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Martha Susiarjo, Ph.D.

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Faculty Appointments

Biography

Research

Martha Susiarjo is an Assistant Professor in the department of Environmental Medicine, and member of the Environmental Health Sciences Center. She received her PhD in Genetics from Case Western Reserve University School of Medicine and completed her postdoctoral fellowship at the Perelman School of Medicine of the University of Pennsylvania. Research in the Susiarjo Lab investigates the underlying mechanisms of the developmental origin of health and disease focusing on how epigenetic mechanisms mediate gene-environment interaction. Her laboratory uses imprinted genes as epigenetic markers to test the effect of environmental exposure on DNA methylation regulation on fetal and placental development. Additional, she is also interested in elucidating the role of environmental exposure on maternal health during pregnancy and the potential beneficial role of nutritional supplementation. Her research is supported by an R00 grant from the NIEHS. The lab employs bisulfite sequencing analysis, mouse genetics and embryology, molecular biology, and next generation sequencing.

Credentials

Education

1999
BA | Case Western Reserve University
Biology

2007
PhD | Case Western Reserve University
Genetics

Post-doctoral Training & Residency

04/01/2008 - 07/24/2015
University of Pennsylvania Mentor: Dr. Marisa Bartolomei Project: Studying effects of environmental exposure on the mammalian epigenome and characterizing the relevant mechanisms leading to abnormal metabolic health in mice exposed to endocrine disrupting compounds

Awards

2013
Susan Heyner Award for Excellence in Research
Sponsor: University of Pennsylvania Center for Research in Reproduction a
Location: University of Pennsylvania

2003
Departmental Symposium Best Poster Award
Sponsor: Case Western Reserve University Department of Genetics

1999
Departmental and University Honors, magna cum laude
Sponsor: Case Western Reserve University

1999
Russell M. Lawall Prize for Excellence in Biology
Sponsor: Case Western Reserve University

1998
Phi Beta Kappa

1998
ASEAN Student Research Award
Sponsor: US-ASEAN Business Council

1995 - 1999
University Dean's High Honor
Sponsor: Case Western Reserve University

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Publications

Journal Articles

3/2019
Flores EM, Woeller CF, Falsetta ML, Susiarjo M, Phipps RP. "Thy1 (CD90) expression is regulated by DNA methylation during adipogenesis." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2019 Mar 0; 33(3):3353-3363. Epub 2018 Oct 30.

1/4/2019
Lerman I, Ma X, Seger C, Maolake A, Garcia-Hernandez ML, Rangel-Moreno J, Ackerman J, Nastiuk KL, Susiarjo M, Hammes SR. "Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression." Molecular cancer research : MCR.. 2019 Jan 4; Epub 2019 Jan 04.

11/7/2018
Spinelli P, Latchney SE, Reed JM, Fields A, Baier BS, Lu X, McCall MN, Murphy SP, Mak W, Susiarjo M. "Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss." Human molecular genetics.. 2018 Nov 7; Epub 2018 Nov 07.

Books & Chapters

2015
Chapter Title: Introduction to Epigenetic Mechanisms: The Probable Common Thread for Various Developmental Origin of Health and Diseases Effects
Book Title: The Epigenome and Developmental Origins of Health and Disease
Author List: Susiarjo, M
Edited By: Cheryl Rosenfeld
Published By: Academic Press 2015

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