Rajnish Bharadwaj, M.B.B.S., Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-3202

Office: (585) 275-5065

Fax: (585) 273-1027

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Not Accepting New Patients

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Faculty Appointments

Assistant Professor - Department of Pathology and Laboratory Medicine (SMD)
Assistant Professor - Department of Neuroscience (SMD) - Joint

Patient Care Setting

Pathology

Biography

Professional Background

Dr. Bharadwaj is a physician-scientist with clinical expertise in neuropathology. He received his MBBS from All India Institute of Medical Sciences, New Delhi and Ph.D. from University of Texas Southwestern Medical Center, Dallas. After finishing his graduate studies, he joined Johns Hopkins University School of Medicine as a postdoctoral fellow and worked on various problems pertaining to muscular and neuronal biology. Subsequently, he completed his residency in anatomic pathology and fellowship in neuropathology from University of Washington Medical Center, Seattle.

Research

Dr. Bharadwaj's primary research interests are in molecular mechanisms of neurodegenerative diseases.
His ongoing research revolves around understanding the role of mitochondrial and lysosomal dysfunction in neurodegeneration, particularly in the context of Parkinsonism, for which these processes are especially important. He is currently focusing on a few genes, implicated in Parkinson's disease and a related movement disorder- Neurodegeneration with Brain Iron Accumulation (NBIA). Using the model organism Drosophila melanogaster as well as in vitro cell culture systems, and employing a combination of genetic, biochemical and cell biological approaches, he is trying to elucidate the roles of these genes in health and disease. To assess the broader relevance of the insights gleaned from basic research, Dr. Bharadwaj also plans to pursue translational research using postmortem brain tissue obtained from human patients.

Credentials

Education

1998
MBBS | All India Institute of Medical Sciences

2004
PhD | University of Texas Southwestern
Clinical Genetics

Post-doctoral Training & Residency

07/01/2016 - 07/31/2018
Fellowship in Neuropathology at University of Washington School of Medicine

07/01/2015 - 06/30/2016
Residency in Anatomic Pathology at University of Washington School of Medicine

07/01/2014 - 06/30/2015
Internship in Anatomic Pathology at University of Washington School of Medicine

11/15/2004 - 12/24/2012
Research in Neuroscience at John Hopkins University School of Hygiene and Public Health

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Awards

2017
Weil Award
Sponsor: American Association of Neuropathologists

2016 - 2017
Environmental Pathology/Toxicology (EP/T) Training Grant T32

Publications

Journal Articles

2/2018
Bharadwaj R, Cimino PJ, Flanagan ME, Latimer CS, Gonzalez-Cuyar LF, Juric-Sekhar G, Montine TJ, Marshall DA, Keene CD. "Application of the condensed protocol for the NIA-AA guidelines for the neuropathological assessment of Alzheimer's disease in an academic clinical practice." Histopathology.. 2018 Feb 0; 72(3):433-440. Epub 2017 Nov 22.

2/15/2016
Bharadwaj R, Cunningham KM, Zhang K, Lloyd TE. "FIG4 regulates lysosome membrane homeostasis independent of phosphatase function." Human molecular genetics.. 2016 Feb 15; 25(4):681-92. Epub 2015 Dec 11.

4/2/2014
Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont J, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K, Wu MN. "WIDE AWAKE mediates the circadian timing of sleep onset." Neuron.. 2014 Apr 2; 82(1):151-66. Epub 2014 Mar 13.

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