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Glynis A. Scott, M.D.

Dermatology, Pathology

Clinical Interests

Anatomic Pathology; Dermatopathology

Contact Information

Phone Numbers

Administrative: (585) 275-3871

Office: (585) 275-8811

Fax: (585) 273-1346

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentNot Accepting New Patients



There are two major projects on going in my laboratory--the first is the investigation into signaling pathways of prostaglandins in human melanocytes and melanoma, and the second is the role of Plexin receptors in melanocyte and melanoma biology.
Melanocytes are pigment producing cells within the epidermis that are progenitor cells for a deadly cancer, melanoma. The production of melanin by melanocytes is a key function of melanocytes and provides photoprotection to the skin. Prostaglandins (PG) are lipid signaling molecules released by keratinocytes and melanocytes in response to ultraviolet irradiation. Our research focus is on defining signaling intermediates that mediate the effect of the two primary PG in the skin, PGE2 & PGF2?? on melanocyte dendrite extension, growth and pigment production. Our laboratory is also investigating the role of semaphorins and their receptors on melanocyte growth, differentiation, and progression to melanoma. Semaphorins are membrane bound and secreted proteins involved in neuronal pathfinding, that we have recently shown to be involved in melanocyte adhesion and dendrite formation. Our particular focus is on Semaphorin 7A and Semaphorin 4D, and their cognate receptors Plexin C1 and Plexin B1, which are lost during progression of melanocytes to melanoma. Integration of signaling intermediates with biologic functions such as proliferation, apoptosis and migration, allow us to dissect the function of PG and semaphorins in melanocyte, and to link signaling by specific receptors to downstream biologic targets important for skin pigmentation and melanoma progression.


Faculty Appointments


  • Anatomic Pathology - American Board of Pathology
  • Dermatopathology - American Board of Dermatology


MD | Albany Medical College

Post-doctoral Training & Residency

07/01/1983 - 06/30/1984
Internship in Internal Medicine at Albany Medical Center

07/01/1984 - 06/30/1987
Residency in Pathology-Anatomic and Clinical at Yale New Haven Hospital

07/01/1987 - 06/30/1988
Fellowship in Dermatology: Dermatopathology at Yale New Haven Hospital

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Title: Small Molecule Modulators of Melanin Expression
U.S. Serial #: 14/861,812
Filed: Sep 22, 2015
Invented By: PeterGareiss, BrianMcNaughton, BenjaminMiller, GlynisScott

Title: Small Molecule Modulators of Melanin Expression
U.S. Serial #: 12/593,673
Filed: Mar 28, 2008
Invented By: PeterGareiss, BrianMcNaughton, BenjaminMiller, GlynisScott


Journal Articles

Barrett MM, Strikwerda AM, Somers K, Beck LA, Scott GA. "Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature." Pediatric dermatology.. 2016 33(2):e52-6. Epub 2016 Jan 14.

Scott GA, Laughlin TS, Rothberg PG. "Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2014 Apr 0; 27(4):516-23. Epub 2013 Sep 13.

Kennedy BS, Bedard B, Younge M, Tuttle D, Ammerman E, Ricci J, Doniger AS, Escuyer VE, Mitchell K, Noble-Wang JA, O'Connell HA, Lanier WA, Katz LM, Betts RF, Mercurio MG, Scott GA, Lewis MA, Goldgeier MH. "Outbreak of Mycobacterium chelonae infection associated with tattoo ink." The New England journal of medicine.. 2012 Sep 13; 367(11):1020-4. Epub 2012 Aug 22.