Dr. Zhang's research centers on finding ways to "revitalize, " or reactivate the healing processes of bone. When people suffer massive bone loss due to traumatic injury or a tumor, bone grafts are used to restore the shape and strength of the bone. Even when a bone graft from the patient's own body is used, healing and strengthening are sometimes never complete.
By studying how our body's cells mature to become bone-forming cells, Dr. Zhang hopes to find ways to turn the process of healing on so that the entire bone graft will heal after surgery.
Adult mesenchymal stem cells (MSCs) have enormous potential for bone tissue repair and regeneration. Our research has been focused on understanding the molecular and cellular mechanisms that control the activation, proliferation and differentiation of mesenchymal stem cells during skeletal repair. We are particularly interested in the periosteal stem cells that play key roles in repair and regeneration. Our current program has integrated the following topics:
1) Molecular signals that control mesenchymal stem cell differentiation.
2) Mechanism of skeletal repair and regeneration
3) Stem cell therapy and bone tissue engineering for repair and reconstruction of large segmental defects.
MD | China-Shanghai Medical University
MS, | China-Shanghai Medical University
PhD, | University of Rochester School of Medicine & Dentistry
MTF J.R. Neff Award
Orthopaedic Research Society New Investigator Recognition Award
Location: Chicago, IL
Orthopaedic Research Society Travel Fellowship Award
Location: Chicago, IL
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Zhai Y, Schilling K, Wang T, El Khatib M, Vinogradov S, Brown EB, Zhang X. "Spatiotemporal blood vessel specification at the osteogenesis and angiogenesis interface of biomimetic nanofiber-enabled bone tissue engineering." Biomaterials.. 2021 Jul 26; 276:121041. Epub 2021 Jul 26.
Lam LRW, Schilling K, Romas S, Misra R, Zhou Z, Caton JG, Zhang X. "Electrospun core-shell nanofibers with encapsulated enamel matrix derivative for guided periodontal tissue regeneration." Dental materials journal.. 2021 Jun 12; Epub 2021 Jun 12.
Zhuang Z, John JV, Liao H, Luo J, Rubery P, Mesfin A, Boda SK, Xie J, Zhang X. "Periosteum Mimetic Coating on Structural Bone Allografts Electrospray Deposition Enhances Repair and Reconstruction of Segmental Defects." . 2020 Nov 9; 6(11):6241-6252. Epub 2020 Oct 22.
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