David C. Linehan, M.D.

Dr. Linehan graduated from the University of Massachusetts Medical School then completed his internship and residency at Deaconess-Harvard Surgical Service. He was chief resident in Surgery at Beth Israel Deaconess Medical Center. He completed a research fellowship at Brigham and Women's Hospital and was then the Kristin Ann Carr Fellow in Surgical Oncology at Memorial Sloan-Kettering Cancer Center.
A cancer surgeon, Dr. Linehan specializes in treating cancers of the liver, pancreas, and gastric and biliary tract. At Washington University, he was recognized for bringing novel and innovative therapies to patients with hard-to-treat cancers. He also brought a compassionate, patient-centered approach to a high-volume surgical oncology practice. Dr. Linehan also treats benign surgical conditions of the liver, pancreas, gallbladder and bile ducts.
Dr. Linehan is an internationally renowned researcher, with more than 85 publications. His primary area of research is finding new ways to attack the biology of pancreatic tumors, such as through drug and genetic therapies.

Credentials

Specialties

Surgery - American Board of Surgery

Education

1990
MD | University of Massachusetts Medical Center

Post-doctoral Training & Residency

07/01/1997 - 06/30/1999
Fellowship in Surgical Oncology at Memorial Sloan-Kettering Cancer Center

09/01/1996 - 06/30/1997
Fellowship in Surgery at Beth Israel Deaconess Medical Center

08/01/1993 - 06/01/1995
Fellowship in at Brigham and Women's Hospital

09/01/1991 - 06/30/1996
Residency in Surgery at Beth Israel Deaconess Medical Center

09/01/1990 - 06/30/1991
Internship in Surgery at Beth Israel Deaconess Medical Center

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Awards

2012
Inaugural Gerry O'Sullivan Memorial Lecturer Award
Sponsor: University College
Location: Cork, Ireland

2006
CTRF Superhero Cancer Researcher Award
Location: Chicago, IL

2004
Evarts A. Graham Teaching Award
Sponsor: Washington University School of Medicine
Location: St. Louis, MO

1999
Young Investigator Award
Sponsor: American Society of Clinical Oncology

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Clinical Trials

Phase I Integrated Biomarker Trial of VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Pancreatic and Colorectal Cancer

Lead Researcher: David C Linehan

This randomized phase I trial studies how well anti-semaphorin 4D (anti-SEMA4D) monoclonal antibody VX15/2503 with or without ipilimumab or nivolumab work in treating patients with stage I-III pancreatic cancer that can be removed by surgery or stage IV colorectal cancer that has spread to the liver and can be removed by surgery. Monoclonal antibodies, such as anti-SEMA4D monoclonal antibody VX15/2503, ipilimumab, and nivolumab, may interfere with the ability of tumor cells to grow and spread.

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Publications

Journal Articles

7/2020
Ahmed R, Ye J, Gerber SA, Linehan DC, Doyley MM. "Preclinical Imaging Using Single Track Location Shear Wave Elastography: Monitoring the Progression of Murine Pancreatic Tumor Liver Metastasis In Vivo." IEEE transactions on medical imaging.. 2020 Jul 0; 39(7):2426-2439. Epub 2020 Feb 03.

6/4/2020
Han BJ, Murphy JD, Qin S, Ye J, Uccello TP, Garrett-Larsen J, Belt BA, Prieto PA, Egilmez NK, Lord EM, Linehan DC, Mills BN, Gerber SA. "Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma." Immunological investigations.. 2020 Jun 4; :1-16. Epub 2020 Jun 04.

6/2020
Dang HX, Krasnick BA, White BS, Grossman JG, Strand MS, Zhang J, Cabanski CR, Miller CA, Fulton RS, Goedegebuure SP, Fronick CC, Griffith M, Larson DE, Goetz BD, Walker JR, Hawkins WG, Strasberg SM, Linehan DC, Lim KH, Lockhart AC, Mardis ER, Wilson RK, Ley TJ, Maher CA, Fields RC. "The clonal evolution of metastatic colorectal cancer." Science advances.. 2020 Jun 0; 6(24):eaay9691. Epub 2020 Jun 10.

Books & Chapters

2007
Book Title: Surgery of the Liver, Biliary Tract and Pancreas
Author List: Linehan DC and Jarnagin WR
Edited By: Blumgart LH, Editor-in-Chief
Published By: Elsevier 2007 in Philadelphia

2002
Chapter Title: Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy
Book Title: Malignant Liver Tumors: Current and Emerging Therapies
Author List: Strasberg SM and Linehan DC
Published By: Bartlett and Barnes 2002 in Chicago

2001
Chapter Title: Active Immunotherapy
Book Title: Surgical Research
Author List: Linehan DC; Amos K; Eberlein TJ
Edited By: Souba WW and Wilmore, DW
Published By: Academic Press 2001 in San Diego, CA

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