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George A. Porter, Jr., M.D., Ph.D.

Publications

Showing all 37 journal articles & 0 books available

Journal Articles

5/20/2019
"Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease." Scientific reports.. 2019 May 20; 9(1):7623. Epub 2019 May 20.

3/23/2019
"ORE Identifies Extreme Expression Effects Enriched for Rare Variants." Bioinformatics.. 2019 Mar 23; Epub 2019 Mar 23.

2/15/2019
"Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation." Archives of biochemistry and biophysics.. 2019 Feb 15; 662:177-189. Epub 2018 Dec 17.

2/2019
"Reply to 'Double-outlet right ventricle is not hypoplastic left heart syndrome'." Nature genetics.. 2019 Feb 0; 51(2):198-199.

11/1/2018
Malik S, Lambert E, Zhang J, Wang T, Clark HL, Cypress M, Goldman BI, Porter GA, Pena S, Nino W, Gray DA. "Potassium conservation is impaired in mice with reduced renal expression of Kir4.1." American journal of physiology. Renal physiology.. 2018 Nov 1; 315(5):F1271-F1282. Epub 2018 Aug 15.

5/4/2018
Peoples JNR, Maxmillian T, Le Q, Nadtochiy SM, Brookes PS, Porter GA, Davidson VL, Ebert SN. "Metabolomics reveals critical adrenergic regulatory checkpoints in glycolysis and pentose-phosphate pathways in embryonic heart." The Journal of biological chemistry.. 2018 May 4; 293(18):6925-6941. Epub 2018 Mar 14.

2018
"The Congenital Heart Disease Genetic Network Study: Cohort description." PloS one.. 2018 13(1):e0191319. Epub 2018 Jan 19.

11/3/2017
Beutner G, Alanzalon RE, Porter GA. "Cyclophilin D regulates the dynamic assembly of mitochondrial ATP synthase into synthasomes." Scientific reports.. 2017 Nov 3; 7(1):14488. Epub 2017 Nov 03.

11/2017
Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M. "Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands." Nature genetics.. 2017 Nov 0; 49(11):1593-1601. Epub 2017 Oct 09.

7/2017
Liu X, Yagi H, Saeed S, Bais AS, Gabriel GC, Chen Z, Peterson KA, Li Y, Schwartz MC, Reynolds WT, Saydmohammed M, Gibbs B, Wu Y, Devine W, Chatterjee B, Klena NT, Kostka D, de Mesy Bentley KL, Ganapathiraju MK, Dexheimer P, Leatherbury L, Khalifa O, Bhagat A, Zahid M, Pu W, Watkins S, Grossfeld P, Murray SA, Porter GA, Tsang M, Martin LJ, Woodrow Benson D, Aronow BJ, Lo CW. "The complex genetics of hypoplastic left heart syndrome." Nature genetics.. 2017 Jul 0; 49(7):1152-1159. Epub 2017 May 22.

6/1/2017
Beutner G, Porter GA. "Analyzing Supercomplexes of the Mitochondrial Electron Transport Chain with Native Electrophoresis, In-gel Assays, and Electroelution." Journal of visualized experiments : JoVE.. 2017 Jun 1; (124)Epub 2017 Jun 01.

6/2017
Lingan JV, Alanzalon RE, Porter GA. "Preventing permeability transition pore opening increases mitochondrial maturation, myocyte differentiation and cardiac function in the neonatal mouse heart." Pediatric research.. 2017 Jun 0; 81(6):932-941. Epub 2017 Jan 31.

2/2017
Mnatsakanyan N, Beutner G, Porter GA, Alavian KN, Jonas EA. "Physiological roles of the mitochondrial permeability transition pore." Journal of bioenergetics and biomembranes.. 2017 Feb 0; 49(1):13-25. Epub 2016 Feb 11.

2017
Yee, M.; Cohen, ED.; Domm, W.; Porter Jr, GA.; McDavid, A.; O'Reilly, MA. "Neonatal hyperoxia depletes pulmonary vein cardiomyocytes in adult mice via mitochondrial oxidation". American Journal of Physiology-Lung Cellular and Molecular Physiology. 2017; .

2017
Beutner G, Kambiz AN, Jonas EA, Porter GA. "The Mitochondrial Permeability Transition Pore and ATP Synthase." Handbook of experimental pharmacology.. 2017 240:21-46.

2/17/2016
Maruyama EO, Lin H, Chiu SY, Yu HM, Porter GA, Hsu W. "Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development." Scientific reports.. 2016 Feb 17; 6:20999. Epub 2016 Feb 17.

12/4/2015
Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK. "De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies." Science.. 2015 Dec 4; 350(6265):1262-6.

9/2015
Jonas EA, Porter GA, Beutner G, Mnatsakanyan N, Alavian KN. "Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase." Pharmacological research.. 2015 Sep 0; 99:382-92. Epub 2015 May 05.

7/22/2014
Alavian KN, Beutner G, Lazrove E, Sacchetti S, Park HA, Licznerski P, Li H, Nabili P, Hockensmith K, Graham M, Porter GA, Jonas EA. "An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore." Proceedings of the National Academy of Sciences of the United States of America.. 2014 Jul 22; 111(29):10580-5. Epub 2014 Jun 16.

6/15/2014
Porter GA, Urciuoli WR, Brookes PS, Nadtochiy SM. "SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts." American journal of physiology. Heart and circulatory physiology.. 2014 Jun 15; 306(12):H1602-9. Epub 2014 Apr 18.

2014
Jonas EA, Porter GA, Alavian KN. "Bcl-xL in neuroprotection and plasticity." Frontiers in physiology.. 2014 5:355. Epub 2014 Sep 17.

2014
Beutner G, Eliseev RA, Porter GA. "Initiation of electron transport chain activity in the embryonic heart coincides with the activation of mitochondrial complex 1 and the formation of supercomplexes." PloS one.. 2014 9(11):e113330. Epub 2014 Nov 26.

6/13/2013
Zaidi S, Choi M, Wakimoto H, Ma L, Jiang J, Overton JD, Romano-Adesman A, Bjornson RD, Breitbart RE, Brown KK, Carriero NJ, Cheung YH, Deanfield J, DePalma S, Fakhro KA, Glessner J, Hakonarson H, Italia MJ, Kaltman JR, Kaski J, Kim R, Kline JK, Lee T, Leipzig J, Lopez A, Mane SM, Mitchell LE, Newburger JW, Parfenov M, Pe'er I, Porter G, Roberts AE, Sachidanandam R, Sanders SJ, Seiden HS, State MW, Subramanian S, Tikhonova IR, Wang W, Warburton D, White PS, Williams IA, Zhao H, Seidman JG, Brueckner M, Chung WK, Gelb BD, Goldmuntz E, Seidman CE, Lifton RP. "De novo mutations in histone-modifying genes in congenital heart disease." Nature.. 2013 Jun 13; 498(7453):220-3. Epub 2013 May 12.

2/15/2013
, Gelb B, Brueckner M, Chung W, Goldmuntz E, Kaltman J, Kaski JP, Kim R, Kline J, Mercer-Rosa L, Porter G, Roberts A, Rosenberg E, Seiden H, Seidman C, Sleeper L, Tennstedt S, Kaltman J, Schramm C, Burns K, Pearson G, Rosenberg E. "The Congenital Heart Disease Genetic Network Study: rationale, design, and early results." Circulation research.. 2013 Feb 15; 112(4):698-706.

10/12/2012
Walters AM, Porter GA, Brookes PS. "Mitochondria as a drug target in ischemic heart disease and cardiomyopathy." Circulation research.. 2012 Oct 12; 111(9):1222-36.

9/13/2011
Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA. "The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation." Developmental cell.. 2011 Sep 13; 21(3):469-78.

5/2011
Porter GA, Hom J, Hoffman D, Quintanilla R, de Mesy Bentley K, Sheu SS. "Bioenergetics, mitochondria, and cardiac myocyte differentiation." Progress in pediatric cardiology.. 2011 May 0; 31(2):75-81.

2010
Hom J, Yu T, Yoon Y, Porter G, Sheu SS. "Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes." Biochimica et biophysica acta.. 2010 1797(6-7):913-21. Epub 2010 Mar 27.

2/10/2006
Lakhani SA, Masud A, Kuida K, Porter GA, Booth CJ, Mehal WZ, Inayat I, Flavell RA. "Caspases 3 and 7: key mediators of mitochondrial events of apoptosis." Science.. 2006 Feb 10; 311(5762):847-51.

6/2003
Porter GA, Makuck RF, Rivkees SA. "Intracellular calcium plays an essential role in cardiac development." Developmental dynamics : an official publication of the American Association of Anatomists.. 2003 Jun 0; 227(2):280-90.

8/9/2002
Porter GA, Makuck RF, Rivkees SA. "Reduction in intracellular calcium levels inhibits myoblast differentiation." The Journal of biological chemistry.. 2002 Aug 9; 277(32):28942-7. Epub 2002 May 31.

8/6/2002
Rentschler S, Zander J, Meyers K, France D, Levine R, Porter G, Rivkees SA, Morley GE, Fishman GI. "Neuregulin-1 promotes formation of the murine cardiac conduction system." Proceedings of the National Academy of Sciences of the United States of America.. 2002 Aug 6; 99(16):10464-9. Epub 2002 Jul 29.

8/2001
Porter GA, Rivkees SA. "Ontogeny of humoral heart rate regulation in the embryonic mouse." American journal of physiology. Regulatory, integrative and comparative physiology.. 2001 Aug 0; 281(2):R401-7.

1997
Porter GA, Scher MG, Resneck WG, Porter NC, Fowler VM, Bloch RJ. "Two populations of beta-spectrin in rat skeletal muscle." Cell motility and the cytoskeleton. 1997 37(1):7-19.

6/1992
Porter GA, Dmytrenko GM, Winkelmann JC, Bloch RJ. "Dystrophin colocalizes with beta-spectrin in distinct subsarcolemmal domains in mammalian skeletal muscle." The Journal of cell biology.. 1992 Jun 0; 117(5):997-1005.

1987
Murphy, CK.; Porter, GA.; Klebba, PE. "Heat modifiability of the Escherichia coli iron-regulated membrane proteins." Membrane Proteins, Proceedings of the Membrane Protein Symposium. 1987; : 149-160.

Yee, M.; Cohen, ED.; Domm, W.; Porter, Jr GA.; McDavid, A.; O'Reilly, MA. "Neonatal hyperoxia depletes pulmonary vein cardiomyocytes in adult mice via mitochondrial oxidation. American Journal of Physiology-Lung Cellular and Molecular Physiology. In revision.".