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Jeffrey J. Hayes, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-4887

Fax: (585) 275-6007

Research Labs

Lab: (585) 275-1706

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Biography

Research

Each eukaryotic cell must execute a complex program of specific gene expression. The DNA of the genome is intimately complexed with proteins into an assembly known as chromatin. Compaction and storage of genomic DNA has long been viewed as the main function of this assembly; however, recent work has demonstrated that in some instances, chromatin structure play an important role in bringing about this pattern of specific expression, and it is likely that the structural elements of chromatin have been integrated into many transcriptional control mechanisms.

The goal of the research in this laboratory is to provide detailed structure information on the protein-DNA interactions and DNA organization within chromatin, and to correlate this information with simple functional assays of the consequences of this organization. Model chromatin complexes will be prepared in vitro and structurally analyzed with chemical approaches. In addition, cloning expression of histone proteins with specific mutations will be useful in the determination of relevant domains within these proteins while facilitating the creation of site-specific probes of protein and DNA structure with chromatin.

Credentials

Faculty Appointments

Education

1983
BS | Bowling Green University
Chemistry

1986
MS | Bowling Green University
Chemistry

1990
PhD | Johns Hopkins University
Chemistry

Publications

Journal Articles

6/1/2017
Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A, Hayes JJ, Schultz P, Angelov D, Petosa C, Dimitrov S. "Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1." Molecular cell.. 2017 Jun 1; 66(5):729.

5/4/2017
Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A, Hayes JJ, Schultz P, Angelov D, Petosa C, Dimitrov S. "Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1." Molecular cell.. 2017 May 4; 66(3):384-397.e8.

4/2017
Cutter AR, Hayes JJ. "Linker histones: novel insights into structure-specific recognition of the nucleosome." Biochemistry and cell biology = Biochimie et biologie cellulaire.. 2017 Apr 0; 95(2):171-178. Epub 2016 Jun 29.

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