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Jeffrey J. Hayes, Ph.D.

Contact Information

Phone Numbers

Fax: (585) 275-6007

Office: (585) 273-4887

Research Labs

William A. Bernhard Memorial Lab

Lab: (585) 275-1706

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Research Network

Biography

Research

Each eukaryotic cell must execute a complex program of specific gene expression. The DNA of the genome is intimately complexed with proteins into an assembly known as chromatin. Compaction and storage of genomic DNA has long been viewed as the main function of this assembly; however, recent work has demonstrated that in some instances, chromatin structure play an important role in bringing about this pattern of specific expression, and it is likely that the structural elements of chromatin have been integrated into many transcriptional control mechanisms. The goal of the research in this laboratory is to provide detailed structure information on the protein-DNA interactions and DNA organization within chromatin, and to correlate this information with simple functional assays of the consequences of this organization. Model chromatin complexes will be prepared in vitro and structurally analyzed with chemical approaches. In addition, cloning expression of histone proteins with specific mutations will be useful in the determination of relevant domains within these proteins while facilitating the creation of site-specific probes of protein and DNA structure with chromatin.

Credentials

Faculty Appointments

Education

1990
PhD | Johns Hopkins University
Chemistry

1986
MS | Bowling Green University
Chemistry

1983
BS | Bowling Green University
Chemistry

Publications

Journal Articles

11/2/2016
Fang H, Wei S, Lee TH, Hayes JJ. "Chromatin structure-dependent conformations of the H1 CTD." Nucleic acids research.. 2016 Nov 2; 44(19):9131-9141. Epub 2016 Jun 30.

11/2016
Black PJ, Miller AS, Hayes JJ. "Radioresistance of GGG sequences to prompt strand break formation from direct-type radiation damage." Radiation and environmental biophysics.. 2016 Nov 0; 55(4):411-422. Epub 2016 Jun 27.

10/6/2016
Mishra LN, Pepenella S, Rogge R, Hansen JC, Hayes JJ. "Acetylation Mimics Within a Single Nucleosome Alter Local DNA Accessibility In Compacted Nucleosome Arrays." Scientific reports.. 2016 Oct 6; 6:34808. Epub 2016 Oct 06.

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