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David G. Hicks, M.D.

David G. Hicks, M.D.

UR Medicine Labs

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Office (585) 275-3191
Fax (585) 273-3637

About Me

Dr. Hicks Professor and Director of IHC-ISH Laboratory and Breast Subspecialty Service at URMC. His innovative approaches to improving efficiency and quality in surgical pathology have been highlighted in publications and invited lectures sponsored by national pathology organizations. He has impleme...
Dr. Hicks Professor and Director of IHC-ISH Laboratory and Breast Subspecialty Service at URMC. His innovative approaches to improving efficiency and quality in surgical pathology have been highlighted in publications and invited lectures sponsored by national pathology organizations. He has implemented a subspecialty-based surgical pathology system, combining disease-specific diagnostic and prognostic expertise with translational research based on organ systems and disease categories.

As a member of the Ad Hoc Committee on Immunohistochemistry Standardization, and co-author of their consensus recommendations, he is a leader in the emerging effort to achieve the full potential of immunostaining as a tissue-based quantitative ELISA test. He has been appointed to an ASCO/CAP panel that is developing national guidelines on estrogen receptor testing in breast cancer, having served recently on a similar panel that made important recommendations to improve HER2 testing in breast cancer.

Certified Specialties

Pathology - Anatomic - American Board of Pathology

Faculty Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Residency & Fellowship

Residency, Pathology - Anatomic, Hospital of the University of Pennsylvania. 1985 - 1989

Internship, Internal Medicine, UPMC Credentials Verification Office. 1984 - 1985

Education

MD | University of Rochester. 1984

Awards

Dr. Edith E. Sproul Teaching Award. 2006

John Beach Hazard Distinguished Teaching Award. 2002

Duthie-Evarts Education Award. 1997

Andrew W. Mellon Dean's Teaching Scholar. 1996 - 1999

Kappa Delta Elizabeth Winston Lanier Award for Outstanding Orthopaedic Research. 1995

Certificate of Commendation for Excellence in Medical Student Teaching. 1993

Arthur Purdy Stout Award. 1991

Stowell-Orbison Award. 1989

Award in Honor of George H. Whipple, M.D.. 1984

Member, Alpha Omega Alpha. 1984

Robert Katz Award for Clinical Research Excellence. 1984

Research

Dr. Hicks' first research interest was in bone pathology. He received NIH funding to study the effects of lead on the epiphyseal plate, and collaborated on related studies with faculty in the Department of Orthopaedics at the University of Rochester. He published extensively on metabolic and neoplas...
Dr. Hicks' first research interest was in bone pathology. He received NIH funding to study the effects of lead on the epiphyseal plate, and collaborated on related studies with faculty in the Department of Orthopaedics at the University of Rochester. He published extensively on metabolic and neoplastic bone disorders. While Director of Surgical Pathology and Co-director of the Morphologic Molecular Pathology translation research resource at the Cleveland Clinic, he expanded his interests in breast pathology, with particular focus on prognostic molecular markers and development of advanced tissue-based diagnostic techniques.

His current clinical translational research interests focus on molecular risk factors for breast cancer and preanalytical variables that affect the accuracy of new diagnostic technology in surgical pathology.

Publications

Journal Articles

Optimized biomarker evaluation and molecular testing in the era of breast cancer precision medicine.

Hicks DG, Turner BM

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2024 September 11 :1-13. Epub 09/11/2024.

Best practices for achieving consensus in HER2-low expression in breast cancer: current perspectives from practising pathologists.

Tozbikian G, Bui MM, Hicks DG, Jaffer S, Khoury T, Wen HY, Krishnamurthy S, Wei S

Histopathology.. 2024 September 85 (3):489-502. Epub 07/08/2024.

Breast Cancer With HER2 Immunohistochemical Score 2 and Average HER2 Signals/Cell 6 or More and HER2/CEP17 Ratio Less Than 2 ('ISH Group 3'): A Multi-Institutional Cohort Analysis Emphasizing Outcome and Molecular Subtype.

Ajabnoor R, Zhang G, Hu Y, Gao Y, Finkelman BS, Turner BM, Yi S, Dhakal A, Audeh W, Li Z, Li X, Hicks DG, Zhang H

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2024 August 37 (8):100530. Epub 05/27/2024.

HER2 evaluation for clinical decision making in human solid tumours: pearls and pitfalls.

Zhang H, Finkelman BS, Ettel MG, Velez MJ, Turner BM, Hicks DG

Histopathology.. 2024 July 85 (1):3-19. Epub 03/05/2024.

Analytical and clinical validation of PATHWAY Anti-HER-2/neu (4B5) antibody to assess HER2-low status for trastuzumab deruxtecan treatment in breast cancer.

Garrido C, Manoogian M, Ghambire D, Lucas S, Karnoub M, Olson MT, Hicks DG, Tozbikian G, Prat A, Ueno NT, Modi S, Feng W, Pugh J, Hsu C, Tsurutani J, Cameron D, Harbeck N, Fang Q, Khambata-Ford S, Liu X, Inge LJ, Vitazka P

Virchows Archiv : an international journal of pathology.. 2024 June 484 (6):1005-1014. Epub 10/20/2023.

Performance of HER2 DAKO HercepTest and Ventana 4B5 immunohistochemical assays on detecting HER2 gene-amplification in uterine serous carcinomas.

Navarro Sanchez JM, Finkelman BS, Tyburski H, Turner BM, Moisini I, Katerji H, Varghese S, Wang X, Schiffhauer LM, Chen JJ, Hicks DG, Zhang H

Human pathology.. 2024 June 148 :51-59. Epub 05/11/2024.

In ER-Positive, HER2-Negative Breast Cancers, HER2 mRNA Levels Correlate Better with Clinicopathologic Features and Oncotype DX Recurrence Score than HER2 Immunohistochemistry.

Tyburski H, Karakas C, Finkelman BS, Turner BM, Zhang H, Hicks DG

Laboratory investigation; a journal of technical methods and pathology.. 2024 March 104 (3):100309. Epub 12/20/2023.

Emerging Landscape of Targeted Therapy of Breast Cancers With Low Human Epidermal Growth Factor Receptor 2 Protein Expression.

Tozbikian G, Krishnamurthy S, Bui MM, Feldman M, Hicks DG, Jaffer S, Khoury T, Wei S, Wen H, Pohlmann P

Archives of pathology & laboratory medicine.. 2024 February 1148 (2):242-255. Epub 1900 01 01.

Validation and interpretation of Pan-TRK immunohistochemistry: a practical approach and challenges with interpretation.

Karakas C, Giampoli EJ, Love T, Hicks DG, Velez MJ

Diagnostic pathology.. 2024 January 1019 (1):10. Epub 01/10/2024.

HER2 categorical changes after neoadjuvant chemotherapy: A study of 192 matched breast cancers with the inclusion of HER2-Low category.

Karakas C, Tyburski H, Turner BM, Weiss A, Akkipeddi SMK, Dhakal A, Skinner K, Hicks DG, Zhang H

Human pathology.. 2023 December 142 :34-41. Epub 11/17/2023.

Interobserver and Interantibody Reproducibility of HER2 Immunohistochemical Scoring in an Enriched HER2-Low-Expressing Breast Cancer Cohort.

Karakas C, Tyburski H, Turner BM, Wang X, Schiffhauer LM, Katerji H, Hicks DG, Zhang H

American journal of clinical pathology.. 2023 May 2159 (5):484-491. Epub 1900 01 01.

The Rochester Modified Magee Algorithm (RoMMa): An Outcomes Based Strategy for Clinical Risk-Assessment and Risk-Stratification in ER Positive, HER2 Negative Breast Cancer Patients Being Considered for Oncotype DX Testing.

Turner BM, Finkelman BS, Hicks DG, Numbereye N, Moisini I, Dhakal A, Skinner K, Sanders MAG, Wang X, Shayne M, Schiffhauer L, Katerji H, Zhang H

Cancers.. 2023 January 3115 (3)Epub 01/31/2023.

The Evolution of Ki-67 and Breast Carcinoma: Past Observations, Present Directions, and Future Considerations.

Finkelman BS, Zhang H, Hicks DG, Turner BM

Cancers.. 2023 January 2815 (3)Epub 01/28/2023.

HER2-low breast cancers: Current insights and future directions.

Zhang H, Karakas C, Tyburski H, Turner BM, Peng Y, Wang X, Katerji H, Schiffhauer L, Hicks DG

Seminars in diagnostic pathology.. 2022 September 39 (5):305-312. Epub 07/09/2022.

Detailed Morphologic Evaluation of Breast Papillary Lesions on Core Biopsy Is Critical for Accurate Classification and Clinical Management: The Experience of an Academic Institute.

Petrolla A, Hicks DG, Skinner KA, Wang X

Clinical breast cancer.. 2022 June 22 (4):e552-e557. Epub 12/14/2021.

HER2-Low Breast Cancers.

Zhang H, Katerji H, Turner BM, Hicks DG

American journal of clinical pathology.. 2022 March 3157 (3):328-336. Epub 1900 01 01.

HER2 Testing: Insights From Pathologists' Perspective on Technically Challenging HER2 FISH Cases.

Grimm EV, Allison KH, Hicks DG, Swenson KK, Krueger J, Yaziji H, Downs-Kelly E, Rendi MH, Susnik B, Tsai ML, Lillemoe TJ

Applied immunohistochemistry & molecular morphology : AIMM. 2021 October 129 (9):635-642. Epub 1900 01 01.

Significance of HER2 in Microinvasive Breast Carcinoma.

Zhang H, Moisini I, Turner BM, Wang X, Dhakal A, Yang Q, Kovar S, Schiffhauer LM, Hicks DG

American journal of clinical pathology.. 2021 June 17156 (1):155-165. Epub 1900 01 01.

Pathologists at the Leading Edge of Optimizing the Tumor Tissue Journey for Diagnostic Accuracy and Molecular Testing.

De Las Casas LE, Hicks DG

American journal of clinical pathology.. 2021 May 18155 (6):781-792. Epub 1900 01 01.

L1CAM Expression in Recurrent Estrogen Positive/HER2 Negative Breast Cancer: A Novel Biomarker Worth Considering.

Moisini I, Zhang H, D'Aguiar M, Hicks DG, Turner BM

Applied immunohistochemistry & molecular morphology : AIMM. 2021 April 129 (4):287-292. Epub 1900 01 01.

Applying the New Guidelines of HER2 Testing in Breast Cancer.

Zhang H, Moisini I, Ajabnoor RM, Turner BM, Hicks DG

Current oncology reports.. 2020 April 2922 (5):51. Epub 04/29/2020.

Frequency, Clinicopathologic Characteristics, and Follow-up of HER2-Positive Nonpleomorphic Invasive Lobular Carcinoma of the Breast.

Zhang H, Moisini I, Ajabnoor RM, Turner BM, D'aguiar M, Cai X, Gao S, Yang Q, Wang X, Schiffhauer L, Hicks DG

American journal of clinical pathology.. 2020 April 15153 (5):583-592. Epub 1900 01 01.

Risk stratification of ER-positive breast cancer patients: A multi-institutional validation and outcome study of the Rochester Modified Magee algorithm (RoMMa) and prediction of an Oncotype DX recurrence score <26.

Turner BM, Gimenez-Sanders MA, Soukiazian A, Breaux AC, Skinner K, Shayne M, Soukiazian N, Ling M, Hicks DG

Cancer medicine. 2019 August 8 (9):4176-4188. Epub 06/14/2019.

Second-harmonic generation directionality is associated with neoadjuvant chemotherapy response in breast cancer core needle biopsies.

Desa DE, Bhanote M, Hill RL, Majeski JB, Buscaglia B, D'Aguiar M, Strawderman R, Hicks DG, Turner BM, Brown EB

Journal of biomedical optics.. 2019 August 24 (8):1-9. Epub 1900 01 01.

Reconsidering "low-risk" criteria for breast cancer recurrence in hormone positive patients.

Turner BM, Hicks DG, Soukiazian A

The breast journal.. 2019 May 25 (3):545-547. Epub 04/10/2019.

Parameter estimation and identifiability in a neural population model for electro-cortical activity.

Hicks DG, Liley DTJ, Cadusch PJ, Hartoyo A

PLoS computational biology.. 2019 May 15 (5):e1006694. Epub 05/30/2019.

Impact of Specimen Type and Specimen Number on HER2 Status in Gastroesophageal Junction and Gastric Adenocarcinoma.

Whitney-Miller CL, Hicks DG, Guo J, McMahon L, Henry J, Koltz BR, Buscaglia B, Huber AR

American journal of clinical pathology.. 2019 April 2151 (5):461-468. Epub 1900 01 01.

Maps of variability in cell lineage trees.

Hicks DG, Speed TP, Yassin M, Russell SM

PLoS computational biology.. 2019 February 15 (2):e1006745. Epub 02/12/2019.

A novel detection methodology for HER2 protein quantitation in formalin-fixed, paraffin embedded clinical samples using fluorescent nanoparticles: an analytical and clinical validation study.

Hicks DG, Buscaglia B, Goda H, McMahon L, Natori T, Turner B, Soukiazian A, Okada H, Nakano Y

BMC cancer.. 2018 December 1818 (1):1266. Epub 12/18/2018.

p53 alteration in morphologically normal/benign breast luminal cells in BRCA carriers with or without history of breast cancer.

Wang X, El-Halaby AA, Zhang H, Yang Q, Laughlin TS, Rothberg PG, Skinner K, Hicks DG

Human pathology.. 2017 October 68 :22-25. Epub 04/21/2017.

The value of algorithms predicting the Oncotype DX recurrence score should not be underestimated!

Turner B, Tang P, Hicks D

Breast cancer research and treatment.. 2017 July 164 (1):249-250. Epub 04/13/2017.

Pathologic diagnosis of breast cancer patients: evolution of the traditional clinical-pathologic paradigm toward "precision" cancer therapy.

Turner BM, Hicks DG

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2017 92 (3):175-200. Epub 03/20/2017.

Optimizing the Use of Gene Expression Profiling in Early-Stage Breast Cancer.

Kim HS, Umbricht CB, Illei PB, Cimino-Mathews A, Cho S, Chowdhury N, Figueroa-Magalhaes MC, Pesce C, Jeter SC, Mylander C, Rosman M, Tafra L, Turner BM, Hicks DG, Jensen TA, Miller DV, Armstrong DK, Connolly RM, Fetting JH, Miller RS, Park BH, Stearns V, Visvanathan K, Wolff AC, Cope L

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2016 December 2034 (36):4390-4397. Epub 10/31/2016.

p53 alteration in morphologically normal/benign breast tissue in patients with triple-negative high-grade breast carcinomas: breast p53 signature?

Wang X, Stolla M, Ring BZ, Yang Q, Laughlin TS, Rothberg PG, Skinner K, G Hicks D

Human pathology.. 2016 September 55 :196-201. Epub 05/28/2016.

In Reply.

Hammond ME, Hicks DG

Archives of pathology & laboratory medicine.. 2016 August 140 (8):741. Epub 1900 01 01.

Core vs Breast Resection Specimen: Does It Make a Difference for HER2 Results?

Hicks DG, Fitzgibbons P, Hammond E

American journal of clinical pathology.. 2015 October 144 (4):533-5. Epub 1900 01 01.

Use of Biomarkers to Guide Decisions on Systemic Therapy for Women With Metastatic Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline.

Van Poznak C, Somerfield MR, Bast RC, Cristofanilli M, Goetz MP, Gonzalez-Angulo AM, Hicks DG, Hill EG, Liu MC, Lucas W, Mayer IA, Mennel RG, Symmans WF, Hayes DF, Harris LN

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2015 August 2033 (24):2695-704. Epub 07/20/2015.

American Society of Clinical Oncology/College of American Pathologists Human Epidermal Growth Factor Receptor 2 Testing Clinical Practice Guideline Upcoming Modifications: Proof That Clinical Practice Guidelines Are Living Documents.

Hammond ME, Hicks DG

Archives of pathology & laboratory medicine.. 2015 August 139 (8):970-1. Epub 04/17/2015.

Use of modified Magee equations and histologic criteria to predict the Oncotype DX recurrence score.

Turner BM, Skinner KA, Tang P, Jackson MC, Soukiazian N, Shayne M, Huston A, Ling M, Hicks DG

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2015 July 28 (7):921-31. Epub 05/01/2015.

College of American Pathologists Guidelines for Reporting HER2 Test Results in Gastric Cancer.

Whitney-Miller C, Hicks DG

Archives of pathology & laboratory medicine.. 2015 June 139 (6):709-10. Epub 10/08/2014.

Reply to E.A. Rakha et al.

Wolff AC, Hammond ME, Hicks DG, Allison KH, Bartlett JM, Bilous M, Fitzgibbons P, Hanna W, Jenkins RB, Mangu PB, Paik S, Perez EA, Press MF, Spears PA, Vance GH, Viale G, Dowsett M, McShane LM, Hayes DF

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2015 April 1033 (11):1302-4. Epub 03/09/2015.

Preanalytical variables and phosphoepitope expression in FFPE tissue: quantitative epitope assessment after variable cold ischemic time.

Vassilakopoulou M, Parisi F, Siddiqui S, England AM, Zarella ER, Anagnostou V, Kluger Y, Hicks DG, Rimm DL, Neumeister VM

Laboratory investigation; a journal of technical methods and pathology.. 2015 March 95 (3):334-41. Epub 11/24/2014.

Pathologic diagnosis, immunohistochemistry, multigene assays and breast cancer treatment: progress toward "precision" cancer therapy.

Hicks D, Turner B

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2015 February 90 (2):81-92. Epub 12/01/2014.

Expression of a-Tocopherol-Associated protein (TAP) is associated with clinical outcome in breast cancer patients.

Wang X, Ring BZ, Seitz RS, Ross DT, Woolf K, Beck RA, Hicks DG, Yeh S

BMC clinical pathology. 2015 15 :21. Epub 12/09/2015.

Pathological features and clinical outcomes of breast cancer according to levels of oestrogen receptor expression.

Zhang Z, Wang J, Skinner KA, Shayne M, Hajdu SI, Hong B, Hicks DG, Tang P

Histopathology.. 2014 October 65 (4):508-16. Epub 08/01/2014.

A new rabbit monoclonal E-cadherin antibody [EP700Y] shows higher sensitivity than mouse monoclonal E-cadherin [HECD-1] antibody in breast ductal carcinomas and does not stain breast lobular carcinomas.

Hoang LL, Tang P, Hicks DG, Chen H, Yang Q, Haas TS, Bremer RE, Tacha D

Applied immunohistochemistry & molecular morphology : AIMM. 2014 September 22 (8):606-12. Epub 1900 01 01.

Expression of androgen receptor and its association with estrogen receptor and androgen receptor downstream proteins in normal/benign breast luminal epithelium.

Wang X, Yarid N, McMahon L, Yang Q, Hicks DG

Applied immunohistochemistry & molecular morphology : AIMM. 2014 August 22 (7):498-504. Epub 1900 01 01.

Folate receptor ? associated with triple-negative breast cancer and poor prognosis.

Zhang Z, Wang J, Tacha DE, Li P, Bremer RE, Chen H, Wei B, Xiao X, Da J, Skinner K, Hicks DG, Bu H, Tang P

Archives of pathology & laboratory medicine.. 2014 July 138 (7):890-5. Epub 09/13/2013.

Progress in implementing HER2 testing guidelines.

Fitzgibbons PL, Hicks DG

Archives of pathology & laboratory medicine.. 2014 July 138 (7):863-4. Epub 1900 01 01.

Reply to R. Bhargava et al and K. Lambein et al.

Wolff AC, Hammond ME, Hicks DG, Dowsett M, Hayes DF, McShane LM

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2014 June 1032 (17):1857-9. Epub 04/28/2014.

Standardization of tissue handling from the OR to the laboratory.

Hicks DG

AORN journal.. 2014 June 99 (6):810-3. Epub 1900 01 01.

Template for reporting results of biomarker testing of specimens from patients with carcinoma of the breast.

Fitzgibbons PL, Dillon DA, Alsabeh R, Berman MA, Hayes DF, Hicks DG, Hughes KS, Nofech-Mozes S

Archives of pathology & laboratory medicine.. 2014 May 138 (5):595-601. Epub 11/15/2013.

A tissue quality index: an intrinsic control for measurement of effects of preanalytical variables on FFPE tissue.

Neumeister VM, Parisi F, England AM, Siddiqui S, Anagnostou V, Zarrella E, Vassilakopolou M, Bai Y, Saylor S, Sapino A, Kluger Y, Hicks DG, Bussolati G, Kwei S, Rimm DL

Laboratory investigation; a journal of technical methods and pathology.. 2014 April 94 (4):467-74. Epub 02/17/2014.

Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.

Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, Allison KH, Allred DC, Bartlett JM, Bilous M, Fitzgibbons P, Hanna W, Jenkins RB, Mangu PB, Paik S, Perez EA, Press MF, Spears PA, Vance GH, Viale G, Hayes DF

Archives of pathology & laboratory medicine.. 2014 February 138 (2):241-56. Epub 10/07/2013.

A pilot study comparing the effect of flaxseed, aromatase inhibitor, and the combination on breast tumor biomarkers.

McCann SE, Edge SB, Hicks DG, Thompson LU, Morrison CD, Fetterly G, Andrews C, Clark K, Wilton J, Kulkarni S

Nutrition and cancer.. 2014 66 (4):566-75. Epub 03/26/2014.

Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.

Wolff AC, Hammond ME, Hicks DG, Dowsett M, McShane LM, Allison KH, Allred DC, Bartlett JM, Bilous M, Fitzgibbons P, Hanna W, Jenkins RB, Mangu PB, Paik S, Perez EA, Press MF, Spears PA, Vance GH, Viale G, Hayes DF, ,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2013 November 131 (31):3997-4013. Epub 10/07/2013.

The evolving role of HER2 evaluation for diagnosis and clinical decision making for breast and gastric adenocarcinoma.

Hicks D, Whitney-Miller C

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2013 May 88 (3-4):121-31. Epub 01/07/2013.

Tissue pattern recognition error rates and tumor heterogeneity in gastric cancer.

Potts SJ, Huff SE, Lange H, Zakharov V, Eberhard DA, Krueger JS, Hicks DG, Young GD, Johnson T, Whitney-Miller CL

Applied immunohistochemistry & molecular morphology : AIMM. 2013 January 21 (1):21-30. Epub 1900 01 01.

Delay to formalin fixation 'cold ischemia time': effect on ERBB2 detection by in-situ hybridization and immunohistochemistry.

Portier BP, Wang Z, Downs-Kelly E, Rowe JJ, Patil D, Lanigan C, Budd GT, Hicks DG, Rimm DL, Tubbs RR

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2013 January 26 (1):1-9. Epub 08/17/2012.

Phase transformations and metallization of magnesium oxide at high pressure and temperature.

McWilliams RS, Spaulding DK, Eggert JH, Celliers PM, Hicks DG, Smith RF, Collins GW, Jeanloz R

Science.. 2012 December 7338 (6112):1330-3. Epub 11/22/2012.

Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.

Neumeister VM, Anagnostou V, Siddiqui S, England AM, Zarrella ER, Vassilakopoulou M, Parisi F, Kluger Y, Hicks DG, Rimm DL

Journal of the National Cancer Institute.. 2012 December 5104 (23):1815-24. Epub 10/22/2012.

GATA binding protein 3 is down-regulated in bladder cancer yet strong expression is an independent predictor of poor prognosis in invasive tumor.

Miyamoto H, Izumi K, Yao JL, Li Y, Yang Q, McMahon LA, Gonzalez-Roibon N, Hicks DG, Tacha D, Netto GJ

Human pathology.. 2012 November 43 (11):2033-40. Epub 05/18/2012.

The surgeon's impact on ER status.

Farkas RL, Mccarthy K, Tang P, Hellman L, Fronk J, Andrus CH, Peacock JL, Hicks DG

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2012 September 2030 (27_suppl):153. Epub 1900 01 01.

Axillary recurrence (AR) after negative sentinel node biopsy (SNB): Who is at risk?

Hicks DG, Tang P, Shayne M, Huston A, Ling MN, Skinner KA

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2012 September 2030 (27_suppl):180. Epub 1900 01 01.

Breast and Prostate Cancer in a BRCA2 Carrier.

Mahar T, Hicks DG

The breast journal.. 2012 September 18 (5):511-3. Epub 08/17/2012.

Predictors of nipple-areolar complex involvement by breast carcinoma: histopathologic analysis of 787 consecutive therapeutic mastectomy specimens.

Wang J, Xiao X, Wang J, Iqbal N, Baxter L, Skinner KA, Hicks DG, Hajdu SI, Tang P

Annals of surgical oncology.. 2012 April 19 (4):1174-80. Epub 10/18/2011.

The challenge and importance of standardizing pre-analytical variables in surgical pathology specimens for clinical care and translational research.

Hicks D, Boyce B

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2012 January 87 (1):14-7. Epub 07/06/2011.

HER2 testing in gastric and esophageal adenocarcinoma: new diagnostic challenges arising from new therapeutic options.

Koltz B, Hicks D, Whitney-Miller C

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2012 January 87 (1):40-5. Epub 07/12/2011.

Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP).

Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 January 27 (1):79-92. Epub 1900 01 01.

Targeted therapies in breast cancer: tailoring treatment to the molecular drivers of disease progression.

Hicks DG

MLO: medical laboratory observer.. 2012 January 44 (1):36, 38-9. Epub 1900 01 01.

Expression of the androgen receptor and its correlation with molecular subtypes in 980 chinese breast cancer patients.

Qi JP, Yang YL, Zhu H, Wang J, Jia Y, Liu N, Song YJ, Zan LK, Zhang X, Zhou M, Gu YH, Liu T, Hicks DG, Tang P

Breast cancer : basic and clinical research.. 2012 6 :1-8. Epub 12/06/2011.

Minocycline-Induced Bone Discoloration: A Case Report.

Chan CM, Hicks DG, Giordano BD

JBJS case connector.. 2012 2 (3):e47. Epub 1900 01 01.

Immunohistochemistry in the diagnostic evaluation of breast lesions.

Hicks DG

Applied immunohistochemistry & molecular morphology : AIMM. 2011 December 19 (6):501-5. Epub 1900 01 01.

HER2 testing in gastric and gastroesophageal junction cancers: a new therapeutic target and diagnostic challenge.

Hicks DG, Whitney-Miller C

Applied immunohistochemistry & molecular morphology : AIMM. 2011 December 19 (6):506-8. Epub 1900 01 01.

Tissue microarray-based immunohistochemical study can significantly underestimate the expression of HER2 and progesterone receptor in ductal carcinoma in situ of the breast.

Lin Y, Hatem J, Wang J, Quinn A, Hicks D, Tang P

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2011 October 86 (5):345-50. Epub 08/12/2010.

HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma.

Hu Y, Bandla S, Godfrey TE, Tan D, Luketich JD, Pennathur A, Qiu X, Hicks DG, Peters JH, Zhou Z

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2011 July 24 (7):899-907. Epub 04/01/2011.

Citius, altius, fortius-self-assessment in pathology and laboratory medicine: College of American Pathologists Self-assessment Module Committee.

Hernandez JS, Hicks DG

Archives of pathology & laboratory medicine.. 2011 June 135 (6):689-90. Epub 1900 01 01.

Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression.

Banerjee S, Lin CF, Skinner KA, Schiffhauer LM, Peacock J, Hicks DG, Redmond EM, Morrow D, Huston A, Shayne M, Langstein HN, Miller-Graziano CL, Strickland J, O'Donoghue L, De AK

Cancer research.. 2011 January 1571 (2):318-27. Epub 01/11/2011.

Breast cancer predictive factor testing: the challenges and importance of standardizing tissue handling.

Hicks DG, Kushner L, McCarthy K

Journal of the National Cancer Institute. Monographs.. 2011 2011 (42):43-5. Epub 1900 01 01.

A lower Allred score for progesterone receptor is strongly associated with a higher recurrence score of 21-gene assay in breast cancer.

Tang P, Wang J, Hicks DG, Wang X, Schiffhauer L, McMahon L, Yang Q, Shayne M, Huston A, Skinner KA, Griggs J, Lyman G

Cancer investigation.. 2010 November 28 (9):978-82. Epub 1900 01 01.

Invasive Lobular Carcinomas Do Not Express Basal Cytokeratin Markers CK5/6, CK14 and CK17.

Khilko N, Wang J, Wei B, Hicks DG, Tang P

Breast cancer : basic and clinical research.. 2010 October 214 :49-55. Epub 10/21/2010.

American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version).

Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC, ,

Archives of pathology & laboratory medicine.. 2010 July 134 (7):e48-72. Epub 1900 01 01.

American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.

Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2010 June 128 (16):2784-95. Epub 04/19/2010.

American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.

Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC

Archives of pathology & laboratory medicine.. 2010 June 134 (6):907-22. Epub 1900 01 01.

The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines.

Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P, Xing L, Hung MC, Bonfiglio T, Hicks DG, Tang P

Breast cancer : basic and clinical research.. 2010 May 204 :35-41. Epub 05/20/2010.

The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence.

Hicks DG, Janarthanan BR, Vardarajan R, Kulkarni SA, Khoury T, Dim D, Budd GT, Yoder BJ, Tubbs R, Schreeder MT, Estopinal NC, Beck RA, Wang Y, Ring BZ, Seitz RS, Ross DT

BMC cancer.. 2010 March 2210 :108. Epub 03/22/2010.

In reply.

Vance GH, Hicks DG

Archives of pathology & laboratory medicine.. 2010 February 134 (2):163. Epub 1900 01 01.

American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer

Hammond ME; Hayes DF; Dowsett M; Allred DC; Hagerty KL; Badve S; Fitzgibbons PL; Francis G; Goldstein NS; Hayes M; Hicks DG; Lester S; Love R; Mangu PB; McShane L; Miller K; Osborne CK; Paik S; Perlmutter J; Rhodes A; Sasano H; Schwartz JN; Sweep FC; Taube S; Torlakovic EE; Valenstein P; Viale G; Visscher D; Wheeler T; Williams RB; Wittliff JL; Wolff AC.

J Clin Oncol. 2010; April 19: [Epub ahead of print].

Malignant solitary fibrous tumor: report of 3 cases with unusual features.

Hu Y, Mahar TJ, Hicks DG, Raymond D, Jones C, Wandtke JC, Powers JM, Xu H

Applied immunohistochemistry & molecular morphology : AIMM. 2009 October 17 (5):451-7. Epub 1900 01 01.

Molecular classification of breast carcinomas by immunohistochemical analysis: are we ready?

Tang P, Skinner KA, Hicks DG

Diagnostic molecular pathology : the American journal of surgical pathology, part B.. 2009 September 18 (3):125-32. Epub 1900 01 01.

HER2 testing and subsequent trastuzumab treatment for breast cancer in a managed care environment.

Barron JJ, Cziraky MJ, Weisman T, Hicks DG

The oncologist.. 2009 August 14 (8):760-8. Epub 08/14/2009.

The 76-gene signature defines high-risk patients that benefit from adjuvant tamoxifen therapy.

Zhang Y, Sieuwerts AM, McGreevy M, Casey G, Cufer T, Paradiso A, Harbeck N, Span PN, Hicks DG, Crowe J, Tubbs RR, Budd GT, Lyons J, Sweep FC, Schmitt M, Schittulli F, Golouh R, Talantov D, Wang Y, Foekens JA

Breast cancer research and treatment.. 2009 July 116 (2):303-9. Epub 09/23/2008.

Dual expression of alpha-tocopherol-associated protein and estrogen receptor in normal/benign human breast luminal cells and the downregulation of alpha-tocopherol-associated protein in estrogen-receptor-positive breast carcinomas.

Johnykutty S, Tang P, Zhao H, Hicks DG, Yeh S, Wang X

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2009 June 22 (6):770-5. Epub 03/20/2009.

HER2: Closing the gap between laboratory testing and clinical practice.

Plebani M, Lippi G, Bartlett JM, Miller K, Hicks DG, Kulkarni S

American journal of clinical pathology.. 2009 June 131 (6):897-8; author reply 898-900. Epub 1900 01 01.

Osteoclastlike giant cell tumor of the salivary gland.

Fang X, Hicks DG, Hicks W, Zhang S

Annals of diagnostic pathology.. 2009 April 13 (2):114-8. Epub 10/24/2007.

Genetic heterogeneity in HER2 testing in breast cancer: panel summary and guidelines.

Vance GH, Barry TS, Bloom KJ, Fitzgibbons PL, Hicks DG, Jenkins RB, Persons DL, Tubbs RR, Hammond ME

Archives of pathology & laboratory medicine.. 2009 April 133 (4):611-2. Epub 1900 01 01.

Intravesical administration of plasminogen activator inhibitor type-1 inhibits in vivo bladder tumor invasion and progression.

Chen SC, Henry DO, Hicks DG, Reczek PR, Wong MK

The Journal of urology.. 2009 January 181 (1):336-42. Epub 11/17/2008.

[Molecular phenotypes of breast cancer and their clinical application].

Tang P, Wei B, Hicks DG, Skinner K, Bu H

Zhonghua bing li xue za zhi = Chinese journal of pathology.. 2009 January 38 (1):13-7. Epub 1900 01 01.

TLE3 as a candidate biomarker of response to taxane therapy.

Kulkarni SA, Hicks DG, Watroba NL, Murekeyisoni C, Hwang H, Khoury T, Beck RA, Ring BZ, Estopinal NC, Schreeder MT, Seitz RS, Ross DT

Breast cancer research : BCR.. 2009 11 (2):R17. Epub 03/23/2009.

Benign inclusion of axillary lymph nodes: report of two cases and literature review.

Chuang C, Hicks DG, Berenson M, Kulkarni S, Tang P

The breast journal.. 2009 15 (6):664-5. Epub 08/17/2009.

Bone metastasis is strongly associated with estrogen receptor-positive/progesterone receptor-negative breast carcinomas.

Wei B, Wang J, Bourne P, Yang Q, Hicks D, Bu H, Tang P

Human pathology.. 2008 December 39 (12):1809-15. Epub 08/19/2008.

Consensus recommendations on estrogen receptor testing in breast cancer by immunohistochemistry.

Yaziji H, Taylor CR, Goldstein NS, Dabbs DJ, Hammond EH, Hewlett B, Floyd AD, Barry TS, Martin AW, Badve S, Baehner F, Cartun RW, Eisen RN, Swanson PE, Hewitt SM, Vyberg M, Hicks DG,

Applied immunohistochemistry & molecular morphology : AIMM. 2008 December 16 (6):513-20. Epub 1900 01 01.

Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling.

Vaidya KS, Harihar S, Phadke PA, Stafford LJ, Hurst DR, Hicks DG, Casey G, DeWald DB, Welch DR

The Journal of biological chemistry.. 2008 October 17283 (42):28354-60. Epub 07/29/2008.

The role of the indispensable surgical pathologist in treatment planning for breast cancer.

Hicks DG, Kulkarni S, Hammond ME

Archives of pathology & laboratory medicine.. 2008 August 132 (8):1226-7. Epub 1900 01 01.

HER2-positive early breast cancer and trastuzumab: a surgeon's perspective.

Kulkarni S, Hicks DG

Annals of surgical oncology.. 2008 June 15 (6):1677-88. Epub 04/09/2008.

Trastuzumab as adjuvant therapy for early breast cancer: the importance of accurate human epidermal growth factor receptor 2 testing.

Hicks DG, Kulkarni S

Archives of pathology & laboratory medicine.. 2008 June 132 (6):1008-15. Epub 1900 01 01.

HER2+ breast cancer: review of biologic relevance and optimal use of diagnostic tools.

Hicks DG, Kulkarni S

American journal of clinical pathology.. 2008 February 129 (2):263-73. Epub 1900 01 01.

Adenocarcinoma arising from chronic perianal Crohn's disease: case report and review of the literature.

Smith R, Hicks D, Tomljanovich PI, Lele SB, Rajput A, Dunn KB

The American surgeon.. 2008 January 74 (1):59-61. Epub 1900 01 01.

Histological changes and temperature distribution studies of a novel bipolar radiofrequency heating system in degenerated and nondegenerated human cadaver lumbar discs.

Kapural L, Mekhail N, Hicks D, Kapural M, Sloan S, Moghal N, Ross J, Petrinec D

Pain medicine : the official journal of the American Academy of Pain Medicine.. 2008 9 (1):68-75. Epub 1900 01 01.

Solitary fibrous tumor of the breast and mammary myofibroblastoma: the same lesion?

Meguerditchian AN, Malik DA, Hicks DG, Kulkarni S

The breast journal.. 2008 14 (3):287-92. Epub 04/01/2008.

Fluorescence in situ hybridization (FISH) as primary methodology for the assessment of HER2 Status in adenocarcinoma of the breast: a single institution experience.

Tubbs RR, Hicks DG, Cook J, Downs-Kelly E, Pettay J, Hartke MB, Hood L, Neelon R, Myles J, Budd GT, Moore HC, Andresen S, Crowe JP

Diagnostic molecular pathology : the American journal of surgical pathology, part B.. 2007 December 16 (4):207-10. Epub 1900 01 01.

Candidate glioblastoma development gene identification using concordance between copy number abnormalities and gene expression level changes.

Lo KC, Rossi MR, LaDuca J, Hicks DG, Turpaz Y, Hawthorn L, Cowell JK

Genes, chromosomes & cancer.. 2007 October 46 (10):875-94. Epub 1900 01 01.

Challenges in array comparative genomic hybridization for the analysis of cancer samples.

Nowak NJ, Miecznikowski J, Moore SR, Gaile D, Bobadilla D, Smith DD, Kernstine K, Forman SJ, Mhawech-Fauceglia P, Reid M, Stoler D, Loree T, Rigual N, Sullivan M, Weiss LM, Hicks D, Slovak ML

Genetics in medicine : official journal of the American College of Medical Genetics.. 2007 September 9 (9):585-95. Epub 1900 01 01.

Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cells.

Sossey-Alaoui K, Safina A, Li X, Vaughan MM, Hicks DG, Bakin AV, Cowell JK

The American journal of pathology.. 2007 June 170 (6):2112-21. Epub 1900 01 01.

Recommendations for improved standardization of immunohistochemistry.

Goldstein NS, Hewitt SM, Taylor CR, Yaziji H, Hicks DG,

Applied immunohistochemistry & molecular morphology : AIMM. 2007 June 15 (2):124-33. Epub 1900 01 01.

SH3BP2 is rarely mutated in exon 9 in giant cell lesions outside cherubism.

Lietman SA, Prescott NL, Hicks DG, Westra WH, Levine MA

Clinical orthopaedics and related research.. 2007 June 459 :22-7. Epub 1900 01 01.

An approach to the validation of novel molecular markers of breast cancer via TMA-based FISH scanning.

Tubbs RR, Swain E, Pettay JD, Hicks DG

Journal of molecular histology.. 2007 May 38 (2):141-50. Epub 01/09/2007.

Defining the expression pattern of the LGI1 gene in BAC transgenic mice.

Head K, Gong S, Joseph S, Wang C, Burkhardt T, Rossi MR, LaDuca J, Matsui S, Vaughan M, Hicks DG, Heintz N, Cowell JK

Mammalian genome : official journal of the International Mammalian Genome Society.. 2007 May 18 (5):328-37. Epub 06/13/2007.

Prostate-derived Ets transcription factor (PDEF) downregulates survivin expression and inhibits breast cancer cell growth in vitro and xenograft tumor formation in vivo.

Ghadersohi A, Pan D, Fayazi Z, Hicks DG, Winston JS, Li F

Breast cancer research and treatment.. 2007 March 102 (1):19-30. Epub 08/08/2006.

A new rabbit monoclonal antibody (4B5) for the immunohistochemical (IHC) determination of the HER2 status in breast cancer: comparison with CB11, fluorescence in situ hybridization (FISH), and interlaboratory reproducibility.

Powell WC, Hicks DG, Prescott N, Tarr SM, Laniauskas S, Williams T, Short S, Pettay J, Nagle RB, Dabbs DJ, Scott KM, Brown RW, Grogan T, Roche PC, Tubbs RR

Applied immunohistochemistry & molecular morphology : AIMM. 2007 March 15 (1):94-102. Epub 1900 01 01.

The expression of the cytoskeletal focal adhesion protein paxillin in breast cancer correlates with HER2 overexpression and may help predict response to chemotherapy: a retrospective immunohistochemical study.

Short SM, Yoder BJ, Tarr SM, Prescott NL, Laniauskas S, Coleman KA, Downs-Kelly E, Pettay JD, Choueiri TK, Crowe JP, Tubbs RR, Budd TG, Hicks DG

The breast journal.. 2007 13 (2):130-9. Epub 1900 01 01.

A data model to predict HER2 status in breast cancer based on the clinical and pathologic profiles of a large patient population at a single institution.

Crowe JP, Patrick RJ, Rybicki LA, Escobar PF, Weng D, Thomas Budd G, Tubbs RR, Procop GW, Hicks DG

The Breast : official journal of the European Society of Mastology.. 2006 December 15 (6):728-35. Epub 05/22/2006.

Automation of manual components and image quantification of direct dual label fluorescence in situ hybridization (FISH) for HER2 gene amplification: A feasibility study.

Tubbs RR, Pettay JD, Swain E, Roche PC, Powell W, Hicks DG, Grogan T

Applied immunohistochemistry & molecular morphology : AIMM. 2006 December 14 (4):436-40. Epub 1900 01 01.

Loss of breast cancer metastasis suppressor 1 protein expression predicts reduced disease-free survival in subsets of breast cancer patients.

Hicks DG, Yoder BJ, Short S, Tarr S, Prescott N, Crowe JP, Dawson AE, Budd GT, Sizemore S, Cicek M, Choueiri TK, Tubbs RR, Gaile D, Nowak N, Accavitti-Loper MA, Frost AR, Welch DR, Casey G

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2006 November 1512 (22):6702-8. Epub 1900 01 01.

Analysis of gene expression in mineralized skeletal tissues by laser capture microdissection and RT-PCR.

Shao YY, Wang L, Hicks DG, Ballock RT

Laboratory investigation; a journal of technical methods and pathology.. 2006 October 86 (10):1089-95. Epub 08/28/2006.

Breast cancer in African-American women: differences in tumor biology from European-American women.

Amend K, Hicks D, Ambrosone CB

Cancer research.. 2006 September 166 (17):8327-30. Epub 1900 01 01.

Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR.

Hicks DG, Short SM, Prescott NL, Tarr SM, Coleman KA, Yoder BJ, Crowe JP, Choueiri TK, Dawson AE, Budd GT, Tubbs RR, Casey G, Weil RJ

The American journal of surgical pathology.. 2006 September 30 (9):1097-104. Epub 1900 01 01.

Vocal fold healing after laser cordectomy with adjuvant cryotherapy.

Knott PD, Byrd MC, Hicks DG, Strome M

The Laryngoscope.. 2006 September 116 (9):1580-4. Epub 1900 01 01.

Novel prognostic immunohistochemical biomarker panel for estrogen receptor-positive breast cancer.

Ring BZ, Seitz RS, Beck R, Shasteen WJ, Tarr SM, Cheang MC, Yoder BJ, Budd GT, Nielsen TO, Hicks DG, Estopinal NC, Ross DT

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2006 July 124 (19):3039-47. Epub 1900 01 01.

Prognostic significance of residual breast disease and axillary node involvement for patients who had primary induction chemotherapy for advanced breast cancer.

Escobar PF, Patrick RJ, Rybicki LA, Hicks D, Weng DE, Crowe JP

Annals of surgical oncology.. 2006 June 13 (6):783-7. Epub 04/12/2006.

Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas.

Chow WA, Bedell V, Gaytan P, Borden E, Goldblum J, Hicks D, Slovak ML

Cancer genetics and cytogenetics.. 2006 April 15166 (2):95-100. Epub 1900 01 01.

In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy.

Haka AS, Volynskaya Z, Gardecki JA, Nazemi J, Lyons J, Hicks D, Fitzmaurice M, Dasari RR, Crowe JP, Feld MS

Cancer research.. 2006 March 1566 (6):3317-22. Epub 1900 01 01.

Myeloma of the breast.

Escobar PF, Patrick RJ, Hicks D, Rim A, Crowe JP

The breast journal.. 2006 12 (4):387-8. Epub 1900 01 01.

HER2 status in bilateral breast cancer.

Crowe JP, Patrick RJ, Rybicki LA, Budd GT, Escobar PF, Tubbs RR, Hicks DG

International journal of fertility and women's medicine. 2006 51 (5):219-23. Epub 1900 01 01.

High-resolution immunophenotyping of subcellular compartments in tissue microarrays by enzyme metallography.

Tubbs R, Pettay J, Powell R, Hicks DG, Roche P, Powell W, Grogan T, Hainfeld JF

Applied immunohistochemistry & molecular morphology : AIMM. 2005 December 13 (4):371-5. Epub 1900 01 01.

Analytical validation and interobserver reproducibility of EnzMet GenePro: a second-generation bright-field metallography assay for concomitant detection of HER2 gene status and protein expression in invasive carcinoma of the breast.

Downs-Kelly E, Pettay J, Hicks D, Skacel M, Yoder B, Rybicki L, Myles J, Sreenan J, Roche P, Powell R, Hainfeld J, Grogan T, Tubbs R

The American journal of surgical pathology.. 2005 November 29 (11):1505-11. Epub 1900 01 01.

The unmet clinical need for new molecular genetic markers in the prognosis and therapeutic management of breast cancer.

Hicks DG, Dawson A, Mattingly S, Crowe JP

Archives of pathology & laboratory medicine.. 2005 November 129 (11):1372-4. Epub 1900 01 01.

Expression and activation of peroxisome proliferator-activated receptors in growth plate chondrocytes.

Shao YY, Wang L, Hicks DG, Tarr S, Ballock RT

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2005 September 23 (5):1139-45. Epub 1900 01 01.

The influence of polysomy 17 on HER2 gene and protein expression in adenocarcinoma of the breast: a fluorescent in situ hybridization, immunohistochemical, and isotopic mRNA in situ hybridization study.

Downs-Kelly E, Yoder BJ, Stoler M, Tubbs RR, Skacel M, Grogan T, Roche P, Hicks DG

The American journal of surgical pathology.. 2005 September 29 (9):1221-7. Epub 1900 01 01.

Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma.

Lin L, Hicks D, Xu B, Sigel JE, Bergfeld WF, Montgomery E, Fisher C, Hartke M, Tubbs R, Goldblum JR

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2005 May 18 (5):705-9. Epub 1900 01 01.

The incidence of topoisomerase II-alpha genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: a fluorescence in situ hybridization study.

Hicks DG, Yoder BJ, Pettay J, Swain E, Tarr S, Hartke M, Skacel M, Crowe JP, Budd GT, Tubbs RR

Human pathology.. 2005 April 36 (4):348-56. Epub 1900 01 01.

Assessment of the HER2 status in breast cancer by fluorescence in situ hybridization: a technical review with interpretive guidelines.

Hicks DG, Tubbs RR

Human pathology.. 2005 March 36 (3):250-61. Epub 1900 01 01.

The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course.

Yoder BJ, Tso E, Skacel M, Pettay J, Tarr S, Budd T, Tubbs RR, Adams JC, Hicks DG

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2005 January 111 (1):186-92. Epub 1900 01 01.

Immunohistochemical evaluation of microphthalmia-associated transcription factor expression in giant cell lesions.

Seethala RR, Goldblum JR, Hicks DG, Lehman M, Khurana JS, Pasha TL, Zhang PJ

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2004 December 17 (12):1491-6. Epub 1900 01 01.

HER-2 testing in breast cancer.

Tubbs RR, Hicks DG

JAMA.. 2004 October 20292 (15):1817-8; author reply 1818. Epub 1900 01 01.

Novel bright field molecular morphology methods for detection of HER2 gene amplification.

Tubbs R, Pettay J, Hicks D, Skacel M, Powell R, Grogan T, Hainfeld J

Journal of molecular histology.. 2004 August 35 (6):589-94. Epub 1900 01 01.

In situ hybridization in the pathology laboratory: general principles, automation, and emerging research applications for tissue-based studies of gene expression.

Hicks DG, Longoria G, Pettay J, Grogan T, Tarr S, Tubbs R

Journal of molecular histology.. 2004 August 35 (6):595-601. Epub 1900 01 01.

Molecular pathology testing of tissues fixed in prefer solution.

Tubbs RR, Hsi ED, Hicks D, Goldblum J

The American journal of surgical pathology.. 2004 March 28 (3):417-9. Epub 1900 01 01.

Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis.

Ritchlin CT, Haas-Smith SA, Li P, Hicks DG, Schwarz EM

The Journal of clinical investigation.. 2003 March 111 (6):821-31. Epub 1900 01 01.

Phase II Study of Ifosfamide+Doxorubicin in Patients With Advanced Synovial Sarcomas (E1793): A Trial of the Eastern Cooperative Oncology Group.

Edmonson JH, Ryan LM, Falkson CI, Hicks DG, Blum RH

Sarcoma.. 2003 7 (1):9-11. Epub 1900 01 01.

Parathyroid hormone-related Peptide expression in cartilaginous tumors.

Pateder DB, Gish MW, O'Keefe RJ, Hicks DG, Teot LA, Rosier RN

Clinical orthopaedics and related research.. 2002 October (403):198-204. Epub 1900 01 01.

Interobserver interpretative reproducibility of GOLDFISH, a first generation gold-facilitated autometallographic bright field in situ hybridization assay for HER-2/neu amplification in invasive mammary carcinoma.

Tubbs R, Skacel M, Pettay J, Powell R, Myles J, Hicks D, Sreenan J, Roche P, Stoler MH, Hainfeld J

The American journal of surgical pathology.. 2002 July 26 (7):908-13. Epub 1900 01 01.

Development of an animal model for prostate cancer cell metastasis to adult human bone.

Tsingotjidou AS, Zotalis G, Jackson KR, Sawyers C, Puzas JE, Hicks DG, Reiter R, Lieberman JR

Anticancer research.. 2001 21 (2A):971-8. Epub 1900 01 01.

Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.

Rapoport AP, Simons-Evelyn M, Chen T, Sidell R, Luhowskyj S, Rosell K, Obrig T, Hicks D, Hinkle PM, Nahm M, Insel RA, Abboud CN

Blood cells, molecules & diseases.. 2001 27 (3):610-24. Epub 1900 01 01.

Osteonecrosis of the temporomandibular joint: correlation of magnetic resonance imaging and histology.

Larheim TA, Westesson PL, Hicks DG, Eriksson L, Brown DA

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.. 1999 August 57 (8):888-98; discussion 899. Epub 1900 01 01.

Histopathology of the palmar beak ligament in trapeziometacarpal osteoarthritis.

Doerschuk SH, Hicks DG, Chinchilli VM, Pellegrini VD

The Journal of hand surgery.. 1999 May 24 (3):496-504. Epub 1900 01 01.

Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway.

Pollice PF, Hsu J, Hicks DG, Bukata S, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1998 November 16 (6):697-704. Epub 1900 01 01.

The potential role of transforming growth factor beta in fracture healing.

Rosier RN, O'Keefe RJ, Hicks DG

Clinical orthopaedics and related research.. 1998 October (355 Suppl):S294-300. Epub 1900 01 01.

Patterns of cytokine production in psoriatic synovium.

Ritchlin C, Haas-Smith SA, Hicks D, Cappuccio J, Osterland CK, Looney RJ

The Journal of rheumatology.. 1998 August 25 (8):1544-52. Epub 1900 01 01.

Treatment of multifocal lymphoma of bone with intensified ProMACE-CytaBOM chemotherapy and involved field radiotherapy.

Rapoport AP, Constine LS, Packman CH, Rosier RN, O'Keefe R, Hicks DG, Rubin SJ, Rowe JM

American journal of hematology.. 1998 May 58 (1):1-7. Epub 1900 01 01.

MR imaging of rabbit hip cartilage with a clinical imager and specifically designed surface coils.

Morishita Y, Rubin SJ, Hicks DG, Kwok E, Seo GS, Totterman SM

Academic radiology.. 1998 May 5 (5):365-73. Epub 1900 01 01.

Leiomyomatosis peritonealis disseminata, endometriosis, and multicystic mesothelioma: an unusual association.

Zotalis G, Nayar R, Hicks DG

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.. 1998 April 17 (2):178-82. Epub 1900 01 01.

Bone morphogenetic protein-7 in growth-plate chondrocytes: regulation by retinoic acid is dependent on the stage of chondrocyte maturation.

Grimsrud CD, Rosier RN, Puzas JE, Reynolds PR, Reynolds SD, Hicks DG, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1998 March 16 (2):247-55. Epub 1900 01 01.

Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction.

O'Keefe RJ, Rosier RN, Teot LA, Stewart JM, Hicks DG

The Iowa orthopaedic journal.. 1998 18 :26-34. Epub 1900 01 01.

P-glycoprotein expression in cartilaginous tumors.

Rosier RN, O'Keefe RJ, Teot LA, Fox EJ, Nester TA, Puzas JE, Reynolds PR, Hicks DG

Journal of surgical oncology.. 1997 June 65 (2):95-105. Epub 1900 01 01.

Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study.

O'Keefe RJ, Teot LA, Singh D, Puzas JE, Rosier RN, Hicks DG

Laboratory investigation; a journal of technical methods and pathology.. 1997 April 76 (4):457-65. Epub 1900 01 01.

Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth-plate chondrocytes.

O'Keefe RJ, Loveys LS, Hicks DG, Reynolds PR, Crabb ID, Puzas JE, Rosier RN

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1997 March 15 (2):162-74. Epub 1900 01 01.

Effects of lead on growth plate chondrocyte phenotype.

Hicks DG, O'Keefe RJ, Reynolds KJ, Cory-Slechta DA, Puzas JE, Judkins A, Rosier RN

Toxicology and applied pharmacology.. 1996 September 140 (1):164-72. Epub 1900 01 01.

Extraosseous primary and recurrent giant cell tumors: transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation.

Teot LA, O'Keefe RJ, Rosier RN, O'Connell JX, Fox EJ, Hicks DG

Human pathology.. 1996 July 27 (7):625-32. Epub 1900 01 01.

Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages.

Hicks DG, Judkins AR, Sickel JZ, Rosier RN, Puzas JE, O'Keefe RJ

The Journal of bone and joint surgery. American volume.. 1996 April 78 (4):482-96. Epub 1900 01 01.

Mastocytosis presenting as a skeletal disorder.

Delsignore JL, Dvoretsky PM, Hicks DG, O'Keefe RJ, Rosier RN

The Iowa orthopaedic journal.. 1996 16 :126-34. Epub 1900 01 01.

Rate of degeneration of human acetabular cartilage after hemiarthroplasty.

Dalldorf PG, Banas MP, Hicks DG, Pellegrini VD

The Journal of bone and joint surgery. American volume.. 1995 June 77 (6):877-82. Epub 1900 01 01.

Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus.

Hughes SS, Hicks DG, O'Keefe RJ, Hurwitz SR, Crabb ID, Krasinskas AM, Loveys L, Puzas JE, Rosier RN

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1995 April 10 (4):533-44. Epub 1900 01 01.

Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells.

Hicks DG, Gokan T, O'Keefe RJ, Totterman SM, Fultz PJ, Judkins AR, Meyers SP, Rubens DJ, Sickel JZ, Rosier RN

Cancer.. 1995 February 1575 (4):973-80. Epub 1900 01 01.

Multiple drug resistance in osteosarcoma.

Rosier RN, Teot LA, Hicks DG, Schwartz C, O'Keefe RJ, Puzas JE

The Iowa orthopaedic journal.. 1995 15 :66-73. Epub 1900 01 01.

Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: rapid induction of type X collagen in culture.

O'Keefe RJ, Puzas JE, Loveys L, Hicks DG, Rosier RN

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1994 November 9 (11):1713-22. Epub 1900 01 01.

Hyperostosis cranii ex vacuo: a rare complication of shunting for hydrocephalus.

Di Preta JA, Powers JM, Hicks DG

Human pathology.. 1994 May 25 (5):545-7. Epub 1900 01 01.

Regulation of osteoclastic activity in infection.

Puzas JE, Hicks DG, Reynolds SD, O'Keefe RJ

Methods in enzymology.. 1994 236 :47-58. Epub 1900 01 01.

Diagnosis of posttransplantation lymphoproliferative disorder by endomyocardial biopsy in a cardiac allograft recipient.

Eisen HJ, Hicks D, Kant JA, Montone KT, Mull R, Pigott J, Tomaszewski JE

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.. 1994 13 (2):241-5. Epub 1900 01 01.

Preliminary findings on the effects of sex hormones on bone metabolism in anorexia nervosa.

Kreipe RE, Hicks DG, Rosier RN, Puzas JE

The Journal of adolescent health : official publication of the Society for Adolescent Medicine.. 1993 June 14 (4):319-24. Epub 1900 01 01.

Epithelioid osteosarcoma of bone. Immunocytochemical evidence suggesting divergent epithelial and mesenchymal differentiation in a primary osseous neoplasm.

Kramer K, Hicks DG, Palis J, Rosier RN, Oppenheimer J, Fallon MD, Cohen HJ

Cancer.. 1993 May 1571 (10):2977-82. Epub 1900 01 01.

Quiz: case report 776. Chondromyxoid fibroma of femur.

Adams MJ, Spencer GM, Totterman S, Hicks DG

Skeletal radiology.. 1993 22 (5):358-61. Epub 1900 01 01.

Extrapelvic compression of the sciatic nerve. An unusual cause of pain about the hip: report of five cases.

Hughes SS, Goldstein MN, Hicks DG, Pellegrini VD

The Journal of bone and joint surgery. American volume.. 1992 December 74 (10):1553-9. Epub 1900 01 01.

Nonradioactive in situ hybridization using digoxigenin-labeled oligonucleotides. Applications to musculoskeletal tissues.

Crabb ID, Hughes SS, Hicks DG, Puzas JE, Tsao GJ, Rosier RN

The American journal of pathology.. 1992 September 141 (3):579-89. Epub 1900 01 01.

Creation of disc displacement in human temporomandibular joint autopsy specimens.

Eriksson L, Westesson PL, Macher D, Hicks D, Tallents RH

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.. 1992 August 50 (8):869-73. Epub 1900 01 01.

Diabetic mastopathy: a distinctive clinicopathologic entity.

Tomaszewski JE, Brooks JS, Hicks D, Livolsi VA

Human pathology.. 1992 July 23 (7):780-6. Epub 1900 01 01.

Coincident Kaposi sarcoma and T-cell lymphoma in a patient with the Wiskott-Aldrich syndrome.

Meropol NJ, Hicks D, Brooks JJ, Siminovitch KA, Fishman NO, Kant JA, Bennett JS

American journal of hematology.. 1992 June 40 (2):126-34. Epub 1900 01 01.

Temporomandibular joint: surgically created disk displacement causes arthrosis in the rabbit.

Macher DJ, Westesson PL, Brooks SL, Hicks DG, Tallents RH

Oral surgery, oral medicine, and oral pathology.. 1992 June 73 (6):645-9. Epub 1900 01 01.

In situ hybridization for Epstein-Barr virus NotI repeats in posttransplant lymphoproliferative disorder.

Montone KT, Friedman H, Hodinka RL, Hicks DG, Kant JA, Tomaszewski JE

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 1992 May 5 (3):292-302. Epub 1900 01 01.

Demonstration of passenger leukocytes in a case of Epstein-Barr virus posttransplant lymphoproliferative disorder using restriction fragment length polymorphism analysis.

Godyn JJ, Hicks DG, Hsu SH, Kant J, Montone KT, Zmijewski CM, Tomaszewski JE

Archives of pathology & laboratory medicine.. 1992 March 116 (3):249-52. Epub 1900 01 01.

Colon invasion by primary splenic lymphoma: a case report and review of the literature.

Karpeh MS, Hicks DG, Torosian MH

Surgery.. 1992 February 111 (2):224-7. Epub 1900 01 01.

Reactive lymphohistiocytosis with recurrence in the optic chiasm.

Galetta SL, Stadtmauer EA, Hicks DG, Raps EC, Plock G, Oberholtzer JC

Journal of clinical neuro-ophthalmology. 1991 March 11 (1):25-30. Epub 1900 01 01.

Clonal analysis of solitary follicular nodules in the thyroid.

Hicks DG, LiVolsi VA, Neidich JA, Puck JM, Kant JA

The American journal of pathology.. 1990 September 137 (3):553-62. Epub 1900 01 01.

Laboratory assessment of poisoning with a carbamate insecticide.

Remaley AT, Hicks DG, Kane MD, Shaw LM

Clinical chemistry.. 1988 September 34 (9):1933-6. Epub 1900 01 01.

Indices of noradrenergic output in depression.

Siever LJ, Uhde TW, Jimerson DC, Lake CR, Kopin IJ, Murphy DL

Psychiatry research.. 1986 September 19 (1):59-73. Epub 1900 01 01.

K562 cell erythroid differentiation: requirement for a factor in fetal bovine serum.

Hicks DG, Ohlsson-Wilhelm BM, Farley BA, Kosciolek BA, Rowley PT

Experimental hematology.. 1985 May 13 (4):273-80. Epub 1900 01 01.

Adenocarcinoma of the stomach following irradiation and chemotherapy for lymphoma in young patients.

Brumback RA, Gerber JE, Hicks DG, Strauchen JA

Cancer.. 1984 September 1554 (6):994-8. Epub 1900 01 01.

Two-dimensional echocardiographic identification of aortico-left ventricular tunnel.

Perry JC, Nanda NC, Hicks DG, Harris JP

The American journal of cardiology.. 1983 October 152 (7):913-4. Epub 1900 01 01.

Two-dimensional echocardiography of intracardiac masses: echo pattern-histopathology correlation.

Bhandari AK, Nanda NC, Hicks DG

Ultrasound in medicine & biology.. 1982 8 (6):673-80. Epub 1900 01 01.

Books

IHC & Antigen Retrieval Technique Based Res & Dx (2010)

Chapter: The pros and cons of automation for immunohistochemistry from the prospective of the pathology laboratory

Authors: Hicks DG, McMahon L

Publisher: Artech House Publishers, Inc., Boston, MA 2010

Bone cancer: progression and therapeutic approaches (2010)

Chapter: The histopathology of skeletal metastases

Authors: Tang P, Hicks DG

Publisher: Academic Press, San Diego, CA 2010

Cell and Tissue Based Molecular Pathology (2008)

Chapter: Molecular Pathology of Breast Cancer

Authors: Hicks DG

Publisher: Saunders 2008

Cancer in the Spine:Handbook of Comprehensive Care (2006)

Chapter: Metastatic Disease to the Musculoskeletal System

Authors: Hicks DG

Publisher: Humanna Press 2006

Molecular Morphology in Human Tissues (2005)

Chapter: Molecular Morphology of Human Tissues. High-Thru-put Morphologic Gene Expression Studies Using Automated mRNA In Situ Hybridiz. Applications & Tissue Microarrays for Post-Genomic and Clinical Research

Authors: Nitta H, Hicks D, Skacel M., Pettay J, Grogan T., and Tubbs RR

Publisher: CRC Press, Boca Raton, FL 2005

Molecular Morphology in Human Tissues (2005)

Chapter: GOLD and SILVER-Facilitated Metallographic In Situ Hybridization Procedures for Detection of HER2 Gene Amplification

Authors: Tubbs RR, Pettay J., Skacel M, Powell R, Hicks D, and Hainfeld J

Publisher: CRC Press, Boca Raton, FL 2005

Immunohistochemistry & In Situ Hybrid. of Human Carcinomas (2004)

Chapter: Tissue Microarrays and their Modifications in High-Throughput Analysis of Clinical Specimens

Authors: Skacel M, Hicks DG, Tubbs RR

Publisher: Humana Press 2004

Assessment and Treatment of Cancer Pain (1998)

Chapter: Mechanisms of Bone Metastasis

Authors: Rosier RN, Hicks DG, Teot LA, Puzas JE, O'Keefe RJ

Publisher: IASP Press, Seattle 1998

Methods in Enzymology. Bacterial Pathogenesis (1994)

Chapter: Regulation of osteoclastic activity in infection

Authors: Puzas JE, Hicks DG, Reynolds SO, O'Keefe RJ

Publisher: Academic Press, San Diego, New York 1994

Surgical Pathology of Lymph Nodes & Related Organs (1994)

Chapter: The interpretation of nonlymphoid elements in lymph node biopsy specimens

Authors: Kant J, Hicks DG

Publisher: WB Saunders Company, Philadelphia 1994

Bone Formation and Repair (1994)

Chapter: Sarcomatous bone formation

Authors: Rosier RN, Hicks DG

Publisher: American Academy of Orthopaedic Surgeons, Rosemont, IL 1994

Regulation of Hemoglobin Biosynthesis (1983)

Chapter: Regulation of hemoglobin synthesis in K-562 human erythroleukemia cells

Authors: Rowley PT, Ohlsson-Wilhelm BM, Hicks DG, Rudolph NS, Farley B, Kosciolek B, LaBella S

Publisher: Paragon Press, Salt Lake City, UT 1983

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