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Frank C. Passero, M.D.
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I obtained my medical degree from Jefferson Medical College in Philadelphia, Pennsylvania and went on to complete internship, residency, and a chief medical residency in Internal Medicine at Scripps Mercy Hospital in San Diego. I pursued my Hematology and Oncology fellowship training at Tufts Medical Center in Boston, Massachusetts where I carried out laboratory research studying the effects of proteasome and HDAC inhibitors in lymphoma.
I have a special interest in plasma cell disorders including myeloma and amyloidosis, and would like to provide patients with the opportunity to participate in well-designed clinical trials for these and other related diseases.
Certified Specialties
Hematology - American Board of Internal Medicine
Internal Medicine - American Board of Internal Medicine
Medical Oncology - American Board of Internal Medicine
Faculty Appointments
Assistant Professor - Department of Medicine, Hematology/Oncology (SMD)
Credentials
Residency & Fellowship
Fellowship, Hematology & Oncology, Tufts Medical Center. 2014 - 2017
Residency, Internal Medicine, Mercy Hospital & Medical Center-San Diego (GME). 2011 - 2014
Internship, Internal Medicine, Mercy Hospital & Medical Center-San Diego (GME). 2010 - 2011
Education
MD | Thomas Jefferson University Hospital. 2010
Research
Clinical Trials
CMMY18034: S1702, A Phase II Study of Isatuximab (SAR650984) for Patients with Previously Treated Amyloid Light Chain Amyloidosis
Lead Researcher: Frank C Passero
All participants will receive the same study drug. If you decide to participate, you will receive up to 24 cycles (1 cycles = 28 days) of the study drug, isatuximab, as an outpatient (meaning you will not be admitted to the hospital to receive study ...
All participants will receive the same study drug. If you decide to participate, you will receive up to 24 cycles (1 cycles = 28 days) of the study drug, isatuximab, as an outpatient (meaning you will not be admitted to the hospital to receive study drug. During the first cycle (or 28 days), you will receive isatuximab on Day 1, 8, 15 and 22 by intravenous (IV) infusion (into your vein). For all other cycles (Cycle 2, up to Cycle 24), you will receive isatuximab on Days 1 and 15.
IMMY17131: A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of Daratumumab in Combination with Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) Compared With CyBorD Alone in Newly Diagnosed Systemic AL Amyloidosis
Lead Researcher: Frank C Passero
There are two treatment groups in this study. The study medication will be given in treatment cycles, and each cycle is 28 days long. Group A: Cyclophosphamide, bortezomib (VELCADE®) and dexamethasone (CyBorD). Group B: Daratumumab plus cyclophospham...
There are two treatment groups in this study. The study medication will be given in treatment cycles, and each cycle is 28 days long. Group A: Cyclophosphamide, bortezomib (VELCADE®) and dexamethasone (CyBorD). Group B: Daratumumab plus cyclophosphamide, bortezomib (VELCADE®) and dexamethasone (CyBorD)
Publications
Journal Articles
Komisarof J, Forman J, Goldman B, Syposs C, Passero F, Garbade E
Case reports in hematology.. 2023 2023 :7803704. Epub 02/18/2023.
Alom MS, Grewal R, Passero FC, Goldman B, Choung HYG
CEN case reports.. 2022 November 11 (4):448-452. Epub 03/22/2022.
Komisarof J, Lipof J, DiTursi J, Chowdhry A, Grace Choung HY, Burack WR, Constine L, Passero F
Case reports in hematology.. 2022 2022 :7531142. Epub 02/21/2022.
Kastritis E, Palladini G, Minnema MC, Wechalekar AD, Jaccard A, Lee HC, Sanchorawala V, Gibbs S, Mollee P, Venner CP, Lu J, Schönland S, Gatt ME, Suzuki K, Kim K, Cibeira MT, Beksac M, Libby E, Valent J, Hungria V, Wong SW, Rosenzweig M, Bumma N, Huart A, Dimopoulos MA, Bhutani D, Waxman AJ, Goodman SA, Zonder JA, Lam S, Song K, Hansen T, Manier S, Roeloffzen W, Jamroziak K, Kwok F, Shimazaki C, Kim JS, Crusoe E, Ahmadi T, Tran N, Qin X, Vasey SY, Tromp B, Schecter JM, Weiss BM, Zhuang SH, Vermeulen J, Merlini G, Comenzo RL,
The New England journal of medicine.. 2021 July 1385 (1):46-58. Epub 1900 01 01.
Ravi D, Beheshti A, Abermil N, Lansigan F, Kinlaw W, Matthan NR, Mokhtar M, Passero FC, Puliti P, David KA, Dolnikowski GG, Su X, Chen Y, Bijan M, Varshney RR, Kim B, Dave SS, Rudolph MC, Evens AM
Frontiers in oncology.. 2021 11 :725137. Epub 10/26/2021.
Evens AM, Konry T, David K, Mokhtar M, Chen Y, Beheshti A, Passero F, Purvey S, Sarkar S, Ravi D
Leukemia.. 2020 May 34 (5):1291-1304. Epub 11/26/2019.
Evens AM, David KA, Beheshti A, McDonald JT, Ravi D, Passero FC
British journal of haematology.. 2020 January 188 (2):295-308. Epub 08/26/2019.
Lipe B, Passero FC, Gleber C, Portuguese AJ
Leukemia research.. 2019 October 85 :106195. Epub 07/29/2019.
Saif MW, Passero FC
Expert opinion on pharmacotherapy.. 2017 October 18 (15):1607-1617. Epub 10/06/2017.
Passero FC, Grapsa D, Syrigos KN, Saif MW
Expert review of anticancer therapy.. 2016 July 16 (7):697-703. Epub 06/03/2016.
Ravi D, Beheshti A, Abermil N, Passero F, Sharma J, Coyle M, Kritharis A, Kandela I, Hlatky L, Sitkovsky MV, Mazar A, Gartenhaus RB, Evens AM
Cancer research.. 2016 June 176 (11):3319-31. Epub 03/17/2016.
Abrams MJ, Rakszawski K, Vasekar M, Passero F, Abbas A, Jia Y, Saif MW
Therapeutic advances in gastroenterology.. 2016 March 9 (2):141-51. Epub 1900 01 01.
Passero FC, Saif MW
JOP : Journal of the pancreas.. 2015 March 2016 (2):99-103. Epub 03/20/2015.
Ahn KJ, Passero F, Crenshaw EB
Genesis : the journal of genetics and development.. 2009 March 47 (3):137-41. Epub 1900 01 01.
Marmura MJ, Passero FC, Young WB
Headache.. 2008 48 (10):1506-10. Epub 09/12/2008.
Ratings & Comments
At URMC, we believe that patients should be empowered to make the right decisions regarding their personal healthcare. To do so, transparency is critical. URMC partners with Press Ganey, to survey our patients about all aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying star ratings for our providers along with anonymous patient comments on our website. This will help you make better-informed choices about how and with whom you seek care. Click here to learn more about the surveys used to generate this vital information. Learn more about our survey process.
Ratings
Care provider's discussion of any proposed treatment (options, risks, benefits, etc.)
Likelihood of recommending this care provider to others
Explanations the care provider gave you about your problem or condition
Care provider's efforts to include you in decisions about your care
Concern the care provider showed for your questions or worries
Patient Comments
Shown respect and understanding
Jan 31, 2025
I find Dr. Passero to be extremely empathetic and in tune with my specific concerns as a musician.
Jan 02, 2025
Dr Biglow and Dr. Passero were both very helpful and very informative
Dec 16, 2024
Dr Passero listened to my experience on Revlimid. He made the decision to stop the medication and suggested an alternative plan. He was aware of my past history on this medication and recommended an alternative plan to meet my needs.
Nov 05, 2024
I'm very thankful for the level of support, respect and knowledge I get from the team at UR
Nov 02, 2024
Just Amazing how happy I was with my appointment.
Oct 08, 2024
Amy Quinlan is the best she listened to all of my concerns and answered all of my questions. She answers all of my messages in a timely manner. Frank Passero, MD and Omar Aljitawi, MBBS are great too very helpful and really make me feel they care.
Aug 19, 2024
Excellent
Apr 24, 2024
I had no problems with the care provider [...].
Apr 22, 2024
Dr. Passero is the absolute best. He is very knowledgeable and caring. You don't come across too many Dr's like him.
Apr 04, 2024
The best care I ever had !
Mar 17, 2024
I would send everyone to this provider
Feb 04, 2024
Dr. Passero is very helpful, informative, and generous with his time.
Jan 23, 2024
Dr. Passero was very patient with our many questions and answered them in the detail we needed yet in a way my we could understand. Our anxiety levels went way down as a result. We feel confident that I am in the best hands in treating my disease.
Dec 09, 2023
I would and did recommend this provider and center. It is worth the trip to Rochester from [...].
Nov 23, 2023
Dr Passero answered all my questions with confidence and patience!
Nov 18, 2023
DR. Passero has treated me FOR A number of YEARS - kind, caring, patient, knowledgeable, patient, answers all of OUR questions, great medical advise.
Oct 19, 2023
Dr Passero has a calm demeanor and answers all questions.
Oct 07, 2023
Very friendly.
Sep 25, 2023
Dr Passero is patient and thorough. He is a good listener
Jul 29, 2023
Dr. Passero listened to me and is extremely competent and caring.
Jun 01, 2023
[...]. excellent care
May 12, 2023
I missed Dr. Ifthi, but was very pleased with Dr. F Passero!
Apr 24, 2023
Dr. Passero listened carefully and patiently, and I had a lot to say. I was surprised at how much time he spent with us. It felt like he Intended to stay there however long I needed him to, although I am sure he had other patients and things to do. His manner was compassionate, friendly, and calm. I feel confident in his knowledge and ability to care for me.
Mar 31, 2023
Excellent provider, knowledgeable, empathetic and professional at all times.
Mar 18, 2023
Dr Passero is an amazing doctor. Knowledge, empathetic and caring
Mar 11, 2023
All good experience
Feb 21, 2023
Explanations were very good, after I asked my ?'s, including review of my results that I had to ask be reviewed w/me. It would have been a better visit had I not had to ask for a review, should be automatic.
Jan 12, 2023
All good experience!
Dec 30, 2022
Dr Passero has always taken the time to answer any of our questions or concerns
Nov 05, 2022
This was a second opinion. I was very pleased and relieved after my appointment.
Oct 24, 2022
All went well.
Oct 20, 2022
Good
Sep 18, 2022
Difficult experience.
Aug 25, 2022
Love Dr. Passero and his group. Would definitely recommend him to others.
Aug 11, 2022
Been with Passero & Brooks since 2018 and he's by-far the best doctor.
Jun 27, 2022
I feel at all times I'm in very good hands !
Jun 12, 2022
Dr. Passero was very nice in explaining about my cancer treatment when the time is needed
May 23, 2022
Dr Passero is always caring and wonderful!
May 15, 2022
Dr. Frank Passero Is very Informative and respectful of my input and questions regarding my care. I really appreciate this particularly when the matter is difficult to take in. Patient and kind.
Apr 19, 2022
Provider was very cool, didn't rush thru explaining questions and answers, very professional.
Mar 02, 2022
Dr. Passero is very kind, knowledgeable, and comprehensive.
Feb 06, 2022