Skip to content
Find a Provider
Hitesh S. Deshmukh, M.D, Ph.D.

Hitesh S. Deshmukh, M.D, Ph.D.

Pediatrics , Neonatology

No ratings currently available, see text in Ratings section below for explanation.

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Fax (585) 461-3614
Administrative (585) 275-2972

About Me

Languages

English, Hindi

Certified Specialties

Pediatrics, Neonatal-Perinatal Medicine - American Board of Pediatrics/Neonatal-Perinatal

Faculty Appointments

Professor - Department of Pediatrics, Neonatology (SMD)

Dean's Professorship - Department of Pediatrics (SMD)

Division Chief - Department of Pediatrics, Neonatology (SMD)

Professor - Department of Microbiology and Immunology (SMD) - Joint

Credentials

Residency & Fellowship

Fellowship, Pediatrics, Neonatal-Perinatal Medicine, Children's Hospital of Philadelphia. 2011 - 2014

Residency, Pediatrics, State University Of New York University Of Buffalo (USA). 2008 - 2011

Fellowship, Research, Duke University School of Medicine. 2006 - 2008

Education

PhD | University of Cincinnati Medical Center. 2006

BMBS | University of Bombay (aka University of Mumbai ) (India). 2000

Awards

ASPIRE Award. 2023

Endowed Scholar. 2022

Procter Scholar Award. 2016

Thomas H Boggs Award. 2015

Parker B. Francis Fellow. 2015

Young Investigator Award. 2015

Fellow Basic Science Research Award. 2014

Resident of the Year. 2011

House Officer Research Award. 2011

Thomas Frawley Young Investigator Award. 2010

Infectious Diseases Fellow Award. 2008

Research

Dr. Deshmukh's research program reframes our understanding of early life, viewing infancy not as a period of vulnerability but as a critical window of opportunity to establish lifelong lung health. His work explores how conditions before and shortly after birth can shape health outcomes through adul...
Dr. Deshmukh's research program reframes our understanding of early life, viewing infancy not as a period of vulnerability but as a critical window of opportunity to establish lifelong lung health. His work explores how conditions before and shortly after birth can shape health outcomes through adulthood. The concept of "fetal origins of health and disease" guides our research, supported by evidence that early life experiences—including those before birth—affect many aspects of lung health, from susceptibility to viral infections (including SARS-CoV-2) to the development of asthma and chronic lung diseases. These early influences can have consequences that extend well beyond childhood.

Publications

Journal Articles

Single cell atlas of lung-resident innate lymphoid cells shows impact of age and dysbiosis on epigenetic and transcriptomic programming.

Bonfield M, Gray J, Ramiriqui A, Stevens J, Pandey U, Canaday L, Feldman HA, Zacharias WJ, Kottyan L, Waggoner SN, Deshmukh H, Steinmeyer S

Mucosal immunology.. 2026 January 17 Epub 01/17/2026.

Microbiota-derived inosine programs protective CD8 T cell responses against influenza in newborns.

Stevens J, Culberson E, Kinder J, Ramiriqui A, Gray J, Bonfield M, Shao TY, Al Gharaibeh F, Peterson L, Steinmeyer S, Eshleman EM, Negi S, Zacharias W, Pryhuber G, Paul O, Sengupta S, Alenghat T, Way SS, Deshmukh H

Cell.. 2025 August 7188 (16):4239-4256.e19. Epub 06/09/2025.

Impact of Viral Lower Respiratory Tract Infection (LRTI) in Early Childhood (0-2 Years) on Lung Growth and Development and Lifelong Trajectories of Pulmonary Health: A National Institutes of Health (NIH) Workshop Summary.

Deshmukh H, Whitsett J, Zacharias W, Way SS, Martinez FD, Mizgerd J, Pryhuber G, Ambalavanan N, Bacharier L, Natarajan A, Tamburro R, Lin S, Randolph A, Nino G, Mejias A, Ramilo O,

Pediatric pulmonology.. 2025 January 60 (1):e27357. Epub 11/20/2024.

Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling.

Ojha M, Smith NJ, Devine AJ, Joshi R, Goodman EM, Fan Q, Schuman R, Porollo A, Wells JM, Tiwary E, Batie MR, Gray J, Deshmukh H, Borchers MT, Ammerman SA, Varisco BM

JCI insight.. 2024 January 99 (1)Epub 01/09/2024.

Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation.

Shao TY, Jiang TT, Stevens J, Russi AE, Troutman TD, Bernieh A, Pham G, Erickson JJ, Eshleman EM, Alenghat T, Jameson SC, Hogquist KA, Weaver CT, Haslam DB, Deshmukh H, Way SS

Cell reports.. 2023 November 2842 (11):113323. Epub 10/26/2023.

Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice.

Wilburn AN, McAlees JW, Haslam DB, Graspeuntner S, Schmudde I, Laumonnier Y, Rupp J, Chougnet CA, Deshmukh H, Zacharias WJ, König P, Lewkowich IP

American journal of respiratory cell and molecular biology.. 2023 May 68 (5):498-510. Epub 1900 01 01.

Gut check: Intestinal microbial diversity empowers lung immunity.

Clark RA

Science immunology.. 2022 July 7 (73):eadd6617. Epub 07/01/2022.

The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota.

Stevens J, Steinmeyer S, Bonfield M, Peterson L, Wang T, Gray J, Lewkowich I, Xu Y, Du Y, Guo M, Wynn JL, Zacharias W, Salomonis N, Miller L, Chougnet C, O'Connor DH, Deshmukh H

Science translational medicine.. 2022 June 1514 (649):eabl3981. Epub 06/15/2022.

A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation.

Jackson CM, Demmert M, Mukherjee S, Isaacs T, Thompson R, Chastain C, Gray J, Senthamaraikannan P, Presicce P, Chetal K, Salomonis N, Miller LA, Jobe AH, Kallapur SG, Zacharias WJ, Lewkowich IP, Deshmukh H, Chougnet CA

Mucosal immunology.. 2022 April 15 (4):730-744. Epub 03/21/2022.

Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates.

Toth A, Steinmeyer S, Kannan P, Gray J, Jackson CM, Mukherjee S, Demmert M, Sheak JR, Benson D, Kitzmiller J, Wayman JA, Presicce P, Cates C, Rubin R, Chetal K, Du Y, Miao Y, Gu M, Guo M, Kalinichenko VV, Kallapur SG, Miraldi ER, Xu Y, Swarr D, Lewkowich I, Salomonis N, Miller L, Sucre JS, Whitsett JA, Chougnet CA, Jobe AH, Deshmukh H, Zacharias WJ

Science translational medicine.. 2022 March 3014 (638):eabl8574. Epub 03/30/2022.

A census of the lung: CellCards from LungMAP.

Sun X, Perl AK, Li R, Bell SM, Sajti E, Kalinichenko VV, Kalin TV, Misra RS, Deshmukh H, Clair G, Kyle J, Crotty Alexander LE, Silva JM, Kitzmiller JA, Wikenheiser-Brokamp KA, Deutsch G, Guo M, Du Y, Morley MP, Valdez MJ, Yu HV, Jin K, Bardes EE, Zepp JA, Neithamer T, Basil MC, Zacharias WJ, Verheyden J, Young R, Bandyopadhyay G, Lin S, Ansong C, Adkins J, Salomonis N, Aronow BJ, Xu Y, Pryhuber G, Whitsett J, Morrisey EE,

Developmental cell.. 2022 January 1057 (1):112-145.e2. Epub 12/21/2021.

Editorial: Pulmonary Innate Lymphoid Cells - Gatekeepers of Respiratory Health.

Starkey MR, Deshmukh H, Lukacs NW, Lloyd CM

Frontiers in immunology.. 2022 13 :871207. Epub 03/01/2022.

Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease.

Sitaraman S, Martin EP, Na CL, Zhao S, Green J, Deshmukh H, Perl AT, Bridges JP, Xu Y, Weaver TE

JCI insight.. 2021 July 226 (14)Epub 07/22/2021.

PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease.

Moreno-Fernandez ME, Giles DA, Oates JR, Chan CC, Damen MSMA, Doll JR, Stankiewicz TE, Chen X, Chetal K, Karns R, Weirauch MT, Romick-Rosendale L, Xanthakos SA, Sheridan R, Szabo S, Shah AS, Helmrath MA, Inge TH, Deshmukh H, Salomonis N, Divanovic S

Cell metabolism.. 2021 June 133 (6):1187-1204.e9. Epub 05/17/2021.

Airway emergency management in a pediatric hospital before and during the COVID-19 pandemic.

Thom CS, Deshmukh H, Soorikian L, Jacobs I, Fiadjoe JE, Lioy J

International journal of pediatric otorhinolaryngology.. 2020 December 139 :110458. Epub 10/17/2020.

Early life antibiotic exposure and host health: Role of the microbiota-immune interaction.

Wang T, Udomkittivorakul N, Bonfield M, Nadeem A, Gray J, Deshmukh H

Seminars in perinatology.. 2020 December 44 (8):151323. Epub 10/12/2020.

The Promise and Peril of Natural Killer Cell Therapies in Pulmonary Infection.

Rajaram S, Canaday LM, Ochayon DE, Rangel KM, Ali A, Gyurova IE, Krishnamurthy D, Fletcher JS, Reighard SD, Cox A, Weirauch MT, Kottyan LC, Deshmukh H, Zacharias WJ, Borchers MT, Waggoner SN

Immunity.. 2020 June 1652 (6):887-889. Epub 05/13/2020.

In Situ Support of ILC Precursors.

Zhou L, Sonnenberg GF

Immunity.. 2020 February 1852 (2):207-209. Epub 1900 01 01.

Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs.

Oherle K, Acker E, Bonfield M, Wang T, Gray J, Lang I, Bridges J, Lewkowich I, Xu Y, Ahlfeld S, Zacharias W, Alenghat T, Deshmukh H

Immunity.. 2020 February 1852 (2):275-294.e9. Epub 1900 01 01.

Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms.

Jackson CM, Mukherjee S, Wilburn AN, Cates C, Lewkowich IP, Deshmukh H, Zacharias WJ, Chougnet CA

Frontiers in immunology.. 2020 11 :1285. Epub 06/19/2020.

Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma.

Kim D, McAlees JW, Bischoff LJ, Kaur D, Houshel LK, Gray J, Hargis J, Davis X, Dudas PL, Deshmukh H, Lewkowich IP

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2019 March 49 (3):317-330. Epub 11/29/2018.

Immunological Basis for Recurrent Fetal Loss and Pregnancy Complications.

Deshmukh H, Way SS

Annual review of pathology.. 2019 January 2414 :185-210. Epub 09/05/2018.

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth.

Guo M, Du Y, Gokey JJ, Ray S, Bell SM, Adam M, Sudha P, Perl AK, Deshmukh H, Potter SS, Whitsett JA, Xu Y

Nature communications.. 2019 January 310 (1):37. Epub 01/03/2019.

The Impact of Maternal Antibiotics on Neonatal Disease.

Reed BD, Schibler KR, Deshmukh H, Ambalavanan N, Morrow AL

The Journal of pediatrics.. 2018 June 197 :97-103.e3. Epub 03/16/2018.

All on "CHIP": using microfluidics to study neutrophil ontogeny.

Allen A, Deshmukh H

Translational research : the journal of laboratory and clinical medicine.. 2017 December 190 :1-3. Epub 10/20/2017.

Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection.

Gray J, Oehrle K, Worthen G, Alenghat T, Whitsett J, Deshmukh H

Science translational medicine.. 2017 February 89 (376)Epub 1900 01 01.

Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans.

Yan Q, Ahn SH, Medie FM, Sharma-Kuinkel BK, Park LP, Scott WK, Deshmukh H, Tsalik EL, Cyr DD, Woods CW, Yu CA, Adams C, Qi R, Hansen B, Fowler VG

PloS one.. 2017 12 (6):e0179033. Epub 06/08/2017.

Center Variation in Intestinal Microbiota Prior to Late-Onset Sepsis in Preterm Infants.

Taft DH, Ambalavanan N, Schibler KR, Yu Z, Newburg DS, Deshmukh H, Ward DV, Morrow AL

PloS one.. 2015 10 (6):e0130604. Epub 06/25/2015.

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice.

Deshmukh HS, Liu Y, Menkiti OR, Mei J, Dai N, O'Leary CE, Oliver PM, Kolls JK, Weiser JN, Worthen GS

Nature medicine.. 2014 May 20 (5):524-30. Epub 04/20/2014.

The use of early lung biopsy in detection of fatal pulmonary disease in the neonate.

Deshmukh H, Lioy J

The Journal of pediatrics.. 2014 April 164 (4):934-6. Epub 12/24/2013.

Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain.

Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Mostafa H, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz PE, Garvin AJ, Petty J, Kiblawi Z, Zuppan C, McConkie-Rosell A, McDonald MT, Peterson-Carmichael SL, Gaede JT, Shivanna B, Schady D, Friedlich PS, Hays SR, Palafoll IV, Siebers-Renelt U, Bohring A, Finn LS, Siebert JR, Galambos C, Nguyen L, Riley M, Chassaing N, Vigouroux A, Rocha G, Fernandes S, Brumbaugh J, Roberts K, Ho-Ming L, Lo IF, Lam S, Gerychova R, Jezova M, Valaskova I, Fellmann F, Afshar K, Giannoni E, Muhlethaler V, Liang J, Beckmann JS, Lioy J, Deshmukh H, Srinivasan L, Swarr DT, Sloman M, Shaw-Smith C, van Loon RL, Hagman C, Sznajer Y, Barrea C, Galant C, Detaille T, Wambach JA, Cole FS, Hamvas A, Prince LS, Diderich KE, Brooks AS, Verdijk RM, Ravindranathan H, Sugo E, Mowat D, Baker ML, Langston C, Welty S, Stankiewicz P

Human mutation.. 2013 June 34 (6):801-11. Epub 04/12/2013.

Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.

Ahn SH, Deshmukh H, Johnson N, Cowell LG, Rude TH, Scott WK, Nelson CL, Zaas AK, Marchuk DA, Keum S, Lamlertthon S, Sharma-Kuinkel BK, Sempowski GD, Fowler VG

PLoS pathogens.. 2010 September 26 (9):e1001088. Epub 09/02/2010.

Intermittent 'bulge' in the umbilical cord.

Deshmukh HS, Caty MG, Ryan RM, Lakshminrusimha S

Journal of perinatology : official journal of the California Perinatal Association.. 2010 July 30 (7):500-2. Epub 1900 01 01.

The role of T cells in the regulation of acrolein-induced pulmonary inflammation and epithelial-cell pathology.

Borchers MT, Wesselkamper SC, Deshmukh H, Beckman E, Medvedovic M, Sartor M, Leikauf GD,

Research report. 2009 December (146):5-29. Epub 1900 01 01.

Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.

Deshmukh HS, McLachlan A, Atkinson JJ, Hardie WD, Korfhagen TR, Dietsch M, Liu Y, Di PY, Wesselkamper SC, Borchers MT, Leikauf GD

American journal of respiratory and critical care medicine.. 2009 November 1180 (9):834-45. Epub 08/06/2009.

Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population.

Guo L, Deshmukh H, Lu R, Vidal GS, Kelly JA, Kaufman KM, Dominguez N, Klein W, Kim-Howard X, Bruner GR, Scofield RH, Moser KL, Gaffney PM, Dozmorov IM, Gilkeson GS, Wakeland EK, Li QZ, Langefeld CD, Marion MC, Williams AH, Divers J, Alarcón GS, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Reveille JD, McGwin G, Vilá LM, Petri MA, Vyse TJ, Merrill JT, James JA, Nath SK, Harley JB, Guthridge JM

Genes and immunity.. 2009 July 10 (5):531-8. Epub 04/02/2009.

Critical role of NOD2 in regulating the immune response to Staphylococcus aureus.

Deshmukh HS, Hamburger JB, Ahn SH, McCafferty DG, Yang SR, Fowler VG

Infection and immunity.. 2009 April 77 (4):1376-82. Epub 01/12/2009.

First reported case of infective endocarditis caused by community-acquired methicillin-resistant Staphylococcus aureus not associated with healthcare contact in Brazil.

Fortes CQ, Espanha CA, Bustorff FP, Zappa BC, Ferreira AL, Moreira RB, Pereira NG, Fowler VG, Deshmukh H

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.. 2008 December 12 (6):541-3. Epub 1900 01 01.

Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.

Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD

American journal of respiratory cell and molecular biology.. 2008 April 38 (4):446-54. Epub 11/15/2007.

Genotypic characteristics of Staphylococcus aureus isolates from a multinational trial of complicated skin and skin structure infections.

Campbell SJ, Deshmukh HS, Nelson CL, Bae IG, Stryjewski ME, Federspiel JJ, Tonthat GT, Rude TH, Barriere SL, Corey R, Fowler VG

Journal of clinical microbiology.. 2008 February 46 (2):678-84. Epub 12/12/2007.

CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure.

Borchers MT, Wesselkamper SC, Harris NL, Deshmukh H, Beckman E, Vitucci M, Tichelaar JW, Leikauf GD

Experimental and molecular pathology.. 2007 December 83 (3):301-10. Epub 09/26/2007.

The role of metallothionein in the pathogenesis of acute lung injury.

Wesselkamper SC, McDowell SA, Medvedovic M, Dalton TP, Deshmukh HS, Sartor MA, Case LM, Henning LN, Borchers MT, Tomlinson CR, Prows DR, Leikauf GD

American journal of respiratory cell and molecular biology.. 2006 January 34 (1):73-82. Epub 09/15/2005.

When wheeze leads to squeeze: growth under pressure.

Leikauf GD, Deshmukh HS

American journal of respiratory cell and molecular biology.. 2005 May 32 (5):366. Epub 1900 01 01.

Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation.

Deshmukh HS, Case LM, Wesselkamper SC, Borchers MT, Martin LD, Shertzer HG, Nadel JA, Leikauf GD

American journal of respiratory and critical care medicine.. 2005 February 15171 (4):305-14. Epub 11/05/2004.

Fatal hemoptysis caused by ruptured giant Rasmussen's aneurysm.

Patankar T, Prasad S, Deshmukh H, Mukherji SK

AJR. American journal of roentgenology.. 2000 January 174 (1):262-3. Epub 1900 01 01.

Books

Disorders of Neonatal Airway: Fundamentals of Practice (2015)

Chapter: Airway Emergencies in the Neonates: Preparedness at the bedside

Authors: Deshmukh H and Lioy JH

Publisher: Springer, Philadelphia 2015

Ratings & Comments

At URMC, we believe that patients should be empowered to make the right decisions regarding their personal healthcare. To do so, transparency is critical. URMC partners with Press Ganey, to survey our patients about all aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying star ratings for our providers along with anonymous patient comments on our website. This will help you make better-informed choices about how and with whom you seek care. Click here to learn more about the surveys used to generate this vital information. Learn more about our survey process.