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Healthy Volunteer Studies

If you would like to participate in health research as the healthy volunteer, below is a list of studies accepting healthy volunteers.


Lead Researcher: Anton Porsteinsson

ADNI3 is not a treatment study. It continues research that began in 2004 (ADNI1) and will follow people over a five year period using the information collected from thinking and memory testing, brain imaging, genetics testing, and blood and brain-spinal fluid testing to help improve the way AD research is conducted. Approximately 1070 - 2000 participants will be enrolled at 59 sites in the US and Canada. Three groups will be enrolled and evaluated: those with normal thinking and memory, those with mild cognition problems, and those with mild Alzheimer's disease. The normal thinking cohort is filled; the study is now only recruiting people with mild cognition problems (MCI) or mild Alzheimer's disease.

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Brain Training to Promote Health in Family Dementia Caregivers

Lead Researcher: Kathi Heffner

The purpose of the study is to determine whether two types of in-home “brain-training” programs may have beneficial health effects, including reduced stress and improved immune health, for individuals caring for a loved one (spouse, parent, friend, etc) who has dementia. Participation involves completing one of our brain training programs with the use of a computer at home a few times a week (when convenient for you), over eight weeks. Experience or skill with computers is not necessary. If you do not own a computer, one may be provided for you to use during the program period.

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Breast Cancer: HOMING Study: Harvest of Circulating Tumor Cells (CTCs) from Patients with Metastatic Breast Cancer (MBC) using the Parsortix PC1 System

Lead Researcher: Richard Moore

If you participate in this study, you will be asked to allow the study doctor to draw 3 tubes of blood (up to a total of 23mL or 1 1/2 tablespoons of your blood) for the evaluation of the presence or absence of CTCs and their characterization as well as to collect information about your health.

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Development of allergies in babies

Lead Researcher: Kirsi Jarvinen-seppo

The purpose of this study is to determine the impact of breast milk immune factors on allergy risk. The immune system protects us from getting diseases, working throughout the body, including secretions such as saliva and breast milk and in the normal bacteria in the stomach and intestines. A baby's immune system develops over time and maybe impacted by the breast milk they consume. By comparing saliva, breast milk (if applicable)and stool, we can study differences among a group of infants at higher risk of developing allergies.

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Effects of Chemotherapy on Cognitive Function in Breast Cancer Patients and Non-Cancer Control Participants With an Optional Sub-Study: Research Brain MRI

Lead Researcher: Michelle Janelsins-Benton

Study is enrolling newly diagnosed breast cancer patients about to start chemotherapy and age-matched control participants. The investigator is trying to better understand the prevalence of cognitive difficulties in cancer patients receiving chemotherapy compared to the general population as well as what biological mechanisms may play a role in the development of these difficulties. Patients will be asked to complete six assessments over the course of approximately 5 months. Assessments 1,3, 4.5 and 5 include computerized and paper and pencil cognitive testing as well as blood draws. Assessments 2 and 4 only involve the collection of a blood sample. An optional sub study is offered after Assessment 1. It involves a research brain MRI at Assessment 4.5 and cognitive testing and another research brain MRI at Assessment 6.

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Evaluation of age, flu exposure, and vaccination for flu on the memory (B cell) cells of the human immune system.

Lead Researcher: Angela Branche

This study is looking at different effects of flu and vaccination upon the B cells.

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Exercise Intervention for LGBT Cancer Survivors

Lead Researcher: Nicole Murray

The purpose of this study is to test preliminary efficacy, as well as acceptability and feasibility, of a dyadic exercise intervention, the current study will randomize LGBT cancer survivors and their non-professional caregivers as dyads to either an individual or a dyadic Exercise for Cancer Patients (EXCAP) intervention. The primary outcome assessed will be psychological distress. Analyses will involve pre-post comparisons of outcomes across the study arms, testing the hypothesis that a 6 week, daily, dyadic exercise intervention will result in greater improvements in psychological distress than an individual intervention.

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Hearing Study: Sensitivity to Features of Speech Sounds

Lead Researcher: Laurel Carney

The purpose of this study is to better understand the sensitivity of listeners to the fast changes in frequency or amplitude of sounds that occur in speech. The investigators are studying ways to manipulate these aspects of sounds in an effort to make speech sounds more clear. We are recruiting listeners age 18 to 80, with either normal hearing or hearing loss. Listeners with hearing loss must similar hearing loss in both ears that is sensorineural in nature and mild or moderate in severity. All listeners will have their hearing tested at the beginning of the study.

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Improving Well-Being for Older Adult Family Dementia Caregivers

Lead Researcher: Kathi Heffner

The purpose of the study is to examine the effects of the Mindfulness-Based Stress Reduction (MBSR) program and the Living Well (LW) for Dementia Caregivers program, compared to any usual care, to see if the programs might be associated with better immune function, physical and emotional health, and well-being. This study is looking for individuals age 55 and up who are caring for a loved one (such as a spouse, parent, close friend) who has dementia. Participation includes attending a weekly small group meeting over eight weeks for one of two study programs (determined randomly). Both programs address ways of improving physical and emotional well-being in the context of dementia caregiving. These 8-week programs typically begin in late August at Monroe Community Hospital.

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NIR Fluorescence Imaging of Lymphatic Transport Using ICG

Lead Researcher: Christopher Ritchlin

Healthy volunteers and patients with Rheumatoid Arthritis (RA) in the developmental arm will have a minimum of two study visits to determine the optimal conditions for visualizing lymphatic transport in the upper extremities. Concentrations of 0.1 mg/ml of Indocyanine Green (ICG) will be injected intradermally into the web spaces of the hands in both upper extremities. Multispectral video and still images will be recorded using the MultiSpectral Imaging System (MSImager). An ultrasound of the upper extremities may be performed after the ICG fluorescence is observed. The exam will help identify the location of the lymphatic vessels and nodes in the areas fluoresced.

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Ovarian Ultrasound for Healthy Women and Women with Polycystic Ovary Syndrome

Lead Researcher: Kathleen Hoeger

This study aims to characterize the affect of age and weight on the size and shape of ovaries. We will compare ovary size and shape in women of varying ages and body sizes. You are eligible if you are female, age 18-45. We plan to recruit up to 120 women with regular menstrual cycles and up to 120 women with histories of Polycystic Ovary Syndrome. This study is being conducted in collaboration with Dr. Lujan’s lab at Cornell University.

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Sound Processing Changes in Babies With Opioid Exposure

Lead Researcher: Perihan Ulema

The purpose of this study is to identify problems with interpreting sounds in babies that have been exposed to opioids prior to birth. Being able to identify these issues in infancy may allow us to find children who may have problems with language learning later in life so that we can try to minimize these.

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Study of Berkeley Life Nitric Oxide on Platelets

Lead Researcher: Scott Cameron

Nitric Oxide has several protective heart benefits. But why it's protective is not known. We will determine if the dietary supplement, Berkeley Life Nitric Oxide, affects the function of platelets. Platelets play a negative role in heart disease. We will determine if nitric oxide affects platelets in such a way as to reduce that negative affect.

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Studying Infant Nutrition and Blood Sugar in Breastfed Infants

Lead Researcher: Bridget Young

This study is for pregnant women who plan on breastfeeding their baby for at least 5 months. You and your baby will have two study visits over the first 6 months of your baby's life at the University of Rochester Medical Center. We will ask for some blood and some breast milk from you. We will ask for some urine and stool, and a heel prick from your baby.

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The Couples Sexual Health Study

Lead Researcher: Natalie Leblanc

The purpose of this study is to better understand Black Heterosexual couples' thoughts and suggestions of an online Sexual Health HIV Prevention Toolkit that has been originally designed for male couples to use together The toolkit is to guide couples to think about their relationship, their relationship goals and their sexual health in order to reduce being exposed to sexually transmitted infections including HIV, and create a plan for optimal sexual health.  The toolkit is to also help guide couples to come to an agreement of their sexual and relationship goals.  We are very interested in finding out whether an online sexual health toolkit that has been found to be acceptable to gay male couples would be accepted by Black heterosexual couples.

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The LGBTQI parental experience with newborn nutrition

Lead Researcher: Rita Dadiz

Eligible participants include parents of a newborn child born within the past 1 year from time of recruitment. Parents must have identified as LGBTQI during the birthing and initial newborn hospitalization period. Adopted parents are eligible if they were involved in the birthing process. Parents must be at least 18 years old. The study includes two brief surveys which can be done online or on paper and a 60-90 minute interview done either in person or through video conferencing.

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