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Carol Fries Simpson, M.D.

Contact Information

Phone Numbers

Appointment: (585) 275-2981

Administrative: (585) 275-2981

Office: (585) 275-2981

Fax: (585) 273-1039

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Setting

Pediatrics

Biography

Dr. Fries’ clinical interests include the evaluation, management, and surveillance of children and adolescents affected by pediatric cancers and blood disorders. She is also an early-career physician/scientist studying the genetic and molecular mechanisms of the most common childhood malignancy, acute lymphoblastic leukemia (ALL). Her ultimate career goal is to improve the personalization of therapy and minimize unnecessary treatment-related toxicity for children and adolescents affected by cancer.

Professional Background

Dr. Fries is a pediatric hematologist/oncologist at the University of Rochester. She completed medical school at the State University of New York Upstate Medical University in Syracuse, NY, followed by pediatric residency, chief residency, and fellowship training at the University of Rochester.

Research

Dr. Fries is an early-career physician/scientist studying the mechanisms of genetic diversity in acute lymphoblastic leukemia (ALL). Her ultimate goal is to construct a career niche focused on improving patient risk stratification and minimizing unnecessary treatment toxicity for affected patients. She has been trained in deep sequencing methods for evaluating subclone variability in lymphoid malignancies and has used ultradeep sequencing of the immunoglobulin heavy chain (IGH) to study ALL subclone variability. Her work has revealed variable mutagenic activity in the genetic drivers of leukemogenesis between leukemic subclones and has demonstrated the feasibility of using the IGH locus to investigate unique subclone characteristics within each patient’s disease.

Credentials

Specialties

  • Pediatrics - American Board of Pediatrics

Education

2012
MD | Upstate Medical University

Post-doctoral Training & Residency

07/01/2016 - 10/05/2019
Fellowship in Pediatric Hematology/Oncology at University of Rochester Medical Center

06/25/2013 - 06/24/2015
Residency in Pediatrics at University of Rochester Medical Center

06/12/2012 - 06/24/2013
Internship in Pediatrics at University of Rochester Medical Center

06/25/15 - 06/23/2016
Residency in Pediatrics at University of Rochester Medical Center

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Awards

2017 - 2019
Department of Pediatrics Dean's Fellowship
Sponsor: University of Rochester
Location: Rochester, New York

2017 - 2017
Fellow Teaching Award
Sponsor: University of Rochester
Location: Rochester, New York

2015 - 2015
House Staff Teaching Award
Sponsor: University of Rochester
Location: Rochester, New York

2014 - 2015
Rochester General Hospital Chief Roundtable Honor
Sponsor: Rochester Regional Health System
Location: Rochester, New York

2014 - 2014
Excellence in Neonatology Award
Sponsor: University of Rochester
Location: Rochester, New York

2012 - 2012
Gold Humanism Honor Society
Sponsor: SUNY Upstate Medical University
Location: Syracuse, NY

2012 - 2012
Herbert Lourie, MD Award
Sponsor: SUNY Upstate Medical University
Location: Syracuse, NY

2008 - 2008
John T. Lowry Jr. Prize for the Outstanding Graduate in Biology
Sponsor: Bucknell University
Location: Lewisburg, PA

2008 - 2008
Phi Beta Kappa
Sponsor: Bucknell University
Location: Lewisburg, PA

2008 - 2008
Phi Sigma Biological Sciences Honor Society
Sponsor: Bucknell University
Location: Lewisburg, PA

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Publications

Journal Articles

4/11/2020
Fries C, Adlowitz DG, Spence JM, Spence JP, Rock PJ, Burack WR. "Acute lymphoblastic leukemia clonal distribution between bone marrow and peripheral blood." Pediatric blood & cancer.. 2020 Apr 11; :e28280. Epub 2020 Apr 11.

1/2019
Fries C, Burack R. "An evolving technology for an evolving disease: A commentary on NGS-based MRD evaluation in B-ALL." Leukemia research.. 2019 Jan 0; 76:105-106. Epub 2018 Nov 16.

2019
Fries C & O'Dwyer K. ""On the road to a better CAR: Identifying the variables associated with a durable response to CAR-T cell therapy in relapsed/refractory B-ALL."" . The Hematologist. 2019; 16(4).

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