Welcome to the URMC Mass Spectrometry Resource Laboratory The Mass Spectrometry Resource Laboratory (MSRL) provides instrumentation and technical expertise to local researchers seeking to conduct MS-based protein or small molecule assays. Staff within the MSRL provide assistance with project design, sample preparation, collection and interpretation of mass spectrometric data. Common analyses include the identification of unknown proteins, characterization of protein complexes, mapping of post-translational modifications (PTMs) and relative quantitation of peptides and small molecules from a range of sample types, including complex clinical matrices, tissue extracts and cell lysates. Specialized MS instrumentation operated and maintained by the core include a Thermo Q Exactive Plus Hybrid Quadrupole-Orbitrap and a TSQ Quantum Access Max Triple Quadrupole. In addition, the laboratory has access to a variety of automated database searching software (Mascot, SEQUEST) as well as resources to facilitate discovery-based proteomics projects.