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Andrew P. Wojtovich, Ph.D.


Showing all 44 journal articles & 0 books available

Journal Articles

Tiwary V, Galow AM, Wojtovich AP, Peleg S. "Using light to drive energy transduction in metazoan aging." Trends in biochemical sciences.. 2023 Sep 11; Epub 2023 Sep 11.

Chaubey AH, Sojka SE, Onukwufor JO, Ezak MJ, Vandermeulen MD, Bowitch A, Vodi?ková A, Wojtovich AP, Ferkey DM. "The C. elegans Innexin INX-20 Regulates Nociceptive Behavioral Sensitivity." Genetics.. 2023 Feb 8; Epub 2023 Feb 08.

Berry BJ, Vodi?ková A, Müller-Eigner A, Meng C, Ludwig C, Kaeberlein M, Peleg S, Wojtovich AP. "Optogenetic rejuvenation of mitochondrial membrane potential extends lifespan." Nature aging.. 2023 Feb; 3(2):157-161. Epub 2022 Dec 30.

Onukwufor JO, Farooqi MA, Vodi?ková A, Koren SA, Baldzizhar A, Berry BJ, Beutner G, Porter GA, Belousov V, Grossfield A, Wojtovich AP. "A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans." Nature communications.. 2022 May 3; 13(1):2403. Epub 2022 May 03.

Kleckner AS, Kleckner IR, Culakova E, Wojtovich AP, Klinedinst NJ, Kerns SL, Hardy SJ, Inglis JE, Padula GDA, Mustian KM, Janelsins MC, Dorsey SG, Saligan LN, Peppone LJ. "Exploratory Analysis of Associations Between Whole Blood Mitochondrial Gene Expression and Cancer-Related Fatigue Among Breast Cancer Survivors." Nursing research.. 2022 Apr 13; Epub 2022 Apr 13.

Onukwufor JO, Dirksen RT, Wojtovich AP. "Iron Dysregulation in Mitochondrial Dysfunction and Alzheimer's Disease." Antioxidants.. 2022 Mar 31; 11(4)Epub 2022 Mar 31.

Vodi?ková A, Koren SA, Wojtovich AP. "Site-specific mitochondrial dysfunction in neurodegeneration." Mitochondrion.. 2022 Feb 16; Epub 2022 Feb 16.

Amitrano AM, Berry BJ, Lim K, Kim KD, Waugh RE, Wojtovich AP, Kim M. "Optical Control of CD8 T Cell Metabolism and Effector Functions." Frontiers in immunology.. 2021 12:666231. Epub 2021 Jun 03.

Berry BJ, Nieves TO, Wojtovich AP. "Decreased Mitochondrial Membrane Potential Activates the Mitochondrial Unfolded Protein Response." microPublication biology.. 2021 2021Epub 2021 Sep 10.

Berry BJ, Baldzizhar A, Nieves TO, Wojtovich AP. "Neuronal AMPK coordinates mitochondrial energy sensing and hypoxia resistance in C. elegans." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2020 Oct 15; Epub 2020 Oct 15.

Berry BJ, Wojtovich AP. "Mitochondrial light switches: optogenetic approaches to control metabolism." The FEBS journal.. 2020 May 27; Epub 2020 May 27.

Berry BJ, Trewin AJ, Milliken AS, Baldzizhar A, Amitrano AM, Lim Y, Kim M, Wojtovich AP. "Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance." EMBO reports.. 2020 Feb 11; :e49113. Epub 2020 Feb 11.

Onukwufor JO, Trewin AJ, Baran TM, Almast A, Foster TH, Wojtovich AP. "Quantification of reactive oxygen species production by the red fluorescent proteins KillerRed, SuperNova and mCherry." Free radical biology & medicine.. 2019 Dec 10; 147:1-7. Epub 2019 Dec 10.

Trewin AJ, Bahr LL, Almast A, Berry BJ, Wei AY, Foster TH, Wojtovich AP. "Mitochondrial Reactive Oxygen Species Generated at the Complex-II Matrix or Intermembrane Space Microdomain Have Distinct Effects on Redox Signaling and Stress Sensitivity in ." Antioxidants & redox signaling.. 2019 Sep 20; 31(9):594-607. Epub 2019 Apr 22.

Wojtovich AP, Berry BJ, Galkin A. "Redox Signaling Through Compartmentalization of Reactive Oxygen Species: Implications for Health and Disease." Antioxidants & redox signaling.. 2019 Sep 20; 31(9):591-593. Epub 2019 Jun 19.

Philip NS, Escobedo F, Bahr LL, Berry BJ, Wojtovich AP. "Element-Mediated CRISPR Integration of Transgenes in ." G3 : genes - genomes - genetics.. 2019 Aug 8; 9(8):2629-2635. Epub 2019 Aug 08.

Onukwufor JO, Berry BJ, Wojtovich AP. "Physiologic Implications of Reactive Oxygen Species Production by Mitochondrial Complex I Reverse Electron Transport." Antioxidants.. 2019 Aug 6; 8(8)Epub 2019 Aug 06.

Trewin AJ, Berry BJ, Wei AY, Bahr LL, Foster TH, Wojtovich AP. "Light-induced oxidant production by fluorescent proteins." Free radical biology & medicine.. 2018 Nov 20; 128:157-164. Epub 2018 Feb 06.

Berry BJ, Trewin AJ, Amitrano AM, Kim M, Wojtovich AP. "Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species." Journal of molecular biology.. 2018 Oct 19; 430(21):3873-3891. Epub 2018 Apr 04.

Barnett ME, Baran TM, Foster TH, Wojtovich AP. "Quantification of light-induced miniSOG superoxide production using the selective marker, 2-hydroxyethidium." Free radical biology & medicine.. 2018 Feb 20; 116:134-140. Epub 2018 Jan 31.

Trewin AJ, Berry BJ, Wojtovich AP. "Exercise and Mitochondrial Dynamics: Keeping in Shape with ROS and AMPK." Antioxidants.. 2018 Jan 6; 7(1)Epub 2018 Jan 06.

Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG. "Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist." Molecular pharmacology.. 2016 Sep; 90(3):214-24. Epub 2016 Jun 23.

Wojtovich AP, Wei AY, Sherman TA, Foster TH, Nehrke K. "Chromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans." Scientific reports.. 2016 Jul 21; 6:29695. Epub 2016 Jul 21.

Wojtovich AP, Smith CO, Urciuoli WR, Wang YT, Xia XM, Brookes PS, Nehrke K. "Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning." Anesthesiology.. 2016 May; 124(5):1065-76.

Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS. "Direct activation of ?-cell KATP channels with a novel xanthine derivative." Molecular pharmacology.. 2014 Jun; 85(6):858-65. Epub 2014 Mar 19.

Wojtovich AP, Foster TH. "Optogenetic control of ROS production." Redox biology.. 2014 2:368-76. Epub 2014 Feb 03.

Wojtovich AP, Urciuoli WR, Chatterjee S, Fisher AB, Nehrke K, Brookes PS. "Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning." American journal of physiology. Heart and circulatory physiology.. 2013 Jun 1; 304(11):H1439-45. Epub 2013 Apr 12.

Wojtovich AP, Smith CO, Haynes CM, Nehrke KW, Brookes PS. "Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel." Biochimica et biophysica acta.. 2013 May; 1827(5):598-611. Epub 2013 Jan 02.

Wojtovich AP, Nadtochiy SM, Urciuoli WR, Smith CO, Grunnet M, Nehrke K, Brookes PS. "A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel." PeerJ.. 2013 1:e48. Epub 2013 Mar 05.

Guo S, Olm-Shipman A, Walters A, Urciuoli WR, Devito S, Nadtochiy SM, Wojtovich AP, Brookes PS. "A cell-based phenotypic assay to identify cardioprotective agents." Circulation research.. 2012 Mar 30; 110(7):948-57. Epub 2012 Mar 06.

Wojtovich AP, Distefano P, Sherman T, Brookes PS, Nehrke K. "Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans." FEBS letters.. 2012 Feb 17; 586(4):428-34. Epub 2012 Jan 21.

Wojtovich AP, Nadtochiy SM, Brookes PS, Nehrke K. "Ischemic preconditioning: the role of mitochondria and aging." Experimental gerontology.. 2012 Jan; 47(1):1-7. Epub 2011 Nov 10.

Queliconi BB, Wojtovich AP, Nadtochiy SM, Kowaltowski AJ, Brookes PS. "Redox regulation of the mitochondrial K(ATP) channel in cardioprotection." Biochimica et biophysica acta.. 2011 Jul; 1813(7):1309-15. Epub 2010 Nov 20.

Wojtovich AP, Sherman TA, Nadtochiy SM, Urciuoli WR, Brookes PS, Nehrke K. "SLO-2 is cytoprotective and contributes to mitochondrial potassium transport." PloS one.. 2011 6(12):e28287. Epub 2011 Dec 01.

Gunter TE, Gerstner B, Lester T, Wojtovich AP, Malecki J, Swarts SG, Brookes PS, Gavin CE, Gunter KK. "An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays." Toxicology and applied pharmacology.. 2010 Nov 15; 249(1):65-75. Epub 2010 Aug 26.

Wojtovich AP, Williams DM, Karcz MK, Lopes CM, Gray DA, Nehrke KW, Brookes PS. "A novel mitochondrial K(ATP) channel assay." Circulation research.. 2010 Apr 16; 106(7):1190-6. Epub 2010 Feb 25.

Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, Perocchi F, Chen W, Clish CB, Ayata C, Brookes PS, Mootha VK. "Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis." Nature biotechnology.. 2010 Mar; 28(3):249-55. Epub 2010 Feb 14.

Roser KS, Brookes PS, Wojtovich AP, Olson LP, Shojaie J, Parton RL, Anders MW. "Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: a prodrug strategy for targeting cytoprotective antioxidants to mitochondria." Bioorganic & medicinal chemistry.. 2010 Feb 15; 18(4):1441-8. Epub 2010 Jan 15.

Wojtovich AP, Nehrke KW, Brookes PS. "The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria." Acta biochimica Polonica. 2010 57(4):431-4. Epub 2010 Nov 19.

Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe JI, Yan C. "Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy." Circulation research.. 2009 Nov 6; 105(10):956-64. Epub 2009 Sep 24.

Wojtovich AP, Brookes PS. "The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels." Basic research in cardiology.. 2009 Mar; 104(2):121-9. Epub 2009 Feb 26.

Wojtovich AP, Burwell LS, Sherman TA, Nehrke KW, Brookes PS. "The C. elegans mitochondrial K+(ATP) channel: a potential target for preconditioning." Biochemical and biophysical research communications.. 2008 Nov 21; 376(3):625-8. Epub 2008 Sep 20.

Wojtovich AP, Brookes PS. "The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioning." Biochimica et biophysica acta.. 2008 1777(7-8):882-9. Epub 2008 Apr 08.

di Bernardo D, Thompson MJ, Gardner TS, Chobot SE, Eastwood EL, Wojtovich AP, Elliott SJ, Schaus SE, Collins JJ. "Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks." Nature biotechnology.. 2005 Mar; 23(3):377-83.