David C. Linehan, M.D.

Dr. Linehan graduated from the University of Massachusetts Medical School then completed his internship and residency at Deaconess-Harvard Surgical Service. He was chief resident in Surgery at Beth Israel Deaconess Medical Center. He completed a research fellowship at Brigham and Women's Hospital and was then the Kristin Ann Carr Fellow in Surgical Oncology at Memorial Sloan-Kettering Cancer Center.
A cancer surgeon, Dr. Linehan specializes in treating cancers of the liver, pancreas, and gastric and biliary tract. At Washington University, he was recognized for bringing novel and innovative therapies to patients with hard-to-treat cancers. He also brought a compassionate, patient-centered approach to a high-volume surgical oncology practice. Dr. Linehan also treats benign surgical conditions of the liver, pancreas, gallbladder and bile ducts.
Dr. Linehan is an internationally renowned researcher, with more than 85 publications. His primary area of research is finding new ways to attack the biology of pancreatic tumors, such as through drug and genetic therapies.

Credentials

Education

1990
MD | University of Massachusetts Medical School

Post-doctoral Training & Residency

07/01/1997 - 06/30/1999
Fellowship in Surgical Oncology at Memorial Sloan-Kettering Cancer Center

09/01/1996 - 06/30/1997
Fellowship in Surgery (General Surgery) at Beth Israel Deaconess Medical Center-Main Campus

08/01/1993 - 06/01/1995
Fellowship at Brigham & Womens Hospital

09/01/1991 - 06/30/1996
Residency in Surgery (General Surgery) at Beth Israel Deaconess Medical Center-Main Campus

09/01/1990 - 06/30/1991
Internship in Surgery (General Surgery) at Beth Israel Deaconess Medical Center-Main Campus

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Awards

2012
Inaugural Gerry O'Sullivan Memorial Lecturer Award
Sponsor: University College
Location: Cork, Ireland

2006
CTRF Superhero Cancer Researcher Award
Location: Chicago, IL

2004
Evarts A. Graham Teaching Award
Sponsor: Washington University School of Medicine
Location: St. Louis, MO

1999
Young Investigator Award
Sponsor: American Society of Clinical Oncology

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Publications

Journal Articles

5/2023
Ye J, Gavras NW, Keeley DC, Hughson AL, Hannon G, Vrooman TG, Lesch ML, Johnston CJ, Lord EM, Belt BA, Linehan DC, Eyles J, Gerber SA. "CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models." Journal for immunotherapy of cancer.. 2023 May; 11(5)

12/2/2022
Williams HL, Dias Costa A, Zhang J, Raghavan S, Winter PS, Kapner KS, Ginebaugh SP, Väyrynen SA, Väyrynen JP, Yuan C, Navia AW, Wang J, Yang A, Bosse TL, Kalekar RL, Lowder KE, Lau MC, Elganainy D, Morales-Oyarvide V, Rubinson DA, Singh H, Perez K, Cleary JM, Clancy TE, Wang J, Mancias JD, Brais LK, Hill ER, Kozak MM, Linehan DC, Dunne RF, Chang DT, Koong AC, Hezel AF, Hahn WC, Shalek AK, Aguirre AJ, Nowak JA, Wolpin BM. "Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity." Cancer research.. 2022 Dec 2; Epub 2022 Dec 02.

10/3/2022
Uccello TP, Lecsh ML, Ullman NA, Kintzel SA, Gradzewicz LB, Velagaleti T, Fleming FJ, Mills BN, Murphy JD, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Johnston CJ, Love TMT, Repasky EA, Linehan DC, Lord EM, Gerber SA. "Radiotherapy exacerbates tumor-promoting innervation and nerve signaling in rectal cancer." International journal of radiation oncology, biology, physics.. 2022 Oct 3; Epub 2022 Oct 03.

Books & Chapters

2007
Book Title: Surgery of the Liver, Biliary Tract and Pancreas
Author List: Linehan DC and Jarnagin WR
Edited By: Blumgart LH, Editor-in-Chief
Published By: Elsevier 2007 in Philadelphia

2002
Chapter Title: Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy
Book Title: Malignant Liver Tumors: Current and Emerging Therapies
Author List: Strasberg SM and Linehan DC
Published By: Bartlett and Barnes 2002 in Chicago

2001
Chapter Title: Soft Tissue Sarcoma
Book Title: Surgical Treatment: Evidence-Based and Problem Oriented
Author List: Linehan DC and Brennan MF
Edited By: Holzheimer RG and Mannick JA
Published By: W Zuckschwerdt Verlag 2001 in Munch

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