Kristin M. Scheible, M.D.

Kristin M. Scheible, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester, NY 14642

Office: (585) 275-2972
Fax: (585) 461-3614

Research Bio

Advanced NICU care has improved survival of very premature infants, but their improved survival is accompanied by long-term complications such as impaired lung function. Infants born prematurely are highly susceptible to recurrent, severe respiratory viruses, suggesting a state of immune deficiency, specifically T cell immunity. They also suffer from diseases characterized by chronic inflammation associated with T cell activation, including bronchopulmonary dysplasia. This clinical paradox (T cells able to activate but not protect) is not well explained.



Our lab is interested in understanding the specific ways in which premature birth disrupts normal T cell development, and the impact of abnormal T cell development on a premature infant's clinical outcomes. Our lab primarily uses high parameter flow cytometric and high-throughput sequencing approaches to interrogate T cell receptor, cytokine signaling and functional differences that are intrinsic to T cells in various stages of fetal development. We work closely with investigators in Neonatology, Obstetrics, Infectious Diseases, Microbiology, Immunology, Genetics, Biostatistics and Computational Biology to understand in vitro T cell behavior in the context of longitudinal, translational human studies, including the Prematurity and Respiratory Outcomes Program and Respiratory Pathogens Research Center.

Dr. Scheible is a member of the Society for Pediatric Research and fellow, of the American Academy of Pediatrics.

Awards & Honors (National)

Ruth L. Kirschtein National Research Service Award 2008 - 2011
NIH Loan Repayment Program (NIAID) | NIH 2008 - 2011

Awards & Honors (Local)

NICHD Fellows Conference (nominated/selected attendee) 2009
Clausen Fellowship | Golisano Children's Hospital, Department of Pediatrics 2008
Janet M. Glascow Memorial Achievement Award | University of Rochester School of Medicine and Dentistry | Rochester, NY 2004
Outstanding Graduate in the Faculty of Arts and Letters | SUNY Buffalo | Buffalo, NY 1993
Lucia Maria Haupt Award in Anthropology | SUNY Buffalo | Buffalo, NY 1993

Recent Journal Articles

Showing the 5 most recent journal articles. 7 available »

2016 May
Szafranski P, Gambin T, Dharmadhikari AV, Akdemir KC, Jhangiani SN, Schuette J, Godiwala N, Yatsenko SA, Sebastian J, Madan-Khetarpal S, Surti U, Abellar RG, Bateman DA, Wilson AL, Markham MH, Slamon J, Santos-Simarro F, Palomares M, Nevado J, Lapunzina P, Chung BH, Wong WL, Chu YW, Mok GT, Kerem E, Reiter J, Ambalavanan N, Anderson SA, Kelly DR, Shieh J, Rosenthal TC, Scheible K, Steiner L, Iqbal MA, McKinnon ML, Hamilton SJ, Schlade-Bartusiak K, English D, Hendson G, Roeder ER, DeNapoli TS, Littlejohn RO, Wolff DJ, Wagner CL, Yeung A, Francis D, Fiorino EK, Edelman M, Fox J, Hayes DA, Janssens S, De Baere E, Menten B, Loccufier A, Vanwalleghem L, Moerman P, Sznajer Y, Lay AS, Kussmann JL, Chawla J, Payton DJ, Phillips GE, Brosens E, Tibboel D, de Klein A, Maystadt I, Fisher R, Sebire N, Male A, Chopra M, Pinner J, Malcolm G, Peters G, Arbuckle S, Lees M, Mead Z, Quarrell O, Sayers R, Owens M, Shaw-Smith C, Lioy J, McKay E, de Leeuw N, Feenstra I, Spruijt L, Elmslie F, Thiruchelvam T, Bacino CA, Langston C, Lupski JR, Sen P, Popek E, Stankiewicz P. "Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins." Human genetics. 2016 May; 135(5):569-86. Epub 2016 Apr 12.
2015 May
Misra R, Shah S, Fowell D, Wang H, Scheible K, Misra S, Huyck H, Wyman C, Ryan RM, Reynolds AM, Mariani T, Katzman PJ, Pryhuber GS. "Preterm cord blood CD4? T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4? T cells in bronchopulmonary dysplasia." Human immunology. 2015 May; 76(5):329-38. Epub 2015 Mar 20.
2015 May
Maitre NL, Ballard RA, Ellenberg JH, Davis SD, Greenberg JM, Hamvas A, Pryhuber GS. "Respiratory consequences of prematurity: evolution of a diagnosis and development of a comprehensive approach." Journal of perinatology : official journal of the California Perinatal Association. 2015 May; 35(5):313-21. Epub 2015 Mar 26.
2015
Pryhuber GS, Maitre NL, Ballard RA, Cifelli D, Davis SD, Ellenberg JH, Greenberg JM, Kemp J, Mariani TJ, Panitch H, Ren C, Shaw P, Taussig LM, Hamvas A, . "Prematurity and respiratory outcomes program (PROP): study protocol of a prospective multicenter study of respiratory outcomes of preterm infants in the United States." BMC pediatrics. 2015 15:37. Epub 2015 Apr 10.
2015
Scheible KM, Emo J, Yang H, Holden-Wiltse J, Straw A, Huyck H, Misra S, Topham DJ, Ryan RM, Reynolds AM, Mariani TJ, Pryhuber GS. "Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants." Clinical immunology : the official journal of the Clinical Immunology Society. 2015 161(2):65-74. Epub 2015 Jul 29.

Current Appointments

Assistant Professor - Department of Pediatrics, Neonatology (SMD) - Primary

Specialties

Neonatal-Perinatal Medicine - American Board of Pediatrics
Pediatrics - American Board of Pediatrics

Education

MD | Medicine | University of Rochester School of Medicine & Dentistry2004
BA | Anthropology and Women's Studies | State University at Buffalo1994

Post-Doctoral Training & Residency

Fellowship in Neonatology at University of Rochester Medical Center07/01/2007 - 06/30/2010
Residency in Pediatrics at University of Rochester Medical Center07/01/2005 - 06/30/2007
Internship in Pediatrics at University of Rochester Medical Center06/15/2004 - 06/30/2005