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Xinping Zhang, B.Med., Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-7928

Research Labs

The Center for Musculoskeletal Research houses nearly 70 MD and PhD researchers and graduate and post-doctoral students. This team has been the top orthopaedics lab in the United States since 2006.

Lab: (585) 273-4255

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Research Network

Biography

Research

Dr. Zhang's research centers on finding ways to "revitalize, " or reactivate the healing processes of bone. When people suffer massive bone loss due to traumatic injury or a tumor, bone grafts are used to restore the shape and strength of the bone. Even when a bone graft from the patient's own body is used, healing and strengthening are sometimes never complete. By studying how our body's cells mature to become bone-forming cells, Dr. Zhang hopes to find ways to turn the process of healing on so that the entire bone graft will heal after surgery. Adult mesenchymal stem cells (MSCs) have enormous potential for bone tissue repair and regeneration. Our research has been focused on understanding the molecular and cellular mechanisms that control the activation, proliferation and differentiation of mesenchymal stem cells during skeletal repair. We are particularly interested in the periosteal stem cells that play key roles in repair and regeneration. Our current program has integrated the following topics: 1) Molecular signals that control mesenchymal stem cell differentiation. 2) Mechanism of skeletal repair and regeneration 3) Stem cell therapy and bone tissue engineering for repair and reconstruction of large segmental defects.

Credentials

Faculty Appointments

Education

1990
MD | China-Shanghai Medical University
Medicine

1999
PhD, | University of Rochester School of Medicine & Dentistry
Biochemistry

1993
MS, | China-Shanghai Medical University
Biochemistry

Awards

2008
MTF J.R. Neff Award

2005
Orthopaedic Research Society New Investigator Recognition Award
Location: Chicago, IL

2002
Orthopaedic Research Society Travel Fellowship Award
Location: Chicago, IL

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Publications

Journal Articles

10/2009
Tsutsumi, R; Xie, C; Wei, X; Zhang, X; Flick, LM; Schwarz, EM; O'Keefe, RJ. "PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis". J Bone Miner Res. 2009; 24(10): 1753-62.

2009
Naik A; Xie, C; Kingsley, P; Zuscik, MJ; Schwarz, EM; Awad, H; Guldberg, R; Drissi, H; Puzas, E; Boyce, B; Zhang, X; O'Keefe, RJ. "Reduced COX-2 expression in aged mice is associated with impaired fracture healing". Journal of Bone & Mineral Research. 2009; 24(2): 251-64.

2009
Xie, C; Liang, B; Xue, M; Lin, ASP; Loiselle, A; Schwarz, EM; Guldberg, RE; O'Keefe, RJ; Zhang, X. "Rescue of Impaired Fracture Healing in Cox-2-/- mice via Activation of Prostaglandin E2 Receptor Subtype 4". The American Journal of Pathology. 2009; 175(2): 772-85.

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