Jeffrey J. Hayes, Ph.D.

Jeffrey J. Hayes, Ph.D.

Contact Information
Rochester, NY 14642

Office: (585) 273-4887
Fax: (585) 275-6007
Lab: (585) 275-1706

Research Bio

Each eukaryotic cell must execute a complex program of specific gene expression. The DNA of the genome is intimately complexed with proteins into an assembly known as chromatin. Compaction and storage of genomic DNA has long been viewed as the main function of this assembly; however, recent work has demonstrated that in some instances, chromatin structure play an important role in bringing about this pattern of specific expression, and it is likely that the structural elements of chromatin have been integrated into many transcriptional control mechanisms.

The goal of the research in this laboratory is to provide detailed structure information on the protein-DNA interactions and DNA organization within chromatin, and to correlate this information with simple functional assays of the consequences of this organization. Model chromatin complexes will be prepared in vitro and structurally analyzed with chemical approaches. In addition, cloning expression of histone proteins with specific mutations will be useful in the determination of relevant domains within these proteins while facilitating the creation of site-specific probes of protein and DNA structure with chromatin.

Recent Journal Articles

Showing the 5 most recent journal articles. 114 available »

2016 Apr 12
Yue H, Fang H, Wei S, Hayes JJ, Lee TH. "Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome." Biochemistry. 2016 Apr 12; 55(14):2069-77. Epub 2016 Mar 29.
2015 Oct 7
Cutter A, Hayes JJ. "A brief review of nucleosome structure." FEBS letters. 2015 Oct 7; 589(20 Pt A):2914-22. Epub 2015 May 14.
Balliano AJ, Hayes JJ. "Base excision repair in chromatin: Insights from reconstituted systems." DNA repair. 2015 36:77-85. Epub 2015 Sep 16.
2014 Sep 26
Pepenella S, Murphy KJ, Hayes JJ. "A distinct switch in interactions of the histone H4 tail domain upon salt-dependent folding of nucleosome arrays." The Journal of biological chemistry. 2014 Sep 26; 289(39):27342-51. Epub 2014 Aug 13.
2014 Mar
Pepenella S, Murphy KJ, Hayes JJ. "Intra- and inter-nucleosome interactions of the core histone tail domains in higher-order chromatin structure." Chromosoma. 2014 Mar; 123(1-2):3-13. Epub 2013 Aug 31.

Current Appointments

Chair - Department of Biochemistry and Biophysics (SMD) - Primary Administrative
Shohei Koide Professor in Biochemistry and Biophysics - Department of Biochemistry and Biophysics (SMD)
Professor - Department of Biochemistry and Biophysics (SMD) - Primary


PhD | Chemistry | Johns Hopkins University1990
MS | Chemistry | Bowling Green University1986
BS | Chemistry | Bowling Green University1983