Skip to main content

Coronavirus (COVID-19): Visitor Restrictions, Resources, and Updates

Explore URMC
menu

Douglas Stuart Portman, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-1749

Office: (585) 275-7414

Fax: (585) 276-1947

Faculty Appointments

Biography

Research

Genetic Control of Sex Differences in Neurobiology and Disease

Though the existence of two sexes is a fundamental characteristic of nearly all animal species, the way biological sex brings about sex differences in the brain and behavior is poorly understood. Moreover, susceptibility to a host of human neurological and mental health disorders is strongly influenced by gender, but in most cases the biological bases for these differences remain opaque. Our research uses a simple, experimentally tractable model system--the small soil nematode C. elegans--to shed light on the genetic underpinnings of sex differences in neural development, behavior, and disease susceptibility.

For more information, please visit the lab website at: http://wormweb.urmc.rochester.edu/

Credentials

Education

1988
BA with Honors, | Univ of Pennsylvania
Biochemistry

1995
PhD | Univ of Pennsylvania
Molecular Biology and Genetics

Publications

Journal Articles

7/19/2020
Lawson HN, Wexler LR, Wnuk HK, Portman DS. "Dynamic, Non-binary Specification of Sexual State in the C. elegans Nervous System." Current biology : CB.. 2020 Jul 19; Epub 2020 Jul 19.

5/28/2020
Wexler LR, Miller RM, Portman DS. "C. elegans Males Integrate Food Signals and Biological Sex to Modulate State-Dependent Chemosensation and Behavioral Prioritization." Current biology : CB.. 2020 May 28; Epub 2020 May 28.

7/2/2019
Lawson H, Vuong E, Miller RM, Kiontke K, Fitch DH, Portman DS. "The Makorin and the lncRNA regulate to schedule sexual maturation of the nervous system." eLife.. 2019 Jul 2; 8Epub 2019 Jul 02.

VIEW ALL PUBLICATIONS