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Mitchell R. O'Connell, Ph.D.


Showing all 21 journal articles & 0 books available

Journal Articles

Joseph Davis Burris B, Moises Molina Vargas A, Park BJ, O'Connell MR. "Optimization of specific RNA knockdown in mammalian cells with CRISPR-Cas13." Methods : a companion to Methods in enzymology.. 2022 Aug 17; Epub 2022 Aug 17.

Walker EJ, Bettinger JQ, Welle KA, Hryhorenko JR, Molina Vargas AM, O'Connell MR, Ghaemmaghami S. "Protein folding stabilities are a major determinant of oxidation rates for buried methionine residues." The Journal of biological chemistry.. 2022 Mar 25; :101872. Epub 2022 Mar 25.

Broly M, Polevoda BV, Awayda KM, Tong N, Lentini J, Besnard T, Deb W, O'Rourke D, Baptista J, Ellard S, Almannai M, Hashem M, Abdulwahab F, Shamseldin H, Al-Tala S, Alkuraya FS, Leon A, van Loon RLE, Ferlini A, Sanchini M, Bigoni S, Ciorba A, van Bokhoven H, Iqbal Z, Al-Maawali A, Al-Murshedi F, Ganesh A, Al-Mamari W, Lim SC, Pais LS, Brown N, Riazuddin S, Bézieau S, Fu D, Isidor B, Cogné B, O'Connell MR. "THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder." American journal of human genetics.. 2022 Feb 11; Epub 2022 Feb 11.

Davis BJ, O'Connell MR. "Put on Your Para-spectacles: The Development of Optimized CRISPR-Cas13-Based Approaches to Image RNA Dynamics in Real Time." Molecular cell.. 2020 Jan 16; 77(2):207-209.

O'Connell M. "Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR-Cas Systems." Journal of molecular biology.. 2019 Jan 4; 431(1):66-87. Epub 2018 Jun 22.

Tambe A, East-Seletsky A, Knott GJ, Doudna JA, O'Connell MR. "RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a." Cell reports.. 2018 Jul 24; 24(4):1025-1036.

De Franco S, O'Connell MR, Vandevenne M. "Engineering RNA-Binding Proteins by Modular Assembly of RanBP2-Type Zinc Fingers." Methods in molecular biology.. 2018 1867:57-74.

Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA. "Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme." Nature structural & molecular biology.. 2017 Oct; 24(10):825-833. Epub 2017 Sep 11.

East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA. "RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes." Molecular cell.. 2017 May 4; 66(3):373-383.e3.

East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA. "Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection." Nature.. 2016 Oct 13; 538(7624):270-273. Epub 2016 Sep 26.

Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna JA, Yeo GW. "Programmable RNA Tracking in Live Cells with CRISPR/Cas9." Cell.. 2016 Apr 7; 165(2):488-96. Epub 2016 Mar 17.

Ma E, Harrington LB, O'Connell MR, Zhou K, Doudna JA. "Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes." Molecular cell.. 2015 Nov 5; 60(3):398-407.

O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA. "Programmable RNA recognition and cleavage by CRISPR/Cas9." Nature.. 2014 Dec 11; 516(7530):263-6. Epub 2014 Sep 28.

Vandevenne M, O'Connell MR, Helder S, Shepherd NE, Matthews JM, Kwan AH, Segal DJ, Mackay JP. "Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA." Angewandte Chemie.. 2014 Jul 21; 53(30):7848-52. Epub 2014 Jul 09.

Clifton MK, Westman BJ, Thong SY, O'Connell MR, Webster MW, Shepherd NE, Quinlan KG, Crossley M, Blobel GA, Mackay JP. "The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins." PloS one.. 2014 9(8):e106011. Epub 2014 Aug 27.

Gamsjaeger R, O'Connell MR, Cubeddu L, Shepherd NE, Lowry JA, Kwan AH, Vandevenne M, Swanton MK, Matthews JM, Mackay JP. "A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers." The Journal of biological chemistry.. 2013 Dec 6; 288(49):35180-91. Epub 2013 Oct 06.

Bendak K, Loughlin FE, Cheung V, O'Connell MR, Crossley M, Mackay JP. "A rapid method for assessing the RNA-binding potential of a protein." Nucleic acids research.. 2012 Aug; 40(14):e105. Epub 2012 Apr 03.

O'Connell MR, Vandevenne M, Nguyen CD, Matthews JM, Gamsjaeger R, Segal DJ, Mackay JP. "Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA." Angewandte Chemie.. 2012 May 29; 51(22):5371-5. Epub 2012 Apr 19.

Burdach J, O'Connell MR, Mackay JP, Crossley M. "Two-timing zinc finger transcription factors liaising with RNA." Trends in biochemical sciences.. 2012 May; 37(5):199-205. Epub 2012 Mar 07.

Hsieh YS, Wilkinson BL, O'Connell MR, Mackay JP, Matthews JM, Payne RJ. "Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants." Organic letters.. 2012 Apr 6; 14(7):1910-3. Epub 2012 Mar 28.

O'Connell MR, Gamsjaeger R, Mackay JP. "The structural analysis of protein-protein interactions by NMR spectroscopy." Proteomics.. 2009 Dec; 9(23):5224-32.