David C. Linehan, M.D.

Dr. Linehan graduated from the University of Massachusetts Medical School then completed his internship and residency at Deaconess-Harvard Surgical Service. He was chief resident in Surgery at Beth Israel Deaconess Medical Center. He completed a research fellowship at Brigham and Women's Hospital and was then the Kristin Ann Carr Fellow in Surgical Oncology at Memorial Sloan-Kettering Cancer Center.
A cancer surgeon, Dr. Linehan specializes in treating cancers of the liver, pancreas, and gastric and biliary tract. At Washington University, he was recognized for bringing novel and innovative therapies to patients with hard-to-treat cancers. He also brought a compassionate, patient-centered approach to a high-volume surgical oncology practice. Dr. Linehan also treats benign surgical conditions of the liver, pancreas, gallbladder and bile ducts.
Dr. Linehan is an internationally renowned researcher, with more than 85 publications. His primary area of research is finding new ways to attack the biology of pancreatic tumors, such as through drug and genetic therapies.

Credentials

Specialties

Surgery - American Board of Surgery

Education

1990
MD | University of Massachusetts Medical Center

Post-doctoral Training & Residency

07/01/1997 - 06/30/1999
Fellowship in Surgical Oncology at Memorial Sloan-Kettering Cancer Center

09/01/1996 - 06/30/1997
Fellowship in Surgery at Beth Israel Deaconess Medical Center

08/01/1993 - 06/01/1995
Fellowship in at Brigham and Women's Hospital

09/01/1991 - 06/30/1996
Residency in Surgery at Beth Israel Deaconess Medical Center

09/01/1990 - 06/30/1991
Internship in Surgery at Beth Israel Deaconess Medical Center

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Awards

2012
Inaugural Gerry O'Sullivan Memorial Lecturer Award
Sponsor: University College
Location: Cork, Ireland

2006
CTRF Superhero Cancer Researcher Award
Location: Chicago, IL

2004
Evarts A. Graham Teaching Award
Sponsor: Washington University School of Medicine
Location: St. Louis, MO

1999
Young Investigator Award
Sponsor: American Society of Clinical Oncology

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Clinical Trials

Phase I Integrated Biomarker Trial of VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Pancreatic and Colorectal Cancer

Lead Researcher: David C Linehan

This randomized phase I trial studies how well anti-semaphorin 4D (anti-SEMA4D) monoclonal antibody VX15/2503 with or without ipilimumab or nivolumab work in treating patients with stage I-III pancreatic cancer that can be removed by surgery or stage IV colorectal cancer that has spread to the liver and can be removed by surgery. Monoclonal antibodies, such as anti-SEMA4D monoclonal antibody VX15/2503, ipilimumab, and nivolumab, may interfere with the ability of tumor cells to grow and spread.

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Publications

Journal Articles

4/26/2021
Rowswell-Turner RB, Singh RK, Urh A, Yano N, Kim KK, Khazan N, Pandita R, Sivagnanalingam U, Hovanesian V, James NE, Ribeiro JR, Kadambi S, Linehan DC, Moore RG. "HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression." The Journal of immunology : official journal of the American Association of Immunologists.. 2021 Apr 26; Epub 2021 Apr 26.

4/23/2021
Jackso K, Ruffolo L, Kozakiewicz L, Qin SS, Chacon AC, Jewell R, Belt B, Scott GA, Linehan DC, Galka E, Prieto PA. "Picomets: Assessing single and few cell metastases in melanoma sentinel lymph node biopsies." Surgery.. 2021 Apr 23; Epub 2021 Apr 23.

12/22/2020
Pineda-Solis K, Burchard PR, Ruffolo LI, Schoeniger LO, Linehan DC, Moalem J, Galka E. "Early Prediction of Length of Stay After Pancreaticoduodenectomy." The Journal of surgical research.. 2020 Dec 22; Epub 2020 Dec 22.

Books & Chapters

2007
Book Title: Surgery of the Liver, Biliary Tract and Pancreas
Author List: Linehan DC and Jarnagin WR
Edited By: Blumgart LH, Editor-in-Chief
Published By: Elsevier 2007 in Philadelphia

2002
Chapter Title: Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy
Book Title: Malignant Liver Tumors: Current and Emerging Therapies
Author List: Strasberg SM and Linehan DC
Published By: Bartlett and Barnes 2002 in Chicago

2001
Chapter Title: Active Immunotherapy
Book Title: Surgical Research
Author List: Linehan DC; Amos K; Eberlein TJ
Edited By: Souba WW and Wilmore, DW
Published By: Academic Press 2001 in San Diego, CA

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David C. Linehan, M.D.

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