Lisa A. Beck, M.D.

Lisa A. Beck, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 697
Rochester, NY 14642

Office: (585) 275-1039

Research Bio

Dr. Beck's research interests are in three interrelated areas. First, we are interested in characterizing the epithelial tight junction defects at the molecular level in atopic dermatitis, the most common inflammatory skin disease in man. Numerous projects radiate from that central theme and include – 1) how do these defects differ in other inflammatory skin diseases such as chronic urticaria, psoriasis, CTCL, 2) what effects do various pharmacologic agents have on TJ function and structure, 3) can protease containing allergens or microbes affect TJ function and if so how. A second area of focus is evaluating the magnitude and character of the microbial responsiveness of keratinocytes (cutaneous epithelial cells) from atopic dermatitis subjects compared to nonatopic healthy controls.

When differences are noted we are trying to determine the basis for these differences and believe this line of inquiry may explain AD subjects' susceptibility to colonization and infection with numerous bacteria, viruses and even yeast. Our third area has been to understand why there is such a paucity of tissue neutrophils in lesions from subjects with atopic dermatitis. These studies are not as advanced but suggest that there are phenotypic differences in AD neutrophils' responsiveness to the potent chemoattractant, IL-8 (CXCL8) compared to nonatopic controls.

Awards & Honors (National)

Physician-Scientist Award | National Institute of Health 1994
Research Award | Dermatology Foundation 1994

Awards & Honors (Local)

Dermatology Faculty Teaching Award | University of Rochester Medical Center 2008
Mentor for NEASE Skin Research Grant Recipient | NEASE 2007
Mentor for AAAAI Summer Research Grant Recipient | AAAAI 2007
Mentor for Astellas Skin Research Grant Recipient | Astellas 2006
Mentor for Fujisawa AAAAI Research Grant Recipient | Fujisawa 2005
Mentor for Howard Hughes Summer Fellowship Recipient | Howard Hughes 1997
Teaching Appreciation Award | Johns Hopkins University | Dermatology Department 1992
Internal Medicine Teaching Award | Francis Scott Key Medical Center 1992

Patents

Reduced Expression of Epidermal Claudin-1 Predisposes to Atopic Dermatitis (and other allergic disorders), Disseminated Cutaneous Viral Infections Such As Herpes Simplex and Other Skin Diseases Such as Psoriasis

United States Serial NO.: 13/576,959
Filed Date: February 7, 2011
Title: Methods of Using Agents That Modulate Claudin Expression
Invented by: Lisa Beck, Anna De Benedetto
Reduced Expression of Epidermal Claudin-1 Predisposes to Atopic Dermatitis (and other allergic disorders), Disseminated Cutaneous Viral Infections Such As Herpes Simplex and Other Skin Diseases Such as Psoriasis

United States Serial NO.: 13/576,968
Filed Date: February 8, 2011
Title: Methods of Using Agents That Modulate Claudin Expresssion
Invented by: Lisa Beck, Anna De Benedetto
Methods of studying human and nonhuman epidermal (= skin epithelium) samples ex vivo

United States Serial NO.: 13/743,879
Filed Date: January 17, 2013
Title: System and Method for Studying Epidermis Samples Ex Vivo
Invented by: Lisa Beck, Anna De Benedetto
Modulation of Epidermal Barrier Function and Composition by Histamine Receptor Agonists and Antagonists

United States Serial NO.: 14/769,549
Filed Date: February 21, 2014
Title: Methods of Using Histamine Receptor Agonists and Antagonists
Invented by: Lisa Beck, Anna De Benedetto, Takeshi Yoshida
Designed Peptides for Tight Junction Barrier Modulation

United States Serial NO.:
Filed Date: August 18, 2014
Title: Designed Peptides for Tight Junction Barrier Modulation
Invented by: Elizabeth Anderson, Anna De Benedetto, Benjamin Miller, Lisa Beck

Recent Journal Articles

Showing the 5 most recent journal articles. 78 available »

2016 Jan 15
Rizzo JM, Oyelakin A, Min S, Smalley K, Bard J, Luo W, Nyquist J, Guttman-Yassky E, Yoshida T, De Benedetto A, Beck LA, Sinha S, Romano RA. "?Np63 regulates IL-33 and IL-31 signaling in atopic dermatitis." Cell death and differentiation. 2016 Jan 15; Epub 2016 Jan 15.
2016 Jan 14
Barrett MM, Strikwerda AM, Somers K, Beck LA, Scott GA. "Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature." Pediatric dermatology. 2016 Jan 14; Epub 2016 Jan 14.
2016 Jan 2
Thaçi D, Simpson EL, Beck LA, Bieber T, Blauvelt A, Papp K, Soong W, Worm M, Szepietowski JC, Sofen H, Kawashima M, Wu R, Weinstein SP, Graham NM, Pirozzi G, Teper A, Sutherland ER, Mastey V, Stahl N, Yancopoulos GD, Ardeleanu M. "Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial." Lancet. 2016 Jan 2; 387(10013):40-52. Epub 2015 Oct 08.
2015 Feb
Borkowski AW, Kuo IH, Bernard JJ, Yoshida T, Williams MR, Hung NJ, Yu BD, Beck LA, Gallo RL. "Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage." The Journal of investigative dermatology. 2015 Feb; 135(2):569-78. Epub 2014 Aug 12.
2015
Brandner JM, Zorn-Kruppa M, Yoshida T, Moll I, Beck LA, De Benedetto A. "Epidermal tight junctions in health and disease." Tissue barriers. 2015 3(1-2):e974451. Epub 2015 Apr 03.

Current Appointments

Dean's Professorship - Department of Dermatology (SMD)
Professor - Department of Dermatology (SMD) - Primary
Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)

Specialties

Dermatology - American Board of Dermatology

Education

MD | Medicine | Stony Brook Univ Health Sciences Center School of Medicine1985
BA | Chemistry | Mount Holyoke College1981

Post-Doctoral Training & Residency

Residency in Dermatology at Duke University Medical Center07/01/1987 - 07/31/1990
Residency in Internal Medicine at University of Rochester Medical Center07/01/1986 - 07/31/1987
Internship in Internal Medicine at University of Rochester Medical Center06/27/1985 - 07/31/1986