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Douglas Stuart Portman, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-1749

Office: (585) 275-7414

Fax: (585) 276-1947

Research Labs

Faculty Appointments

Biography

Research

Genetic Control of Sex Differences in Neurobiology and Disease

Though the existence of two sexes is a fundamental characteristic of nearly all animal species, the way biological sex brings about sex differences in the brain and behavior is poorly understood. Moreover, susceptibility to a host of human neurological and mental health disorders is strongly influenced by gender, but in most cases the biological bases for these differences remain opaque. Our research uses a simple, experimentally tractable model system--the small soil nematode C. elegans--to shed light on the genetic underpinnings of sex differences in neural development, behavior, and disease susceptibility.

For more information, please visit the lab website at: http://wormweb.urmc.rochester.edu/

Credentials

Education

1988
BA with Honors, | Univ of Pennsylvania
Biochemistry

1995
PhD | Univ of Pennsylvania
Molecular Biology and Genetics

Publications

Journal Articles

1/1/2019
Pereira L, Aeschimann F, Wang C, Lawson H, Serrano-Saiz E, Portman DS, Großhans H, Hobert O. "Timing mechanism of sexually dimorphic nervous system differentiation." eLife.. 2019 Jan 1; 8Epub 2019 Jan 01.

3/19/2018
Fagan KA, Luo J, Lagoy RC, Schroeder FC, Albrecht DR, Portman DS. "A Single-Neuron Chemosensory Switch Determines the Valence of a Sexually Dimorphic Sensory Behavior." Current biology : CB.. 2018 Mar 19; 28(6):902-914.e5. Epub 2018 Mar 08.

3/2018
Barr MM, García LR, Portman DS. "Sexual Dimorphism and Sex Differences in Neuronal Development and Behavior." Genetics.. 2018 Mar 0; 208(3):909-935.

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