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Douglas Stuart Portman, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-1749

Office: (585) 275-7414

Fax: (585) 276-1947

Faculty Appointments

Biography

Research

Genetic Control of Sex Differences in Neurobiology and Disease

Though the existence of two sexes is a fundamental characteristic of nearly all animal species, the way biological sex brings about sex differences in the brain and behavior is poorly understood. Moreover, susceptibility to a host of human neurological and mental health disorders is strongly influenced by gender, but in most cases the biological bases for these differences remain opaque. Our research uses a simple, experimentally tractable model system--the small soil nematode C. elegans--to shed light on the genetic underpinnings of sex differences in neural development, behavior, and disease susceptibility.

For more information, please visit the lab website at: http://wormweb.urmc.rochester.edu/

Credentials

Education

1988
BA with Honors, | Univ of Pennsylvania
Biochemistry

1995
PhD | Univ of Pennsylvania
Molecular Biology and Genetics

Publications

Journal Articles

7/2/2019
Lawson H, Vuong E, Miller RM, Kiontke K, Fitch DH, Portman DS. "The Makorin and the lncRNA regulate to schedule sexual maturation of the nervous system." eLife.. 2019 Jul 2; 8Epub 2019 Jul 02.

7/2019
Portman DS. "Neural networks mapped in both sexes of the worm." Nature.. 2019 Jul 0; 571(7763):40-42.

5/20/2019
Kiontke KC, Herrera RA, Vuong E, Luo J, Schwarz EM, Fitch DHA, Portman DS. "The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28." Developmental cell.. 2019 May 20; 49(4):542-555.e9. Epub 2019 Apr 04.

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