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Minsoo Kim, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-1400

Office: (585) 276-3917

Fax: (585) 273-2452

Research Labs

Biography

Cell migration is central to many biological and pathological processes, including embryogenesis, tissue repair and regeneration as well as cancer and the inflammatory response. Inflammatory recruitment of leukocytes is critical in initiation and progression of a wide range of diseases. Cell surface adhesion molecule, integrin is a critical component in the effective trafficking of leukocytes.

Research

Unlike cells within solid tissues, circulating leukocytes relocate during the course of immune reactions and dynamically adhere and de-adhere to cells of the vasculature and to other immune cells, as well as to components of the extracellular matrix. A subset of integrins (LFA-1, Mac-1, and VLA4) are expressed on leukocytes and play a major role in regulating leukocyte adhesion and recruitment to damaged or infected tissues during inflammatory responses. The activity of integrins to bind ligands is dynamically and tightly regulated through conformational changes from inactive form to the active one that binds ligands with high affinity. Under a wide range of pathologic conditions, these mechanisms of integrin activation are misregulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying tissue making leukocyte integrins a promising therapeutic target for anti-inflammation therapy. Therefore, it would be critical to understand how integrins and their ligands bind to one another, the flow of conformational changes from one integrin domain to another, and the connections to other signaling molecules.
In order to visualize the conformational changes in integrin LFA-1 and its dynamic redistribution on the plasma membrane, we applied the quantitative imaging technique FRET (fluorescence resonance energy transfer) to living cells. Our current research focuses on integrin-mediated leukocyte migration during inflammation. By employing advanced imaging techniques including FRET, live cell imaging, 3D confocal-image reconstruction, IRM (interference reflection microscopy), and TIRFM (total internal reflection fluorescence microscopy), we are trying to improve our understanding of the supramolecular/architectural properties of leukocyte integrins with particular emphasis on their relationship with leukocyte migration. In addition, we are interested in visualizing dynamic interactions of intracellular signaling molecules and identifying new molecules that regulate integrin activation during the leukocyte chemotaxis.

Credentials

Faculty Appointments

Education

1993
BS | Korea-Korea University
Genetic Engineering

2001
PhD | Ohio State University
Pharmacology

Awards

2016
Dolph O. Adams Award
Sponsor: Society for Leukocyte Biology

2015
University of Rochester School of Medicine and Dentistry Trainee Academic Mentoring Award

2007
Brown University Seed Fund Award (Co-investigator)

2005
Rhode Island Foundation, Medical Research Grant

2005
American Heart Association, Scientist Developmental Grant

2001
DDW Poster of Distinction

2000
DDW Poster of Distinction

2000
American Digestive Health Foundation Student Abstract Award

1999
Digestive Disease Week (DDW) Poster of Distinction

1992
Honor student of 1992 by Korea University

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Publications

Journal Articles

5/15/2017
Kim KD, Bae S, Capece T, Nedelkovska H, de Rubio RG, Smrcka AV, Jun CD, Jung W, Park B, Kim TI, Kim M. "Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment." Nature communications. 2017 May 15; 8:15365. Epub 2017 May 15.

1/1/2017
Johnson CM, O'Brien XM, Byrd AS, Parisi VE, Loosely AJ, Li W, Witt H, Faridi HM, Lefort CT, Gupta V, Kim M, Reichner JS. "Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal ?-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response." The Journal of immunology : official journal of the American Association of Immunologists.. 2017 Jan 1; 198(1):318-334. Epub 2016 Nov 16.

12/27/2016
Connolly KA, Belt BA, Figueroa NM, Murthy A, Patel A, Kim M, Lord EM, Linehan DC, Gerber SA. "Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes." Oncotarget. 2016 Dec 27; 7(52):86522-86535.

Books & Chapters

2011
Chapter Title: Fluorescence resonance energy transfer in the studies of integrin activation.
Book Title: Current Topics in Membrane
Author List: CT Lefort and M. Kim
Published By: Academic Press2011

2006
Chapter Title: Adhesion Molecules: Function and Inhibition.
Book Title: Progress in Inflammation Research,
Author List: A. Schenkel and M. Kim
Edited By: M.J. Parnham
Published By: Birkhauser Publishing2006 in Basel, Switzerland

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