Glynis A. Scott, M.D.

Glynis A. Scott, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 697
Rochester, NY 14642

Office: (585) 275-8811
Fax: (585) 273-1346
Administrative: (585) 275-3871

Research Bio

There are two major projects on going in my laboratory--the first is the investigation into signaling pathways of prostaglandins in human melanocytes and melanoma, and the second is the role of Plexin receptors in melanocyte and melanoma biology.
Melanocytes are pigment producing cells within the epidermis that are progenitor cells for a deadly cancer, melanoma. The production of melanin by melanocytes is a key function of melanocytes and provides photoprotection to the skin. Prostaglandins (PG) are lipid signaling molecules released by keratinocytes and melanocytes in response to ultraviolet irradiation. Our research focus is on defining signaling intermediates that mediate the effect of the two primary PG in the skin, PGE2 & PGF2??

on melanocyte dendrite extension, growth and pigment production. Our laboratory is also investigating the role of sempahorins and their receptors on melanocyte growth, differentiation, and progression to melanoma. Semaphorins are membrane bound and secreted proteins involved in neuronal pathfinding, that we have recently shown to be involved in melanocyte adhesion and dendrite formation. Our particular focus is on Semaphorin 7A and Semaphorin 4D, and their cognate receptors Plexin C1 and Plexin B1, which are lost during progression of melanocytes to melanoma. Integration of signaling intermediates with biologic functions such as proliferation, apoptosis and migration, allow us to dissect the function of PG and semaphorins in melanocyte, and to link signaling by specific receptors to downstream biologic targets important for skin pigmentation and melanoma progression.

Patents

Small-Molecule Modulators of Melanin Expression

United States Serial NO.: 12/593,673
Filed Date: March 28, 2008
Title: Small Molecule Modulators of Melanin Expression
Invented by: Benjamin Miller, Brian McNaughton, Peter Gareiss, Glynis Scott
Small-Molecule Modulators of Melanin Expression

United States Serial NO.: 14/861,712
Filed Date: September 22, 2015
Title: Small Molecule Modulators of Melanin Expression
Invented by: Benjamin Miller, Brian McNaughton, Peter Gareiss, Glynis Scott

Recent Journal Articles

Showing the 5 most recent journal articles. 35 available »

2016
Barrett MM, Strikwerda AM, Somers K, Beck LA, Scott GA. "Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature." Pediatric dermatology. 2016 33(2):e52-6. Epub 2016 Jan 14.
2014 Apr
Scott GA, Laughlin TS, Rothberg PG. "Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2014 Apr; 27(4):516-23. Epub 2013 Sep 13.
2012 Sep 13
Kennedy BS, Bedard B, Younge M, Tuttle D, Ammerman E, Ricci J, Doniger AS, Escuyer VE, Mitchell K, Noble-Wang JA, O'Connell HA, Lanier WA, Katz LM, Betts RF, Mercurio MG, Scott GA, Lewis MA, Goldgeier MH. "Outbreak of Mycobacterium chelonae infection associated with tattoo ink." The New England journal of medicine. 2012 Sep 13; 367(11):1020-4. Epub 2012 Aug 22.
2012 Apr
Soong J, Chen Y, Shustef EM, Scott GA. "Sema4D, the ligand for Plexin B1, suppresses c-Met activation and migration and promotes melanocyte survival and growth." The Journal of investigative dermatology. 2012 Apr; 132(4):1230-8. Epub 2011 Dec 22.
2012 Feb
Lai KW, Brodell LA, Lambert E, Menegus M, Scott GA, Tu JH. "Primary cutaneous Nocardia brasiliensis infection isolated in an immunosuppressed patient: a case report." Cutis. 2012 Feb; 89(2):75-7.

Current Appointments

Professor - Department of Dermatology (SMD) - Primary

Specialties

Dermatopathology - American Board of Dermatology
Anatomic Pathology - American Board of Pathology

Education

MD | Medicine | Albany Medical College1983

Post-Doctoral Training & Residency

Fellowship in Dermatopathology at Yale New Haven Hospital07/01/1987 - 06/30/1988
Residency in Anatomic Pathology at Yale New Haven Hospital07/01/1984 - 06/30/1987
Internship in Internal Medicine at Albany Medical Center07/01/1983 - 06/30/1984