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Aram F. Hezel, M.D.

Publications

Showing all 69 journal articles & 1 books available

Journal Articles

8/19/2021
Ruffolo LI, Jackson KM, Kuhlers PC, Dale BS, Figueroa Guilliani NM, Ullman NA, Burchard PR, Qin SS, Juviler PG, Keilson JM, Morrison AB, Georger M, Jewell R, Calvi LM, Nywening TM, O'Dell MR, Hezel AF, De Las Casas L, Lesinski GB, Yeh JJ, Hernandez-Alejandro R, Belt BA, Linehan DC. "GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity." Gut.. 2021 Aug 19; Epub 2021 Aug 19.

7/13/2021
Mohamed MR, Kyi K, Mohile SG, Xu H, Culakova E, Loh KP, Flannery M, Obrecht S, Ramsdale E, Patil A, Dunne RF, DiGiovanni G, Hezel A, Burnette B, Desai N, Giguere J, Magnuson A. "Prevalence of and factors associated with treatment modification at first cycle in older adults with advanced cancer receiving palliative treatment." Journal of geriatric oncology.. 2021 Jul 13; Epub 2021 Jul 13.

4/14/2021
Vallejo A, Erice O, Entrialgo-Cadierno R, Feliu I, Guruceaga E, Perugorria MJ, Olaizola P, Muggli A, Macaya I, O'Dell M, Cordoba BR, Ortiz-Espinosa S, Hezel AF, Arozarena I, Lecanda F, Avila MA, Fernández-Barrena MG, Evert M, Ponz-Sarvise M, Calvisi DF, Banales JM, Vicent S. "FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted." Journal of hepatology.. 2021 Apr 14; Epub 2021 Apr 14.

12/1/2020
Väyrynen SA, Zhang J, Yuan C, Väyrynen JP, Dias Costa A, Williams H, Morales-Oyarvide V, Lau MC, Rubinson DA, Dunne RF, Kozak MM, Wang W, Agostini-Vulaj D, Drage MG, Brais LK, Reilly E, Rahma OE, Clancy TE, Wang J, Linehan DC, Aguirre A, Fuchs CS, Coussens LM, Chang DT, Koong AC, Hezel AF, Ogino S, Nowak JA, Wolpin BM. "Composition, spatial characteristics, and prognostic significance of myeloid cell infiltration in pancreatic cancer." Clinical cancer research : an official journal of the American Association for Cancer Research.. 2020 Dec 1; Epub 2020 Dec 01.

5/28/2020
Du C, da Silva A, Morales-Oyarvide V, Dias Costa A, Kozak MM, Dunne RF, Rubinson DA, Perez K, Masugi Y, Hamada T, Brais LK, Yuan C, Babic A, Ducar MD, Thorner AR, Aguirre A, Kulke MH, Ng K, Clancy TE, Findeis-Hosey JJ, Chang DT, Hornick JL, Fuchs CS, Ogino S, Koong AC, Hezel AF, Wolpin BM, Nowak JA. "Insulin-like growth factor-1 receptor expression and disease recurrence and survival in patients with resected pancreatic ductal adenocarcinoma." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2020 May 28; Epub 2020 May 28.

4/16/2020
Chung KM, Singh J, Lawres L, Dorans KJ, Garcia C, Burkhardt DB, Robbins R, Bhutkar A, Cardone R, Zhao X, Babic A, Vayrynen SA, Dias Costa A, Nowak JA, Chang DT, Dunne RF, Hezel AF, Koong AC, Wilhelm JJ, Bellin MD, Nylander V, Gloyn AL, McCarthy MI, Kibbey RG, Krishnaswamy S, Wolpin BM, Jacks T, Fuchs CS, Muzumdar MD. "Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma." Cell.. 2020 Apr 16; Epub 2020 Apr 16.

4/14/2020
Li F, Nielsen G, Baran A, Hu J, Wallace D, Preslar M, Fleming F, Temple L, Dunne RF, Noel M, Hezel AF, Tejani MA. "Adjuvant Chemotherapy Use in Patients With Locally Advanced Rectal Cancer: A Single-Institution Experience." Clinical colorectal cancer.. 2020 Apr 14; Epub 2020 Apr 14.

7/18/2019
O'Reilly EM, Oh DY, Dhani N, Renouf DJ, Lee MA, Sun W, Fisher G, Hezel A, Chang SC, Vlahovic G, Takahashi O, Yang Y, Fitts D, Philip PA. "Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma: A Phase 2 Randomized Clinical Trial." JAMA oncology.. 2019 Jul 18; Epub 2019 Jul 18.

1/2019
Yurgelun MB, Chittenden AB, Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Qian ZR, Welch MW, Brais LK, Da Silva A, Bui JL, Yuan C, Li T, Li W, Masuda A, Gu M, Bullock AJ, Chang DT, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar MD, Wollison BM, Khalaf N, Perez K, Syngal S, Aguirre AJ, Hahn WC, Meyerson ML, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Nowak JA, Wolpin BM. "Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer." Genetics in medicine : official journal of the American College of Medical Genetics.. 2019 Jan 0; 21(1):213-223. Epub 2018 Jul 02.

9/18/2018
Wang W, Friedland SC, Guo B, O'Dell MR, Alexander WB, Whitney-Miller CL, Agostini-Vulaj D, Huber AR, Myers JR, Ashton JM, Dunne RF, Steiner LA, Hezel AF. "ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas." Gut.. 2018 Sep 18; Epub 2018 Sep 18.

8/15/2018
Hill MA, Alexander WB, Guo B, Kato Y, Patra KC, O'Dell MR, McCall MN, Whitney-Miller CL, Bardeesy N, Hezel AF. "and Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma." Cancer research.. 2018 Aug 15; 78(16):4445-4451. Epub 2018 Jun 05.

8/2018
Fabrizio DA, George TJ, Dunne RF, Frampton G, Sun J, Gowen K, Kennedy M, Greenbowe J, Schrock AB, Hezel AF, Ross JS, Stephens PJ, Ali SM, Miller VA, Fakih M, Klempner SJ. "Beyond microsatellite testing: assessment of tumor mutational burden identifies subsets of colorectal cancer who may respond to immune checkpoint inhibition." Journal of gastrointestinal oncology.. 2018 Aug 0; 9(4):610-617.

3/8/2018
Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, Masugi Y, Bui J, Zellers CL, Yuan C, Babic A, Khalaf N, Aguirre A, Ng K, Miksad RA, Bullock AJ, Chang DT, Tseng JF, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar M, Wollison B, Laing A, Hahn WC, Meyerson M, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Wolpin BM. "Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma." JAMA oncology.. 2018 Mar 8; 4(3):e173420. Epub 2018 Mar 08.

3/2018
Leichman CG, McDonough SL, Smalley SR, Billingsley KG, Lenz HJ, Beldner MA, Hezel AF, Velasco MR, Guthrie KA, Blanke CD, Hochster HS. "Cetuximab Combined With Induction Oxaliplatin and Capecitabine, Followed by Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer: SWOG 0713." Clinical colorectal cancer.. 2018 Mar 0; 17(1):e121-e125. Epub 2017 Oct 24.

2/2018
Guo B, Lyu Q, Slivano OJ, Dirkx R, Christie CK, Czyzyk J, Hezel AF, Gharavi AG, Small EM, Miano JM. "Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function." Journal of the American Society of Nephrology : JASN.. 2018 Feb 0; 29(2):416-422. Epub 2017 Nov 07.

12/5/2017
Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Bui JL, Yuan C, Qian ZR, Babic A, Da Silva A, Nowak JA, Khalaf N, Brais LK, Welch MW, Zellers CL, Ng K, Chang DT, Miksad RA, Bullock AJ, Tseng JF, Swanson RS, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Hornick JL, Ogino S, Fuchs CS, Hezel AF, Koong AC, Wolpin BM. "Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival." British journal of cancer.. 2017 Dec 5; 117(12):1874-1882. Epub 2017 Oct 05.

12/2017
Dunne RF, Mustian KM, Garcia JM, Dale W, Hayward R, Roussel B, Buschmann MM, Caan BJ, Cole CL, Fleming FJ, Chakkalakal JV, Linehan DC, Hezel AF, Mohile SG. "Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia." Current opinion in supportive and palliative care.. 2017 Dec 0; 11(4):278-286.

7/2016
Saha SK, Gordan JD, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, Jenkins RL, Rieger-Christ KM, Sullivan TB, Hezel AF, Liss AS, Mizukami Y, Goyal L, Ferrone CR, Zhu AX, Joung JK, Shokat KM, Benes CH, Bardeesy N. "Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma." Cancer discovery.. 2016 Jul 0; 6(7):727-39. Epub 2016 May 26.

5/15/2016
Adjei AA, Richards DA, El-Khoueiry A, Braiteh F, Becerra CH, Stephenson JJ, Hezel AF, Sherman M, Garbo L, Leffingwell DP, Iverson C, Miner JN, Shen Z, Yeh LT, Gunawan S, Wilson DM, Manhard KJ, Rajagopalan P, Krissel H, Clendeninn NJ. "A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research.. 2016 May 15; 22(10):2368-76. Epub 2015 Dec 07.

5/2016
Deshpande V, Konstantinidis IT, Castillo CF, Hezel AF, Haigis KM, Ting DT, Bardeesy N, Goyal L, Zhu AX, Warshaw AL, Lillemoe KD, Ferrone CR. "Intra-pancreatic Distal Bile Duct Carcinoma is Morphologically, Genetically, and Clinically Distinct from Pancreatic Ductal Adenocarcinoma." Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.. 2016 May 0; 20(5):953-9. Epub 2016 Mar 08.

2016
Mohamed M, Katz AW, Tejani MA, Sharma AK, Kashyap R, Noel MS, Qiu H, Hezel AF, Ramaraju GA, Dokus MK, Orloff MS. "Comparison of outcomes between SBRT, yttrium-90 radioembolization, transarterial chemoembolization, and radiofrequency ablation as bridge to transplant for hepatocellular carcinoma." Advances in radiation oncology.. 2016 1(1):35-42. Epub 2015 Dec 29.

12/3/2015
Saha SK, Parachoniak CA, Ghanta KS, Fitamant J, Ross KN, Najem MS, Gurumurthy S, Akbay EA, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J, Popovici-Muller J, Gliser C, Ferrone CR, Apte U, Llovet JM, Wong KK, Ramaswamy S, Bardeesy N. "Corrigendum: Mutant IDH inhibits HNF-4? to block hepatocyte differentiation and promote biliary cancer." Nature.. 2015 Dec 3; 528(7580):152. Epub 2015 Nov 18.

8/2015
Dunne RF, Hezel AF. "Genetics and Biology of Pancreatic Ductal Adenocarcinoma." Hematology/oncology clinics of North America.. 2015 Aug 0; 29(4):595-608. Epub 2015 Jun 10.

7/1/2015
Ramanathan RK, McDonough SL, Kennecke HF, Iqbal S, Baranda JC, Seery TE, Lim HJ, Hezel AF, Vaccaro GM, Blanke CD. "Phase 2 study of MK-2206, an allosteric inhibitor of AKT, as second-line therapy for advanced gastric and gastroesophageal junction cancer: A SWOG cooperative group trial (S1005)." Cancer.. 2015 Jul 1; 121(13):2193-7. Epub 2015 Mar 30.

1/15/2015
Alagesan B, Contino G, Guimaraes AR, Corcoran RB, Deshpande V, Wojtkiewicz GR, Hezel AF, Wong KK, Loda M, Weissleder R, Benes CH, Engelman J, Bardeesy N. "Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer." Clinical cancer research : an official journal of the American Association for Cancer Research.. 2015 Jan 15; 21(2):396-404. Epub 2014 Oct 27.

9/4/2014
Saha SK, Parachoniak CA, Ghanta KS, Fitamant J, Ross KN, Najem MS, Gurumurthy S, Akbay EA, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J, Popovici-Muller J, Gliser C, Ferrone CR, Apte U, Llovet JM, Wong KK, Ramaswamy S, Bardeesy N. "Mutant IDH inhibits HNF-4? to block hepatocyte differentiation and promote biliary cancer." Nature.. 2014 Sep 4; 513(7516):110-4. Epub 2014 Jul 02.

7/29/2014
Hezel AF, Noel MS, Allen JN, Abrams TA, Yurgelun M, Faris JE, Goyal L, Clark JW, Blaszkowsky LS, Murphy JE, Zheng H, Khorana AA, Connolly GC, Hyrien O, Baran A, Herr M, Ng K, Sheehan S, Harris DJ, Regan E, Borger DR, Iafrate AJ, Fuchs C, Ryan DP, Zhu AX. "Phase II study of gemcitabine, oxaliplatin in combination with panitumumab in KRAS wild-type unresectable or metastatic biliary tract and gallbladder cancer." British journal of cancer.. 2014 Jul 29; 111(3):430-6. Epub 2014 Jun 24.

5/22/2014
Kinsey C, Balakrishnan V, O'Dell MR, Huang JL, Newman L, Whitney-Miller CL, Hezel AF, Land H. "Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression." Cell reports.. 2014 May 22; 7(4):1143-55. Epub 2014 May 01.

1/2014
Mazloom A, Hezel AF, Katz AW. "Stereotactic body radiation therapy as a bridge to transplantation and for recurrent disease in the transplanted liver of a patient with hepatocellular carcinoma." Case reports in oncology.. 2014 Jan 0; 7(1):18-22. Epub 2014 Jan 10.

12/2013
Goyal L, Supko JG, Berlin J, Blaszkowsky LS, Carpenter A, Heuman DM, Hilderbrand SL, Stuart KE, Cotler S, Senzer NN, Chan E, Berg CL, Clark JW, Hezel AF, Ryan DP, Zhu AX. "Phase 1 study of N(1),N(11)?diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma." Cancer chemotherapy and pharmacology.. 2013 Dec 0; 72(6):1305-14.

10/30/2013
Noel MS, Hezel AF. "New and emerging treatment options for biliary tract cancer." OncoTargets and therapy.. 2013 Oct 30; 6:1545-52. Epub 2013 Oct 30.

3/2013
McCleary NJ, Odejide O, Szymonifka J, Ryan D, Hezel A, Meyerhardt JA. "Safety and effectiveness of oxaliplatin-based chemotherapy regimens in adults 75 years and older with colorectal cancer." Clinical colorectal cancer.. 2013 Mar 0; 12(1):62-9. Epub 2012 Oct 24.

1/20/2013
Mondo EL, Noel MS, Katz AW, Schoeniger LO, Hezel AF. "Unresectable locally advanced pancreatic cancer: treatment with neoadjuvant leucovorin, fluorouracil, irinotecan, and oxaliplatin and assessment of surgical resectability." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2013 Jan 20; 31(3):e37-9. Epub 2012 Dec 10.

1/14/2013
Connolly GC, Safadjou S, Kashyap R, Chen R, Orloff MS, Hezel AF. "Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinoma." BMC gastroenterology. 2013 Jan 14; 13:9. Epub 2013 Jan 14.

12/2012
Connolly GC, Safadjou S, Chen R, Nduaguba A, Dunne R, Khorana AA, Hezel AF. "Diabetes mellitus is associated with the presence of metastatic spread at disease presentation in hepatocellular carcinoma." Cancer investigation.. 2012 Dec 0; 30(10):698-702. Epub 2012 Oct 16.

9/15/2012
Hezel AF, Deshpande V, Zimmerman SM, Contino G, Alagesan B, O'Dell MR, Rivera LB, Harper J, Lonning S, Brekken RA, Bardeesy N. "TGF-? and ?v?6 integrin act in a common pathway to suppress pancreatic cancer progression." Cancer research.. 2012 Sep 15; 72(18):4840-5. Epub 2012 Jul 11.

8/2012
Faris JE, Arnott J, Zheng H, Ryan DP, Abrams TA, Blaszkowsky LS, Clark JW, Enzinger PC, Hezel AF, Ng K, Wolpin BM, Kwak EL. "A phase 2 study of oral MKC-1, an inhibitor of importin-?, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer." Investigational new drugs.. 2012 Aug 0; 30(4):1614-20. Epub 2011 Jul 29.

7/1/2012
Katz AW, Chawla S, Qu Z, Kashyap R, Milano MT, Hezel AF. "Stereotactic hypofractionated radiation therapy as a bridge to transplantation for hepatocellular carcinoma: clinical outcome and pathologic correlation." International journal of radiation oncology, biology, physics.. 2012 Jul 1; 83(3):895-900. Epub 2011 Dec 13.

7/1/2012
Huang JL, Hezel AF. "Autophagy in intra-hepatic cholangiocarcinoma." Autophagy.. 2012 Jul 1; 8(7):1148-9. Epub 2012 Jul 01.

4/27/2012
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA. "Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism." Cell.. 2012 Apr 27; 149(3):656-70.

3/15/2012
O'Dell MR, Huang JL, Whitney-Miller CL, Deshpande V, Rothberg P, Grose V, Rossi RM, Zhu AX, Land H, Bardeesy N, Hezel AF. "Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma." Cancer research.. 2012 Mar 15; 72(6):1557-67. Epub 2012 Jan 20.

2012
Borger DR, Tanabe KK, Fan KC, Lopez HU, Fantin VR, Straley KS, Schenkein DP, Hezel AF, Ancukiewicz M, Liebman HM, Kwak EL, Clark JW, Ryan DP, Deshpande V, Dias-Santagata D, Ellisen LW, Zhu AX, Iafrate AJ. "Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping." The oncologist.. 2012 17(1):72-9. Epub 2011 Dec 16.

2012
Wadlow RC, Hezel AF, Abrams TA, Blaszkowsky LS, Fuchs CS, Kulke MH, Kwak EL, Meyerhardt JA, Ryan DP, Szymonifka J, Wolpin BM, Zhu AX, Clark JW. "Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab." The oncologist.. 2012 17(1):14. Epub 2011 Dec 30.

7/2011
Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, DePinho RA. "PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-?B-cytokine network." Cancer discovery.. 2011 Jul 0; 1(2):158-69. Epub 2011 May 23.

7/2011
Alexander BM, Fernandez-Del Castillo C, Ryan DP, Kachnic LA, Hezel AF, Niemierko A, Willett CG, Kozak KR, Blaszkowsky LS, Clark JW, Warshaw AL, Hong TS. "Intraductal papillary mucinous adenocarcinoma of the pancreas: clinical outcomes, prognostic factors, and the role of adjuvant therapy." Gastrointestinal cancer research : GCR.. 2011 Jul 0; 4(4):116-21.

2/8/2011
Deshpande V, Nduaguba A, Zimmerman SM, Kehoe SM, Macconaill LE, Lauwers GY, Ferrone C, Bardeesy N, Zhu AX, Hezel AF. "Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma." BMC cancer.. 2011 Feb 8; 11:60. Epub 2011 Feb 08.

2/2011
Zhu AX, Hezel AF. "Development of molecularly targeted therapies in biliary tract cancers: reassessing the challenges and opportunities." Hepatology : official journal of the American Association for the Study of Liver Diseases.. 2011 Feb 0; 53(2):695-704.

7/20/2010
Hezel AF, Deshpande V, Zhu AX. "Genetics of biliary tract cancers and emerging targeted therapies." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2010 Jul 20; 28(21):3531-40. Epub 2010 Jun 14.

2010
Zhu AX, Hong TS, Hezel AF, Kooby DA. "Current management of gallbladder carcinoma." The oncologist.. 2010 15(2):168-81. Epub 2010 Feb 10.

6/20/2009
Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK. "Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2009 Jun 20; 27(18):3027-35. Epub 2009 May 26.

5/2009
Plentz R, Park JS, Rhim AD, Abravanel D, Hezel AF, Sharma SV, Gurumurthy S, Deshpande V, Kenific C, Settleman J, Majumder PK, Stanger BZ, Bardeesy N. "Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma." Gastroenterology.. 2009 May 0; 136(5):1741-9.e6. Epub 2009 Jan 14.

1/10/2009
Wolpin BM, Hezel AF, Abrams T, Blaszkowsky LS, Meyerhardt JA, Chan JA, Enzinger PC, Allen B, Clark JW, Ryan DP, Fuchs CS. "Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2009 Jan 10; 27(2):193-8. Epub 2008 Dec 01.

12/9/2008
Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RA. "Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer." Proceedings of the National Academy of Sciences of the United States of America.. 2008 Dec 9; 105(49):19372-7. Epub 2008 Dec 02.

11/24/2008
Hezel AF, Bardeesy N. "LKB1; linking cell structure and tumor suppression." Oncogene.. 2008 Nov 24; 27(55):6908-19.

9/2008
Hezel AF, Bardeesy N. "Prognostic markers in pancreatic ductal adenocarcinomas." Cancer biology & therapy.. 2008 Sep 0; 7(9):1360-1. Epub 2008 Sep 06.

4/2008
Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA. "Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms." Molecular and cellular biology.. 2008 Apr 0; 28(7):2414-25. Epub 2008 Jan 28.

4/2008
Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK. "Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer." Carcinogenesis.. 2008 Apr 0; 29(4):747-53. Epub 2008 Feb 17.

4/2008
Hezel AF, Zhu AX. "Systemic therapy for biliary tract cancers." The oncologist.. 2008 Apr 0; 13(4):415-23.

1/1/2008
Gurumurthy S, Hezel AF, Sahin E, Berger JH, Bosenberg MW, Bardeesy N. "LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis." Cancer research.. 2008 Jan 1; 68(1):55-63.

6/2007
Hezel AF, Ryan DP. "Emerging therapies for colorectal cancer." Expert opinion on investigational drugs.. 2007 Jun 0; 16(6):867-76.

2007
Geyer N, Bartges JW, Kirk CA, Cox S, Hezel A, Moyers T, Hayes J. "Influence of prednisolone on urinary calcium oxalate and struvite relative supersaturation in healthy young adult female domestic shorthaired cats." Veterinary therapeutics : research in applied veterinary medicine. 2007 8(4):239-46.

11/15/2006
Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA. "Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer." Genes & development.. 2006 Nov 15; 20(22):3130-46.

5/15/2006
Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA. "Genetics and biology of pancreatic ductal adenocarcinoma." Genes & development.. 2006 May 15; 20(10):1218-49.

4/11/2006
Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA. "Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse." Proceedings of the National Academy of Sciences of the United States of America.. 2006 Apr 11; 103(15):5947-52. Epub 2006 Apr 03.

3/30/2006
Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK. "K-ras activation generates an inflammatory response in lung tumors." Oncogene.. 2006 Mar 30; 25(14):2105-12.

3/2005
Hezel AF, Bardeesy N, Maser RS. "Telomere induced senescence: end game signaling." Current molecular medicine.. 2005 Mar 0; 5(2):145-52.

9/12/2002
Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. "Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation." Nature.. 2002 Sep 12; 419(6903):162-7.

3/2001
Bardeesy N, Bastian BC, Hezel A, Pinkel D, DePinho RA, Chin L. "Dual inactivation of RB and p53 pathways in RAS-induced melanomas." Molecular and cellular biology.. 2001 Mar 0; 21(6):2144-53.

2/4/1999
Giese H, Dollé ME, Hezel A, van Steeg H, Vijg J. "Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA." Oncogene.. 1999 Feb 4; 18(5):1257-60.

Books & Chapters

2007
Chapter Title: "Stromal biology of pancreatic cancer."
Book Title: Journal of cellular biochemistry
Author List: Chu GC; Kimmelman AC; Hezel AF; DePinho RA
Published By: Journal of Cellular Biochemistry2007