PBRT17119 / ACNS1422 / Korones
Research Question:
Does reducing the amount of radiation therapy a person gets help reduce side effects
in patients with medulloblastoma?
Basic Study Information
Purpose:
This phase II trial studies how well reduced doses of radiation therapy to the brain
and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed
type of brain tumor called WNT)/Wingless (WNT)-driven medulloblastoma. Recent studies
using chemotherapy and radiation therapy have been shown to be effective in treating
patients with WNT-driven medulloblastoma. However, there is a concern about the late
side effects of treatment, such as learning difficulties, lower amounts of hormones,
or other problems in performing daily activities. Radiotherapy uses high-energy radiation
from x-rays to kill cancer cells and shrink tumors. Drugs used in chemotherapy, such
as cisplatin, vincristine sulfate, cyclophosphamide and lomustine, work in different
ways to stop the growth of tumor cells, either by killing the cells, by stopping them
from dividing, or by stopping them from spreading. Giving reduced craniospinal radiation
therapy and chemotherapy may kill tumor cells and may also reduce the late side effects
of treatment.
Location: University of Rochester
Lead Researcher (Principal Investigator)
Lead Researcher:
David Korones
Study Contact Information
Study Contact: Clinical Trials Office
Study Location: Wilmot Cancer Institute, University of Rochester Medical Center
Study Email: WCICTOResearch@urmc.rochester.edu
Additional Study Details
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