CONTACT INFORMATIONCREDENTIALSPUBLICATIONSJeffrey J. Hayes, Ph.D.Contact InformationPhone NumbersOffice: (585) 273-4887Fax: (585) 271-2683Research LabsVisit Lab WebsiteLocationsJeffrey_Hayes@urmc.rochester.eduRochester, NY 14642Faculty AppointmentsProfessor - Department of Biochemistry and Biophysics (SMD) Chair - Department of Biochemistry and Biophysics (SMD) Shohei Koide Professor in Biochemistry and Biophysics - Department of Biochemistry and Biophysics (SMD) BiographyResearchEach eukaryotic cell must execute a complex program of specific gene expression. The DNA of the genome is intimately complexed with proteins into an assembly known as chromatin. Compaction and storage of genomic DNA has long been viewed as the main function of this assembly; however, recent work has demonstrated that in some instances, chromatin structure play an important role in bringing about this pattern of specific expression, and it is likely that the structural elements of chromatin have been integrated into many transcriptional control mechanisms. The goal of the research in this laboratory is to provide detailed structure information on the protein-DNA interactions and DNA organization within chromatin, and to correlate this information with simple functional assays of the consequences of this organization. Model chromatin complexes will be prepared in vitro and structurally analyzed with chemical approaches. In addition, cloning expression of histone proteins with specific mutations will be useful in the determination of relevant domains within these proteins while facilitating the creation of site-specific probes of protein and DNA structure with chromatin.CredentialsEducation1983BS | Bowling Green UniversityChemistry1986MS | Bowling Green UniversityChemistry1990PhD | Johns Hopkins UniversityChemistryPublicationsJournal Articles5/23/2022Hao F, Mishra L, Jaya P, Jones R, Hayes JJ. "Identification and analysis of six phosphorylation sites within the Xenopus laevis H1.0 C-terminal domain indicate distinct effects on nucleosome structure." Molecular & cellular proteomics : MCP.. 2022 May 23; :100250. Epub 2022 May 23. 2/15/2022Marr LT, Jaya P, Mishra LN, Hayes JJ. "Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin." Biochemical Society transactions.. 2022 Feb 15; Epub 2022 Feb 15. 12/2021Poulet A, Mishra LN, Téletchéa S, Hayes JJ, Jacob Y, Thiriet C, Duc C. "Identification and characterization of histones in evidence a phylogenetic vicinity of Mycetozoans to the animal kingdom." . 2021 Dec 0; 3(4):lqab107. Epub 2021 Nov 17. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Jeffrey J. Hayes, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Jeffrey J. Hayes, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.