek ND, Hsu P, Meijer P, Smock KJ, Plumhoff EA, Refaai MA, Van Cott EM

International journal of laboratory hematology.. 2015 May 37 Suppl 1 :99-107. Epub 1900 01 01.

Platelet transfusion - the new immunology of an old therapy.

Stolla M, Refaai MA, Heal JM, Spinelli SL, Garraud O, Phipps RP, Blumberg N

Frontiers in immunology.. 2015 6 :28. Epub 02/02/2015.

Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro.

Spinelli SL, Lannan KL, Casey AE, Croasdell A, Curran TM, Henrichs KF, Pollock SJ, Milne GA, Refaai MA, Francis CW, Phipps RP, Blumberg N

Transfusion.. 2014 June 54 (6):1569-79. Epub 11/05/2013.

Transfusion immunomodulation from a clinical perspective: an update.

Refaai MA, Blumberg N

Expert review of hematology.. 2013 December 6 (6):653-63. Epub 10/30/2013.

Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study.

Sarode R, Milling TJ, Refaai MA, Mangione A, Schneider A, Durn BL, Goldstein JN

Circulation.. 2013 September 10128 (11):1234-43. Epub 08/09/2013.

Factor VII assay performance: an analysis of the North American Specialized Coagulation Laboratory Association proficiency testing results.

Zantek ND, Hsu P, Refaai MA, Ledford-Kraemer M, Meijer P, Van Cott EM

International journal of laboratory hematology.. 2013 June 35 (3):314-21. Epub 1900 01 01.

The transfusion dilemma--weighing the known and newly proposed risks of blood transfusions against the uncertain benefits.

Refaai MA, Blumberg N

Best practice & research. Clinical anaesthesiology.. 2013 March 27 (1):17-35. Epub 1900 01 01.

Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B.

Refaai MA, Carter J, Henrichs KF, Davidson DC, Pollock SJ, Casey AE, Spinelli SL, Phipps RP, Francis CW, Blumberg N

Transfusion.. 2013 February 53 (2):382-93. Epub 05/25/2012.

Providing ABO-identical platelets and cryoprecipitate to (almost) all patients: approach, logistics, and associated decreases in transfusion reaction and red blood cell alloimmunization incidence.

Henrichs KF, Howk N, Masel DS, Thayer M, Refaai MA, Kirkley SA, Heal JM, Blumberg N

Transfusion.. 2012 March 52 (3):635-40. Epub 09/02/2011.

An association of ABO non-identical platelet and cryoprecipitate transfusions with altered red cell transfusion needs in surgical patients.

Refaai MA, Fialkow LB, Heal JM, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Corsetti JP, Francis CW, Bankey PE, Blumberg N

Vox sanguinis.. 2011 July 101 (1):55-60. Epub 03/18/2011.

Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes.

Refaai MA, Phipps RP, Spinelli SL, Blumberg N

Thrombosis research.. 2011 April 127 (4):287-91. Epub 11/19/2010.

Platelet Activation Following Exposure to Anti-ABO Antibodies-An In Vitro Study.

Refaai MA, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Francis CW, Blumberg N

US oncology & hematology.. 2011 January 17 (1):72-74. Epub 1900 01 01.

Platelet storage and transfusions: new concerns associated with an old therapy.

Sahler J, Grimshaw K, Spinelli SL, Refaai MA, Phipps RP, Blumberg N

Drug discovery today. Disease mechanisms. 2011 8 (1-2):e9-e14. Epub 07/20/2011.

An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions.

Blumberg N, Heal JM, Gettings KF, Phipps RP, Masel D, Refaai MA, Kirkley SA, Fialkow LB

Transfusion.. 2010 December 50 (12):2738-44. Epub 1900 01 01.

Outcomes after platelet transfusion in patients with heparin-induced thrombocytopenia.

Refaai MA, Chuang C, Menegus M, Blumberg N, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2010 June 8 (6):1419-21. Epub 03/19/2010.

Prospective monitoring of plasma and platelet transfusions in a large teaching hospital results in significant cost reduction.

Sarode R, Refaai MA, Matevosyan K, Burner JD, Hampton S, Rutherford C

Transfusion.. 2010 February 50 (2):487-92. Epub 10/05/2009.

Platelet aggregation responses vary over a period of time in healthy controls.

Refaai MA, Frenkel E, Sarode R

Platelets.. 2010 21 (6):460-3. Epub 1900 01 01.

Suboptimal effect of a three-factor prothrombin complex concentrate (Profilnine-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdose.

Holland L, Warkentin TE, Refaai M, Crowther MA, Johnston MA, Sarode R

Transfusion.. 2009 June 49 (6):1171-7. Epub 02/06/2009.

Check Sample Abstracts.

Alter D, Grenache DG, Bosler DS, Karcher RE, Nichols J, Rajadhyaksha A, Camelo-Piragua S, Rauch C, Huddleston BJ, Frank EL, Sluss PM, Lewandrowski K, Eichhorn JH, Hall JE, Rahman SS, McPherson RA, Kiechle FL, Hammett-Stabler C, Pierce KA, Kloehn EA, Thomas PA, Walts AE, Madan R, Schlesinger K, Nawgiri R, Bhutani M, Kanber Y, Abati A, Atkins KA, Farrar R, Gopez EV, Jhala D, Griffin S, Jhala K, Jhala N, Bentz JS, Emerson L, Chadwick BE, Barroeta JE, Baloch ZW, Collins BT, Middleton OL, Davis GG, Haden-Pinneri K, Chu AY, Keylock JB, Ramoso R, Thoene CA, Stewart D, Pierce A, Barry M, Aljinovic N, Gardner DL, Barry M, Shields LB, Arnold J, Stewart D, Martin EL, Rakow RJ, Paddock C, Zaki SR, Prahlow JA, Stewart D, Shields LB, Rolf CM, Falzon AL, Hudacki R, Mazzella FM, Bethel M, Zarrin-Khameh N, Gresik MV, Gill R, Karlon W, Etzell J, Deftos M, Karlon WJ, Etzell JE, Wang E, Lu CM, Manion E, Rosenthal N, Wang E, Lu CM, Tang P, Petric M, Schade AE, Hall GS, Oethinger M, Hall G, Picton AR, Hoang L, Imperial MR, Kibsey P, Waites K, Duffy L, Hall GS, Salangsang JA, Bravo LT, Oethinger MD, Veras E, Silva E, Vicens J, Silva E, Keylock J, Hempel J, Rushing E, Posligua LE, Deavers MT, Nash JW, Basturk O, Perle MA, Greco A, Lee P, Maru D, Weydert JA, Stevens TM, Brownlee NA, Kemper AE, Williams HJ, Oliverio BJ, Al-Agha OM, Eskue KL, Newlands SD, Eltorky MA, Puri PK, Royer MC, Rush WL, Tavora F, Galvin JR, Franks TJ, Carter JE, Kahn AG, Lozada Muñoz LR, Houghton D, Land KJ, Nester T, Gildea J, Lefkowitz J, Lacount RA, Thompson HW, Refaai MA, Quillen K, Lopez AO, Goldfinger D, Muram T, Thompson H

American journal of clinical pathology.. 2009 February 131 (2):286-299. Epub 1900 01 01.

Low CD34 collection from a healthy blood progenitor cell donor: a case report.

Refaai MA, Cusick RM, Paranjape G, Sutor LJ

Journal of clinical apheresis.. 2009 24 (6):262-4. Epub 1900 01 01.

Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer.

Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai MA, Lyman GH

Archives of internal medicine.. 2008 November 24168 (21):2377-81. Epub 1900 01 01.

A massive transfusion protocol to decrease blood component use and costs.

O'Keeffe T, Refaai M, Tchorz K, Forestner JE, Sarode R

Archives of surgery.. 2008 July 143 (7):686-90; discussion 690-1. Epub 1900 01 01.

Delayed-onset heparin-induced thrombocytopenia, venous thromboembolism, and cerebral venous thrombosis: a consequence of heparin "flushes".

Refaai MA, Warkentin TE, Axelson M, Matevosyan K, Sarode R

Thrombosis and haemostasis.. 2007 November 98 (5):1139-40. Epub 1900 01 01.

Protein Z and ZPI levels and cardiovascular events.

Refaai MA, Ahn C, Lu L, Wu K, Broze GJ

Journal of thrombosis and haemostasis : JTH.. 2006 July 4 (7):1628-9. Epub 1900 01 01.

Ischemia-modified albumin increases after skeletal muscle ischemia during arthroscopic knee surgery.

Refaai MA, Wright RW, Parvin CA, Gronowski AM, Scott MG, Eby CS

Clinica chimica acta; international journal of clinical chemistry.. 2006 April 366 (1-2):264-8. Epub 12/07/2005.

Loss of factor VIII and von Willebrand factor activities during cold storage of whole blood is reversed by rewarming.

Refaai MA, Van Cott EM, Lukoszyk M, Hughes J, Eby CS

Laboratory hematology : official publication of the International Society for Laboratory Hematology.. 2006 12 (2):99-102. Epub 1900 01 01.

Cold-dependent loss of factor VIII von Willebrand factor activities in citrated whole blood is reversed by rewarming.

Refaai MA, Lukoszyk M, Hughes J, Eby CS, Van Cott EM

American journal of clinical pathology.. 2005 December 124 (6):972; author reply 973. Epub 1900 01 01.

The timing of a positive test result for heparin-induced thrombocytopenia relative to the platelet count and anticoagulant therapy in 43 consecutive cases.

Refaai MA, Van Cott EM, Laposata M

American journal of clinical pathology.. 2003 April 119 (4):497-504. Epub 1900 01 01.

Ethyl arachidonate is the predominant fatty acid ethyl ester in the brains of alcohol-intoxicated subjects at autopsy.

Refaai MA, Nguyen PN, Cluette-Brown JE, Laposata M

Lipids.. 2003 March 38 (3):269-73. Epub 1900 01 01.

Clinical significance of a borderline titer in a negative ELISA test for heparin-induced thrombocytopenia.

Refaai MA, Laposata M, Van Cott EM

American journal of clinical pathology.. 2003 January 119 (1):61-5. Epub 1900 01 01.

Liver and adipose tissue fatty acid ethyl esters obtained at autopsy are postmortem markers for premortem ethanol intake.

Refaai MA, Nguyen PN, Steffensen TS, Evans RJ, Cluette-Brown JE, Laposata M

Clinical chemistry.. 2002 January 48 (1):77-83. Epub 1900 01 01.

Fatty acid ethyl esters: recent observations.

Laposata M, Hasaba A, Best CA, Yoerger DM, McQuillan BM, Salem RO, Refaai MA, Soderberg BL

Prostaglandins, leukotrienes, and essential fatty acids.. 2002 67 (2-3):193-6. Epub 1900 01 01.

Fatty acid ethyl esters in liver and adipose tissues as postmortem markers for ethanol intake.

Salem RO, Refaai MA, Cluette-Brown JE, Russo JW, Laposata M

Clinical chemistry.. 2001 April 47 (4):722-5. Epub 1900 01 01.

Differences in the fatty acid composition of fatty acid ethyl esters in organs and their secretions.

Laposata M, Kabakibi A, Walden MP, Cluette-Brown JE, Nanji AA, Refaai MA, Werner J, Nanji AA

Alcoholism, clinical and experimental research.. 2000 October 24 (10):1488-91. Epub 1900 01 01.

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