Clinical Trials
UGIM-16011: Evaluating the Effects of a 12 Week Home-based Exercise Intervention on Physical Performance in patients with Cancer of the Upper Gastrointestinal Tract with Pre-cachexia or Cachexia: A Pilot Study
Lead Researcher: Richard F Dunne
We would also like to find out if this exercise intervention improves physical performance, day-to-day function, quality of life, and how the exercise may affect markers of inflammation in the blood over time.
Cancer cachexia is a complex condition that can result in weight loss, muscle weakness, and/or tiredness, and may affect your normal daily activities and quality of life. Cachexia is common in patients with upper gastrointestinal tract cancers (esophageal, stomach, bile duct or liver cancer, and pancreatic cancer). There is little information on how these symptoms may develop or change as cachexia progresses, or how exercise may help improve these symptoms. Currently more information is needed on how physical performance and quality of life is affected by cachexia. There are no drugs approved for cachexia so understanding cachexia and its effect on the body may guide the development of interventions to help other patients with cancer cachexia.
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Publications
Journal Articles
7/15/2022
Ullman NA, Burchard PR, Dunne RF, Linehan DC. "Immunologic Strategies in Pancreatic Cancer: Making Tumors ." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2022 Jul 15; :JCO2102616. Epub 2022 Jul 15.
4/28/2022
Garcia-Aguilar J, Patil S, Gollub MJ, Kim JK, Yuval JB, Thompson HM, Verheij FS, Omer DM, Lee M, Dunne RF, Marcet J, Cataldo P, Polite B, Herzig DO, Liska D, Oommen S, Friel CM, Ternent C, Coveler AL, Hunt S, Gregory A, Varma MG, Bello BL, Carmichael JC, Krauss J, Gleisner A, Paty PB, Weiser MR, Nash GM, Pappou E, Guillem JG, Temple L, Wei IH, Widmar M, Lin S, Segal NH, Cercek A, Yaeger R, Smith JJ, Goodman KA, Wu AJ, Saltz LB. "Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2022 Apr 28; :JCO2200032. Epub 2022 Apr 28.
3/1/2022
Jensen-Battaglia M, Lei L, Xu H, Kehoe L, Patil A, Loh KP, Ramsdale E, Magnuson A, Kleckner AS, Wildes TM, Lin PJ, Mustian KM, Giri G, Whitehead M, Bearden J, Burnette BL, Geer J, Mohile SG, Dunne RF. "Association of Oncologist-Patient Communication With Functional Status and Physical Performance in Older Adults: A Secondary Analysis of a Cluster Randomized Clinical Trial." JAMA network open.. 2022 Mar 1; 5(3):e223039. Epub 2022 Mar 01.
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