Charlotte K. Ryan, M.D.

Contact Information

Phone Numbers

Office: (585) 275-1662

Fax: (585) 273-3637

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Faculty Appointments

Professor Emeritus - Department of Pathology and Laboratory Medicine (SMD) - Primary

Biography

Dr. Ryan participates in gastrointestinal, liver transplant and hepatobiliary working conferences for clinicians. Strong Memorial Hospital is a United Network for Organ Sharing (UNOS) transplant center for adult and pediatric transplant surgery and the only hospital in New York serving the upstate and western regions. Dr. Ryan is responsible for diagnosing the great majority of liver transplant biopsies and has received additional training at the University of Pittsburgh in the interpretation of both liver and small bowel transplant biopsies. She has also studied heart transplant pathology at the Mt. Sinai Medical Center in New York City and has helped cover that service for the last 9 years.

Research

Dr. Ryan's research endeavors with the liver transplant program include the study of post transplant biopsies in hepatitis C patients more particularly regarding response to antiviral therapy and the treatment of acute cellular rejection. Additional projects have included liver grafts from donors with CNS tumors and analysis of outcomes in patients with primary sclerosing cholangitis. Collaboration with Oncology is ongoing and involves the association of tissue factor (TF) with VEGF expression in colorectal, pancreatic and gastric carcinomas, suggesting a link between hemostatic activation and angiogenesis. Past studies included EGFR and VEGF expression and mutated K12-ras as indicators of survival in colon cancer. Another field of investigation concerns the development and evaluation of microtubule-targeting agents as therapeutic candidates in hepatic and colorectal cancers.

Credentials

Specialties

Clinical Pathology/Laboratory Medicine - American Board of Pathology

Education

1971
BA | Hofstra University
Chemistry

1975
MD | Johns Hopkins U Sch Medicine
Medicine

Post-doctoral Training & Residency

01/02/1990 - 01/01/1991
Fellowship in Pathology at University of Rochester Medical Center

07/01/1977 - 06/30/1981
Residency in Pathology at University of Rochester Medical Center

07/01/1975 - 06/30/1976
Internship in Pathology at University of Rochester Medical Center

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Publications

Journal Articles

2/2012
Barry CT, D'Souza M, McCall M, Safadjou S, Ryan C, Kashyap R, Marroquin C, Orloff M, Almudevar A, Godfrey TE. "Micro RNA expression profiles as adjunctive data to assess the risk of hepatocellular carcinoma recurrence after liver transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.. 2012 Feb 0; 12(2):428-37. Epub 2011 Oct 18.

5/19/2010
Wu MH, Ma WL, Hsu CL, Chen YL, Ou JH, Ryan CK, Hung YC, Yeh S, Chang C. "Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription." Science translational medicine.. 2010 May 19; 2(32):32ra35.

11/2006
Saad, WEA; Ryan, CK; Davies, MG; Fultz, PJ; Rubens, DJ; Patel, NC; Sahler, LG; Lee, DE; Kitanosono, T; Sasson, T; Waldman, DL. "Safety and efficacy of fluoroscopic versus ultrasound guided core liver biopsies for potential living related liver transplant donors." J. Vasc Interv Radiol. 2006; 17(11).

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