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Study of Oxygen Therapy in Improving Stem Cell Transplant

Research Question:
Will the use of hyperbaric oxygen (HBO) therapy prior to the UCB transplant improve the stem cell homing, and subsequently, the engraftment?

Basic Study Information

Purpose:
Umbilical Cord Blood (UCB) as a graft source for a bone marrow transplant has drawbacks related to the limited cell dose available for transplant and defects in homing. Homing is the process of UCB stem cell lodging in the bone marrow. If the homing is not efficient it could delay the re-population of the stem cells (or engraftment), possibly lead to engraftment failure, and delay the rebuilding of the immune system after transplant. This could, in turn, provide a higher risk to infection after the UCB transplant. This research study is aimed at investigating the use of hyperbaric oxygen (HBO) therapy prior to the UCB transplant to find out if it will improve the stem cell homing, and subsequently, the engraftment. HBO therapy involves breathing 100% pure oxygen while in a sealed chamber that has been pressurized at 2 ½ times the normal atmospheric pressure. There is a specific hormone which tells stem cells in the bone marrow to make more red blood cells. This hormone (called EPO) is increased when blood oxygen levels are low. When the EPO is increased, it might impair the bone marrow homing process of your transplant. Therefore, the researchers conducting this study hope to determine if providing 100% pure oxygen to you prior to your UCB transplant will decrease this hormone, and in turn, improve the homing process after your transplant.

Location: University of Rochester Medical Center
Study Reference #: UBMT17044

Lead Researcher (Principal Investigator)

Lead Researcher:  Omar Aljitawi

Study Contact Information

Study Coordinator: Kaitlyn Burrows
Phone: (585) 275-5150
Email: Kaitlyn_Burrows@URMC.Rochester.edu

Additional Study Details

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