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George A. Porter, M.D., Ph.D.


Clinical Interests


Contact Information

Phone Numbers

Administrative: (585) 275-6096

Appointment: (585) 275-6108

Fax: (585) 442-0104

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients


General Pediatric Cardiology Pediatric Cardiology Research


Dr. Porter's laboratory studies mechanisms that control cardiac development, concentrating on the roles played by the intracellular organelles, mitochondria. Using in vivo and in vitro mouse models of cardiac development, the lab has shown that mitochondrial structure and function changes dramatically in cardiac myocytes as the embryonic heart forms. In particular, we have found that closure of the mitochondrial permeability transition pore (PTP) between the early and mid-embryonic period leads to a maturation of the structure of individual mitochondria and of the mitochondrial network throughout the cell. This also leads to an activation of oxidative phosphorylation, or ATP production, by mitochondria as the heart develops. These changes also cause a drop in cellular oxidative stress due to altered mitochondrial production of reactive oxygen species, and this signals to the myocytes to undergo further differentiation. More recent research finds that the same phenomena occur in the neonatal heart, and that closure of the PTP in the neonate increases cardiac function in vivo. These findings have led to additional studies. 1. Determining that the PTP is derived from ATP synthase the electron transport chain complex that makes ATP. 2. Determining the mechanisms that control the activity of the PTP. 3. Investigating the mechanisms by which mitochondria control oxidative stress in the embryonic heart. 5. Determining how mitochondria regulate differentiation of cardiac myocytes in the neonatal period and how oxygen levels regulate these changes and cause maturation of the infant heart. Finally, Dr. Porter is the site principal investigator at the University of Rochester for the Pediatric Cardiac Genomics Consortium. This international, multicenter arm of the NIH Bench to Bassinet program ( has enrolled over 10,000 patients with congenital heart defects to perform genotype-phenotype correlation using advanced genetic testing. This data derived from this study is being used to discover new genes that cause human congenital heart defects and to test the pathogenesis of these genes in animal models through collaboration with the Cardiovascular Development Consortium of the Bench to Bassinet program. The most recent version of this study will determine the relationship between genetic mutations, heart defects, and neurodevelopmental outcomes. These studies have been funded by the Charles H. Hood Foundation, the Children's Cardiomyopathy Foundation, Founder's Affiliate of American Heart Association, the NIH, Pfizer, the Strong Children's Research Center, and the University of Rochester Clinical and Translational Science Institute (CTSI), the Aab Cardiovascular Research Institute (CVRI), and the United Mitochondrial Disease Foundation.


Faculty Appointments


  • Pediatrics
  • Pediatric Cardiology - American Board of Pediatrics


B.S. | University of Notre Dame

Ph.D. | University of Maryland School of Medicine

M.D. | University of Maryland School of Medicine

Post-doctoral Training & Residency

07/01/1997 - 06/20/2000
Fellowship in Pediatrics: Pediatric Cardiology at Yale New Haven Hospital

07/01/1994 - 06/30/1995
Internship in Pediatrics at Yale New Haven Hospital

07/01/1995 - 06/30/1997
Residency in Pediatrics at Yale New Haven Hospital

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Ruth A. Lawrence Academic Faculty Service Award in Research, UR Medicine, Department of Pediatrics

Second place, Basic Cardiovascular Science Poster Competion (Research Symposium)
Location: Upstate, New York

The Mae Gailani Junior Faculty Award for Uncompromising Dedication to Research and Patient Care
Location: Yale Department of Pediatrics

AHA Travel Award to the 1999 Weinstein Cardiovascular Development Conference

The American Federation for Clinical Research Medical Student Award
Location: University of Maryland School of Medicine

Dr. J. Edmund Bradley Award for Excellence in Pediatrics
Location: University of Maryland School of Medicine

Extended Neuroscience Research Award, The American Academy of Neurology

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Journal Articles

Mnatsakanyan N, Beutner G, Porter GA, Alavian KN, Jonas EA. "Physiological roles of the mitochondrial permeability transition pore." Journal of bioenergetics and biomembranes.. 2017 Feb 0; 49(1):13-25. Epub 2016 Feb 11.

Beutner G, Kambiz AN, Jonas EA, Porter GA. "The Mitochondrial Permeability Transition Pore and ATP Synthase." Handbook of experimental pharmacology.. 2016 Sep 3; Epub 2016 Sep 03.

Maruyama EO, Lin H, Chiu SY, Yu HM, Porter GA, Hsu W. "Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development." Scientific reports.. 2016 Feb 17; 6:20999. Epub 2016 Feb 17.