CONTACT INFORMATIONBIOGRAPHYCREDENTIALSCLINICAL TRIALSPUBLICATIONSFrank C. Passero, M.D.Contact InformationPhone NumbersAppointment: (585) 276-3000A member of the University of Rochester Medical Faculty GroupgroupAn Accountable Health PartnerassignmentAccepting New PatientsLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 704Rochester, NY 14642Faculty AppointmentsAssistant Professor - Department of Medicine , Hematology/Oncology (SMD) Patient Care SettingCancerBiographyAs a physician I aim to provide patients with an understanding of their medical condition and guidance as they navigate complex medical decisions. I consider honesty, compassion and my medical knowledge as foundational principles upon which I seek to build a trusting patient-physician relationship. Getting to know my patients, their unique circumstances and goals is a key aspect of my practice, in order to provide patients with a personalized plan of care. I obtained my medical degree from Jefferson Medical College in Philadelphia, Pennsylvania and went on to complete internship, residency, and a chief medical residency in Internal Medicine at Scripps Mercy Hospital in San Diego. I pursued my Hematology and Oncology fellowship training at Tufts Medical Center in Boston, Massachusetts where I carried out laboratory research studying the effects of proteasome and HDAC inhibitors in lymphoma. I have a special interest in plasma cell disorders including myeloma and amyloidosis, and would like to provide patients with the opportunity to participate in well-designed clinical trials for these and other related diseases.CredentialsSpecialtiesHematology - American Board of Internal MedicineInternal Medicine - American Board of Internal MedicineMedical Oncology - American Board of Internal MedicineEducation2010MD | Thomas Jefferson University Hospital (USA)Post-doctoral Training & Residency07/01/2014 - 06/30/2017Fellowship in Hematology & Oncology at Tufts Medical Center07/01/2011 - 06/30/2014Residency in Internal Medicine at Mercy Hospital & Medical Center-San Diego (GME)06/24/2010 - 06/23/2011Internship in Internal Medicine at Mercy Hospital & Medical Center-San Diego (GME)VIEW ALL expand_moreClinical TrialsA Phase II Study of Steroid Sparing Treatment With Daratumumab and Lenalidomide in Newly Diagnosed Transplant Ineligible Patients With Multiple MyelomaLead Researcher: Frank C Passero The purpose of this study is to determine the effects of daratumumab and lenalidomide without steroids for treating patients with multiple myeloma. View Study Details A Phase 3, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of CAEL-101 and Plasma Cell Dyscrasia Treatment Versus Placebo and Plasma Cell Dyscrasia Treatment in Plasma Cell Dyscrasia Treatment Naïve Patients With Mayo Stage IIIb AL AmyloidosisLead Researcher: Frank C Passero AL (or light chain) amyloidosis begins in the bone marrow where abnormal proteins misfold and create free light chains that cannot be broken down. These free light chains bind together to form amyloid fibrils that build up in the extracellular space of organs, affecting the kidneys, heart, liver, spleen, nervous system and digestive tract. The primary purpose of this study is to determine whether CAEL-101, a monoclonal antibody that removes AL amyloid deposits from tissues and organs, improves overall survival and it is safe and well tolerated in patients with stage IIIb AL amyloidosis. View Study Details A Phase 3, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of CAEL-101 and Plasma Cell Dyscrasia Treatment Versus Placebo and Plasma Cell Dyscrasia Treatment in Plasma Cell Dyscrasia Treatment Naïve Patients With Mayo Stage IIIa AL AmyloidosisLead Researcher: Frank C Passero AL (or light chain) amyloidosis begins in the bone marrow where abnormal proteins misfold and create free light chains that cannot be broken down. These free light chains bind together to form amyloid fibrils that build up in the extracellular space of organs, affecting the kidneys, heart, liver, spleen, nervous system and digestive tract. The primary purpose of this study is to determine whether CAEL-101, a monoclonal antibody that removes AL amyloid deposits from tissues and organs, improves overall survival and it is safe and well tolerated in patients with stage IIIa AL amyloidosis. View Study Details PublicationsJournal Articles2023Komisarof J, Forman J, Goldman B, Syposs C, Passero F, Garbade E. "A Rare Case of Renal Thrombotic Microangiopathy and Focal Segmental Glomerulosclerosis Secondary to Plasma Cell Leukemia." Case reports in hematology.. 2023 2023:7803704. Epub 2023 Feb 18. 3/22/2022Alom MS, Grewal R, Passero FC, Goldman B, Choung HYG. "Light chain deposition disease masquerading as smoking-associated nodular glomerulosclerosis with deposits identified by electron microscopy only." CEN case reports.. 2022 Mar 22; Epub 2022 Mar 22. 2022Komisarof J, Lipof J, DiTursi J, Chowdhry A, Grace Choung HY, Burack WR, Constine L, Passero F. "An Unusual Case of Multiple Myeloma with Light-Chain Cast Nephropathy Secondary to a Very Large Plasmacytoma without Bone Marrow Involvement." Case reports in hematology.. 2022 2022:7531142. Epub 2022 Feb 21. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Frank C. Passero, M.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Frank C. Passero, M.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.