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IMMY18128 / Seattle / Brea Lipe

Research Question:
Is SEA-BCMA tan effective treatment for multiple myeloma (MM) and what side effects (unwanted effects) may occur?

Basic Study Information

Purpose:
This trial will study SEA-BCMA to find out whether it is an effective treatment for multiple myeloma (MM) and what side effects (unwanted effects) may occur. The study will have three parts. In the first part, participants get SEA-BCMA by itself. This part of the study will find out how much SEA-BCMA should be given for treatment and how often. It will also find out how safe the treatment is and how well it works. In the second part of the study, participants will get SEA-BCMA and dexamethasone. In the third part, participants will get SEA-BCMA, dexamethasone, and either pomalidomide or nirogacestat. Dexamethasone and pomalidomide are both drugs that can be used to treat multiple myeloma. Nirogacestat is an experimental drug that can be used with SEA-BCMA to treat multiple myeloma. These parts of the study will find out whether these drugs are safe when used together.

Location: University of Rochester Medical Center
Study Reference #: IMMY18128

Lead Researcher (Principal Investigator)

Lead Researcher:  Brea Lipe

Study Contact Information

Study Contact: Clinical Trials Office
Study Location: Wilmot Cancer Institute, University of Rochester Medical Center
Study Email: WCICTOResearch@urmc.rochester.edu

Additional Study Details

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