Skip to main content
Explore URMC
menu

Jeffrey J. Hayes, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-4887

Fax: (585) 271-2683

Research Labs

Faculty Appointments

Biography

Research

Each eukaryotic cell must execute a complex program of specific gene expression. The DNA of the genome is intimately complexed with proteins into an assembly known as chromatin. Compaction and storage of genomic DNA has long been viewed as the main function of this assembly; however, recent work has demonstrated that in some instances, chromatin structure play an important role in bringing about this pattern of specific expression, and it is likely that the structural elements of chromatin have been integrated into many transcriptional control mechanisms.

The goal of the research in this laboratory is to provide detailed structure information on the protein-DNA interactions and DNA organization within chromatin, and to correlate this information with simple functional assays of the consequences of this organization. Model chromatin complexes will be prepared in vitro and structurally analyzed with chemical approaches. In addition, cloning expression of histone proteins with specific mutations will be useful in the determination of relevant domains within these proteins while facilitating the creation of site-specific probes of protein and DNA structure with chromatin.

Credentials

Education

1983
BS | Bowling Green University
Chemistry

1986
MS | Bowling Green University
Chemistry

1990
PhD | Johns Hopkins University
Chemistry

Publications

Journal Articles

7/8/2021
Hao F, Kale S, Dimitrov S, Hayes JJ. "Unraveling linker histone interactions in nucleosomes." Current opinion in structural biology.. 2021 Jul 8; 71:87-93. Epub 2021 Jul 08.

5/2021
Sah SK, Hayes JJ, Rustchenko E. "The role of aneuploidy in the emergence of echinocandin resistance in human fungal pathogen Candida albicans." PLoS pathogens.. 2021 May 0; 17(5):e1009564. Epub 2021 May 27.

1/11/2021
Marr LT, Ocampo J, Clark DJ, Hayes JJ. "Global histone protein surface accessibility in yeast indicates a uniformly loosely packed genome with canonical nucleosomes." Epigenetics & chromatin. 2021 Jan 11; 14(1):5. Epub 2021 Jan 11.

VIEW ALL PUBLICATIONS