Phase I Integrated Biomarker Trial of VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Pancreatic and Colorectal Cancer
Lead Researcher: David C Linehan
This randomized phase I trial studies how well a monoclonal antibody, anti-SEMA4D monoclonal antibody VX15/2503, works in treating patients with stage I-III pancreatic cancer. It will be used with or without another monoclonal antibody, ipilimumab or nivolumab. Monoclonal antibodies, such as anti-SEMA4D monoclonal antibody VX15/2503, ipilimumab, and nivolumab, may interfere with the ability of tumor cells to grow and spread.
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Han BJ, Murphy JD, Qin S, Ye J, Uccello TP, Garrett-Larsen J, Belt BA, Prieto PA, Egilmez NK, Lord EM, Linehan DC, Mills BN, Gerber SA. "Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma." Immunological investigations.. 2020 Jun 4; :1-16. Epub 2020 Jun 04.
Dang HX, Krasnick BA, White BS, Grossman JG, Strand MS, Zhang J, Cabanski CR, Miller CA, Fulton RS, Goedegebuure SP, Fronick CC, Griffith M, Larson DE, Goetz BD, Walker JR, Hawkins WG, Strasberg SM, Linehan DC, Lim KH, Lockhart AC, Mardis ER, Wilson RK, Ley TJ, Maher CA, Fields RC. "The clonal evolution of metastatic colorectal cancer." Science advances.. 2020 Jun 0; 6(24):eaay9691. Epub 2020 Jun 10.
DeCaporale-Ryan LN, Salloum R, Linehan DC. "We Orient Residents to Surgical Life: Why Not Their Families Too?" Journal of surgical education.. 2020 Mar 13; Epub 2020 Mar 13.
Books & Chapters
Book Title: Surgery of the Liver, Biliary Tract and Pancreas
Author List: Linehan DC and Jarnagin WR
Edited By: Blumgart LH, Editor-in-Chief
Published By: Elsevier 2007 in Philadelphia
Chapter Title: Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy
Book Title: Malignant Liver Tumors: Current and Emerging Therapies
Author List: Strasberg SM and Linehan DC
Published By: Bartlett and Barnes 2002 in Chicago
Chapter Title: Active Immunotherapy
Book Title: Surgical Research
Author List: Linehan DC; Amos K; Eberlein TJ
Edited By: Souba WW and Wilmore, DW
Published By: Academic Press 2001 in San Diego, CA
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