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Xinping Zhang, B.Med., Ph.D.

Publications

Showing all 83 journal articles & 0 books available

Journal Articles

11/12/2021
Schilling K, Brown E, Zhang X. "NAD(P)H autofluorescence lifetime imaging enables single cell analyses of cellular metabolism of osteoblasts in vitro and in vivo via two-photon microscopy." Bone.. 2021 Nov 12; :116257. Epub 2021 Nov 12.

7/26/2021
Zhai Y, Schilling K, Wang T, El Khatib M, Vinogradov S, Brown EB, Zhang X. "Spatiotemporal blood vessel specification at the osteogenesis and angiogenesis interface of biomimetic nanofiber-enabled bone tissue engineering." Biomaterials.. 2021 Jul 26; 276:121041. Epub 2021 Jul 26.

6/12/2021
Lam LRW, Schilling K, Romas S, Misra R, Zhou Z, Caton JG, Zhang X. "Electrospun core-shell nanofibers with encapsulated enamel matrix derivative for guided periodontal tissue regeneration." Dental materials journal.. 2021 Jun 12; Epub 2021 Jun 12.

11/9/2020
Zhuang Z, John JV, Liao H, Luo J, Rubery P, Mesfin A, Boda SK, Xie J, Zhang X. "Periosteum Mimetic Coating on Structural Bone Allografts Electrospray Deposition Enhances Repair and Reconstruction of Segmental Defects." . 2020 Nov 9; 6(11):6241-6252. Epub 2020 Oct 22.

9/18/2019
Schilling K, El Khatib M, Plunkett S, Xue J, Xia Y, Vinogradov SA, Brown E, Zhang X. "Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair." ACS applied materials & interfaces.. 2019 Sep 18; 11(37):33548-33558. Epub 2019 Sep 04.

11/2018
Wang T, Zhai Y, Nuzzo M, Yang X, Yang Y, Zhang X. "Layer-by-layer nanofiber-enabled engineering of biomimetic periosteum for bone repair and reconstruction." Biomaterials.. 2018 Nov 0; 182:279-288. Epub 2018 Aug 14.

5/2018
Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. "Teriparatide (human PTH) compensates for impaired fracture healing in COX-2 deficient mice." Bone.. 2018 May 0; 110:150-159. Epub 2018 Feb 03.

2018
Zhang X. "Intravital Imaging to Understand Spatiotemporal Regulation of Osteogenesis and Angiogenesis in Cranial Defect Repair and Regeneration." Methods in molecular biology.. 2018 1842:229-239.

9/2017
Zhang L, Wang T, Chang M, Kaiser C, Kim JD, Wu T, Cao X, Zhang X, Schwarz EM. "Teriparatide Treatment Improves Bone Defect Healing Via Anabolic Effects on New Bone Formation and Non-Anabolic Effects on Inhibition of Mast Cells in a Murine Cranial Window Model." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 Sep 0; 32(9):1870-1883. Epub 2017 Jul 19.

5/2017
Wang T, Zhang X, Bikle DD. "Osteogenic Differentiation of Periosteal Cells During Fracture Healing." Journal of cellular physiology.. 2017 May 0; 232(5):913-921. Epub 2016 Oct 26.

3/2016
Antebi B, Zhang L, Sheyn D, Pelled G, Zhang X, Gazit Z, Schwarz EM, Gazit D. "Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts." Bioengineering.. 2016 Mar 0; 3(1)

1/11/2016
Antebi B, Zhang L, Sheyn D, Pelled G, Zhang X, Gazit Z, Schwarz EM, Gazit D. "Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts." Bioengineering.. 2016 Jan 11; 3(1)Epub 2016 Jan 11.

7/2015
Huang C, Ness VP, Yang X, Chen H, Luo J, Brown EB, Zhang X. "Spatiotemporal Analyses of Osteogenesis and Angiogenesis via Intravital Imaging in Cranial Bone Defect Repair." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2015 Jul 0; 30(7):1217-30.

5/2014
Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. "Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment." Bone.. 2014 May 0; 62:79-89. Epub 2014 Feb 12.

2/2014
Huang C, Tang M, Yehling E, Zhang X. "Overexpressing sonic hedgehog peptide restores periosteal bone formation in a murine bone allograft transplantation model." Molecular therapy : the journal of the American Society of Gene Therapy.. 2014 Feb 0; 22(2):430-439. Epub 2013 Oct 03.

2014
Huang C, Xue M, Chen H, Jiao J, Herschman HR, O'Keefe RJ, Zhang X. "The spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of periosteum-derived mesenchymal progenitors in fracture repair." PloS one.. 2014 9(7):e100079. Epub 2014 Jul 02.

11/2013
Hoffman MD, Xie C, Zhang X, Benoit DS. "The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing." Biomaterials.. 2013 Nov 0; 34(35):8887-98. Epub 2013 Aug 16.

9/2013
Lyu S, Huang C, Yang H, Zhang X. "Electrospun fibers as a scaffolding platform for bone tissue repair." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2013 Sep 0; 31(9):1382-9. Epub 2013 Apr 11.

8/2011
Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM. "Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur." Molecular therapy : the journal of the American Society of Gene Therapy.. 2011 Aug 0; 19(8):1416-25. Epub 2011 Jan 04.

3/1/2011
Wang Q, Huang C, Xue M, Zhang X. "Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healing." Bone.. 2011 Mar 1; 48(3):524-32. Epub 2010 Nov 05.

12/2010
Wang Q, Huang C, Zeng F, Xue M, Zhang X. "Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair." The American journal of pathology.. 2010 Dec 0; 177(6):3100-11. Epub 2010 Oct 22.

6/11/2010
Liu Y, Zhang X, Xia Y, Yang H. "Magnetic-field-assisted electrospinning of aligned straight and wavy polymeric nanofibers." Advanced materials.. 2010 Jun 11; 22(22):2454-7.

10/2009
Tsutsumi, R; Xie, C; Wei, X; Zhang, X; Flick, LM; Schwarz, EM; O'Keefe, RJ. "PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis". J Bone Miner Res. 2009; 24(10): 1753-62.

10/2009
Tsutsumi R, Xie C, Wei X, Zhang X, Flick LM, Schwarz EM, O'Keefe RJ. "PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 Oct 0; 24(10):1753-62.

8/2009
Wei X, Zhang X, Flick LM, Drissi H, Schwarz EM, O'Keefe RJ. "Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway." American journal of physiology. Cell physiology.. 2009 Aug 0; 297(2):C310-20. Epub 2009 Jun 03.

8/2009
Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. "Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4." The American journal of pathology.. 2009 Aug 0; 175(2):772-85. Epub 2009 Jul 23.

6/2009
Clark CA, Li TF, Kim KO, Drissi H, Zuscik MJ, Zhang X, O'Keefe RJ. "Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 Jun 0; 27(6):785-92.

2/2009
Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ. "Reduced COX-2 expression in aged mice is associated with impaired fracture healing." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 Feb 0; 24(2):251-64.

2009
Naik A; Xie, C; Kingsley, P; Zuscik, MJ; Schwarz, EM; Awad, H; Guldberg, R; Drissi, H; Puzas, E; Boyce, B; Zhang, X; O'Keefe, RJ. "Reduced COX-2 expression in aged mice is associated with impaired fracture healing". Journal of Bone & Mineral Research. 2009; 24(2): 251-64.

2009
Xie, C; Liang, B; Xue, M; Lin, ASP; Loiselle, A; Schwarz, EM; Guldberg, RE; O'Keefe, RJ; Zhang, X. "Rescue of Impaired Fracture Healing in Cox-2-/- mice via Activation of Prostaglandin E2 Receptor Subtype 4". The American Journal of Pathology. 2009; 175(2): 772-85.

2009
Clark, CA; Li, TF; Kim, KO; Drissi, H; Zuscik, MJ; Zhang, X; O'Keefe, RJ. "Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation". J. Orthop. Res. 2009; 27(6): 785-92.

2009
Xie, C., Liang, B., Xue, M., Lin, ASP., Loiselle, A. Schwarz, EM, Guildberg, RE., O'Keefe, RJ, Zhang, X. "Rescue of impaired fracture healing in COX-2 mice via activation of prostaglandin E2 receptor subtype 4." The American Journal of Pathology. 2009; 175(2): 772-85.

12/2008
Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. "COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing." Bone.. 2008 Dec 0; 43(6):1075-83. Epub 2008 Aug 16.

10/2008
Yazici C, Yanoso L, Xie C, Reynolds DG, Samulski RJ, Samulski J, Yannariello-Brown J, Gertzman AA, Zhang X, Awad HA, Schwarz EM. "The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings." Biomaterials.. 2008 Oct 0; 29(28):3882-7. Epub 2008 Jun 30.

8/2008
Zhang X, Awad HA, O'Keefe RJ, Guldberg RE, Schwarz EM. "A perspective: engineering periosteum for structural bone graft healing." Clinical orthopaedics and related research.. 2008 Aug 0; 466(8):1777-87. Epub 2008 May 29.

2/2008
Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ. "Regulation of chondrogenesis and chondrocyte differentiation by stress." The Journal of clinical investigation.. 2008 Feb 0; 118(2):429-38.

2/2008
Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X. "Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation." The Journal of bone and joint surgery. American volume.. 2008 Feb 0; 90 Suppl 1:9-13.

2008
Zhang, X., Awad, A.H., O'Keefe, R.J., Guldberg, R.J., Schwarz, E.M. "Periosteum is essential for the initiation of structural bone graft healing: implication for tissue engineering." Clinical Orthopaedics and Related Research. 2008; .

2008
Zhang, X; Awad, HA; O'Keefe, RJ; Guldberg, RE, Schwarz, EM;. "Perspective: Engineering Periosteum for Structural Bone Graft Healing". Clinical Orthopaedics & Related Research. 2008; 466(8): 1777-87.

2008
Xie, C; Xue, M; Lin, A; Schwarz, E; Guldberg, R; O'Keefe, R, Zhang, X. "COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing". Bone. 2008; 43(6): 1075-83.

2008
Yazici, C; Yanoso, L; Xie, C; Reynolds, DG; Samulski, RJ; Samulski, J; Yannariello-Brown, J; Gertzmann, AA; Zhang, X; Awad, HA; Schwarz, EM. "The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings". Biomaterials. 2008; 29(28): 3882-7.

9/20/2007
Zhang X, Sun B. "Organic crystal fibers aligned into oriented bundles with polarized emission." The journal of physical chemistry. B. 2007 Sep 20; 111(37):10881-5. Epub 2007 Aug 28.

8/2007
Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM. "Recent advances in gene delivery for structural bone allografts." Tissue engineering.. 2007 Aug 0; 13(8):1973-85.

7/20/2007
Bärnighausen T, Liu Y, Zhang X, Sauerborn R. "Willingness to pay for social health insurance among informal sector workers in Wuhan, China: a contingent valuation study." BMC health services research.. 2007 Jul 20; 7:114. Epub 2007 Jul 20.

4/6/2007
Wang Q, Wei X, Zhu T, Zhang M, Shen R, Xing L, O'Keefe RJ, Chen D. "Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2." The Journal of biological chemistry.. 2007 Apr 6; 282(14):10742-8. Epub 2007 Jan 10.

3/2007
Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X. "Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering." Tissue engineering.. 2007 Mar 0; 13(3):435-45.

1/2007
Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O'Keefe RJ, Chen D. "Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase." Genesis : the journal of genetics and development.. 2007 Jan 0; 45(1):44-50.

2007
Reynolds, D.G., Hock, C., Shaikh, S., Jacobson, J., Zhang, X., Rubery, P.T., Beck, C., O'Keefe, R.J., Lerner, A., Schwarz, E.M., Awad H. "Radiographic Prediction of Biomechanical Strength in Structural Bone Grafts." J. Biomech. 40(14):3178-86. 2007; : 3178-86.

2007
Xie, C., Xue, M., Naik, A., Lin, A., Schwarz, E., Guldberg, R., O'Keefe R, J., and Zhang, X. "Cox-2 deficient bone healing environment impairs initiation of periosteum dependent endochondral bone repair. (under review in JBMR)". JBMR (under review). 2007; .

2007
Ghen, M; Lichtler, AC; Sheu, TJ; Xie, C; Zhang X; O'Keefe, RJ; Chen D. "Targeted Gene Delivery for Femoral Allografts: A Novel Acellular Tissue Engineering Approach". Genesis. 2007; 45(1): 44-50.

2007
Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA. "Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts." Journal of biomechanics.. 2007 40(14):3178-86. Epub 2007 May 23.

4/2006
Zhang X, Sun B, Friend RH, Guo H, Nau D, Giessen H. "Metallic photonic crystals based on solution-processible gold nanoparticles." Nano letters.. 2006 Apr 0; 6(4):651-5.

4/2006
O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X. "COX-2 has a critical role during incorporation of structural bone allografts." Annals of the New York Academy of Sciences.. 2006 Apr 0; 1068:532-42.

3/2006
Murugan R, Ramakrishna S. "Nano-featured scaffolds for tissue engineering: a review of spinning methodologies." Tissue engineering.. 2006 Mar 0; 12(3):435-47.

2006
Robertson, G., Xie, C., Chen, D., Awad, H., Schwarz, E.M., O'Keefe, R.J., Guldberg R.E., Zhang, X. "Alteration of femoral bone morphology and density in cox-2-/- mice." Bone Oct. 2006; : 767-72.

12/2005
Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE. "Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 Dec 0; 20(12):2124-37. Epub 2005 Aug 08.

8/2005
Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM. "Biological effects of rAAV-caAlk2 coating on structural allograft healing." Molecular therapy : the journal of the American Society of Gene Therapy.. 2005 Aug 0; 12(2):212-8.

7/2005
Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ. "Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 Jul 0; 20(7):1136-48. Epub 2005 Feb 14.

6/2005
Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. "Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency." Environmental health perspectives.. 2005 Jun 0; 113(6):749-55.

3/18/2005
Clark CA, Schwarz EM, Zhang X, Ziran NM, Drissi H, O'Keefe RJ, Zuscik MJ. "Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation." Biochemical and biophysical research communications.. 2005 Mar 18; 328(3):764-76.

3/2005
Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM. "Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy." Nature medicine.. 2005 Mar 0; 11(3):291-7. Epub 2005 Feb 13.

2005
Zhang X, Naik A, Xie C, Reynolds D, Palmer J, Lin A, Awad H, Guldberg R, Schwarz E, O'Keefe R. "Periosteal stem cells are essential for bone revitalization and repair." Journal of musculoskeletal & neuronal interactions.. 2005 5(4):360-2.

2005
Gu X, Feng Y, Shi C, Li M, Fu Z, Zhang X. "Antiapoptotic mechanism of insulin in reoxygenation-induced injury in cultured cardiomyocytes of neonatal rats." Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2005 25(6):632-5.

12/2004
Guldberg RE, Oest M, Lin AS, Ito H, Chao X, Gromov K, Goater JJ, Koefoed M, Schwarz EM, O'Keefe RJ, Zhang X. "Functional integration of tissue-engineered bone constructs." Journal of musculoskeletal & neuronal interactions.. 2004 Dec 0; 4(4):399-400.

11/2004
Tiyapatanaputi P, Rubery PT, Carmouche J, Schwarz EM, O'keefe RJ, Zhang X. "A novel murine segmental femoral graft model." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Nov 0; 22(6):1254-60.

10/15/2004
Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ. "PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling." Experimental cell research.. 2004 Oct 15; 300(1):159-69.

5/2004
Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. "Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation." Bone.. 2004 May 0; 34(5):809-17.

1/2004
Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ. "PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jan 0; 22(1):6-12.

2004
Bukata, S., Gelinas, J., Wei, X., Rosier, R. N., Puzas, J. E., Zhang, X., Schwarz, E. M., Song, X. R., Griswold, D. E., O'Keefe, R. J. "PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a COX-2 dependent pathway. ." J. of Orthopaedic Research. 2004; : 6-12.

2004
Tiyapatanaputi, P., Rubery, P. T, Carmouche, J, Schwarz, E. M., O'Keefe, R. J. and Zhang, X. "A Novel Murine Segmental Femoral Graft Model. J. of Othopaedic Research." J. of Othopaedic Research. 2004; : 1254-60.

9/2003
Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. "Smad6 is induced by BMP-2 and modulates chondrocyte differentiation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Sep 0; 21(5):908-13.

7/2003
Flick LM, Weaver JM, Ulrich-Vinther M, Abuzzahab F, Zhang X, Dougall WC, Anderson D, O'Keefe RJ, Schwarz EM. "Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Jul 0; 21(4):676-84.

2003
Flick, L. M., Weaver, J. M., Ulrich-Vinther, M., Abuzzahab, F., Zhang, X., Dougal, W.C., Anderson, D., O'Keefe, R. J., Schwarz, E. M. "Effects of receptor activator of NFkB (RANK) signaling blockade on fracture healing." J. of Orthopaedic Research. 2003; : 676-84.

6/2002
Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. "Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair." The Journal of clinical investigation.. 2002 Jun 0; 109(11):1405-15.

1/2002
Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. "COX-1 and COX-2 expression in osteoid osteomas." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jan 0; 20(1):159-62.

2002
Zhang, X., Schwarz, E. M., Young, D. A., R., Puzas, J. E., Rosier, R. N., O'Keefe, R.J. "COX-2 Regulates Mesenchymal Cell Differentiation into Osteoblast Lineage and is Critically Involved in Bone Repair. Journal of Clinical Investigation". 2002; : 1405-15.

2001
Zhang, X., Morham, S. G., Langenback, R., Young, D. A., Xing, L., Boyce, B. F., Puzas, J. E., Rosier, R. N., O'Keefe, R. J., and Schwarz, E. M. "Evidence for a 4 Direct Role of COX-2 in Implant Wear Debris Induced Osteolysis". J. Bone. Min. Res. 2001; 16 (4): 660-669.

2001
Zhang, X., Zhang, Y, Schwarz, E., O'Keefe, R. J. "The role of COX-2 in bone repair." Current opinion in Orthopaedics. 2001; : 397-402,.

2/1/2000
Zhang X, Morham SG, Langenbach R, Baggs RB, Young DA. "Lack of cyclooxygenase-2 inhibits growth of teratocarcinomas in mice." Experimental cell research.. 2000 Feb 1; 254(2):232-40.

8/16/1999
Zhang X, Morham SG, Langenbach R, Young DA. "Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts." The Journal of experimental medicine.. 1999 Aug 16; 190(4):451-59.

Mungo, D. V., Zhang, X., O'Keefe, R.J., Rosier, R.N., Puzas, J.E., Schwarz, E.M. "2001. COX-1 and COX-2 expression in osteoid osteomas. J. Ortho. Res.,". 20(1): 159-62.

Puzas, J.E., O'Keefe, R.J., Schwarz, E.M., and Zhang, X. "2003. Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition." J Musculoskelet Neuronal Interact. : 308-312; Discussion 320-301.

Clark, CA, Li, RF., Kim, KO., Drissi, H., Zuscik, MJ., Zhang, X., O'Keefe, RJ. "Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation." Journal of Orthopaedic Research. 6: 785-92.