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Kristin Scheible, M.D.

Kristin Scheible, M.D.

Pediatrics , Neonatology

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UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
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Contact

Office (585) 275-2972
Fax (585) 756-7780

About Me

As a neonatologist, Dr. Scheible's first and foremost goal is to provide excellent clinical care to her patients. She believes it is critical to work collaboratively with parents and bedside care providers to achieve the best outcomes for our babies, even in highly complex clinical situations. Sh...
As a neonatologist, Dr. Scheible's first and foremost goal is to provide excellent clinical care to her patients. She believes it is critical to work collaboratively with parents and bedside care providers to achieve the best outcomes for our babies, even in highly complex clinical situations. She encourages her care team to incorporate parental concerns into their daily assessment. By doing so, they can have a complete understanding of the patient's condition not just based on objective data available to us, but also the more subtle, and difficult to gather, "intuition" that only a parent can provide.

As part of the extracorporeal membrane oxygenation team (ECMO) team, Dr. Scheible has a special interest in caring for babies with persistent pulmonary hypertension, who struggle with adapting their circulation to an ex-utero environment. The complex, labile physiology and individual variability that such babies experience is exceptionally challenging, and requires an intensive, interdisciplinary approach to help them transition.

She feels that as neonatologists her job is not to just address the immediate problem, but also understand the long-term risks and benefits of each of our treatments. For her, balancing these short and long term goals, in cooperation with the parents and care team, is the most difficult and rewarding aspect of being a Neonatologist.

Dr. Scheible has received the "Patient and Family Centered Care Award" and holds "Bronze Star" level which is direct recognition from the families and patients in which she serves.

Faculty Appointments

Associate Professor - Department of Pediatrics, Neonatology (SMD)

Dean's Associate Professorship - Department of Pediatrics (SMD)

Associate Professor - Department of Microbiology and Immunology (SMD) - Joint

Credentials

Residency & Fellowship

Fellowship, Neonatology, University of Rochester Medical Center. 2007 - 2010

Residency, Pediatrics, University of Rochester Medical Center. 2005 - 2007

Internship, Pediatrics, University of Rochester Medical Center. 2004 - 2005

Education

MD | University of Rochester School of Medicine/Dentistry (USA). 2004

Awards

American Thoracic Society Abstract Award. 2017

University of Rochester Bronze Star. 2014

Patient-and Family-Centered Care Award. 2013

Patient-and Family-Centered Care Award. 2012

University of Rochester Strong Star. 2011 - 2016

Pediatric Research Society, Young Investigator. 2011

NICHD Fellows Conference (nominated/selected attendee). 2009

Ruth L. Kirschstein National Research Service Award, (T32, Francis Gigliotti). 2008 - 2011

Janet M. Glascow Memorial Achievement Award. 2004

Summer Fellowship in Anesthesiology. 2000

Outstanding Graduate in the Faculty of Arts and Letters. 1993

Lucia Maria Haupt Award in Anthropology. 1993

Kreyer Prize for Excellence in German. 1991

Research

Advanced NICU care has improved survival of very premature infants, but their improved survival is accompanied by long-term complications such as impaired lung function. Infants born prematurely are highly susceptible to recurrent, severe respiratory viruses, suggesting a state of immune deficiency,...
Advanced NICU care has improved survival of very premature infants, but their improved survival is accompanied by long-term complications such as impaired lung function. Infants born prematurely are highly susceptible to recurrent, severe respiratory viruses, suggesting a state of immune deficiency, specifically T cell immunity. They also suffer from diseases characterized by chronic inflammation associated with T cell activation, including bronchopulmonary dysplasia. This clinical paradox (T cells able to activate but not protect) is not well explained.

Our lab is interested in understanding the specific ways in which premature birth disrupts normal T cell development, and the impact of abnormal T cell development on a premature infant's clinical outcomes. Our lab primarily uses high parameter flow cytometric and high-throughput sequencing approaches to interrogate T cell receptor, cytokine signaling and functional differences that are intrinsic to T cells in various stages of fetal development. We work closely with investigators in Neonatology, Obstetrics, Infectious Diseases, Microbiology, Immunology, Genetics, Biostatistics and Computational Biology to understand in vitro T cell behavior in the context of longitudinal, translational human studies, including the Prematurity and Respiratory Outcomes Program and Respiratory Pathogens Research Center.

Dr. Scheible is a member of the Society for Pediatric Research and fellow, of the American Academy of Pediatrics.

Research Lab

Publications

Journal Articles

In utero exposure to per - and polyfluoroalkyl substances (PFAS) associates with altered human infant T helper cell development.

Meléndez DC, Laniewski N, Jusko TA, Qiu X, Paige Lawrence B, Rivera-Núñez Z, Brunner J, Best M, Macomber A, Leger A, Kannan K, Miller RK, Barrett ES, O'Connor TG, Scheible K

medRxiv : the preprint server for health sciences.. 2024 November 18 Epub 11/18/2024.

Short term air pollution exposure during pregnancy and associations with maternal immune markers.

Yount CS, Scheible K, Thurston SW, Qiu X, Ge Y, Hopke PK, Lin Y, Miller RK, Murphy SK, Brunner J, Barrett E, O'Connor TG, Zhang J, Rich DQ

Environmental research.. 2024 November 1260 :119639. Epub 07/19/2024.

Prenatal maternal immune activation predicts observed fearfulness in infancy.

Serrano J, Womack S, Yount C, Chowdhury SF, Arnold M, Brunner J, Duberstein Z, Barrett ES, Scheible K, Miller RK, O'Connor TG

Developmental psychology.. 2024 November 60 (11):2052-2061. Epub 03/28/2024.

Affective symptoms in pregnancy are associated with the vaginal microbiome.

Scheible K, Beblavy R, Sohn MB, Qui X, Gill AL, Narvaez-Miranda J, Brunner J, Miller RK, Barrett ES, O'Connor TG, Gill SR

Journal of affective disorders.. 2024 September 16 Epub 09/16/2024.

Gene Regulatory Programs that Specify Age-Related Differences during Thymocyte Development.

Sankaran DG, Zhu H, Maymi VI, Forlastro IM, Jiang Y, Laniewski N, Scheible KM, Rudd BD, Grimson AW

bioRxiv : the preprint server for biology.. 2024 June 17 Epub 06/17/2024.

Affective Symptoms in Pregnancy are Associated with the Vaginal Microbiome.

Scheible K, Beblavy R, Sohn MB, Qui X, Gill AL, Narvaez-Miranda J, Brunner J, Miller RK, Barrett ES, O'Connor TG, Gill SR

bioRxiv : the preprint server for biology.. 2024 April 12 Epub 04/12/2024.

The gene regulatory basis of bystander activation in CD8 T cells.

Watson NB, Patel RK, Kean C, Veazey J, Oyesola OO, Laniewski N, Grenier JK, Wang J, Tabilas C, Yee Mon KJ, McNairn AJ, Peng SA, Wesnak SP, Nzingha K, Davenport MP, Tait Wojno ED, Scheible KM, Smith NL, Grimson A, Rudd BD

Science immunology.. 2024 February 239 (92):eadf8776. Epub 02/23/2024.

Transfusion of Adult, but Not Neonatal, Platelets Promotes Monocyte Trafficking in Neonatal Mice.

Maurya P, Ture SK, Li C, Scheible KM, McGrath KE, Palis J, Morrell CN

Arteriosclerosis, thrombosis, and vascular biology.. 2023 June 43 (6):873-885. Epub 03/23/2023.

Leveraging Microbial Symbiosis to Modulate Bronchopulmonary Dysplasia.

Peterson LS, Scheible K

American journal of respiratory cell and molecular biology.. 2023 March 68 (3):235-236. Epub 1900 01 01.

Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry.

Hudak ML, Flannery DD, Barnette K, Getzlaff T, Gautam S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Ellington SR, Galang RR, Snead MC, Woodworth KR, Zapata LB, Puopolo KM,

Pediatrics.. 2023 February 1151 (2)Epub 1900 01 01.

Aberrant newborn T cell and microbiota developmental trajectories predict respiratory compromise during infancy.

McDavid A, Laniewski N, Grier A, Gill AL, Kessler HA, Huyck H, Carbonell E, Holden-Wiltse J, Bandyopadhyay S, Carnahan J, Dylag AM, Topham DJ, Falsey AR, Caserta MT, Pryhuber GS, Gill SR, Scheible KM

iScience.. 2022 April 1525 (4):104007. Epub 03/01/2022.

A Multilingual Browser Platform for Medical Subject Headings.

Scheible R, Strecker P, Yazijy S, Thomczyk F, Talpa R, Puhl A, Boeker M

Studies in health technology and informatics.. 2022 January 14289 :384-387. Epub 1900 01 01.

MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response.

Yee Mon KJ, Zhu H, Daly CWP, Vu LT, Smith NL, Patel R, Topham DJ, Scheible K, Jambo K, Le MTN, Rudd BD, Grimson A

Cell reports.. 2021 November 937 (6):109969. Epub 1900 01 01.

Dynamic Biomechanical Analysis of Vocal Folds Using Pipette Aspiration Technique.

Scheible F, Lamprecht R, Semmler M, Sutor A

Sensors.. 2021 April 2121 (9)Epub 04/21/2021.

Cohort profile: Understanding Pregnancy Signals and Infant Development (UPSIDE): a pregnancy cohort study on prenatal exposure mechanisms for child health.

O'Connor T, Best M, Brunner J, Ciesla AA, Cunning A, Kapula N, Kautz A, Khoury L, Macomber A, Meng Y, Miller RK, Murphy H, Salafia CM, Vallejo Sefair A, Serrano J, Barrett E,

BMJ open.. 2021 April 111 (4):e044798. Epub 04/01/2021.

Eight practices for data management to enable team data science.

McDavid A, Corbett AM, Dutra JL, Straw AG, Topham DJ, Pryhuber GS, Caserta MT, Gill SR, Scheible KM, Holden-Wiltse J

Journal of clinical and translational science.. 2020 June 235 (1):e14. Epub 06/23/2020.

Disruption of normal patterns of FOXF1 expression in a lethal disorder of lung development.

Steiner LA, Getman M, Schiralli Lester GM, Iqbal MA, Katzman P, Szafranski P, Stankiewicz P, Bhattacharya S, Mariani T, Pryhuber G, Lin X, Young JL, Dean DA, Scheible K

Journal of medical genetics.. 2020 May 57 (5):296-300. Epub 10/29/2019.

Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants.

Caserta MT, Yang H, Bandyopadhyay S, Qiu X, Gill SR, Java J, McDavid A, Falsey AR, Topham DJ, Holden-Wiltse J, Scheible K, Pryhuber G

The Journal of pediatrics.. 2019 November 214 :12-19.e3. Epub 07/31/2019.

Respiratory Medications in Infants <29 Weeks during the First Year Postdischarge: The Prematurity and Respiratory Outcomes Program (PROP) Consortium.

Ryan RM, Keller RL, Poindexter BB, D'Angio CT, Shaw PA, Bellamy SL, Moore PE, McPherson C, Greenberg JM,

The Journal of pediatrics.. 2019 May 208 :148-155.e3. Epub 03/08/2019.

Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia.

Ryan RM, Feng R, Bazacliu C, Ferkol TW, Ren CL, Mariani TJ, Poindexter BB, Wang F, Moore PE,

The Journal of pediatrics.. 2019 April 207 :130-135.e2. Epub 01/04/2019.

Neonatal gut and respiratory microbiota: coordinated development through time and space.

Grier A, McDavid A, Wang B, Qiu X, Java J, Bandyopadhyay S, Yang H, Holden-Wiltse J, Kessler HA, Gill AL, Huyck H, Falsey AR, Topham DJ, Scheible KM, Caserta MT, Pryhuber GS, Gill SR

Microbiome.. 2018 October 266 (1):193. Epub 10/26/2018.

Exome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth.

Hamvas A, Feng R, Bi Y, Wang F, Bhattacharya S, Mereness J, Kaushal M, Cotten CM, Ballard PL, Mariani TJ,

BMC genetics.. 2018 October 2019 (1):94. Epub 10/20/2018.

Acute Responses to Diuretic Therapy in Extremely Low Gestational Age Newborns: Results from the Prematurity and Respiratory Outcomes Program Cohort Study.

Blaisdell CJ, Troendle J, Zajicek A,

The Journal of pediatrics.. 2018 June 197 :42-47.e1. Epub 03/26/2018.

T cell developmental arrest in former premature infants increases risk of respiratory morbidity later in infancy.

Scheible KM, Emo J, Laniewski N, Baran AM, Peterson DR, Holden-Wiltse J, Bandyopadhyay S, Straw AG, Huyck H, Ashton JM, Tripi KS, Arul K, Werner E, Scalise T, Maffett D, Caserta M, Ryan RM, Reynolds AM, Ren CL, Topham DJ, Mariani TJ, Pryhuber GS

JCI insight.. 2018 February 223 (4)Epub 02/22/2018.

Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth.

Grier A, Qiu X, Bandyopadhyay S, Holden-Wiltse J, Kessler HA, Gill AL, Hamilton B, Huyck H, Misra S, Mariani TJ, Ryan RM, Scholer L, Scheible KM, Lee YH, Caserta MT, Pryhuber GS, Gill SR

Microbiome.. 2017 December 115 (1):158. Epub 12/11/2017.

Immune and neuroendocrine correlates of temperament in infancy.

O'Connor TG, Scheible K, Sefair AV, Gilchrist M, Blackmore ER, Winter MA, Gunnar MR, Wyman C, Carnahan J, Moynihan JA, Caserta MT

Development and psychopathology.. 2017 December 29 (5):1589-1600. Epub 1900 01 01.

Bronchopulmonary Dysplasia and Perinatal Characteristics Predict 1-Year Respiratory Outcomes in Newborns Born at Extremely Low Gestational Age: A Prospective Cohort Study.

Keller RL, Feng R, DeMauro SB, Ferkol T, Hardie W, Rogers EE, Stevens TP, Voynow JA, Bellamy SL, Shaw PA, Moore PE,

The Journal of pediatrics.. 2017 August 187 :89-97.e3. Epub 05/17/2017.

Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins.

Szafranski P, Gambin T, Dharmadhikari AV, Akdemir KC, Jhangiani SN, Schuette J, Godiwala N, Yatsenko SA, Sebastian J, Madan-Khetarpal S, Surti U, Abellar RG, Bateman DA, Wilson AL, Markham MH, Slamon J, Santos-Simarro F, Palomares M, Nevado J, Lapunzina P, Chung BH, Wong WL, Chu YW, Mok GT, Kerem E, Reiter J, Ambalavanan N, Anderson SA, Kelly DR, Shieh J, Rosenthal TC, Scheible K, Steiner L, Iqbal MA, McKinnon ML, Hamilton SJ, Schlade-Bartusiak K, English D, Hendson G, Roeder ER, DeNapoli TS, Littlejohn RO, Wolff DJ, Wagner CL, Yeung A, Francis D, Fiorino EK, Edelman M, Fox J, Hayes DA, Janssens S, De Baere E, Menten B, Loccufier A, Vanwalleghem L, Moerman P, Sznajer Y, Lay AS, Kussmann JL, Chawla J, Payton DJ, Phillips GE, Brosens E, Tibboel D, de Klein A, Maystadt I, Fisher R, Sebire N, Male A, Chopra M, Pinner J, Malcolm G, Peters G, Arbuckle S, Lees M, Mead Z, Quarrell O, Sayers R, Owens M, Shaw-Smith C, Lioy J, McKay E, de Leeuw N, Feenstra I, Spruijt L, Elmslie F, Thiruchelvam T, Bacino CA, Langston C, Lupski JR, Sen P, Popek E, Stankiewicz P

Human genetics.. 2016 May 135 (5):569-586. Epub 04/12/2016.

Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants.

Scheible KM, Emo J, Yang H, Holden-Wiltse J, Straw A, Huyck H, Misra S, Topham DJ, Ryan RM, Reynolds AM, Mariani TJ, Pryhuber GS

Clinical immunology : the official journal of the Clinical Immunology Society.. 2015 December 161 (2):65-74. Epub 07/29/2015.

Comparisons and Limitations of Current Definitions of Bronchopulmonary Dysplasia for the Prematurity and Respiratory Outcomes Program.

Poindexter BB, Feng R, Schmidt B, Aschner JL, Ballard RA, Hamvas A, Reynolds AM, Shaw PA, Jobe AH,

Annals of the American Thoracic Society.. 2015 December 12 (12):1822-30. Epub 1900 01 01.

Preterm cord blood CD4? T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4? T cells in bronchopulmonary dysplasia.

Misra R, Shah S, Fowell D, Wang H, Scheible K, Misra S, Huyck H, Wyman C, Ryan RM, Reynolds AM, Mariani T, Katzman PJ, Pryhuber GS

Human immunology.. 2015 May 76 (5):329-338. Epub 03/20/2015.

Respiratory consequences of prematurity: evolution of a diagnosis and development of a comprehensive approach.

Maitre NL, Ballard RA, Ellenberg JH, Davis SD, Greenberg JM, Hamvas A, Pryhuber GS

Journal of perinatology : official journal of the California Perinatal Association.. 2015 May 35 (5):313-321. Epub 03/26/2015.

Prematurity and respiratory outcomes program (PROP): study protocol of a prospective multicenter study of respiratory outcomes of preterm infants in the United States.

Pryhuber GS, Maitre NL, Ballard RA, Cifelli D, Davis SD, Ellenberg JH, Greenberg JM, Kemp J, Mariani TJ, Panitch H, Ren C, Shaw P, Taussig LM, Hamvas A,

BMC pediatrics.. 2015 April 1015 :37. Epub 04/10/2015.

Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection.

Scheible K, Secor-Socha S, Wightman T, Wang H, Mariani TJ, Topham DJ, Pryhuber G, Quataert S

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2012 November 81 (11):937-49. Epub 10/01/2012.

CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses.

Scheible K, Zhang G, Baer J, Azadniv M, Lambert K, Pryhuber G, Treanor JJ, Topham DJ

Vaccine.. 2011 March 329 (11):2159-68. Epub 01/04/2011.

T-Lymphocytes in human infants with bronchopulmonary dysplasia (in revision).

Scheible K, Ryan R, Ahmed Q, D'Angelis C, Kumar V, Lakshinrishimha S, Metlay L, Nickerson P, Wang H, Huycke H, Rangel-Moreno J, Misra R, Pryhuber G.

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