Awards
2022 - 2027
Cancer Grand Challenges: Understand and Reverse Cachexia
Sponsor: National Cancer Institute and Cancer Research UK
2019 - 2021
CTSI KL2 Career Development Award
Location: University of Rochester Medical Center
2017 - 2018
Department of Medicine Research Pilot Grant Award
2016 - 2019
NIH R25 Fellowship Training Program in Cancer Control
Location: University of Rochester Medical Center
2015 - 2018
Wilmot Foundation for Cancer Research Fellowship Award
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Clinical Trials
UGIM-16011: Evaluating the Effects of a 12 Week Home-based Exercise Intervention on Physical Performance in patients with Cancer of the Upper Gastrointestinal Tract with Pre-cachexia or Cachexia: A Pilot Study
Lead Researcher: Richard F Dunne
We would also like to find out if this exercise intervention improves physical performance, day-to-day function, quality of life, and how the exercise may affect markers of inflammation in the blood over time.
Cancer cachexia is a complex condition that can result in weight loss, muscle weakness, and/or tiredness, and may affect your normal daily activities and quality of life. Cachexia is common in patients with upper gastrointestinal tract cancers (esophageal, stomach, bile duct or liver cancer, and pancreatic cancer). There is little information on how these symptoms may develop or change as cachexia progresses, or how exercise may help improve these symptoms. Currently more information is needed on how physical performance and quality of life is affected by cachexia. There are no drugs approved for cachexia so understanding cachexia and its effect on the body may guide the development of interventions to help other patients with cancer cachexia.
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Publications
Journal Articles
12/2/2022
Williams HL, Dias Costa A, Zhang J, Raghavan S, Winter PS, Kapner KS, Ginebaugh SP, Väyrynen SA, Väyrynen JP, Yuan C, Navia AW, Wang J, Yang A, Bosse TL, Kalekar RL, Lowder KE, Lau MC, Elganainy D, Morales-Oyarvide V, Rubinson DA, Singh H, Perez K, Cleary JM, Clancy TE, Wang J, Mancias JD, Brais LK, Hill ER, Kozak MM, Linehan DC, Dunne RF, Chang DT, Koong AC, Hezel AF, Hahn WC, Shalek AK, Aguirre AJ, Nowak JA, Wolpin BM. "Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity." Cancer research.. 2022 Dec 2; Epub 2022 Dec 02.
11/28/2022
Loria A, Glance LG, Melucci AD, Boodry C, Justiniano CF, Dunne RF, Mustian KM, Becerra AZ, Jusko TA, Temple LK, Fleming FJ. "Low Preoperative Serum Creatinine is Common and Associated with Poor outcomes following Non-emergent Inpatient Surgery." Annals of surgery.. 2022 Nov 28; Epub 2022 Nov 28.
9/22/2022
Dunne RF, Roeland EJ. "The Interplay Among Pancreatic Cancer, Cachexia, Body Composition, and Diabetes." Hematology/oncology clinics of North America.. 2022 Sep 22; Epub 2022 Sep 22.
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