Skip to content
Frank C. Passero, M.D.

Frank C. Passero, M.D.


5 out of 5 stars
UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients


Appointment (585) 275-5863

About Me

As a physician I aim to provide patients with an understanding of their medical condition and guidance as they navigate complex medical decisions. I consider honesty, compassion and my medical knowledge as foundational principles upon which I seek to build a trusting patient-physician relationship. ...
As a physician I aim to provide patients with an understanding of their medical condition and guidance as they navigate complex medical decisions. I consider honesty, compassion and my medical knowledge as foundational principles upon which I seek to build a trusting patient-physician relationship. Getting to know my patients, their unique circumstances and goals is a key aspect of my practice, in order to provide patients with a personalized plan of care.

I obtained my medical degree from Jefferson Medical College in Philadelphia, Pennsylvania and went on to complete internship, residency, and a chief medical residency in Internal Medicine at Scripps Mercy Hospital in San Diego. I pursued my Hematology and Oncology fellowship training at Tufts Medical Center in Boston, Massachusetts where I carried out laboratory research studying the effects of proteasome and HDAC inhibitors in lymphoma.

I have a special interest in plasma cell disorders including myeloma and amyloidosis, and would like to provide patients with the opportunity to participate in well-designed clinical trials for these and other related diseases.

Certified Specialties

Hematology - American Board of Internal Medicine

Internal Medicine - American Board of Internal Medicine

Medical Oncology - American Board of Internal Medicine

Faculty Appointments

Assistant Professor - Department of Medicine, Hematology/Oncology (SMD)


Residency & Fellowship

Fellowship, Hematology & Oncology, Tufts Medical Center. 2014 - 2017

Residency, Internal Medicine, Mercy Hospital & Medical Center-San Diego (GME). 2011 - 2014

Internship, Internal Medicine, Mercy Hospital & Medical Center-San Diego (GME). 2010 - 2011


MD | Thomas Jefferson University Hospital. 2010


Clinical Trials

CMMY18034: S1702, A Phase II Study of Isatuximab (SAR650984) for Patients with Previously Treated Amyloid Light Chain Amyloidosis

Lead Researcher: Frank C Passero

All participants will receive the same study drug. If you decide to participate, you will receive up to 24 cycles (1 cycles = 28 days) of the study drug, isatuximab, as an outpatient (meaning you will not be admitted to the hospital to receive study ...

IMMY17131: A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of Daratumumab in Combination with Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) Compared With CyBorD Alone in Newly Diagnosed Systemic AL Amyloidosis

Lead Researcher: Frank C Passero

There are two treatment groups in this study. The study medication will be given in treatment cycles, and each cycle is 28 days long. Group A: Cyclophosphamide, bortezomib (VELCADE®) and dexamethasone (CyBorD). Group B: Daratumumab plus cyclophospham...


Journal Articles

A Rare Case of Renal Thrombotic Microangiopathy and Focal Segmental Glomerulosclerosis Secondary to Plasma Cell Leukemia.

Komisarof J, Forman J, Goldman B, Syposs C, Passero F, Garbade E

Case reports in hematology.. 2023 2023 :7803704. Epub 02/18/2023.

Light chain deposition disease masquerading as smoking-associated nodular glomerulosclerosis with deposits identified by electron microscopy only.

Alom MS, Grewal R, Passero FC, Goldman B, Choung HYG

CEN case reports.. 2022 November 11 (4):448-452. Epub 03/22/2022.

An Unusual Case of Multiple Myeloma with Light-Chain Cast Nephropathy Secondary to a Very Large Plasmacytoma without Bone Marrow Involvement.

Komisarof J, Lipof J, DiTursi J, Chowdhry A, Grace Choung HY, Burack WR, Constine L, Passero F

Case reports in hematology.. 2022 2022 :7531142. Epub 02/21/2022.

Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis.

Kastritis E, Palladini G, Minnema MC, Wechalekar AD, Jaccard A, Lee HC, Sanchorawala V, Gibbs S, Mollee P, Venner CP, Lu J, Schönland S, Gatt ME, Suzuki K, Kim K, Cibeira MT, Beksac M, Libby E, Valent J, Hungria V, Wong SW, Rosenzweig M, Bumma N, Huart A, Dimopoulos MA, Bhutani D, Waxman AJ, Goodman SA, Zonder JA, Lam S, Song K, Hansen T, Manier S, Roeloffzen W, Jamroziak K, Kwok F, Shimazaki C, Kim JS, Crusoe E, Ahmadi T, Tran N, Qin X, Vasey SY, Tromp B, Schecter JM, Weiss BM, Zhuang SH, Vermeulen J, Merlini G, Comenzo RL,

The New England journal of medicine.. 2021 July 1385 (1):46-58. Epub 1900 01 01.

Oncogenic Integration of Nucleotide Metabolism Fatty Acid Synthase in Non-Hodgkin Lymphoma.

Ravi D, Beheshti A, Abermil N, Lansigan F, Kinlaw W, Matthan NR, Mokhtar M, Passero FC, Puliti P, David KA, Dolnikowski GG, Su X, Chen Y, Bijan M, Varshney RR, Kim B, Dave SS, Rudolph MC, Evens AM

Frontiers in oncology.. 2021 11 :725137. Epub 10/26/2021.

Interaction kinetics with transcriptomic and secretory responses of CD19-CAR natural killer-cell therapy in CD20 resistant non-hodgkin lymphoma.

Evens AM, Konry T, David K, Mokhtar M, Chen Y, Beheshti A, Passero F, Purvey S, Sarkar S, Ravi D

Leukemia.. 2020 May 34 (5):1291-1304. Epub 11/26/2019.

Combinatorial ixazomib and belinostat therapy induces NFE2L2-dependent apoptosis in Hodgkin and T-cell lymphoma.

Evens AM, David KA, Beheshti A, McDonald JT, Ravi D, Passero FC

British journal of haematology.. 2020 January 188 (2):295-308. Epub 08/26/2019.

A review of thrombotic microangiopathies in multiple myeloma.

Lipe B, Passero FC, Gleber C, Portuguese AJ

Leukemia research.. 2019 October 85 :106195. Epub 07/29/2019.

Second line treatment options for pancreatic cancer.

Saif MW, Passero FC

Expert opinion on pharmacotherapy.. 2017 October 18 (15):1607-1617. Epub 10/06/2017.

The safety and efficacy of Onivyde (irinotecan liposome injection) for the treatment of metastatic pancreatic cancer following gemcitabine-based therapy.

Passero FC, Grapsa D, Syrigos KN, Saif MW

Expert review of anticancer therapy.. 2016 July 16 (7):697-703. Epub 06/03/2016.

Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma.

Ravi D, Beheshti A, Abermil N, Passero F, Sharma J, Coyle M, Kritharis A, Kandela I, Hlatky L, Sitkovsky MV, Mazar A, Gartenhaus RB, Evens AM

Cancer research.. 2016 June 176 (11):3319-31. Epub 03/17/2016.

Recent advances in pancreatic cancer: updates and insights from the 2015 annual meeting of the American Society of Clinical Oncology.

Abrams MJ, Rakszawski K, Vasekar M, Passero F, Abbas A, Jia Y, Saif MW

Therapeutic advances in gastroenterology.. 2016 March 9 (2):141-51. Epub 1900 01 01.

Otic mesenchyme expression of Cre recombinase directed by the inner ear enhancer of the Brn4/Pou3f4 gene.

Ahn KJ, Passero F, Crenshaw EB

Genesis : the journal of genetics and development.. 2009 March 47 (3):137-41. Epub 1900 01 01.

Mexiletine for refractory chronic daily headache: a report of nine cases.

Marmura MJ, Passero FC, Young WB

Headache.. 2008 48 (10):1506-10. Epub 09/12/2008.

Ratings & Comments

At URMC, we believe that patients should be empowered to make the right decisions regarding their personal healthcare. To do so, transparency is critical. URMC partners with Press Ganey, to survey our patients about all aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying star ratings for our providers along with anonymous patient comments on our website. This will help you make better-informed choices about how and with whom you seek care. Click here to learn more about the surveys used to generate this vital information. Learn more about our survey process.


During this visit, did this provider spend enough time with you?

4.9 stars

During this visit, did this provider show respect for what you had to say?

5.0 stars

During this visit, did this provider give you easy to understand information about these health questions or concerns?

5.0 stars

During this visit, did this provider listen carefully to you?

5.0 stars

During this visit, did this provider explain things in a way that was easy to understand?

4.9 stars

Patient Comments

5.0 stars


Apr 24, 2024

I had no problems with the care provider [...].

Apr 22, 2024

5.0 stars

Dr. Passero is the absolute best. He is very knowledgeable and caring. You don't come across too many Dr's like him.

Apr 04, 2024

5.0 stars

The best care I ever had !

Mar 17, 2024

5.0 stars

I would send everyone to this provider

Feb 04, 2024

Dr. Passero is very helpful, informative, and generous with his time.

Jan 23, 2024

5.0 stars

Dr. Passero was very patient with our many questions and answered them in the detail we needed yet in a way my we could understand. Our anxiety levels went way down as a result. We feel confident that I am in the best hands in treating my disease.

Dec 09, 2023

5.0 stars

I would and did recommend this provider and center. It is worth the trip to Rochester from [...].

Nov 23, 2023

5.0 stars

Dr Passero answered all my questions with confidence and patience!

Nov 18, 2023

5.0 stars

DR. Passero has treated me FOR A number of YEARS - kind, caring, patient, knowledgeable, patient, answers all of OUR questions, great medical advise.

Oct 19, 2023


Dr Passero has a calm demeanor and answers all questions.

Oct 07, 2023


Very friendly.

Sep 25, 2023


Dr Passero is patient and thorough. He is a good listener

Jul 29, 2023


Dr. Passero listened to me and is extremely competent and caring.

Jun 01, 2023


[...]. excellent care

May 12, 2023


I missed Dr. Ifthi, but was very pleased with Dr. F Passero!

Apr 24, 2023


Dr. Passero listened carefully and patiently, and I had a lot to say. I was surprised at how much time he spent with us. It felt like he Intended to stay there however long I needed him to, although I am sure he had other patients and things to do. His manner was compassionate, friendly, and calm. I feel confident in his knowledge and ability to care for me.

Mar 31, 2023


Excellent provider, knowledgeable, empathetic and professional at all times.

Mar 18, 2023


Dr Passero is an amazing doctor. Knowledge, empathetic and caring

Mar 11, 2023


All good experience

Feb 21, 2023


Explanations were very good, after I asked my ?'s, including review of my results that I had to ask be reviewed w/me. It would have been a better visit had I not had to ask for a review, should be automatic.

Jan 12, 2023


All good experience!

Dec 30, 2022

Dr Passero has always taken the time to answer any of our questions or concerns

Nov 05, 2022


This was a second opinion. I was very pleased and relieved after my appointment.

Oct 24, 2022


All went well.

Oct 20, 2022



Sep 18, 2022


Difficult experience.

Aug 25, 2022


Love Dr. Passero and his group. Would definitely recommend him to others.

Aug 11, 2022


Been with Passero & Brooks since 2018 and he's by-far the best doctor.

Jun 27, 2022


I feel at all times I'm in very good hands !

Jun 12, 2022


Dr. Passero was very nice in explaining about my cancer treatment when the time is needed

May 23, 2022

Dr Passero is always caring and wonderful!

May 15, 2022

Dr. Frank Passero Is very Informative and respectful of my input and questions regarding my care. I really appreciate this particularly when the matter is difficult to take in. Patient and kind.

Apr 19, 2022


Provider was very cool, didn't rush thru explaining questions and answers, very professional.

Mar 02, 2022

Dr. Passero is very kind, knowledgeable, and comprehensive.

Feb 06, 2022