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Gloria S. Pryhuber, M.D.

Pediatrics

Clinical Interests

Neonatology

Contact Information

Phone Numbers

Administrative: (585) 275-2972

Office: (585) 275-5948

Fax: (585) 461-3614

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

Pryhuber Lab

Lab: (585) 275-1496

Visit Lab Website

Research Network

Biography

Acute and Chronic Lung Disease in Neonates

Professional Background

Dr. Pryhuber trained in Cincinnati, Ohio and in addition to her research work, serves as an attending neonatologist at URMC In collaboration with other members of the neonatal team. She passionately enjoys providing thoughtful, detailed, cutting-edge medical care to at-risk or critically ill newborns and their families. She embraces the team-approach to medicine involving nurses, mid-level providers, social workers and care coordinators, as well as the family in decision making as much as possible. Dr. Pryhuber's particular clinical interests are care of infants with pulmonary hypertension, lung injury, growth and developmental failure, often complicated by chronic and inflammatory disease. She leads the neonatal pulmonary hypertension consultation team.

Research

Research interests:
1) Chronic Lung Disease of Prematurity
2) Lung Development

Dr. Pryhuber trained as a post-doctoral Proctor Research Scholar and participant in the University of Cincinnati Program of Excellence in Molecular Biology of the Heart and Lung. She has since accumulated > 20 years as independent researcher and author in lung injury and immunology. She serves on NIH study sections and as reviewer for journals in her area of expertise, manages an active laboratory, supervises students in pulmonary biology and epithelial cell research and has received awards recognizing both teaching and original research accomplishments. She teaches regularly for the UofR Toxicology graduate program, Medical School and Pediatric Residency.
An NIH-funded physician-scientist with expertise in human perinatal lung injury and repair, Dr. Pryhuber also served nine years as Perinatal-Neonatal Fellowship Associate Director and mentors undergraduate, graduate and post-doctural students. She is honored to be a member of the American Pediatric Society, the Perinatal Research Society, and the Society for Pediatric Research, the American Thoracic Society, the American Academy of Pediatrics, the International Cytokine Society and the American Physiological Society. As Professor in the Departments of Pediatrics and Environmental Medicine, Dr. Pryhuber also acts as communicating PI for the UofR / University at Buffalo Center for the Prematurity and Respiratory Outcomes Program (PROP, NHLBI U01), as Lead Site Investigator for the UR-Respiratory Pathogens Research Center Clinical Study I (NIAID / DMID Contract), PI for the Lung Molecular Atlas Program Human Tissue Core (NHLBI U01) and remains active as clinical academic Neonatologist and Pulmonary Hypertension Team member. Dr. Pryhuber directs the UofR Pediatric and Environmental Health Sciences Center Histology Facility since 2009 and Pediatric Processing Lab since 2011, providing, through the work of talented technicians and University resources, technical support and training for preparation and analysis of tissues and cells of organisms ranging from human to drosophila. Dr. Pryhuber has also provided access to an archive of neonatal lung tissue acquired by expedited autopsy at gestational ages varying from 24 to 43 weeks. In collaboration with investigators in multiple centers, subsets of the archive are published, contributing novel observations pertaining to vascular development, epithelial cell abnormalities and inflammation in bronchopulmonary dysplasia. This repository is expanded by the LungMAP to collect donated human lung across the developmental spectrum from pseudoglandular through alveologenesis. These successful clinical and research programs demonstrate particular interests and strengths in creating multi-disciplinary teams of investigators, coordinators, nurses, technicians, and information specialists. They create and foster active collaborations of investigators and clinicians in neonatology, pulmonology, infectious disease, obstetrics/perinatology, immunology, microbiology, pathology, toxicology and genomics, as well as extramural collaborations around perinatal development and disease.
Clinically, preterm infant cohorts are enrolled in longitudinal studies. In the laboratory, fresh isolated cells, cell lines and whole animal models are utilized to understand cellular interactions during development and inflammation. Specific studies determined parenchymal TNF receptor signaling mechanisms that regulate gene expression, inflammation and apoptosis in the lung. More recently, high-dimensional flow cytometry, cell sorting, transcriptomic and genomic techniques are applied to understand the effects of in utero environment, premature birth and microbial colonization on the adaptive immune system and lung. The impact on respiratory morbidity and mortality of alterations in CD4 and CD8 lymphocyte responses to stimuli are the focus of active studies.

Credentials

Faculty Appointments

Specialties

  • Neonatal-Perinatal Medicine - American Board of Pediatrics
  • Pediatrics

Education

1981
B.S. with Distinction, | Cornell University
Arts and Sciences

1985
M.D., Cum Laude, | SUNY at Upstate Medical Center
Medicine

Post-doctoral Training & Residency

07/01/1985 - 06/30/1986
Internship in Pediatrics at SUNY Health Science Center at Syracuse

07/01/1986 - 06/30/1988
Residency in Pediatrics at SUNY Health Science Center at Syracuse

07/01/1988 - 06/30/1991
Fellowship in Pediatrics: Neonatal-Perinatal Medicine at University of Cincinnati College of Medicine

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Awards

2014
Ruth A. Lawrence Academic Faculty Service Award for Excellence in Research
Location: Department of Pediatrics, Univ of Rochester

2013
American Pediatric Society Membe

2011 - 2014
George Washington Goler Professor of Pediatrics
Location: University of Rochester

2006 - Present
Best Doctors in America Database
Sponsor: America's Best Doctors

2005
Ruth A. Lawrence Academic Faculty Service Award for Excellence in Training, Department of Pediatrics, University of Rochester, R

2001
University of Rochester Environmental Health Sciences Center, Pulmonary Core - Member

1999
Society for Pediatric Research - Member

1989
Chief Fellow in Neonatology, University of Cincinnati, Cincinnati, OH

1986 - 1987
Resident Teaching Award

1985 - 1986
Resident Teaching Award

1985
Janet M. Glascow Memorial Achievement Award
Sponsor: American Medical Women's Association
Location: SUNY Health Science Center at Syracuse

1984
Annual Clinical Campus Pediatric Award
Sponsor: SUNY Health Science Center at Syracuse

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Publications

Journal Articles

6/2017
D'Angio CT, Wang H, Hunn JE, Pryhuber GS, Chess PR, Lakshminrusimha S. "Permission form synopses to improve parents' understanding of research: a randomized trial." Journal of perinatology : official journal of the California Perinatal Association.. 2017 Jun 0; 37(6):735-739. Epub 2017 Mar 30.

5/4/2017
Durrani-Kolarik S, Pool CA, Gray A, Heyob KM, Cismowski MJ, Pryhuber GS, Lee LJ, Yang Z, Tipple TE, Rogers LK. "Mir-29b Supplementation Decreases Expression of Matrix Proteins and Improves Alveolarization in Mice Exposed to Maternal Inflammation and Neonatal Hyperoxia." American journal of physiology. Lung cellular and molecular physiology.. 2017 May 4; :ajplung.00273.2016. Epub 2017 May 04.

5/2017
Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y. "Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development." Thorax.. 2017 May 0; 72(5):481-484. Epub 2017 Jan 09.

Books & Chapters

2015
Chapter Title: Acute Respiratory Disorders of the Newborn
Book Title: Neonatology: Pathophysiology and Management of the Newborn.
Author List: Whitsett JA, Rice WR, Pryhuber GS and Wert SE.
Edited By: Mhairi G. MacDonald, MD Mullett and MMK Seshia.
Published By: Lippencott, Williams and Wilkins2015 in New York, New York

2005
Chapter Title: Combined-Modality Therapy for Lung Injury
Book Title: Lung Injury: Mechanisms, Pathophysiology, and Therapy
Author List: Pryhuber GS, D'Angio CT, Finkelstein JN, Notter RH
Edited By: Notter R, Finkelstein J, Holm BA
Published By: Marcel-Dekker2005 in New York, NY

2005
Chapter Title: Acute Respiratory Disorders of the Newborn
Book Title: Neonatology: Pathophysiology and Management of the Newborn
Author List: Whitsett JA, Rice WR, Warner BB, Wert SE, Pryhuber GS
Edited By: Mhairi G. MacDonald, MD Mullett and MMK Seshia
Published By: Lippencott, Williams and Wilkins2005 in New York, NY

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