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David G. Hicks, M.D.

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Appointment: (585) 276-3000

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

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Dr. Hicks Professor and Director of IHC-ISH Laboratory and Breast Subspecialty Service at URMC. His innovative approaches to improving efficiency and quality in surgical pathology have been highlighted in publications and invited lectures sponsored by national pathology organizations. He has implemented a subspecialty-based surgical pathology system, combining disease-specific diagnostic and prognostic expertise with translational research based on organ systems and disease categories.

As a member of the Ad Hoc Committee on Immunohistochemistry Standardization, and co-author of their consensus recommendations, he is a leader in the emerging effort to achieve the full potential of immunostaining as a tissue-based quantitative ELISA test. He has been appointed to an ASCO/CAP panel that is developing national guidelines on estrogen receptor testing in breast cancer, having served recently on a similar panel that made important recommendations to improve HER2 testing in breast cancer.


Dr. Hicks' first research interest was in bone pathology. He received NIH funding to study the effects of lead on the epiphyseal plate, and collaborated on related studies with faculty in the Department of Orthopaedics at the University of Rochester. He published extensively on metabolic and neoplastic bone disorders. While Director of Surgical Pathology and Co-director of the Morphologic Molecular Pathology translation research resource at the Cleveland Clinic, he expanded his interests in breast pathology, with particular focus on prognostic molecular markers and development of advanced tissue-based diagnostic techniques.

His current clinical translational research interests focus on molecular risk factors for breast cancer and preanalytical variables that affect the accuracy of new diagnostic technology in surgical pathology.



MD | University of Rochester

Post-doctoral Training & Residency

07/02/1985 - 06/30/1989
Residency in Pathology - Anatomic at Hospital of the University of Pennsylvania

07/01/1984 - 07/01/1985
Internship in Internal Medicine at UPMC Credentials Verification Office


Dr. Edith E. Sproul Teaching Award
Sponsor: Pathology, Roswell Park Cancer Institute

John Beach Hazard Distinguished Teaching Award
Sponsor: Pathology, Cleveland Clinic Foundation

Duthie-Evarts Education Award
Sponsor: Dept of Orthopaedics, URMC

1996 - 1999
Andrew W. Mellon Dean's Teaching Scholar
Sponsor: University of Rochester

Kappa Delta Elizabeth Winston Lanier Award for Outstanding Orthopaedic Research
Sponsor: American Academy of Orthopaedic Surgeons

Certificate of Commendation for Excellence in Medical Student Teaching
Sponsor: University of Rochester

Arthur Purdy Stout Award
Sponsor: US and Canadian Academy of Pathology

Stowell-Orbison Award
Sponsor: US and Canadian Academy of Pathology

Award in Honor of George H. Whipple, M.D.
Sponsor: Rochester Academy of Medicine

Member, Alpha Omega Alpha

Robert Katz Award for Clinical Research Excellence
Sponsor: University of Rochester

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Journal Articles

Tozbikian G, Krishnamurthy S, Bui MM, Feldman M, Hicks DG, Jaffer S, Khoury T, Wei S, Wen H, Pohlmann P. "Emerging Landscape of Targeted Therapy of Breast Cancers With Low HER2 Protein Expression." Archives of pathology & laboratory medicine.. 2023 Apr 5; Epub 2023 Apr 05.

Karakas C, Tyburski H, Turner BM, Wang X, Schiffhauer LM, Katerji H, Hicks DG, Zhang H. "Interobserver and Interantibody Reproducibility of HER2 Immunohistochemical Scoring in an Enriched HER2-Low-Expressing Breast Cancer Cohort." American journal of clinical pathology.. 2023 Feb 28; Epub 2023 Feb 28.

Turner BM, Finkelman BS, Hicks DG, Numbereye N, Moisini I, Dhakal A, Skinner K, Sanders MAG, Wang X, Shayne M, Schiffhauer L, Katerji H, Zhang H. "The Rochester Modified Magee Algorithm (RoMMa): An Outcomes Based Strategy for Clinical Risk-Assessment and Risk-Stratification in ER Positive, HER2 Negative Breast Cancer Patients Being Considered for Oncotype DX Testing." Cancers.. 2023 Jan 31; 15(3)Epub 2023 Jan 31.

Books & Chapters

Chapter Title: The pros and cons of automation for immunohistochemistry from the prospective of the pathology laboratory
Book Title: IHC & Antigen Retrieval Technique Based Res & Dx
Author List: Hicks DG, McMahon L
Edited By: Shi S, ed.
Published By: Artech House Publishers, Inc. 2010 in Boston, MA

Chapter Title: The histopathology of skeletal metastases
Book Title: Bone cancer: progression and therapeutic approaches
Author List: Tang P, Hicks DG
Edited By: Heymann D (ed.)
Published By: Academic Press 2010 in San Diego, CA

Chapter Title: Molecular Pathology of Breast Cancer
Book Title: Cell and Tissue Based Molecular Pathology
Author List: Hicks DG
Edited By: Series Editors: Tubbs R, and Stoler M
Published By: Saunders 2008