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Glynis A. Scott, M.D.

Contact Information

Phone Numbers

Administrative: (585) 275-3871

Office: (585) 275-8811

Fax: (585) 273-1346

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentNot Accepting New Patients

Faculty Appointments

Patient Care Settings

Dermatology, Pathology

Biography

Research

There are two major projects on going in my laboratory--the first is the investigation into signaling pathways of prostaglandins in human melanocytes and melanoma, and the second is the role of Plexin receptors in melanocyte and melanoma biology.
Melanocytes are pigment producing cells within the epidermis that are progenitor cells for a deadly cancer, melanoma. The production of melanin by melanocytes is a key function of melanocytes and provides photoprotection to the skin. Prostaglandins (PG) are lipid signaling molecules released by keratinocytes and melanocytes in response to ultraviolet irradiation. Our research focus is on defining signaling intermediates that mediate the effect of the two primary PG in the skin, PGE2 & PGF2?? on melanocyte dendrite extension, growth and pigment production. Our laboratory is also investigating the role of semaphorins and their receptors on melanocyte growth, differentiation, and progression to melanoma. Semaphorins are membrane bound and secreted proteins involved in neuronal pathfinding, that we have recently shown to be involved in melanocyte adhesion and dendrite formation. Our particular focus is on Semaphorin 7A and Semaphorin 4D, and their cognate receptors Plexin C1 and Plexin B1, which are lost during progression of melanocytes to melanoma. Integration of signaling intermediates with biologic functions such as proliferation, apoptosis and migration, allow us to dissect the function of PG and semaphorins in melanocyte, and to link signaling by specific receptors to downstream biologic targets important for skin pigmentation and melanoma progression.

Credentials

Education

1983
MD | Albany Medical College of Union University

Post-doctoral Training & Residency

07/01/1987 - 06/30/1988
Fellowship in Dermatopathology at Yale New Haven Hospital

07/01/1984 - 06/30/1987
Residency in Anatomic Pathology at Yale New Haven Hospital

07/01/1983 - 06/30/1984
Internship in Internal Medicine at Albany Medical Center

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Patents

Patent Title: Small Molecule Modulators of Melanin Expression
Patent #: 9,162,984
Issue Date: Oct 20, 2015
Country: United States
Invented By: Peter Gareiss, Brian R McNaughton, Benjamin L Miller, Glynis A Scott

Publications

Journal Articles

11/2019
Mitchell DC, Agnihothri R, Scott GA, Korman B, Richardson CT. "A case of concurrent systemic sclerosis and scleredema." JAAD case reports.. 2019 Nov; 5(11):940-942. Epub 2019 Oct 24.

11/2019
Lerman I, Agnihothri R, Scott GA, Richardson CT. "An atypical clinical presentation of alopecia in 2 patients with systemic lupus erythematosus." JAAD case reports.. 2019 Nov; 5(11):953-956. Epub 2019 Oct 24.

8/2017
Bax MJ, Brown MD, Rothberg PG, Laughlin TS, Scott GA. "Pigmented epithelioid melanocytoma (animal-type melanoma): An institutional experience." Journal of the American Academy of Dermatology.. 2017 Aug; 77(2):328-332. Epub 2017 Apr 14.

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