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Jeffrey J. Hayes, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-4887

Fax: (585) 271-2683

Research Labs

Faculty Appointments

Biography

Research

Each eukaryotic cell must execute a complex program of specific gene expression. The DNA of the genome is intimately complexed with proteins into an assembly known as chromatin. Compaction and storage of genomic DNA has long been viewed as the main function of this assembly; however, recent work has demonstrated that in some instances, chromatin structure play an important role in bringing about this pattern of specific expression, and it is likely that the structural elements of chromatin have been integrated into many transcriptional control mechanisms.

The goal of the research in this laboratory is to provide detailed structure information on the protein-DNA interactions and DNA organization within chromatin, and to correlate this information with simple functional assays of the consequences of this organization. Model chromatin complexes will be prepared in vitro and structurally analyzed with chemical approaches. In addition, cloning expression of histone proteins with specific mutations will be useful in the determination of relevant domains within these proteins while facilitating the creation of site-specific probes of protein and DNA structure with chromatin.

Credentials

Education

1983
BS | Bowling Green University
Chemistry

1986
MS | Bowling Green University
Chemistry

1990
PhD | Johns Hopkins University
Chemistry

Publications

Journal Articles

1/11/2021
Marr LT, Ocampo J, Clark DJ, Hayes JJ. "Global histone protein surface accessibility in yeast indicates a uniformly loosely packed genome with canonical nucleosomes." Epigenetics & chromatin. 2021 Jan 11; 14(1):5. Epub 2021 Jan 11.

10/30/2020
Hao F, Murphy KJ, Kujirai T, Kamo N, Kato J, Koyama M, Okamato A, Hayashi G, Kurumizaka H, Hayes JJ. "Acetylation-modulated communication between the H3 N-terminal tail domain and the intrinsically disordered H1 C-terminal domain." Nucleic acids research.. 2020 Oct 30; Epub 2020 Oct 30.

3/15/2020
Jalil SA, Akram M, Bhat JA, Hayes JJ, Singh SC, ElKabbash M, Guo C. "Creating superhydrophobic and antibacterial surfaces on gold by femtosecond laser pulses." . 2020 Mar 15; 506:144952.

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