Skip to content
Home
Huina Zhang, B.Med., Ph.D.

Huina Zhang, B.Med., Ph.D.

Contact

About Me

Faculty Appointments

Associate Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Post-doctoral Training & Residency

Fellowship, Pathology, Magee-Womens Hospital of UPMC. 2017 - 2018

Residency, Pathology, Loma Linda University Hospital Medical Center. 2014 - 2017

Internship, Pathology, Loma Linda University Hospital Medical Center. 2013 - 2014

Education

PHD | Peking University Health Science Center. 2003

MS | Guiyang Medical College (China). 2000

MB | Henan Medical University (China). 1997

Awards

The Resident's Award (The Best Team Player). 2017

The Resident's Award (The Most Valuable Resident). 2016

The Outstanding Graduate. 2003

Kwang-Hua Scholarship. 2002

Publications

Journal Articles

Performance of HER2 DAKO HercepTest and Ventana 4B5 Immunohistochemical Assays on Detecting HER2 Gene-Amplification in Uterine Serous Carcinomas.

Navarro Sanchez JM, Finkelman BS, Tyburski H, Turner BM, Moisini I, Katerji H, Varghese S, Wang X, Schiffhauer LM, Chen JJ, Hicks DG, Zhang H

Human pathology.. 2024 May 11 Epub 05/11/2024.

HER2 evaluation for clinical decision making in human solid tumours: pearls and pitfalls.

Zhang H, Finkelman BS, Ettel MG, Velez MJ, Turner BM, Hicks DG

Histopathology.. 2024 March 5 Epub 03/05/2024.

Associations of Single versus Multiple HPV-infection with the Prevalence of Cervical CIN2+ Lesions: HPV type-specific attribution.

Zhong F, Wang T, Li W, Zhang H, Zeng X, Geisler D, Zhou X, Cong Q, Sui L, Tao X, Zhao C

Laboratory investigation; a journal of technical methods and pathology.. 2024 January 16 :100328. Epub 01/16/2024.

Malignant Brenner tumor of the ovary: Pathologic evaluation, molecular insights and clinical management

Wang T; Huang W,; Finkelman BS, Zhang H.

Human Pathology Reports. 2024; June(36): 300739.

Correlation of HER2 Protein Level with mRNA Level Quantified by RNAscope in Breast Cancer.

Li X, Lee JH, Gao Y, Zhang J, Bates KM, Rimm DL, Zhang H, Smith GH, Lawson D, Meisel J, Chang J, Huo L

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2023 December 20 :100408. Epub 12/20/2023.

In ER Positive, HER2 Negative Breast Cancers, HER2 mRNA Levels Correlate Better with Clinicopathologic Features and Oncotype DX® Recurrence Score than HER2 Immunohistochemistry.

Tyburski H, Karakas C, Finkelman BS, Turner BM, Zhang H, Hicks DG

Laboratory investigation; a journal of technical methods and pathology.. 2023 December 20 :100309. Epub 12/20/2023.

HER2 categorical changes after neoadjuvant chemotherapy: A study of 192 matched breast cancers with the inclusion of HER2-Low category.

Karakas C, Tyburski H, Turner BM, Weiss A, Akkipeddi SMK, Dhakal A, Skinner K, Hicks DG, Zhang H

Human pathology.. 2023 November 16 Epub 11/16/2023.

A Systematic Review of Breast Implant-Associated Squamous Cell Carcinoma.

Niraula S, Katel A, Barua A, Weiss A, Strawderman MS, Zhang H, Manrique O, O'Connell A, Pandey SR, Dhakal A

Cancers.. 2023 September 1215 (18)Epub 09/12/2023.

Comprehensive Clinical-Pathologic Assessment of Malignant Phyllodes Tumors: Proposing Refined Diagnostic Criteria.

Turashvili G, Ding Q, Liu Y, Peng L, Mrkonjic M, Mejbel H, Wang Y, Zhang H, Zhang G, Wang J, Wei S, Li X

The American journal of surgical pathology.. 2023 September 11 Epub 09/11/2023.

Is HER2 ultra-low breast cancer different from HER2 null or HER2 low breast cancer? A study of 1363 patients.

Chen Z, Jia H, Zhang H, Chen L, Zhao P, Zhao J, Fu G, Xing X, Li Y, Wang C

Breast cancer research and treatment.. 2023 August 28 Epub 08/28/2023.

Single and multiple high-risk human papillomavirus infections in histopathologically confirmed cervical squamous lesions: incidences, distribution, and associated detection rates for precancerous and cancerous lesions.

Tang X, Zhang H, Wang T, Jiang W, Jones TE, He Y, Li L, Tong L, Wang C, Wang W, Yang K, Yin R, Zhao C

Laboratory investigation; a journal of technical methods and pathology.. 2023 August 11 :100234. Epub 08/11/2023.

Erratum to Metaplastic breast carcinoma: a clinical-pathologic study of 97 cases with subset analysis of response to neoadjuvant chemotherapy [Modern Pathology 32(6) (2019) 807-816].

Han M, Salamat A, Zhu L, Zhang H, Clark BZ, Dabbs DJ, Carter GJ, Brufsky AM, Jankowitz RC, Puhalla SL, Johnson RR, Soran A, Steiman JG, McAuliffe PF, Diego EJ, Bhargava R

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2023 July 1336 (8):100267. Epub 07/13/2023.

HER2 in uterine serous carcinoma: Current state and clinical perspectives.

Navarro Sanchez JM, Finkelman BS, Turner BM, Katerji H, Wang X, Varghese S, Wang T, Peng Y, Hicks DG, Zhang H

American journal of clinical pathology.. 2023 June 2 Epub 06/02/2023.

Updates in Cervical Cancer Screening Guidelines, The Bethesda System for Reporting Cervical Cytology, and Clinical Management Recommendations.

Wang T, Zhang H, Liu Y, Zhao C

Journal of clinical and translational pathology.. 2023 June 3 (2):75-83. Epub 04/21/2023.

Low-grade adenosquamous carcinoma of the breast: a clinical, morphological and immunohistochemical analysis of 25 patients.

Lewis G, Fong N, Gjeorgjievski SG, Li XB, Li Z, Wei S, Sturgis CD, Wang C, Komforti M, Zhang H, Downs E, Cui X, McIntire P, Hoda RS, Rowe JJ, Sciallis A, Zhang G

Histopathology.. 2023 April 17 Epub 04/17/2023.

Interobserver and Interantibody Reproducibility of HER2 Immunohistochemical Scoring in an Enriched HER2-Low-Expressing Breast Cancer Cohort.

Karakas C, Tyburski H, Turner BM, Wang X, Schiffhauer LM, Katerji H, Hicks DG, Zhang H

American journal of clinical pathology.. 2023 February 28 Epub 02/28/2023.

The Rochester Modified Magee Algorithm (RoMMa): An Outcomes Based Strategy for Clinical Risk-Assessment and Risk-Stratification in ER Positive, HER2 Negative Breast Cancer Patients Being Considered for Oncotype DX Testing.

Turner BM, Finkelman BS, Hicks DG, Numbereye N, Moisini I, Dhakal A, Skinner K, Sanders MAG, Wang X, Shayne M, Schiffhauer L, Katerji H, Zhang H

Cancers.. 2023 January 3115 (3)Epub 01/31/2023.

The Evolution of Ki-67 and Breast Carcinoma: Past Observations, Present Directions, and Future Considerations.

Finkelman BS, Zhang H, Hicks DG, Turner BM

Cancers.. 2023 January 2815 (3)Epub 01/28/2023.

The Role of Artificial Intelligence in Accurate Interpretation of HER2 Immunohistochemical Scores 0 and 1+ in Breast Cancer.

Wu S, Yue M, Zhang J, Li X, Li Z, Zhang H, Wang X, Han X, Cai L, Shang J, Jia Z, Wang X, Li J, Liu Y

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2023 January 1036 (3):100054. Epub 01/10/2023.

Publication Link

Wang T, Baloda V, Harinath L, Jones T, Zhang H, Bhargava R, Zhao C.

Clinicopathologic diagnosis of dVIN related vulvar squamous cell

Current Biological, Pathological and Clinical Landscape of HER2-Low Breast Cancer.

Zhang H, Peng Y

Cancers.. 2022 December 2515 (1)Epub 12/25/2022.

The Clinical Utility of Extended High-Risk HPV Genotyping in Women With ASC-US Cytology.

Jiang W, Austin RM, Zhang H, He Y, Xu L, Wu X, Kuang W, Tong L, Li L, Zhao C

American journal of clinical pathology.. 2022 July 16 Epub 07/16/2022.

HER2-low breast cancers: Current insights and future directions.

Zhang H, Karakas C, Tyburski H, Turner BM, Peng Y, Wang X, Katerji H, Schiffhauer L, Hicks DG

Seminars in diagnostic pathology.. 2022 July 9 Epub 07/09/2022.

The clinical utility of extended high-risk HPV genotyping in risk-stratifying women with L-SIL cytology: A retrospective study of 8726 cases.

Tao X, Zhang H, Zhang H, Xiao Y, Zhong F, Zhou X, Cong Q, Sui L, Zhao C

Cancer cytopathology.. 2022 March 21 Epub 03/21/2022.

HER2-low breast cancers: incidence, HER2 staining patterns, clinicopathologic features, MammaPrint and BluePrint genomic profiles.

Zhang H, Katerji H, Turner BM, Audeh W, Hicks DG

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2022 February 19 Epub 02/19/2022.

Associations of RBC and Serum Folate Concentrations with Cervical Intraepithelial Neoplasia and High-Risk Human Papillomavirus Genotypes in Female Chinese Adults.

Wang W, Yang A, Zhang H, Li Y, Yang J, Zhao W, Wang Z, Lou H, Wang W, Liang T, Zhang L, Su X, Wang C, Wang J, Song J, Li L, Lv W, Zhao C, Hao M

The Journal of nutrition.. 2021 November 22 Epub 11/22/2021.

HER2-Low Breast Cancers.

Zhang H, Katerji H, Turner BM, Hicks DG

American journal of clinical pathology.. 2021 September 14 Epub 09/14/2021.

Prevalence and carcinogenic risk of high-risk human papillomavirus subtypes in different cervical cytology: a study of 124,251 cases from the largest academic center in China.

Tao X, Zhang H, Wang S, Chen T, Cong Q, Wang L, Zhou X, Zhao C

Journal of the American Society of Cytopathology.. 2021 April 6 Epub 04/06/2021.

L1CAM Expression in Recurrent Estrogen Positive/HER2 Negative Breast Cancer: A Novel Biomarker Worth Considering.

Moisini I, Zhang H, D'Aguiar M, Hicks DG, Turner BM

Applied immunohistochemistry & molecular morphology : AIMM. 2021 April 129 (4):287-292. Epub 1900 01 01.

Aptima HPV messenger RNA testing and histopathologic follow-up in women with HSIL cytology: A study emphasizing additional review of HPV-negative cases.

Li A, Li J, Austin RM, Wang T, Ashman D, Zhang H, Matsko J, Zhao C

Cancer cytopathology.. 2021 March 25 Epub 03/25/2021.

Significance of HER2 in Microinvasive Breast Carcinoma.

Zhang H, Moisini I, Turner BM, Wang X, Dhakal A, Yang Q, Kovar S, Schiffhauer LM, Hicks DG

American journal of clinical pathology.. 2021 January 25 Epub 01/25/2021.

Vascular lesions of the breast: Essential pathologic features and diagnostic pitfalls (Invited)

Zhang H, Turner BM, Katerji H, Hicks DG, Wang X.

Human Pathology Reports. 2021; 26(300570).

The evolution of prognostic and predictive markers in breast cancer.

Katerji H, Zhang H, Hicks DG, Turner BM.

Chinese Journal of New Clinical Medicine (Invited review). 2021; 14(12): 1169-1181.

Efficient combination of Human Papillomavirus Genotyping for the triage of women with Atypical Squamous Cells of Undetermined Significance in Chinese rural population: A population-based study.

Wang W, Zhang H, Lin L, Yang A, Yang J, Zhao W, Wang Z, Zhang L, Su X, Wang Z, Wang C, Zhang H, Feng B, Li D, Liu H, Niu X, Wang J, Song J, Li L, Lv W, Zhao C, Hao M

Journal of Cancer.. 2021 12 (10):2815-2824. Epub 03/14/2021.

Clinical performance of the aptima HPV assay in 4196 women with positive high-risk HPV and ASC-US cytology: A large women hospital experience.

Wang T, Pradhan D, Zhang H, Matsko J, Zhao C

Diagnostic cytopathology.. 2020 August 28 Epub 08/28/2020.

Best Practice (Efficient) Immunohistologic Panel for Diagnosing Metaplastic Breast Carcinoma.

Han M, Zhang H, Dabbs DJ

Applied immunohistochemistry & molecular morphology : AIMM. 2020 August 27 Epub 08/27/2020.

HPV detection rates and histopathologic follow-up of patients with HSIL cytology in a large academic women's hospital laboratory.

Ashman D, Zhang H, Li J, Austin M, Wang T, Pradhan D, Zhao C

Journal of the American Society of Cytopathology.. 2020 May 6 Epub 05/06/2020.

Applying the New Guidelines of HER2 Testing in Breast Cancer.

Zhang H, Moisini I, Ajabnoor RM, Turner BM, Hicks DG

Current oncology reports.. 2020 April 2922 (5):51. Epub 04/29/2020.

Frequency, Clinicopathologic Characteristics, and Follow-up of HER2-Positive Nonpleomorphic Invasive Lobular Carcinoma of the Breast.

Zhang H, Moisini I, Ajabnoor RM, Turner BM, D'aguiar M, Cai X, Gao S, Yang Q, Wang X, Schiffhauer L, Hicks DG

American journal of clinical pathology.. 2019 November 30 Epub 11/30/2019.

Human Papillomavirus (HPV) 16 and 18/45 Genotyping-Directed Follow-up of Women With Messenger RNA HPV-Positive, Cytology-Negative Cervical Screening Test Results.

Zhao C, Zhang H, Varma KR, Austin M, Li J, Han M

American journal of clinical pathology.. 2019 October 11 Epub 10/11/2019.

Prevalence of HPV-16/18 genotypes and immediate histopathologic correlation results in a Chinese population with negative cytology and positive high-risk HPV testing.

Zhao C, Wang L, Sui L, Zhou X, Zhang L, Xiao J, Zhang H, Li J, Zhang H, Tao X

Cancer cytopathology.. 2019 September 18 Epub 09/18/2019.

Atypical Squamous Cells of Undetermined Significance Cervical Cytology Report Rate and Histologic Follow-up Findings From the Largest College of American Pathologists-Certified Laboratory in China.

Zheng B, Yang H, Li Z, You J, Wei G, Zhang H, Zeng Z, Xie F, Zhao C

Archives of pathology & laboratory medicine.. 2019 June 143 (6):748-752. Epub 12/28/2018.

Follow-up outcomes of benign vascular lesions of breast diagnosed on core needle biopsy: A study of 117 cases.

Zhang H, Han M, Varma K, Dabbs DJ

The breast journal.. 2019 April 18 Epub 04/18/2019.

Follow-up with histopathology and HPV testing on LSIL cytology in China's largest academic woman's hospital.

Tao X, Zhang H, Zhang H, Xiao J, Li J, Zhou X, Wang L, Zhao C

Cancer cytopathology.. 2019 March 20 Epub 03/20/2019.

Metaplastic breast carcinoma: a clinical-pathologic study of 97 cases with subset analysis of response to neoadjuvant chemotherapy.

Han M, Salamat A, Zhu L, Zhang H, Clark BZ, Dabbs DJ, Carter GJ, Brufsky AM, Jankowitz RC, Puhalla SL, Johnson RR, Soran A, Steiman JG, McAuliffe PF, Diego EJ, Bhargava R

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2019 February 5 Epub 02/05/2019.

Systemic cervical cytology training and quality control programs can improve the interpretation of Papanicolaou tests.

Xie F, Li Z, Zhang L, Zhang H, Qi D, Zhao D, Zhang X, Wang X, Zhao C

Journal of the American Society of Cytopathology.. 2019 8 (1):27-33. Epub 06/15/2018.

Immediate histopathologic follow-up of cervista and aptima high-risk HPV assays in women with LSIL cytology.

Zhang H, Varma KR, Han M, Matsko J, Zhao C

Cancer cytopathology.. 2018 August 126 (8):525-532. Epub 05/24/2018.

Composite Angioimmunoblastic T-Cell Lymphoma and B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Involving Both Lymph Node and Bone Marrow With Digital Gangrene

Guang Yang, Fouad M Abdelhalim, Yan Chen Wongworawat, Huina Zhang, Jeffrey D. Cao, and Jun Wang.

Hematopathology. 2018; Volume 3(Issue 1): 14-21.

High Fidelity of Breast Biomarker Metrics: A 10-Year Experience in a Single, Large Academic Institution.

Zhang H, Han M, Varma KR, Clark BZ, Bhargava R, Dabbs DJ

Applied immunohistochemistry & molecular morphology : AIMM. 2018 26 (10):697-700. Epub 1900 01 01.

Undifferentiated embryonal sarcoma of the liver with an unusual presentation: case report and review of the literature.

Zhang H, Lei L, Zuppan CW, Raza AS

Journal of gastrointestinal oncology.. 2016 April 7 (Suppl 1):S100-6. Epub 1900 01 01.

Consensus and conflict in invasive micropapillary carcinoma: a case report and review of the literature.

Lei L, Zhang H, Zhang XB, Lonser R, Thompson K, Raza A

Journal of gastrointestinal oncology.. 2016 April 7 (Suppl 1):S55-61. Epub 1900 01 01.

Cytotoxic Molecule-positive Epstein-Barr Virus-associated Peripheral T-cell Lymphoma in a 20-Month-old Child: A Case Report and Review of the Literature.

Zhang H, Kheradpour A, Rowsell EH, Zuppan CW, Weiss LM, Wang J

Journal of pediatric hematology/oncology.. 2015 November 37 (8):e475-80. Epub 1900 01 01.

Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease.

Than KD, Rahman SU, Wang L, Khan A, Kyere KA, Than TT, Miyata Y, Park YS, La Marca F, Kim HM, Zhang H, Park P, Lin CY

The spine journal : official journal of the North American Spine Society.. 2014 June 114 (6):1017-28. Epub 12/01/2013.

BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation.

Wang L, Park P, Zhang H, La Marca F, Claeson A, Than K, Rahman S, Lin CY

International journal of cancer.. 2012 October 15131 (8):1941-50. Epub 03/08/2012.

Simvastatin maintains osteoblastic viability while promoting differentiation by partially regulating the expressions of estrogen receptors ?.

Park JB, Zhang H, Lin CY, Chung CP, Byun Y, Park YS, Yang VC

The Journal of surgical research.. 2012 May 15174 (2):278-83. Epub 01/15/2011.

Bone morphogenetic proteins and degenerative disk disease.

Than KD, Rahman SU, Vanaman MJ, Wang AC, Lin CY, Zhang H, La Marca F, Park P

Neurosurgery.. 2012 April 70 (4):996-1002; discussion 1002. Epub 1900 01 01.

Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine: laboratory investigation.

Zhang H, Yang S, Wang L, Park P, La Marca F, Hollister SJ, Lin CY

Journal of neurosurgery. Spine.. 2011 October 15 (4):404-13. Epub 07/01/2011.

BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line.

Wang L, Park P, Zhang H, La Marca F, Claeson A, Valdivia J, Lin CY

Cancer biology & therapy.. 2011 March 111 (5):457-63. Epub 03/01/2011.

Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration.

Feng G, Zhao X, Liu H, Zhang H, Chen X, Shi R, Liu X, Zhao X, Zhang W, Wang B

Journal of neurosurgery. Spine.. 2011 March 14 (3):322-9. Epub 01/21/2011.

Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity.

Wang L, Park P, Zhang H, La Marca F, Lin CY

International journal of cancer.. 2011 January 15128 (2):294-303. Epub 03/22/2010.

Chemically-conjugated bone morphogenetic protein-2 on three-dimensional polycaprolactone scaffolds stimulates osteogenic activity in bone marrow stromal cells.

Zhang H, Migneco F, Lin CY, Hollister SJ

Tissue engineering. Part A.. 2010 November 16 (11):3441-8. Epub 07/23/2010.

The interaction between bone marrow stromal cells and RGD-modified three-dimensional porous polycaprolactone scaffolds.

Zhang H, Lin CY, Hollister SJ

Biomaterials.. 2009 September 30 (25):4063-9. Epub 05/31/2009.

Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture.

Zhang H, La Marca F, Hollister SJ, Goldstein SA, Lin CY

Journal of neurosurgery. Spine.. 2009 June 10 (6):522-30. Epub 1900 01 01.

Comparison of bone marrow stromal cell behaviors on poly(caprolactone) with or without surface modification: studies on cell adhesion, survival and proliferation.

Zhang H, Hollister S

Journal of biomaterials science. Polymer edition.. 2009 20 (14):1975-93. Epub 1900 01 01.

Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury.

Zhang H, Wang L, Park JB, Park P, Yang VC, Hollister SJ, La Marca F, Lin CY

Arthritis research & therapy.. 2009 11 (6):R172. Epub 11/13/2009.

Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies.

Zhang H, Shi YG, Woods JH, Watson SJ, Ko MC

European journal of pharmacology.. 2007 September 10570 (1-3):89-96. Epub 06/09/2007.

Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects.

Zhang H, Torregrossa MM, Jutkiewicz EM, Shi YG, Rice KC, Woods JH, Watson SJ, Ko MC

The European journal of neuroscience.. 2006 February 23 (4):984-94. Epub 1900 01 01.

Effect of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in mice.

He JH, Zhang HN, Lin ZB

World journal of gastroenterology.. 2005 January 2811 (4):573-6. Epub 1900 01 01.

Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms.

Lin ZB, Zhang HN

Acta pharmacologica Sinica.. 2004 November 25 (11):1387-95. Epub 1900 01 01.

Hypoglycemic effect of Ganoderma lucidum polysaccharides.

Zhang HN, Lin ZB

Acta pharmacologica Sinica.. 2004 February 25 (2):191-5. Epub 1900 01 01.

In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage.

Zhang HN, He JH, Yuan L, Lin ZB

Life sciences.. 2003 September 1973 (18):2307-19. Epub 1900 01 01.

Epidemiological and histopathological study of relevance of Guizhou Maotai liquor and liver diseases.

Wu J, Cheng ML, Zhang GH, Zhai RW, Huang NH, Li CX, Luo TY, Lu S, Yu ZQ, Yao YM, Zhang YY, Ren LZ, Ye L, Li L, Zhang HN

World journal of gastroenterology.. 2002 June 8 (3):571-4. Epub 1900 01 01.

Books

Practical Oncologic Molecular Pathology (2021)

Chapter: Breast and Gynecologic Tumors

Authors: Zhang H, Hicks DG

Publisher: Springer 2021