Carol Fries Simpson, M.D.

About Me

Dr. Fries’ clinical interests include the evaluation, management, and surveillance of children and adolescents affected by pediatric cancers and blood disorders. She is also an early-career physician/scientist studying the genetic and molecular mechanisms of the most common childhood malignancy, acu...

Dr. Fries’ clinical interests include the evaluation, management, and surveillance of children and adolescents affected by pediatric cancers and blood disorders. She is also an early-career physician/scientist studying the genetic and molecular mechanisms of the most common childhood malignancy, acute lymphoblastic leukemia (ALL). Her ultimate career goal is to improve the personalization of therapy and minimize unnecessary treatment-related toxicity for children and adolescents affected by cancer.

Professional Background

Dr. Fries is a pediatric hematologist/oncologist at the University of Rochester. She completed medical school at the State University of New York Upstate Medical University in Syracuse, NY, followed by pediatric residency, chief residency, and fellowship training at the University of Rochester.

Faculty Appointments

Assistant Professor - Department of Pediatrics, Hematology and Oncology (SMD)

Assistant Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Credentials

Residency & Fellowship

Fellowship, Pediatric Hematology-Oncology, University of Rochester Medical Center. 2016 - 2019

Residency, Pediatrics, University of Rochester Medical Center. 2015 - 2016

Residency, Pediatrics, University of Rochester Medical Center. 2013 - 2015

Internship, Pediatrics, University of Rochester Medical Center. 2012 - 2013

Awards

Clinical and Translational Science Institute (CTSI) Pilot Studies Trainee Award. 2018 - 2019

Department of Pediatrics Dean's Fellowship. 2017 - 2019

Fellow Teaching Award. 2017 - 2017

House Staff Teaching Award. 2015 - 2015

Rochester General Hospital Chief Roundtable Honor. 2014 - 2015

Excellence in Neonatology Award. 2014 - 2014

Gold Humanism Honor Society. 2012 - 2012

Herbert Lourie, MD Award. 2012 - 2012

John T. Lowry Jr. Prize for the Outstanding Graduate in Biology. 2008 - 2008

Phi Beta Kappa. 2008 - 2008

Phi Sigma Biological Sciences Honor Society. 2008 - 2008

Research

Dr. Fries is an early-career physician/scientist with an interest in translational research efforts to improve the care of children with lymphoid malignancies, particularly acute lymphoblastic leukemia (ALL) and lymphoma. Her ultimate goal is to construct a career niche focused on improving patient ...

Dr. Fries is an early-career physician/scientist with an interest in translational research efforts to improve the care of children with lymphoid malignancies, particularly acute lymphoblastic leukemia (ALL) and lymphoma. Her ultimate goal is to construct a career niche focused on improving patient risk stratification to prevent relapse while minimizing unnecessary treatment toxicity. She has been trained in deep sequencing methods for evaluating genetic variation in lymphoid malignancies, with a particular interest in immunoglobulin sequencing techniques for the study of diverse clonal composition in B cell ALL.

Publications

Journal Articles

How I approach B-lymphoblastic lymphoma in children.

Devine KJ, Fries C, Hermiston M, Wistinghausen B

Pediatric blood & cancer.. 2023 May 9 :e30401. Epub 05/09/2023.

Prognostic impact of pre-treatment immunoglobulin clonal composition in pediatric Blymphoblastic leukemia.

Fries C, Lee LW, Devidas M, Dai Y, Rabin KR, Gupta S, Loh ML, Kirsch IR, Wood B, Rau RE

Haematologica.. 2022 November 3 Epub 11/03/2022.

Allogeneic Bone Marrow Transplant as a Cure for Refractory T-Cell Large Granular Lymphocytic Leukemia in an Adolescent.

Fries C, Evans AG, Cheon H, Korones DN, Loughran TP, Andolina JR

Journal of pediatric hematology/oncology.. 2022 August 144 (6):e960-e963. Epub 12/29/2021.

Migratory Arthralgia in a 3-year-old Girl.

Fries C, Long AM, Marston BA, Andolina JR

Pediatrics in review. 2022 January 143 (1):41-44. Epub 1900 01 01.

Transplacental transfer of congenital B-cell acute lymphoblastic leukemia to the maternal vasculature.

Fries C, Noronha SA, Metlay L, Zhang B

Pediatric blood & cancer.. 2021 June 14 :e29142. Epub 06/14/2021.

Myeloablative Carboplatin and Thiotepa With Autologous Stem Cell Rescue for Nonmedulloblastoma High-risk CNS Tumors in Young Children.

Fries C, Girvin AR, Korones DN, Weintraub L, Fitzpatrick L, Andolina JR

Journal of pediatric hematology/oncology.. 2021 May 18 Epub 05/18/2021.

Successful Bone Marrow Transplantation With Intensive Post-transplant Intrathecal Chemotherapy for CNS Relapsed AML in 2 Infants.

Andolina JR, Fries C, Boulware R, Vargas A, Fraint E, Barth M, Abrusko S, Comito M, Monteleone P

Journal of pediatric hematology/oncology.. 2021 April 9 Epub 04/09/2021.

Acute lymphoblastic leukemia clonal distribution between bone marrow and peripheral blood.

Fries C, Adlowitz DG, Spence JM, Spence JP, Rock PJ, Burack WR

Pediatric blood & cancer.. 2020 April 11 :e28280. Epub 04/11/2020.

An evolving technology for an evolving disease: A commentary on NGS-based MRD evaluation in B-ALL.

Fries C, Burack R

Leukemia research.. 2019 January 76 :105-106. Epub 11/16/2018.

"On the road to a better CAR: Identifying the variables associated with a durable response to CAR-T cell therapy in relapsed/refractory B-ALL."

O'Dwyer K, Fries C.

The Hematologist. 2019; 16(4).

A clinical perspective on immunoglobulin heavy chain clonal heterogeneity in B cell acute lymphoblastic leukemia.

Fries C, Burack WR

Leukemia research.. 2018 December 75 :15-22. Epub 11/03/2018.

Ratings & Reviews

At URMC, we believe that patients should be empowered to make the right decisions regarding their personal healthcare. To do so, transparency is critical. URMC partners with Press Ganey, to survey our patients about all aspects of their care experience. We are now putting this pertinent information at your fingertips by displaying star ratings for our providers along with anonymous patient comments on our website. This will help you make better-informed choices about how and with whom you seek care. Click here to learn more about the surveys used to generate this vital information. Learn more about our survey process.