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Coronavirus (COVID-19) Research Studies

Carefully conducted clinical trials are the safest and fastest way to find effective vaccines, treatments, and new ways to improve health. The University of Rochester Medical Center is currently conducting several coronavirus clinical trials that are in need of volunteers. To volunteer, take our survey to find out if you qualify. We will contact you now or in the future when a coronavirus study meets your needs or interests. To find studies on other conditions that are currently enrolling, you can visit our Clinical Trials & Research page and search by keyword.

The National Institutes of Health (NIH) offers public resources for use in talking with community organizations or individuals about the NIH's COVID-19 vaccine research initiatives as well as the importance of being included in research studies. Visit the NIH COVID-19 Communities Responding Together website to learn more and download resources.

 

Volunteer

Take a short survey to learn about future coronavirus studies.

 

FAQs

Find answers to the most frequently asked questions.

 

Contact Us

Contact us for more information about open coronavirus studies.

Current Studies

A Study of Immune Responses to the Virus That Causes COVID-19

This study will help us learn how the body's immune system responds to the SARS-CoV-2 virus. Some people know this virus by the name "coronavirus." It can cause the disease called COVID-19. The information gained from the study can be used to help develop better tests for SARS-CoV-2 infection and COVID-19 disease and may help in developing future vaccines, other prevention strategies, and treatments.

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Characterizing SARS-CoV-2-specific Immunity in Individuals Who Have Recovered from COVID-19

The purpose of this study is to learn more about infection with and recovery from the virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some people know this virus by the name "coronavirus." It can cause the disease called COVID-19. The information gained from the study will be used to help develop better tests for SARS-CoV-2 infection and COVID-19 disease and may help in developing future vaccines and treatments by allowing researchers to determine the difference between the body's immune response to natural SARS-CoV-2 infection and immunization with a SARS-CoV-2 vaccine. Inclusion Criteria: Age 18 or older / Have had a positive test for SARS-CoV-2 / Reports resolution of COVID-19 within 1-8 weeks of enrollment OR, if asymptomatic infection, reports positive SARS-CoV-2 test within 2-10 weeks of enrollment.

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Collecting Breast Milk Samples for Future Research

When some research ideas are initially formed, they need to be tested on small amounts of human breast milk before moving on to large studies. This study will collect a one-time breast milk sample and questionnaire from each participant for that purpose. Participants will be compensated $5 per breast milk sample (up to 4 samples). Additionally, this study will collect multiple breast milk samples from two different groups of mothers who can collect samples at home. The first group will help us learn more about food allergies by collecting samples before a meal and 1, 2, 6, and 24 hours after a meal containing one egg, one cup of milk, or a small handful of peanuts. If a woman is experiencing COVID-19 symptoms, they may join a different group that will provide samples over time to help us learn how long the virus is present in breast milk.

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Convalescent Plasma to Limit SARS-CoV-2 Associated Complications (CSSC-004)

Lead Researcher: Martin Zand

The purpose of this study is to is to determine if convalescent plasma will help a person with COVID-19 symptoms improve and prevent admission into the hospital. Convalescent plasma is plasma from a person who has recovered from a COVID-19 infection. Participants in this study will receive either control or convalescent plasma. COVID-19 symptoms include but are not limited to fever, cough, or loss of taste or smell. You must be 18 years or older to participate.

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Convalescent Plasma to Stem Coronavirus in COVID Negative Participants (CSSC-001)

This study will determine if plasma collected from the blood of people who have recovered from COVID-19 infection will help others who are at risk for getting COVID-19. Participants should be people who are at high risk for COVID-19 infection. They will receive a one-time infusion of convalescent or control plasma. Convalescent plasma is from a person who has recovered from a COVID-19 infection. Plasma will not have COVID-19 but will have antibodies to the virus. The purpose of this study is to determine if these antibodies will help keep people who are at high risk for getting COVID from getting infected. To be eligible you must have had close contact with someone who is COVID-19 positive and have a high risk for illness such as >=65, reside in a nursing home or long-term care facility, have chronic lung disease, asthma, heart disease, obesity, uncontrolled diabetes, renal failure, liver disease or cancer. Or you must be a healthcare professional with high risk exposure such as have had prolonged close contact with patients with COVID-19 who were not wearing a facemask while HCP nose and mouth were exposed to material potentially infectious with the virus causing COVID-19.

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COVID-19 and Breastfeeding Mothers

We are seeking breastfeeding moms – with a baby under 6 months old – who have recently been diagnosed with COVID-19, ideally within the previous 7 days. The purpose of this study is to determine if there may be COVID-19 virus in various samples we collect from mother and child. These samples include mother’s breast milk, skin swab, saliva, and blood sample, as well as infant stool samples. These will be taken within certain windows of time at your convenience inside the home. Participation in this study will be for 90 days. You will be reimbursed a total of $60 ($30 after day 10 collection and another $30 after the day 90 collection) via check.

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COVID-19 Vaccine Studies

URMC is studying several variations of a COVID-19 vaccine. Compensation: $500-$900. Participation Requirements: Age 18+; Have not been infected with COVID-19.

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Describing the Infection/Illness Mechanisms for Influenza and COVID-19

This study will obtain timed samples of blood and nasal secretions from adults, children, and the elderly with influenza-like illness. It will look to characterize the pathogenesis (mechanisms of infection/illness) and the responses that occur within the immune system - for both COVID-19 and influenza.

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HOPE-Helping Older People Engage

The purpose of this study is to compare two activities — reflecting on one’s past (called “life review”) and volunteering in the community ("volunteering"). We are interested in learning how these activities may improve social connectedness and well-being among adults age 60 and older. Additionally, we may ask questions about social distancing, so to that end this study is relevant to managing the psychosocial implications of COVID-19. Volunteering involves participate weekly in a flexible volunteer program with Lifespan that involves a menu of options including helping at senior centers, co-leading classes, mentoring/tutoring and many other options. Life review involves participating in a one-year reminiscence program that is self-guided and involves completing monthly exercises such as writing about one’s memories.

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Parent and Children Conversations about COVID-19

This is a study that will examine conversations parents are having with their children with respect to the situation caused by COVID-19. Furthermore, we will examine how stress related to the pandemic influences family dynamics. Rochester area parents with at least one child ages 3-7 may be eligible to complete this survey. Participants will fill out a 35-minute online survey. Participants that complete the survey will be eligible to win a $25 gift card.

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Talk Therapy by Phone to Promote Treatment for Alcohol Problems

A small percentage of individuals with alcohol use disorder (AUD) obtain alcohol-related care despite research showing that treatment is effective. This randomized controlled trial tests the efficacy of a brief, phone based cognitive behavioral intervention to increase treatment engagement, improve alcohol related outcomes, and show that treatment engagement is a mechanism for the improved outcomes in individuals with AUD. This study will also asses the impact of COVID-19 on alcohol use and other quality of life measures.

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