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Edward M. Schwarz, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Research Labs

Biography

Dr. Edward Schwarz is the Burton Professor of Orthopaedics and Director of the Center for Musculoskeletal Research at the University of Rochester Medical Center, in Rochester, NY. His laboratory focuses on inflammatory bone loss, such as that seen in rheumatoid arthritis, infections, tumor metastasis and wear debris-induced osteolysis around loose prosthetic implants.

Dr. Schwarz is also a leader in orthopaedic biologic therapy and stem cell research, for which his lab has developed a novel passive immunization for MRSA and revitalizing allograft approaches for bone and tendon regeneration.

Dr. Schwarz's lab is also interested in developing translational in vivo imaging outcome measures include near infrared imaging of lymphatic flow to detect arthritic flare, and cone beam CT to assess bone healing in patients with orthopaedic implants. More recently, Dr. Schwarz's lab has combined these biologic therapy technologies and outcome measures with biocompatible carriers and stem cells to generate novel tissue engineering constructs for bone, cartilage, ligament and tendon.

Research

Dr. Edward Schwarz is the Burton Professor of Orthopaedics and Director of the Center for Musculoskeletal Research at the University of Rochester Medical Center, in Rochester, NY. His laboratory focuses on inflammatory bone loss, such as that seen in rheumatoid arthritis, infections, tumor metastasis and wear debris-induced osteolysis around loose prosthetic implants.
Dr. Schwarz is also a leader in orthopaedic biologic therapy and stem cell research, for which his lab has developed a novel passive immunization for MRSA and revitalizing allograft approaches for bone and tendon regeneration.

Dr. Schwarz's lab is also interested in developing translational in vivo imaging outcome measures include near infrared imaging of lymphatic flow to detect arthritic flare, and cone beam CT to assess bone healing in patients with orthopaedic implants. More recently, Dr. Schwarz's lab has combined these biologic therapy technologies and outcome measures with biocompatible carriers and stem cells to generate novel tissue engineering constructs for bone, cartilage, ligament and tendon.

Credentials

Faculty Appointments

Education

1988
BS | Worcester Polytech Inst
Biology

1990
MA | Einstein College Medicine
Immunology, All Other

1993
PhD | Einstein College Medicine
Immunology, All Other

Post-doctoral Training & Residency

1993 - 1997
Laboratory of Inder M. Verma, Ph.D., Laboratory of Genetics The Salk Institute, La Jolla, California, Concentrations: Gene Therapy, NFkB Signal, Transduction, Transgenic Mice.

1988 - 1993
Training - Pre-doctoral Fellow, Laboratory of Barry R. Bloom, Ph.D., Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York

1987 - 0
Training - Summer Student - Laboratory of Carl Shilkraut, Ph.D., Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York

1987 - 1988
Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts

1986 - 0
Training - Summer Student - Laboratory of Fritz Herz, Ph.D., Department of Pathology, Montefiore Medical Center, Bronx, New York

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Awards

2007
J.R. Neff Award, Musculoskeletal Research Foundation

2005
Orthopaedic Research Society's Kappa Delta Young Investigator Award

2003
Orthopaedic Research Society's Harris Award

1999
University of Rochester Nominee for the Elison Award.

1999
University of Rochester Nominee for the Sinshimmer Award.

1999
New Investigator Research Award, The Association of Bone & Joint Surgeons .

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Publications

Journal Articles

1/11/2018
Bouta EM, Bell RD, Rahimi H, Xing L, Wood RW, Bingham CO, Ritchlin CT, Schwarz EM. "Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis." Nature reviews. Rheumatology.. 2018 Jan 11; Epub 2018 Jan 11.

2018
Bell RD, Rudmann C, Wood RW, Schwarz EM, Rahimi H. "Longitudinal micro-CT as an outcome measure of interstitial lung disease in TNF-transgenic mice." PloS one.. 2018 13(1):e0190678. Epub 2018 Jan 10.

12/11/2017
Farnsworth CW, Schott EM, Benvie AM, Zukoski J, Kates SL, Schwarz EM, Gill SR, Zuscik MJ, Mooney RA. "Obesity/type 2 diabetes increases inflammation, periosteal reactive bone formation, and osteolysis during Staphylococcus aureus implant-associated bone infection." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2017 Dec 11; Epub 2017 Dec 11.

Books & Chapters

2003
Chapter Title: Signal Transduction in Rheumatic Diseases
Book Title: Kelley's Textbook of Rheumatology
Author List: Schwarz, E.M.
Published By: W.B. Saunders Company2003

2003
Chapter Title: Biologic Agents as Antiresorptive Therapy
Book Title: Molecular Biology in Orthopaedics
Author List: Schwarz, E.M.
Edited By: Rosier, R.N. & Evans, C.H.
Published By: American Academy of Orthopaedic Surgeons: 2412003

2001
Book Title: Implant Wear in Total Joint Replacement
Author List: Wright. T.M. Goodman, S.B., Schwarz, E.M.
Published By: American Academy of Orthopaedic Surgeons2001

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