Jeffrey J. Hayes, Ph.D.

Jeffrey J. Hayes, Ph.D.

Contact Information

Jeffrey_Hayes@urmc.rochester.edu
Rochester, NY 14642

Office: (585) 273-4887
Fax: (585) 275-6007
Lab: (585) 275-1706

Research Bio

Each eukaryotic cell must execute a complex program of specific gene expression. The DNA of the genome is intimately complexed with proteins into an assembly known as chromatin. Compaction and storage of genomic DNA has long been viewed as the main function of this assembly; however, recent work has demonstrated that in some instances, chromatin structure play an important role in bringing about this pattern of specific expression, and it is likely that the structural elements of chromatin have been integrated into many transcriptional control mechanisms.



The goal of the research in this laboratory is to provide detailed structure information on the protein-DNA interactions and DNA organization within chromatin, and to correlate this information with simple functional assays of the consequences of this organization. Model chromatin complexes will be prepared in vitro and structurally analyzed with chemical approaches. In addition, cloning expression of histone proteins with specific mutations will be useful in the determination of relevant domains within these proteins while facilitating the creation of site-specific probes of protein and DNA structure with chromatin.

Recent Journal Articles

Showing the 5 most recent journal articles. 117 available »

2016 Nov 2
Fang H, Wei S, Lee TH, Hayes JJ. "Chromatin structure-dependent conformations of the H1 CTD." Nucleic acids research. 2016 Nov 2; 44(19):9131-9141. Epub 2016 Jun 30.
2016 Nov
Black PJ, Miller AS, Hayes JJ. "Radioresistance of GGG sequences to prompt strand break formation from direct-type radiation damage." Radiation and environmental biophysics. 2016 Nov; 55(4):411-422. Epub 2016 Jun 27.
2016 Oct 6
Mishra LN, Pepenella S, Rogge R, Hansen JC, Hayes JJ. "Acetylation Mimics Within a Single Nucleosome Alter Local DNA Accessibility In Compacted Nucleosome Arrays." Scientific reports. 2016 Oct 6; 6:34808. Epub 2016 Oct 06.
2016 Apr 12
Yue H, Fang H, Wei S, Hayes JJ, Lee TH. "Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome." Biochemistry. 2016 Apr 12; 55(14):2069-77. Epub 2016 Mar 29.
2015 Dec
Balliano AJ, Hayes JJ. "Base excision repair in chromatin: Insights from reconstituted systems." DNA repair. 2015 Dec; 36:77-85. Epub 2015 Sep 16.

Current Appointments

Chair - Department of Biochemistry and Biophysics (SMD) - Primary Administrative
Shohei Koide Professor in Biochemistry and Biophysics - Department of Biochemistry and Biophysics (SMD)
Professor - Department of Biochemistry and Biophysics (SMD) - Primary

Education

PhD | Chemistry | Johns Hopkins University1990
MS | Chemistry | Bowling Green University1986
BS | Chemistry | Bowling Green University1983