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Fabeha Fazal, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-5948

Fax: (585) 756-7780

Office: (585) 275-9917

Biography

Research

A major focus of research in my laboratory deals with understanding the role and regulation of actin-myosin interactions in endothelial cell (EC) inflammation, permeability, and apoptosis, especially in the settings of acute and chronic lung injury. We study pathways of EC inflammation, barrier dysfunction and apoptosis on the molecular, cellular, and animal level. We have uncovered novel and previously unrecognized role of actin cytoskeleton and non-muscle myosin light chain kinase (nmMLCK) in the regulation of cytoplasmic trafficking of NF-k? for its nuclear import to cause EC inflammation associate with intravascular coagulation and sepsis. More recently we have been involved in the identification of endoplasmic reticulum (ER) stress as an important determinant of EC inflammation and permeability associated with acute lung injury (ALI). In our most recent work, we have focused on understanding the role of nmMLCK in the pathogenesis of pulmonary emphysema caused by cigarette smoke (CS). The approaches ranging from biochemical, cellular, and molecular biology to in vivo gene delivery and lung physiology to study how pulmonary endothelium responds during acute and chronic lung inflammation/injury.

Credentials

Faculty Appointments

Education

1985
BSc | A.M. University
Chemistry

1992
PhD | A.M. University
Biochemistry

1987
MSc | A.M. University
Biochemistry

Awards

1987
University Gold Medal for standing first in M.S. Examination

1985
University Gold Medal for standing first in B.S. Examination

Publications

Journal Articles

12/2014
Bijli KM, Kanter BG, Minhajuddin M, Leonard A, Xu L, Fazal F, Rahman A. "Regulation of endothelial cell inflammation and lung polymorphonuclear lymphocyte infiltration by transglutaminase 2." Shock.. 2014 Dec 0; 42(6):562-9.

2014
Leonard A, Paton AW, El-Quadi M, Paton JC, Fazal F. "Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation." PloS one. 2014 9(10):e110949. Epub 2014 Oct 30.

11/1/2013
Leonard A, Marando C, Rahman A, Fazal F. "Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-?B activation and endothelial cell inflammation." American journal of physiology. Lung cellular and molecular physiology.. 2013 Nov 1; 305(9):L651-64. Epub 2013 Sep 13.

Books & Chapters

1993
Chapter Title: Strand scission in DNA induced by dietary flavonoids: Role of Cu (II) and oxygen free radicals.
Book Title: Glimpses in Plant Research XI: Medicinal Plants; New Vistas of Research [Part 2]
Author List: Rahman A, Fazal F, Hadi SM
Edited By: Govil JN, Singh VK, Hashmi S
Published By: Today and Tomorrow's Printers and Publishers1993 in New Delhi, India

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