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Randall J. Kimple, M.D., Ph.D., M.B.A.

Randall J. Kimple, M.D., Ph.D., M.B.A.

he/him/his

Specialties

Radiation Oncology

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URochester Medical Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
Accepting New Patients

Contact

Call Center (585) 276-3000

About Me

Certified Specialties

Radiation Oncology - American Board of Radiology

Faculty Appointments

Professor - Department of Radiation Oncology (SMD)

Chair - Department of Radiation Oncology (SMD)

Philip Rubin Professorship in Radiation Oncology - Department of Radiation Oncology (SMD)

Professor - Cancer Center - Joint

Credentials

Residency & Fellowship

Fellowship, Research, University of Wisconsin at Madison. 2010 - 2012

Fellowship, Research, University of North Carolina at Chapel Hill. 2007 - 2010

Residency, Radiation Oncology, University of North Carolina Hospitals. 2006 - 2010

Internship, Internal Medicine, University of North Carolina at Chapel Hill. 2005 - 2006

Education

MBA | Edgewood College. 2023

MD | University of North Carolina at Chapel Hill School of Medicine. 2005

PhD | The University Of North Carolina At Chapel Hill. 2003

Publications

Journal Articles

The Role of Low-Energy Virtual Monoenergetic Images Derived From Dual-Energy Computed Tomography in Tumor Segmentation for Head and Neck Radiation Therapy: A Contouring Study.

Miller JR, Lawless M, DiMaso-Myers L, Morris B, Blitzer G, Schuster J, Merfeld E, Kimple RJ, Kennedy T, Shah J, Wohlfahrt P, Harari PM, Burr A

Advances in radiation oncology.. 2026 October 11 (10):102089. Epub 05/20/2026.

Pretreatment Chromosomal Instability Correlates With Radiation Sensitivity in Squamous Cell Cancers.

Cosper PF, Paracha M, Jones KM, Hrycyniak L, Henderson L, Bryan A, Eyzaguirre D, McCunn E, Boulanger E, Wan J, Nickel KP, Horner V, Hu R, Harari PM, Kimple RJ, Weaver BA

International journal of radiation oncology, biology, physics.. 2026 July 15125 (4):1176-1189. Epub 01/21/2026.

High Throughput In vivo Imaging; A Pipeline for Automated Analysis of Longitudinal Preclinical Studies.

Tchinov M, Gurberg Z, Möckel D, Rosenhain S, Marsilio J, Schraven S, Ott K, LeBeau A, Kimple RJ, Gremse F

Current protocols.. 2026 July 6 (7):e70414. Epub 1900 01 01.

Inhibition of autophagy increases head and neck cancer sensitivity to cetuximab and radiation therapy.

Lee YS, Nickel KP, Bradley ST, Skiba JH, Eckers JC, Swick AD, Hu R, Iida M, Gurel Z, Wheeler DL, Kimple RJ

Scientific reports.. 2026 May 2816 (1)Epub 05/28/2026.

Introducing ARONG, A 3D Reconstruction Method for Highly Deformed Histology.

Lee Y, Nickel KP, Kiernan MJ, Al Mukaddim R, Liu Y, Mitchell V, Ngawang T, Salamat S, Wilbrand SM, Graham M, Eliceiri KW, Kimple RJ, Dempsey RJ, Varghese T

Journal of imaging informatics in medicine.. 2026 March 31 Epub 03/31/2026.

A MET-Targeted Variable New Antigen Receptor (VNAR) Theranostic for Non-Small Cell Lung Cancer.

Minne RL, West JL, Luo NY, Nickel KP, Gunaratne GS, Ott KL, Gallant JP, Barrett KE, Mork CM, Javeri S, Wopat MR, Lopez LDR, Toscano WA, Zitzer NC, Kwon O, Teague J, Bunker B, Phillips JM, Idrissou MB, Rojas HC, Mixdorf JC, Aluicio-Sarduy E, Engle JW, Bednarz B, Hernandez R, Kimple RJ, Baschnagel AM, LeBeau AM

bioRxiv : the preprint server for biology.. 2026 March 11 Epub 03/11/2026.

STING predicts patterns of failure in locally advanced head and neck squamous cell carcinoma.

MacNeil T, Hayman TJ, Li S, Moutafi M, Martinez-Morilla S, Vathiotis IA, Hu R, Harari PM, Burtness B, Liu H, Kimple RJ, Rimm DL, Contessa JN

JNCI cancer spectrum.. 2026 March 310 (2)Epub 1900 01 01.

Shared PRAME epitopes are T-cell targets in NUT carcinoma.

Jensen JL, Peterson SK, Sambade MJ, Alley JR, Yu S, Kinjo T, Bennett SN, Vensko SP, Shabrang M, Debetta JD, Geyer JK, Price BA, Nickel KP, Kimple RJ, Kotecha RS, Herring LE, Davis IJ, Wang JR, French CA, Kuhlman B, Weiss JM, Rubinsteyn A, Vincent BG

Journal for immunotherapy of cancer.. 2026 February 514 (2)Epub 02/05/2026.

Combined innate immune cell therapy, tumor-specific antibody, and radiation prompt antitumor response in pancreatic cancer models.

Rahman MM, Pennati A, Atajanova T, Debnath T, Allawi RH, Meyers RO, Berg TJ, Gurel Z, Uboha NV, Bassetti MF, Mao L, Sondel PM, Kimple RJ, Capitini CM, Sodji QH, Galipeau J, Morris ZS

Science advances.. 2025 December 511 (49):eadx2984. Epub 12/05/2025.

IFNγ and TNFα optimize salivary gland mesenchymal stromal cells: an alternative to marrow- and adipose-MSCs for radiation xerostomia.

Larsen MC, Gurevic I, Berube L, Vande Loo A, Hanson E, Adam R, Manfrè V, Parker M, Paz C, Galipeau J, Kimple RJ, Blitzer G, McCoy SS

Regenerative therapy.. 2025 December 30 :1086-1100. Epub 11/14/2025.

Shared PRAME Epitopes are T-Cell Targets in NUT Carcinoma.

Jensen JL, Peterson SK, Sambade M, Alley JR, Yu S, Kinjo T, Bennett SN, Vensko SP, Shabrang M, DeBetta JD, Geyer JK, Price BA, Nickel KP, Kimple RJ, Kotecha RS, Herring LE, Davis IJ, Wang JR, French CA, Kuhlman B, Weiss J, Rubinsteyn A, Vincent BG

bioRxiv : the preprint server for biology.. 2025 November 22 Epub 11/22/2025.

Immune and Genomic Heterogeneity of MET-Altered Non-Small Cell Lung Cancer.

Liu M, Minne RL, Javeri S, Johnson DB, Tomlins SA, Kimple RJ, Baschnagel AM

JCO precision oncology.. 2025 September 9 :e2500048. Epub 09/26/2025.

Poly (hydroxyethyl methacrylate) Saliva-Gel: A Polymer-Based Solution for Xerostomia Treatment.

Debnath S, Paz C, Scofield D, Rogus-Pulia N, Kimple RJ, Malandraki GA, Boudouris BW

ACS applied polymer materials.. 2025 July 17 Epub 07/17/2025.

Exercise May Improve Completion of Standard and Emerging Cancer Treatments.

Catalá-Vilaplana I, Cao SE, Zadravec K, LeVasseur N, Kimple RJ, Lim AJ, Courneya KS, Campbell KL

Exercise and sport sciences reviews.. 2025 July 153 (3):110-124. Epub 02/18/2025.

National Institutes of Health Funding to Support Radiation Oncology Research: A Comparative Trend Analysis Over a Decade, 2011-2021.

Razavi A, Rooney MK, Fuller CD, Yu JB, Pfister NT, Thomas CR, Buatti JM, Kamran SC, McGee HM, Yeboa DN, Kiess AP, Baschnagel AM, Kimple RJ

Advances in radiation oncology.. 2025 June 10 (6):101767. Epub 04/22/2025.

Clinicopathologic and Molecular Characterization of SMARCB1-Deificient Sinonasal Carcinomas -A Systematic Study from a Single Institution Cohort.

Li Q, Abi-Saab T, Prilutskiy A, Horner V, Frater-Rubsam L, Peng Y, Huang W, Kimple RJ, Harari PM, Lloyd RV, Hu R

Head and neck pathology.. 2025 May 1419 (1):60. Epub 05/14/2025.

Still thirsting for a fix.

Blitzer GC, Galipeau J, McCoy SS, Kimple RJ

Translational cancer research.. 2025 April 3014 (4):2175-2177. Epub 04/15/2025.

Subclonal response heterogeneity to define cancer organoid therapeutic sensitivity.

Kratz JD, Rehman S, Johnson KA, Gillette AA, Sunil A, Favreau PF, Pasch CA, Miller D, Zarling LC, Yeung AH, Clipson L, Anderson SJ, Steimle AK, Sprackling CM, Lemmon KK, Abbott DE, Burkard ME, Bassetti MF, Eickhoff JC, Foley EF, Heise CP, Kimple RJ, Lawson EH, LoConte NK, Lubner SJ, Mulkerin DL, Matkowskyj KA, Sanger CB, Uboha NV, Mcilwain SJ, Ong IM, Carchman EH, Skala MC, Deming DA

Scientific reports.. 2025 April 915 (1):12072. Epub 04/09/2025.

Radiation-Therapy Related Salivary Dysfunction.

Blitzer GC, Paz C, McCoy SS, Kimple RJ

Seminars in radiation oncology.. 2025 April 35 (2):278-284. Epub 1900 01 01.

Safety and toxicity of Iopofosine I 131 (CLR 131) with external beam radiation therapy in recurrent or metastatic head and neck cancer: results of a phase 1 single-centre, open-label, single-arm, dose escalation and dose expansion study.

Bruce JY, Burr A, Kimple RJ, Adam DP, Yu M, Piaskowski SM, Glazer TA, Hill P, Hartig GK, McCulloch TM, Wieland AM, Trask D, Oliver K, Longcor J, Rogus-Pulia N, Cho SY, Bednarz B, Harari PM

EBioMedicine.. 2025 January 111 :105496. Epub 12/12/2024.

Evaluation of a Novel MET-Targeting Camelid-Derived Antibody in Head and Neck Cancer.

Minne RL, Luo NY, Mork CM, Wopat MR, Esbona K, Javeri S, Nickel KP, Hernandez R, LeBeau AM, Kimple RJ, Baschnagel AM

Molecular pharmaceutics.. 2024 December 221 (12):6376-6384. Epub 11/08/2024.

Loss of MK2 Enhances Radiation-Mediated Apoptosis in Bladder Cancer.

Morgan D, Berggren KL, Millington G, Smith H, Spiess C, Hixon M, Woolbright BL, Taylor JA, Kimple RJ, Chen R, Shen X, Gan GN

World journal of oncology.. 2024 December 15 (6):871-881. Epub 12/11/2024.

Uncommon and Challenging Phenotypes of High-Risk Human Papillomavirus-Associated Head and Neck Carcinomas Revealed by High-Throughput Studies.

Tannenbaum AP, Lozar T, Lu C, Schumacher M, Golfinos A, Dinh HQ, Taylor N, Kimple RJ, Yang D, Harari PM, Lambert PF, Lloyd RV, Hu R

Head and neck pathology.. 2024 October 2218 (1):112. Epub 10/22/2024.

From Bench to Bedside: A Team's Approach to Multidisciplinary Strategies to Combat Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma.

Crossman BE, Harmon RL, Kostecki KL, McDaniel NK, Iida M, Corday LW, Glitchev CE, Crow MT, Harris MA, Lin CY, Adams JM, Longhurst CA, Nickel KP, Ong IM, Alexandridis RA, Yu M, Yang DT, Hu R, Morris ZS, Hartig GK, Glazer TA, Ramisetty S, Kulkarni P, Salgia R, Kimple RJ, Bruce JY, Harari PM, Wheeler DL

Journal of clinical medicine.. 2024 October 1013 (20)Epub 10/10/2024.

Challenges and opportunities for early phase clinical trials of novel drug-radiotherapy combinations: recommendations from NRG Oncology, the American Society for Radiation Oncology (ASTRO), the American College of Radiology (ACR), the Sarah Cannon Research Institute, and the American College of Radiation Oncology (ACRO).

Zumsteg ZS, Sheth S, Jabbour SK, Patel KR, Kimple RJ, Williams TM, Xu-Welliver M, Torres-Saavedra PA, Monjazeb AM, Mayadev J, Finkelstein SE, Buatti JM, Patel SP, Lin SH

The Lancet. Oncology.. 2024 October 25 (10):e489-e500. Epub 1900 01 01.

Chromosomal instability increases radiation sensitivity.

Cosper PF, Paracha M, Jones KM, Hrycyniak L, Henderson L, Bryan A, Eyzaguirre D, McCunn E, Boulanger E, Wan J, Nickel KP, Horner V, Hu R, Harari PM, Kimple RJ, Weaver BA

bioRxiv : the preprint server for biology.. 2024 September 19 Epub 09/19/2024.

Cancer therapy-related salivary dysfunction.

Paz C, Glassey A, Frick A, Sattar S, Zaorsky NG, Blitzer GC, Kimple RJ

The Journal of clinical investigation.. 2024 September 3134 (17)Epub 09/03/2024.

Genomic and Immune Landscape Comparison of MET Exon 14 Skipping and MET-Amplified Non-small Cell Lung Cancer.

Minne RL, Luo NY, Traynor AM, Huang M, DeTullio L, Godden J, Stoppler M, Kimple RJ, Baschnagel AM

Clinical lung cancer.. 2024 September 25 (6):567-576.e1. Epub 05/10/2024.

Morphologic Spectrum of HPV-associated Sinonasal Carcinomas.

Abi-Saab T, Lozar T, Chen Y, Tannenbaum AP, Geye H, Yu M, Weisman P, Harari PM, Kimple RJ, Lambert PF, Lloyd RV, Hu R

Head and neck pathology.. 2024 August 518 (1):67. Epub 08/05/2024.

A Phase 2 Randomized Clinical Trial Evaluating 4-Dimensional Computed Tomography Ventilation-Based Functional Lung Avoidance Radiation Therapy for Non-Small Cell Lung Cancer.

Baschnagel AM, Flakus MJ, Wallat EM, Wuschner AE, Chappell RJ, Bayliss RA, Kimple RJ, Christensen GE, Reinhardt JM, Bassetti MF, Bayouth JE

International journal of radiation oncology, biology, physics.. 2024 August 1119 (5):1393-1402. Epub 02/20/2024.

Multidisciplinary Management of Advanced Thyroid Cancer.

Bruce JY, Glazer TA, Kimple RJ

JCO oncology practice.. 2024 July 20 (7):877-878. Epub 03/29/2024.

Network analyses: Inhibition of androgen receptor signaling reduces inflammation in the lung through AR-MAF-IL6 signaling axes.

Wang AR, Baschnagel AM, Ni Z, Brennan SR, Newton HK, Buehler D, Kendziorski C, Kimple RJ, Iyer G

Genes & diseases.. 2024 May 11 (3):101072. Epub 08/18/2023.

An algorithm for standardization of tumor Infiltrating lymphocyte evaluation in head and neck cancers.

Xirou V, Moutafi M, Bai Y, Nwe Aung T, Burela S, Liu M, Kimple RJ, Shabbir Ahmed F, Schultz B, Flieder D, Connolly DC, Psyrri A, Burtness B, Rimm DL

Oral oncology.. 2024 May 152 :106750. Epub 03/27/2024.

MET Inhibitor Capmatinib Radiosensitizes MET Exon 14-Mutated and MET-Amplified Non-Small Cell Lung Cancer.

Ramesh S, Cifci A, Javeri S, Minne RL, Longhurst CA, Nickel KP, Kimple RJ, Baschnagel AM

International journal of radiation oncology, biology, physics.. 2024 April 1118 (5):1379-1390. Epub 11/16/2023.

Development of an Engineered Single-Domain Antibody for Targeting MET in Non-Small Cell Lung Cancer.

Luo NY, Minne RL, Gallant JP, Gunaratne GS, West JL, Javeri S, Robertson AJ, Lake EW, Engle JW, Mixdorf JC, Aluicio-Sarduy E, Nickel KP, Hernandez R, Kimple RJ, Baschnagel AM, LeBeau AM

Bioconjugate chemistry.. 2024 March 2035 (3):389-399. Epub 03/12/2024.

Functionality of bone marrow mesenchymal stromal cells derived from head and neck cancer patients - A FDA-IND enabling study regarding MSC-based treatments for radiation-induced xerostomia.

Blitzer GC, Paz C, Glassey A, Ganz OR, Giri J, Pennati A, Meyers RO, Bates AM, Nickel KP, Weiss M, Morris ZS, Mattison RJ, McDowell KA, Croxford E, Chappell RJ, Glazer TA, Rogus-Pulia NM, Galipeau J, Kimple RJ

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2024 March 192 :110093. Epub 01/13/2024.

Targeted inhibition of BET proteins in HPV16-positive head and neck squamous cell carcinoma reveals heterogeneous transcriptional responses.

Rao A, Stosic MS, Mohanty C, Suresh D, Wang AR, Lee DL, Nickel KP, Chandrashekar DS, Kimple RJ, Lambert PF, Kendziorski C, Rounge TB, Iyer G

Frontiers in oncology.. 2024 14 :1440836. Epub 09/05/2024.

Metabolic modulation of melanoma enhances the therapeutic potential of immune checkpoint inhibitors.

Gurel Z, Luy MS, Luo Q, Arp NL, Erbe AK, Kesarwala AH, Fan J, Kimple RJ

Frontiers in oncology.. 2024 14 :1428802. Epub 10/01/2024.

Marrow-Derived Autologous Stromal Cells for the Restoration of Salivary Hypofunction (MARSH): A pilot, first-in-human study of interferon gamma-stimulated marrow mesenchymal stromal cells for treatment of radiation-induced xerostomia.

Blitzer GC, Glazer T, Burr A, Gustafson S, Ganz O, Meyers R, McDowell KA, Nickel KP, Mattison RJ, Weiss M, Chappell R, Rogus-Pulia NM, Galipeau J, Kimple RJ

Cytotherapy.. 2023 November 25 (11):1139-1144. Epub 08/15/2023.

MET Inhibitor Capmatinib Radiosensitizes MET Exon 14-Mutated and MET-Amplified Non-Small Cell Lung Cancer.

Ramesh S, Cifci A, Javeri S, Minne R, Longhurst CA, Nickel KP, Kimple RJ, Baschnagel AM

bioRxiv : the preprint server for biology.. 2023 October 27 Epub 10/27/2023.

Acrylamide-based Saliva-gels as a Potential Xerostomia Treatment.

Debnath S, Woeppel AB, Paz C, Rogus-Pulia N, Kimple RJ, Malandraki GA, Boudouris BW

ACS applied polymer materials.. 2023 October 135 (10):7698-7704. Epub 09/18/2023.

Radiation Sensitivity: The Rise of Predictive Patient-Derived Cancer Models.

Berube LL, Nickel KP, Iida M, Ramisetty S, Kulkarni P, Salgia R, Wheeler DL, Kimple RJ

Seminars in radiation oncology.. 2023 July 33 (3):279-286. Epub 1900 01 01.

Circulating tumor cell abundance in head and neck squamous cell carcinoma decreases with successful chemoradiation and cetuximab treatment.

Poellmann MJ, Bu J, Kim D, Iida M, Hong H, Wang AZ, Wheeler DL, Kimple RJ, Hong S

Cancer letters.. 2023 May 28562 :216187. Epub 04/15/2023.

Biological Characterization of the Effects of Filtration on the Xoft Axxent® Electronic Brachytherapy Source for Cervical Cancer Applications.

Walter AE, Cosper PF, Nickel KP, Ramesh S, Khan AU, DeWerd LA, Kimple RJ

Radiation research.. 2023 May 1199 (5):429-438. Epub 1900 01 01.

HPV16 E6 induces chromosomal instability due to polar chromosomes caused by E6AP-dependent degradation of the mitotic kinesin CENP-E.

Cosper PF, Hrycyniak LCF, Paracha M, Lee DL, Wan J, Jones K, Bice SA, Nickel K, Mallick S, Taylor AM, Kimple RJ, Lambert PF, Weaver BA

Proceedings of the National Academy of Sciences of the United States of America.. 2023 April 4120 (14):e2216700120. Epub 03/29/2023.

Safety of Nivolumab Added to Chemoradiation Therapy Platforms for Intermediate and High-Risk Locoregionally Advanced Head and Neck Squamous Cell Carcinoma: RTOG Foundation 3504.

Gillison ML, Ferris RL, Harris J, Colevas AD, Mell LK, Kong C, Jordan RC, Moore KL, Truong MT, Kirsch C, Chakravarti A, Blakaj DM, Clump DA, Ohr JP, Deeken JF, Gensheimer MF, Saba NF, Dorth JA, Rosenthal DI, Leidner RS, Kimple RJ, Machtay M, Curran WJ, Torres-Saavedra P, Le QT

International journal of radiation oncology, biology, physics.. 2023 March 15115 (4):847-860. Epub 10/11/2022.

Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTN.

Stueven NA, Beauvais DM, Hu R, Kimple RJ, Rapraeger AC

Cancer research communications.. 2023 January 3 (1):97-108. Epub 01/19/2023.

Interstitial Brachytherapy for Lip Cancer: Technical Aspects to Individualize Treatment Approach and Optimize Outcomes.

Merfeld EC, Witek ME, Francis DM, Burr AR, Wallace CR, Kuczmarska-Haas A, Lamichhane N, Kimple RJ, Glazer TA, Wieland AM, McCulloch TM, Hartig GK, Harari PM

Practical radiation oncology.. 2023 13 (4):340-345. Epub 01/25/2023.

Bimodal liquid biopsy for cancer immunotherapy based on peptide engineering and nanoscale analysis.

Bu J, Jeong WJ, Jafari R, Kubiatowicz LJ, Nair A, Poellmann MJ, Hong RS, Liu EW, Owen RH, Rawding PA, Hopkins CM, Kim D, George DJ, Armstrong AJ, Král P, Wang AZ, Bruce J, Zhang T, Kimple RJ, Hong S

Biosensors & bioelectronics.. 2022 October 1213 :114445. Epub 06/01/2022.

Quantification of very late xerostomia in head and neck cancer patients after irradiation.

Blitzer GC, Rogus-Pulia NM, Paz C, Nickel KP, Cannaday VL, Kelm-Nelson CA, Sudakaran S, Chappell RJ, Glazer T, Kimple RJ

Laryngoscope investigative otolaryngology.. 2022 August 7 (4):1018-1024. Epub 07/12/2022.

Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade.

Wang W, Lozar T, Golfinos AE, Lee D, Gronski E, Ward-Shaw E, Hayes M, Bruce JY, Kimple RJ, Hu R, Harari PM, Xu J, Keske A, Sondel PM, Fitzpatrick MB, Dinh HQ, Lambert PF

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2022 July 128 (13):2953-2968. Epub 1900 01 01.

Using 4D dose accumulation to calculate organ-at-risk dose deviations from motion-synchronized liver and lung tomotherapy treatments.

Ferris WS, Chao EH, Smilowitz JB, Kimple RJ, Bayouth JE, Culberson WS

Journal of applied clinical medical physics. 2022 July 23 (7):e13627. Epub 04/29/2022.

Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer.

Carper MB, Goel S, Zhang AM, Damrauer JS, Cohen S, Zimmerman MP, Gentile GM, Parag-Sharma K, Murphy RM, Sato K, Nickel KP, Kimple RJ, Yarbrough WG, Amelio AL

Neoplasia : an international journal for oncology research.. 2022 July 29 :100799. Epub 04/30/2022.

Prospective Study of PET/MRI Tumor Response During Chemoradiotherapy for Patients With Low-risk and Intermediate-risk p16-positive Oropharynx Cancer.

Witek ME, Kimple RJ, Avey GD, Burr AR, Chandereng T, Yu M, Hu R, Wieland AM, Labby ZE, Bruce JY, Brower JV, Hartig GK, Harari PM

American journal of clinical oncology.. 2022 May 145 (5):202-207. Epub 04/12/2022.

Marrow-Derived Autologous Stromal Cells for the Restoration of Salivary Hypofunction (MARSH): Study protocol for a phase 1 dose-escalation trial of patients with xerostomia after radiation therapy for head and neck cancer: MARSH: Marrow-Derived Autologous Stromal Cells for the Restoration of Salivary Hypofunction.

Blitzer GC, Rogus-Pulia NM, Mattison RJ, Varghese T, Ganz O, Chappell R, Galipeau J, McDowell KA, Meyers RO, Glazer TA, Kimple RJ

Cytotherapy.. 2022 May 24 (5):534-543. Epub 02/16/2022.

Advances in Organ Preservation for Laryngeal Cancer.

Campbell G, Glazer TA, Kimple RJ, Bruce JY

Current treatment options in oncology.. 2022 April 23 (4):594-608. Epub 03/18/2022.

Defining high-risk elective contralateral neck radiation volumes for oropharynx cancer.

Witek ME, Woody NM, Musunuru HB, Hill PM, Yadav P, Burr AR, Ko HC, Ross RB, Kimple RJ, Harari PM

Head & neck.. 2022 February 44 (2):317-324. Epub 11/11/2021.

Autophagy awakens-the myriad roles of autophagy in head and neck cancer development and therapeutic response.

Bradley ST, Lee YS, Gurel Z, Kimple RJ

Molecular carcinogenesis.. 2022 February 61 (2):243-253. Epub 11/15/2021.

Retraction.

Brand TM, Iida M, Corrigan KL, Braverman CM, Coan JP, Flanigan BG, Stein AP, Salgia R, Rolff J, Kimple RJ, Wheeler DL

Science signaling.. 2021 November 914 (708):eabn0168. Epub 11/09/2021.

ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non-Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts.

Baschnagel AM, Elnaggar JH, VanBeek HJ, Kromke AC, Skiba JH, Kaushik S, Abel L, Clark PA, Longhurst CA, Nickel KP, Leal TA, Zhao SG, Kimple RJ

Molecular cancer therapeutics.. 2021 November 20 (11):2129-2139. Epub 08/19/2021.

Biology of HPV Mediated Carcinogenesis and Tumor Progression.

Cosper PF, Bradley S, Luo L, Kimple RJ

Seminars in radiation oncology.. 2021 October 31 (4):265-273. Epub 1900 01 01.

Mentorship Initiatives in Radiation Oncology: A Scoping Review of the Literature.

Marsiglio JA, Rosenberg DM, Rooney MK, Goodman CR, Gillespie EF, Hirsch AE, Holliday EB, Kimple RJ, Thomas CR, Golden DW

International journal of radiation oncology, biology, physics.. 2021 June 1110 (2):292-302. Epub 01/04/2021.

Impact of immediate cryopreservation on the establishment of patient derived xenografts from head and neck cancer patients.

Abel L, Durmaz A, Hu R, Longhurst C, Baschnagel AM, Wheeler D, Scott JG, Kimple RJ

Journal of translational medicine.. 2021 April 2819 (1):180. Epub 04/28/2021.

Clinical Cancer Advances 2021: ASCO's Report on Progress Against Cancer.

Smith SM, Wachter K, Burris HA, Schilsky RL, George DJ, Peterson DE, Johnson ML, Markham MJ, Mileham KF, Beg MS, Bendell JC, Dreicer R, Keedy VL, Kimple RJ, Knoll MA, LoConte N, MacKay H, Meisel JL, Moynihan TJ, Mulrooney DA, Mulvey TM, Odenike O, Pennell NA, Reeder-Hayes K, Smith C, Sullivan RJ, Uzzo R

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2021 April 139 (10):1165-1184. Epub 02/02/2021.

Immunotherapy in Head and Neck Cancer-Ready for Prime Time or More Research Needed?

Karam SD, Anderson CM, Ma D, Chua MLK, Kimple RJ

International journal of radiation oncology, biology, physics.. 2021 March 1109 (3):647-650. Epub 1900 01 01.

Development and characterization of patient-derived xenografts from non-small cell lung cancer brain metastases.

Baschnagel AM, Kaushik S, Durmaz A, Goldstein S, Ong IM, Abel L, Clark PA, Gurel Z, Leal T, Buehler D, Iyer G, Scott JG, Kimple RJ

Scientific reports.. 2021 January 2811 (1):2520. Epub 01/28/2021.

Dichotomic Potency of IFNγ Licensed Allogeneic Mesenchymal Stromal Cells in Animal Models of Acute Radiation Syndrome and Graft Host Disease.

Chinnadurai R, Bates PD, Kunugi KA, Nickel KP, DeWerd LA, Capitini CM, Galipeau J, Kimple RJ

Frontiers in immunology.. 2021 12 :708950. Epub 07/26/2021.

AXL Mediates Cetuximab and Radiation Resistance Through Tyrosine 821 and the c-ABL Kinase Pathway in Head and Neck Cancer.

McDaniel NK, Iida M, Nickel KP, Longhurst CA, Fischbach SR, Rodems TS, Kranjac CA, Bo AY, Luo Q, Gallagher MM, Welke NB, Mitchell KR, Schulz AE, Eckers JC, Hu R, Salgia R, Hong S, Bruce JY, Kimple RJ, Wheeler DL

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2020 August 1526 (16):4349-4359. Epub 05/21/2020.

Immunoavidity-Based Capture of Tumor Exosomes Using Poly(amidoamine) Dendrimer Surfaces.

Poellmann MJ, Nair A, Bu J, Kim JKH, Kimple RJ, Hong S

Nano letters.. 2020 August 1220 (8):5686-5692. Epub 05/19/2020.

Clinical outcomes for larynx patients with cancer treated with refinement of high-dose radiation treatment volumes.

Burr AR, Harari PM, Haasl AM, Wieland AM, Bruce JY, Kimple RJ, Hartig GK, McCulloch TM, Witek ME

Head & neck.. 2020 August 42 (8):1874-1881. Epub 02/14/2020.

Fibroblast Growth Factor Receptors as Targets for Radiosensitization in Head and Neck Squamous Cell Carcinomas.

Fisher MM, SenthilKumar G, Hu R, Goldstein S, Ong IM, Miller MC, Brennan SR, Kaushik S, Abel L, Nickel KP, Iyer G, Harari PM, Kimple RJ, Baschnagel AM

International journal of radiation oncology, biology, physics.. 2020 July 15107 (4):793-803. Epub 04/13/2020.

FGFR Inhibition Enhances Sensitivity to Radiation in Non-Small Cell Lung Cancer.

SenthilKumar G, Fisher MM, Skiba JH, Miller MC, Brennan SR, Kaushik S, Bradley ST, Longhurst CA, Buehler D, Nickel KP, Iyer G, Kimple RJ, Baschnagel AM

Molecular cancer therapeutics.. 2020 June 19 (6):1255-1265. Epub 05/05/2020.

Clinical Cancer Advances 2020: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology.

Markham MJ, Wachter K, Agarwal N, Bertagnolli MM, Chang SM, Dale W, Diefenbach CSM, Rodriguez-Galindo C, George DJ, Gilligan TD, Harvey RD, Johnson ML, Kimple RJ, Knoll MA, LoConte N, Maki RG, Meisel JL, Meyerhardt JA, Pennell NA, Rocque GB, Sabel MS, Schilsky RL, Schneider BJ, Tap WD, Uzzo RG, Westin SN

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2020 April 138 (10):1081. Epub 02/04/2020.

Four Influential Clinical Trials in Human Papilloma Virus-Associated Oropharynx Cancer.

Margalit DN, Karam SD, Chua MLK, Anderson C, Kimple RJ

International journal of radiation oncology, biology, physics.. 2020 April 1106 (5):893-899. Epub 1900 01 01.

Patient Derived Models to Study Head and Neck Cancer Radiation Response.

Cosper PF, Abel L, Lee YS, Paz C, Kaushik S, Nickel KP, Alexandridis R, Scott JG, Bruce JY, Kimple RJ

Cancers.. 2020 February 1212 (2)Epub 02/12/2020.

Interstitial diffuse optical probe with spectral fitting to measure dynamic tumor hypoxia.

Che Fru L, Jacques SL, Nickel KP, Varghese T, Kissick MW, DeWerd LA, Kimple RJ

Biomedical physics & engineering express.. 2020 January 6 (1)Epub 01/31/2020.

Follow-Up and Management of Patients With Head and Neck Cancer During the 2019 Novel Coronavirus (SARS-CoV-2) Disease Pandemic.

Chua MLK, Ma DJ, Anderson CM, Karam SD, Margalit DN, Kimple RJ

Advances in radiation oncology.. 2020 5 (4):631-636. Epub 05/15/2020.

Opioid use in patients undergoing treatment for oral cavity cancer.

Ko HC, Mehra MN, Burr AR, Wieland AM, Kimple RJ, Hartig GK, Harari PM, Witek ME

Journal of pain management.. 2020 13 (2):167-173. Epub 1900 01 01.

Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation.

Pasch CA, Favreau PF, Yueh AE, Babiarz CP, Gillette AA, Sharick JT, Karim MR, Nickel KP, DeZeeuw AK, Sprackling CM, Emmerich PB, DeStefanis RA, Pitera RT, Payne SN, Korkos DP, Clipson L, Walsh CM, Miller D, Carchman EH, Burkard ME, Lemmon KK, Matkowskyj KA, Newton MA, Ong IM, Bassetti MF, Kimple RJ, Skala MC, Deming DA

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2019 September 125 (17):5376-5387. Epub 06/07/2019.

Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells.

Ayuso JM, Vitek R, Swick AD, Skala MC, Wisinski KB, Kimple RJ, Lambert PF, Beebe DJ

Scientific reports.. 2019 August 289 (1):12480. Epub 08/28/2019.

High-throughput quantitative detection of basal autophagy and autophagic flux using image cytometry.

SenthilKumar G, Skiba JH, Kimple RJ

BioTechniques.. 2019 August 67 (2):70-73. Epub 06/26/2019.

De-Escalation Strategies in HPV-Associated Oropharynx Cancer-Are we Putting the Cart Before the Horse?

Anderson CM, Kimple RJ, Lin A, Karam SD, Margalit DN, Chua MLK

International journal of radiation oncology, biology, physics.. 2019 July 15104 (4):705-709. Epub 1900 01 01.

Reducing radiotherapy target volume expansion for patients with HPV-associated oropharyngeal cancer.

Burr AR, Harari PM, Ko HC, Bruce JY, Kimple RJ, Witek ME

Oral oncology.. 2019 May 92 :52-56. Epub 03/22/2019.

Analysis of the 2017 American Society for Radiation Oncology (ASTRO) Research Portfolio.

Yu JB, Beck TF, Anscher MS, Baschnagel AM, Brock KK, Carlson DJ, Dominello MM, Kimple RJ, Knisely JP, Mendonca MS, Mian OY, Singh AK, Moros EG, Keen JC

International journal of radiation oncology, biology, physics.. 2019 February 1103 (2):297-304. Epub 1900 01 01.

The ASTRO Research Portfolio: Where Do We Go From Here?

Yu JB, Beck TF, Anscher MS, Baschnagel AM, Brock KK, Carlson DJ, Dominello MM, Kimple RJ, Knisely JPS, Mendonca MS, Mian OY, Singh AK, Moros EG, Keen JC

International journal of radiation oncology, biology, physics.. 2019 February 1103 (2):308-309. Epub 1900 01 01.

STAT-ART: The Promise and Practice of a Rapid Palliative Single Session of MR-Guided Online Adaptive Radiotherapy (ART).

Mittauer KE, Hill PM, Geurts MW, De Costa AM, Kimple RJ, Bassetti MF, Bayouth JE

Frontiers in oncology.. 2019 9 :1013. Epub 10/22/2019.

Correction: AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma.

Brand TM, Iida M, Stein AP, Corrigan KL, Braverman CM, Coan JP, Pearson HE, Bahrar H, Fowler TL, Bednarz BP, Saha S, Yang D, Gill PS, Lingen MW, Saloura V, Villaflor VM, Salgia R, Kimple RJ, Wheeler DL

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2018 December 124 (23):6099. Epub 1900 01 01.

Beyond 'charting outcomes' in the radiation oncology match: analysis of self-reported applicant data.

Jang S, Rosenberg SA, Hullett C, Bradley KA, Kimple RJ

Medical education online.. 2018 December 23 (1):1489691. Epub 1900 01 01.

In Reply to Lin and Golden.

Jang S, Rosenberg SA, Bradley KA, Kimple RJ

International journal of radiation oncology, biology, physics.. 2018 November 1102 (3):672. Epub 1900 01 01.

MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents.

McDaniel NK, Cummings CT, Iida M, Hülse J, Pearson HE, Vasileiadi E, Parker RE, Orbuch RA, Ondracek OJ, Welke NB, Kang GH, Davies KD, Wang X, Frye SV, Earp HS, Harari PM, Kimple RJ, DeRyckere D, Graham DK, Wheeler DL

Molecular cancer therapeutics.. 2018 November 17 (11):2297-2308. Epub 08/09/2018.

Results From 10 Years of a Free Oral Cancer Screening Clinic at a Major Academic Health Center.

Blitzer GC, Rosenberg SA, Anderson BM, McCulloch TM, Wieland AM, Hartig GK, Bruce JY, Witek ME, Kimple RJ, Harari PM

International journal of radiation oncology, biology, physics.. 2018 September 1102 (1):146-148. Epub 07/03/2018.

Impact of HPV Status on the Prognostic Potential of the AJCC Staging System for Larynx Cancer.

Davidson SM, Ko HC, Harari PM, Wieland AM, Chen S, Baschnagel AM, Kimple RJ, Witek ME

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 2018 September 159 (3):456-465. Epub 04/03/2018.

The Resident Individual Development Plan as a Guide for Radiation Oncology Mentorship.

Ko HC, Kimple RJ

International journal of radiation oncology, biology, physics.. 2018 July 15101 (4):786-788. Epub 03/06/2018.

Corrigendum: Potential role of the glycolytic oscillator in acute hypoxia in tumors (2015.9215).

Che Fru L, Adamson EB, Campos DD, Fain SB, Jacques SL, van der Kogel AJ, Nickel KP, Song C, Kimple RJ, Kissick MW

Physics in medicine and biology.. 2018 June 2763 (13)Epub 06/27/2018.

Identity Crisis - Rigor and Reproducibility in Human Cell Lines.

Eckers JC, Swick AD, Kimple RJ

Radiation research.. 2018 June 189 (6):551-552. Epub 04/13/2018.

Genomics Reloaded: Rise of the Expression Profiles.

Gan GN, Kimple RJ

International journal of radiation oncology, biology, physics.. 2018 May 1101 (1):1-3. Epub 1900 01 01.

The Future of Radiobiology.

Kirsch DG, Diehn M, Kesarwala AH, Maity A, Morgan MA, Schwarz JK, Bristow R, Demaria S, Eke I, Griffin RJ, Haas-Kogan D, Higgins GS, Kimmelman AC, Kimple RJ, Lombaert IM, Ma L, Marples B, Pajonk F, Park CC, Schaue D, Tran PT, Willers H, Wouters BG, Bernhard EJ

Journal of the National Cancer Institute.. 2018 April 1110 (4):329-340. Epub 1900 01 01.

In Reply to Hamstra.

Rosenberg SA, Bradley KA, Kimple RJ

International journal of radiation oncology, biology, physics.. 2018 April 1100 (5):1293-1294. Epub 1900 01 01.

Value of Elective Radiation Oncology Rotations: How Many Is Too Many?

Jang S, Rosenberg SA, Hullet C, Bradley KA, Kimple RJ

International journal of radiation oncology, biology, physics.. 2018 March 1100 (3):558-559. Epub 11/06/2017.

Primary intracranial leiomyosarcoma in an immunocompetent patient: Case report and review of the literature.

Gallagher SJ, Rosenberg SA, Francis D, Salamat S, Howard SP, Kimple RJ

Clinical neurology and neurosurgery.. 2018 February 165 :76-80. Epub 01/06/2018.

Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma.

Redlich N, Robinson AM, Nickel KP, Stein AP, Wheeler DL, Adkins DR, Uppaluri R, Kimple RJ, Van Tine BA, Michel LS

Cell death & disease.. 2018 January 59 (1):5. Epub 01/05/2018.

Overcoming Resistance to Cetuximab with Honokiol, A Small-Molecule Polyphenol.

Pearson HE, Iida M, Orbuch RA, McDaniel NK, Nickel KP, Kimple RJ, Arbiser JL, Wheeler DL

Molecular cancer therapeutics.. 2018 January 17 (1):204-214. Epub 10/20/2017.

HPV impacts survival of stage IVC non-oropharyngeal HNSCC cancer patients.

Burr AR, Harari PM, Ko HC, Chen S, Yu M, Baschnagel AM, Kimple RJ, Witek ME

Otorhinolaryngology-head and neck surgery.. 2018 3 (1)Epub 02/24/2018.

RTAnswers Online Patient Education Materials Deviate From Recommended Reading Levels.

Rosenberg SA, Denu RA, Francis D, Hullett CR, Fisher M, Schuster JM, Bassetti MF, Kimple RJ

Applied radiation oncology.. 2018 7 (2):26-30. Epub 06/19/2018.

The Second Stain: A Viral Whodunnit.

Rosenberg SA, Kimple RJ

International journal of radiation oncology, biology, physics.. 2017 December 199 (5):1061. Epub 1900 01 01.

Survival Outcomes for Patients With T3N0M0 Squamous Cell Carcinoma of the Glottic Larynx.

Ko HC, Harari PM, Chen S, Wieland AM, Yu M, Baschnagel AM, Kimple RJ, Witek ME

JAMA otolaryngology-- head & neck surgery.. 2017 November 1143 (11):1126-1133. Epub 1900 01 01.

Prognostic implications of human papillomavirus status for patients with non-oropharyngeal head and neck squamous cell carcinomas.

Ko HC, Harari PM, Sacotte RM, Chen S, Wieland AM, Yu M, Baschnagel AM, Bruce JY, Kimple RJ, Witek ME

Journal of cancer research and clinical oncology.. 2017 November 143 (11):2341-2350. Epub 07/27/2017.

Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition.

Prabakaran PJ, Javaid AM, Swick AD, Werner LR, Nickel KP, Sampene E, Hu R, Ong IM, Bruce JY, Hartig GK, Wieland AM, Canon J, Harari PM, Kimple RJ

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2017 October 1523 (20):6044-6053. Epub 06/28/2017.

Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC.

Swick AD, Prabakaran PJ, Miller MC, Javaid AM, Fisher MM, Sampene E, Ong IM, Hu R, Iida M, Nickel KP, Bruce JY, Wheeler DL, Kimple RJ

Molecular cancer therapeutics.. 2017 July 16 (7):1257-1268. Epub 04/26/2017.

Potential Mechanisms of Vascular Thrombosis after Microwave Ablation in an in Vivo Liver.

Chiang J, Nickel K, Kimple RJ, Brace CL

Journal of vascular and interventional radiology : JVIR.. 2017 July 28 (7):1053-1058. Epub 04/26/2017.

Clinical Outcomes and Prognostic Factors of Adenoid Cystic Carcinoma of the Head and Neck.

Jang S, Patel PN, Kimple RJ, McCulloch TM

Anticancer research.. 2017 June 37 (6):3045-3052. Epub 1900 01 01.

Small cell carcinoma of the head and neck: An analysis of the National Cancer Database.

Pointer KB, Ko HC, Brower JV, Witek ME, Kimple RJ, Lloyd RV, Harari PM, Baschnagel AM

Oral oncology.. 2017 June 69 :92-98. Epub 04/25/2017.

RETRACTED: The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor.

Brand TM, Iida M, Corrigan KL, Braverman CM, Coan JP, Flanigan BG, Stein AP, Salgia R, Rolff J, Kimple RJ, Wheeler DL

Science signaling.. 2017 January 310 (460)Epub 01/03/2017.

Defining the boundaries and expanding the utility of head and neck cancer patient derived xenografts.

Swick AD, Stein AP, McCulloch TM, Hartig GK, Ong IM, Sampene E, Prabakaran PJ, Liu CZ, Kimple RJ

Oral oncology.. 2017 January 64 :65-72. Epub 12/08/2016.

Online patient information from radiation oncology departments is too complex for the general population.

Rosenberg SA, Francis DM, Hullet CR, Morris ZS, Brower JV, Anderson BM, Bradley KA, Bassetti MF, Kimple RJ

Practical radiation oncology.. 2017 7 (1):57-62. Epub 08/01/2016.

Biological characterization of a novel in vitro cell irradiator.

Fowler TL, Fisher MM, Bailey AM, Bednarz BP, Kimple RJ

PloS one.. 2017 12 (12):e0189494. Epub 12/12/2017.

Outcomes for patients with head and neck squamous cell carcinoma presenting with N3 nodal disease.

Witek ME, Wieland AM, Chen S, Kennedy TA, Hullett CR, Liang E, Hartig GK, Kimple RJ, Harari PM

Cancers of the head & neck.. 2017 2 Epub 11/14/2017.

Improved survival with dose-escalated radiotherapy in stage III non-small-cell lung cancer: analysis of the National Cancer Database.

Brower JV, Amini A, Chen S, Hullett CR, Kimple RJ, Wojcieszynski AP, Bassetti M, Witek ME, Yu M, Harari PM, Baschnagel AM

Annals of oncology : official journal of the European Society for Medical Oncology. 2016 October 27 (10):1887-94. Epub 08/08/2016.

Targeting the HER Family with Pan-HER Effectively Overcomes Resistance to Cetuximab.

Iida M, Bahrar H, Brand TM, Pearson HE, Coan JP, Orbuch RA, Flanigan BG, Swick AD, Prabakaran PJ, Lantto J, Horak ID, Kragh M, Salgia R, Kimple RJ, Wheeler DL

Molecular cancer therapeutics.. 2016 September 15 (9):2175-86. Epub 07/15/2016.

Readability of Online Patient Educational Resources Found on NCI-Designated Cancer Center Web Sites.

Rosenberg SA, Francis D, Hullett CR, Morris ZS, Fisher MM, Brower JV, Bradley KA, Anderson BM, Bassetti MF, Kimple RJ

Journal of the National Comprehensive Cancer Network : JNCCN.. 2016 June 14 (6):735-40. Epub 1900 01 01.

Radiation Promptly Alters Cancer Live Cell Metabolic Fluxes: An In Vitro Demonstration.

Campos D, Peeters W, Nickel K, Burkel B, Bussink J, Kimple RJ, van der Kogel A, Eliceiri KW, Kissick MW

Radiation research.. 2016 May 185 (5):496-504. Epub 04/29/2016.

Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.

Romick-Rosendale LE, Hoskins EE, Privette Vinnedge LM, Foglesong GD, Brusadelli MG, Potter SS, Komurov K, Brugmann SA, Lambert PF, Kimple RJ, Virts EL, Hanenberg H, Gillison ML, Wells SI

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2016 April 1522 (8):2062-73. Epub 11/24/2015.

Acute Toxicity From Breast Cancer Radiation Using Helical Tomotherapy With a Simultaneous Integrated Boost.

Wojcieszynski AP, Olson AK, Rong Y, Kimple RJ, Yadav P

Technology in cancer research & treatment.. 2016 April 15 (2):257-65. Epub 03/16/2015.

Pan-HER Inhibitor Augments Radiation Response in Human Lung and Head and Neck Cancer Models.

Francis DM, Huang S, Armstrong EA, Werner LR, Hullett C, Li C, Morris ZS, Swick AD, Kragh M, Lantto J, Kimple RJ, Harari PM

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2016 February 122 (3):633-43. Epub 09/29/2015.

Potential role of the glycolytic oscillator in acute hypoxia in tumors.

Fru LC, Adamson EB, Campos DD, Fain SB, Jacques SL, van der Kogel AJ, Nickel KP, Song C, Kimple RJ, Kissick MW

Physics in medicine and biology.. 2015 December 2160 (24):9215-25. Epub 11/18/2015.

Therapeutic combination of radiolabeled CLR1404 with external beam radiation in head and neck cancer model systems.

Morris ZS, Weichert JP, Saker J, Armstrong EA, Besemer A, Bednarz B, Kimple RJ, Harari PM

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2015 September 116 (3):504-9. Epub 06/26/2015.

Modulation of therapeutic sensitivity by human papillomavirus.

Swick AD, Chatterjee A, De Costa AM, Kimple RJ

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2015 September 116 (3):342-5. Epub 09/10/2015.

AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma.

Brand TM, Iida M, Stein AP, Corrigan KL, Braverman CM, Coan JP, Pearson HE, Bahrar H, Fowler TL, Bednarz BP, Saha S, Yang D, Gill PS, Lingen MW, Saloura V, Villaflor VM, Salgia R, Kimple RJ, Wheeler DL

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2015 June 121 (11):2601-12. Epub 03/12/2015.

Human papillomavirus and head and neck cancer.

Kimple RJ, Sher DJ

International journal of radiation oncology, biology, physics.. 2015 June 192 (2):196-9. Epub 1900 01 01.

Xenograft assessment of predictive biomarkers for standard head and neck cancer therapies.

Stein AP, Swick AD, Smith MA, Blitzer GC, Yang RZ, Saha S, Harari PM, Lambert PF, Liu CZ, Kimple RJ

Cancer medicine. 2015 May 4 (5):699-712. Epub 01/26/2015.

The prognostic value of HPV in head and neck cancer patients undergoing postoperative chemoradiotherapy.

Kimple RJ, Harari PM

Annals of translational medicine.. 2015 May 3 (Suppl 1):S14. Epub 1900 01 01.

DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.

Adams AK, Hallenbeck GE, Casper KA, Patil YJ, Wilson KM, Kimple RJ, Lambert PF, Witte DP, Xiao W, Gillison ML, Wikenheiser-Brokamp KA, Wise-Draper TM, Wells SI

Oncogene.. 2015 February 1234 (7):868-77. Epub 03/10/2014.

High-throughput detection of DNA double-strand breaks using image cytometry.

Fowler TL, Bailey AM, Bednarz BP, Kimple RJ

BioTechniques.. 2015 January 58 (1):37-9. Epub 01/01/2015.

Prevalence of Human Papillomavirus in Oropharyngeal Cancer: A Systematic Review.

Stein AP, Saha S, Kraninger JL, Swick AD, Yu M, Lambert PF, Kimple RJ

The cancer journal.. 2015 21 (3):138-46. Epub 1900 01 01.

Merkel Cell Carcinoma Analysis of Outcomes: A 30-Year Experience.

Liang E, Brower JV, Rice SR, Buehler DG, Saha S, Kimple RJ

PloS one.. 2015 10 (6):e0129476. Epub 06/08/2015.

Human papillomavirus type 16 E7 oncoprotein causes a delay in repair of DNA damage.

Park JW, Nickel KP, Torres AD, Lee D, Lambert PF, Kimple RJ

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2014 December 113 (3):337-44. Epub 09/09/2014.

Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC.

Zhang K, Jones L, Lim S, Maher CA, Adkins D, Lewis J, Kimple RJ, Fertig EJ, Chung CH, Van Tine BA, Ellis MJ, Herrlich A, Michel LS

Oncotarget.. 2014 October 155 (19):9281-94. Epub 1900 01 01.

AXL mediates resistance to cetuximab therapy.

Brand TM, Iida M, Stein AP, Corrigan KL, Braverman CM, Luthar N, Toulany M, Gill PS, Salgia R, Kimple RJ, Wheeler DL

Cancer research.. 2014 September 1574 (18):5152-64. Epub 08/18/2014.

Wetting the whistle: neurotropic factor improves salivary function.

Swick A, Kimple RJ

The Journal of clinical investigation.. 2014 August 124 (8):3282-4. Epub 07/18/2014.

Is radiation dose reduction the right answer for HPV-positive head and neck cancer?

Kimple RJ, Harari PM

Oral oncology.. 2014 June 50 (6):560-4. Epub 10/14/2013.

Prevalence of human papillomavirus in oropharyngeal squamous cell carcinoma in the United States across time.

Stein AP, Saha S, Yu M, Kimple RJ, Lambert PF

Chemical research in toxicology.. 2014 April 2127 (4):462-9. Epub 04/02/2014.

A novel high-throughput irradiator for in vitro radiation sensitivity bioassays.

Fowler TL, Fulkerson RK, Micka JA, Kimple RJ, Bednarz BP

Physics in medicine and biology.. 2014 March 2159 (6):1459-70. Epub 02/28/2014.

Review of the clinical and biologic aspects of human papillomavirus-positive squamous cell carcinomas of the head and neck.

Blitzer GC, Smith MA, Harris SL, Kimple RJ

International journal of radiation oncology, biology, physics.. 2014 March 1588 (4):761-70. Epub 1900 01 01.

Influence of handling conditions on the establishment and propagation of head and neck cancer patient derived xenografts.

Stein AP, Saha S, Liu CZ, Hartig GK, Lambert PF, Kimple RJ

PloS one.. 2014 9 (6):e100995. Epub 06/26/2014.

Applicability of randomized trials in radiation oncology to standard clinical practice.

Apisarnthanarax S, Swisher-McClure S, Chiu WK, Kimple RJ, Harris SL, Morris DE, Tepper JE

Cancer.. 2013 August 15119 (16):3092-9. Epub 05/14/2013.

Enhanced radiation sensitivity in HPV-positive head and neck cancer.

Kimple RJ, Smith MA, Blitzer GC, Torres AD, Martin JA, Yang RZ, Peet CR, Lorenz LD, Nickel KP, Klingelhutz AJ, Lambert PF, Harari PM

Cancer research.. 2013 August 173 (15):4791-800. Epub 06/07/2013.

Phase 2 study of pre-excision single-dose intraoperative radiation therapy for early-stage breast cancers: six-year update with application of the ASTRO accelerated partial breast irradiation consensus statement criteria.

Vanderwalde NA, Jones EL, Kimple RJ, Moore DT, Klauber-Demore N, Sartor CI, Ollila DW

Cancer.. 2013 May 1119 (9):1736-43. Epub 01/29/2013.

A 10-year analysis of American Society For Radiation Oncology Junior Faculty Career Development Awards.

Kimple RJ, Kao GD,

International journal of radiation oncology, biology, physics.. 2013 March 1585 (4):924-8. Epub 08/25/2012.

Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts.

Kimple RJ, Harari PM, Torres AD, Yang RZ, Soriano BJ, Yu M, Armstrong EA, Blitzer GC, Smith MA, Lorenz LD, Lee D, Yang DT, McCulloch TM, Hartig GK, Lambert PF

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2013 February 1519 (4):855-64. Epub 12/18/2012.

The role of chemoradiation for patients with resectable or potentially resectable pancreatic cancer.

Kimple RJ, Russo S, Monjazeb A, Blackstock AW

Expert review of anticancer therapy.. 2012 April 12 (4):469-80. Epub 1900 01 01.

HPV-associated head and neck cancer: molecular and nano-scale markers for prognosis and therapeutic stratification.

Kimple AJ, Torres AD, Yang RZ, Kimple RJ

Sensors.. 2012 12 (4):5159-69. Epub 04/20/2012.

Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer.

Kimple RJ, Horton JK, Livasy CA, Shields JM, Lawrence JA, Chiu WM, Ivanova A, Ollila DW, Carey LA, Halle JS, Sartor CI, Dees EC

The oncologist.. 2012 17 (12):1496-503. Epub 09/24/2012.

Association of p16(INK4a) overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue.

Harris SL, Thorne LB, Seaman WT, Hayes DN, Couch ME, Kimple RJ

Head & neck.. 2011 November 33 (11):1622-7. Epub 12/28/2010.

Local control following single-dose intraoperative radiotherapy prior to surgical excision of early-stage breast cancer.

Kimple RJ, Klauber-DeMore N, Kuzmiak CM, Pavic D, Lian J, Livasy CA, Chiu WM, Moore DT, Sartor CI, Ollila DW

Annals of surgical oncology.. 2011 April 18 (4):939-45. Epub 1900 01 01.

Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032.

Sambade MJ, Peters EC, Thomas NE, Kaufmann WK, Kimple RJ, Shields JM

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2011 March 98 (3):394-9. Epub 02/04/2011.

Cosmetic outcomes for accelerated partial breast irradiation before surgical excision of early-stage breast cancer using single-dose intraoperative radiotherapy.

Kimple RJ, Klauber-DeMore N, Kuzmiak CM, Pavic D, Lian J, Livasy CA, Esler L, Moore DT, Sartor CI, Ollila DW

International journal of radiation oncology, biology, physics.. 2011 February 179 (2):400-7. Epub 04/13/2010.

First use of electromagnetic setup and real-time tracking in a pediatric patient with vaginal rhabdomyosarcoma.

Kimple RJ, Wallen KE, Person T, Erwin RN, Helmrath MA, Gold S, Morris DE

Practical radiation oncology.. 2011 1 (1):47-51. Epub 01/14/2011.

Strategizing the clone wars: pharmacological control of cellular sensitivity to radiation.

Kimple RJ

Molecular interventions.. 2010 December 10 (6):341-53. Epub 1900 01 01.

Lapatinib in combination with radiation diminishes tumor regrowth in HER2+ and basal-like/EGFR+ breast tumor xenografts.

Sambade MJ, Kimple RJ, Camp JT, Peters E, Livasy CA, Sartor CI, Shields JM

International journal of radiation oncology, biology, physics.. 2010 June 177 (2):575-81. Epub 1900 01 01.

Concurrent temozolomide and radiation, a reasonable option for elderly patients with glioblastoma multiforme?

Kimple RJ, Grabowski S, Papez M, Collichio F, Ewend MG, Morris DE

American journal of clinical oncology.. 2010 June 33 (3):265-70. Epub 1900 01 01.

Never-smokers, never-drinkers: unique clinical subgroup of young patients with head and neck squamous cell cancers.

Harris SL, Kimple RJ, Hayes DN, Couch ME, Rosenman JG

Head & neck.. 2010 April 32 (4):499-503. Epub 1900 01 01.

Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status.

Kimple RJ, Vaseva AV, Cox AD, Baerman KM, Calvo BF, Tepper JE, Shields JM, Sartor CI

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2010 February 116 (3):912-23. Epub 01/26/2010.

High-affinity immobilization of proteins using biotin- and GST-based coupling strategies.

Hutsell SQ, Kimple RJ, Siderovski DP, Willard FS, Kimple AJ

Methods in molecular biology.. 2010 627 :75-90. Epub 1900 01 01.

A simple algorithm to assess patient suitability for Calypso-seed implantation for four-dimensional prostate localization.

Kimple RJ, Wallen EM, Pruthi R, Marks LB

Journal of applied clinical medical physics. 2009 December 311 (1):3107. Epub 12/03/2009.

Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK.

Sambade MJ, Camp JT, Kimple RJ, Sartor CI, Shields JM

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.. 2009 December 93 (3):639-44. Epub 10/23/2009.

Normal tissue tolerance for high-grade gliomas: is it an issue?

Morris DE, Kimple RJ

Seminars in radiation oncology.. 2009 July 19 (3):187-92. Epub 1900 01 01.

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.

Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP

PloS one.. 2009 4 (3):e4884. Epub 03/25/2009.

Structure-based protocol for identifying mutations that enhance protein-protein binding affinities.

Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B

Journal of molecular biology.. 2007 August 31371 (5):1392-404. Epub 06/08/2007.

G alpha selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN.

McCudden CR, Willard FS, Kimple RJ, Johnston CA, Hains MD, Jones MB, Siderovski DP

Biochimica et biophysica acta.. 2005 September 101745 (2):254-64. Epub 1900 01 01.

G-protein signaling: back to the future.

McCudden CR, Hains MD, Kimple RJ, Siderovski DP, Willard FS

Cellular and molecular life sciences : CMLS.. 2005 March 62 (5):551-77. Epub 1900 01 01.

D2 dopamine receptor activation of potassium channels is selectively decoupled by Galpha-specific GoLoco motif peptides.

Webb CK, McCudden CR, Willard FS, Kimple RJ, Siderovski DP, Oxford GS

Journal of neurochemistry.. 2005 March 92 (6):1408-18. Epub 1900 01 01.

RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote.

Martin-McCaffrey L, Willard FS, Oliveira-dos-Santos AJ, Natale DR, Snow BE, Kimple RJ, Pajak A, Watson AJ, Dagnino L, Penninger JM, Siderovski DP, D'Souza SJ

Developmental cell.. 2004 November 7 (5):763-9. Epub 1900 01 01.

What do surgery residents do on their call nights?

Morton JM, Baker CC, Farrell TM, Yohe ME, Kimple RJ, Herman DC, Udekwu P, Galanko JA, Behrns KE, Meyer AA

American journal of surgery.. 2004 September 188 (3):225-9. Epub 1900 01 01.

Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif.

Kimple RJ, Willard FS, Hains MD, Jones MB, Nweke GK, Siderovski DP

The Biochemical journal.. 2004 March 15378 (Pt 3):801-8. Epub 1900 01 01.

Return of the GDI: the GoLoco motif in cell division.

Willard FS, Kimple RJ, Siderovski DP

Annual review of biochemistry.. 2004 73 :925-51. Epub 1900 01 01.

Fluorescence-based assays for RGS box function.

Willard FS, Kimple RJ, Kimple AJ, Johnston CA, Siderovski DP

Methods in enzymology.. 2004 389 :56-71. Epub 1900 01 01.

Purification and in vitro functional analyses of RGS12 and RGS14 GoLoco motif peptides.

Kimple RJ, Willard FS, Siderovski DP

Methods in enzymology.. 2004 390 :416-36. Epub 1900 01 01.

Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.

Colombo K, Grill SW, Kimple RJ, Willard FS, Siderovski DP, Gönczy P

Science.. 2003 June 20300 (5627):1957-61. Epub 05/15/2003.

Established and emerging fluorescence-based assays for G-protein function: heterotrimeric G-protein alpha subunits and regulator of G-protein signaling (RGS) proteins.

Kimple RJ, Jones MB, Shutes A, Yerxa BR, Siderovski DP, Willard FS

Combinatorial chemistry & high throughput screening.. 2003 June 6 (4):399-407. Epub 1900 01 01.

Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases.

Rojas RJ, Kimple RJ, Rossman KL, Siderovski DP, Sondek J

Combinatorial chemistry & high throughput screening.. 2003 June 6 (4):409-18. Epub 1900 01 01.

Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.

Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP

Nature.. 2002 April 25416 (6883):878-81. Epub 1900 01 01.

The GoLoco motif: heralding a new tango between G protein signaling and cell division.

Kimple RJ, Willard FS, Siderovski DP

Molecular interventions.. 2002 April 2 (2):88-100. Epub 1900 01 01.

RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.

Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP

The Journal of biological chemistry.. 2001 August 3276 (31):29275-81. Epub 05/31/2001.

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