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Fabeha Fazal, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-5948

Office: (585) 275-9917

Fax: (585) 756-7780

Research Labs

Faculty Appointments

Biography

Research

My lab focuses on understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition, which affects over a quarter of million patients in the U.S. with a mortality rate of approximately 40 percent. It is associated with pneumonia, sepsis, and trauma, leading to pulmonary insufficiency and eventually multisystem organ failure. So far, there are no effective therapy targeting the underlying molecular and cellular mechanisms. The two major pathogenic features of ALI involves disruption of pulmonary vascular endothelial barrier and acquisition of a proinflammatory phenotype. The long term goal of my research is to identify novel mechanistic targets and assess the preventive and therapeutic benefit of targeting them against evolving ALI. In our lab we use integration of in vitro and in vivo techniques to dissect the pathways that are critical to endothelial cell (EC) inflammation and permeability. We use multidisciplinary approaches ranging from biochemical, cellular, and molecular biology to in vivo gene delivery and lung physiology.

Credentials

Education

1985
BSc | A.M. University
Chemistry

1987
MSc | A.M. University
Biochemistry

1992
PhD | A.M. University
Biochemistry

Post-doctoral Training & Residency

2003 - 2011
Research Assistant Professor, Department of Pediatrics, University of Rochester, Rochester, NY

1999 - 2003
Research Assistant Professor, Department of Physiology and Biophysics, University of Illinois, Chicago, IL

1995 - 1998
Research Associate, Loyola University Medical Center, Maywood, IL

1992 - 1995
Research Associate, Loyola University Medical Center, Maywood, IL; Advisor: Susan Baker, PhD

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Awards

1987
University Gold Medal for standing first in M.S. Examination

1985
University Gold Medal for standing first in B.S. Examination

Publications

Journal Articles

9/4/2019
Leonard A, Su PY, Yule DI, Rahman A, Fazal F. "Critical Role of Mortalin/GRP75 In Endothelial Cell Dysfunction Associated With Acute Lung Injury." Shock.. 2019 Sep 4; Epub 2019 Sep 04.

5/1/2019
"Critical role of autophagy regulator Beclin1 in endothelial cell inflammation and barrier disruption." Cellular signalling.. 2019 May 1; Epub 2019 May 01.

2/14/2019
"Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury." Scientific reports.. 2019 Feb 14; 9(1):2096. Epub 2019 Feb 14.

Books & Chapters

1993
Chapter Title: Strand scission in DNA induced by dietary flavonoids: Role of Cu (II) and oxygen free radicals.
Book Title: Glimpses in Plant Research XI: Medicinal Plants; New Vistas of Research [Part 2]
Author List: Rahman A, Fazal F, Hadi SM
Edited By: Govil JN, Singh VK, Hashmi S
Published By: Today and Tomorrow's Printers and Publishers 1993 in New Delhi, India

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