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Jeffrey J. Hayes, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-4887

Fax: (585) 271-2683

Research Labs

Faculty Appointments

Biography

Research

Each eukaryotic cell must execute a complex program of specific gene expression. The DNA of the genome is intimately complexed with proteins into an assembly known as chromatin. Compaction and storage of genomic DNA has long been viewed as the main function of this assembly; however, recent work has demonstrated that in some instances, chromatin structure play an important role in bringing about this pattern of specific expression, and it is likely that the structural elements of chromatin have been integrated into many transcriptional control mechanisms.

The goal of the research in this laboratory is to provide detailed structure information on the protein-DNA interactions and DNA organization within chromatin, and to correlate this information with simple functional assays of the consequences of this organization. Model chromatin complexes will be prepared in vitro and structurally analyzed with chemical approaches. In addition, cloning expression of histone proteins with specific mutations will be useful in the determination of relevant domains within these proteins while facilitating the creation of site-specific probes of protein and DNA structure with chromatin.

Credentials

Education

1983
BS | Bowling Green University
Chemistry

1986
MS | Bowling Green University
Chemistry

1990
PhD | Johns Hopkins University
Chemistry

Publications

Journal Articles

8/22/2023
Kanti Das S, Kumar A, Hao F, Cutter DiPiazza AR, Fang H, Lee TH, Hayes JJ. "Histone H3 tail modifications alter structure and dynamics of the H1 C-terminal domain within nucleosomes." Journal of molecular biology.. 2023 Aug 22; :168242. Epub 2023 Aug 22.

5/12/2023
Das SK, Kumar A, Hao F, DiPiazza ARC, Lee TH, Hayes JJ. "Histone H3 tail modifications regulate structure and dynamics of the H1 C-terminal domain within nucleosomes." bioRxiv : the preprint server for biology.. 2023 May 12; Epub 2023 May 12.

1/11/2023
Kumar A, Maurya P, Hayes JJ. "Post-Translation Modifications and Mutations of Human Linker Histone Subtypes: Their Manifestation in Disease." International journal of molecular sciences.. 2023 Jan 11; 24(2)Epub 2023 Jan 11.

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