URMC / Biochemistry & Biophysics / Research / Recent Publications Recent Publications Smith BSchafer XLAmbeskovic ASpencer CMLand HMunger J (2016 Oct 11). Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells. Cell reports. Mishra LNPepenella SRogge RHansen JCHayes JJ (2016 Oct 06). Acetylation Mimics Within a Single Nucleosome Alter Local DNA Accessibility In Compacted Nucleosome Arrays. Scientific reports. Walling LRButler JS (2016 Sep 26). Structural determinants for antitoxin identity and insulation of cross talk between homologous toxin-antitoxin systems. Journal of bacteriology. Sparks RPJenkins JLMiner GEWang YGuida WCSparks CEFratti RASparks JD (2016 Sep 22). Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding. Biochemical and biophysical research communications. Sridharan RConnelly SMNaider FDumont ME (2016 Sep 19). Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein Coupled Receptor in Yeast. The Journal of biological chemistry. Nadtochiy SMSchafer XFu DNehrke KMunger JBrookes PS (2016 Aug 10). Acidic pH is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling. The Journal of biological chemistry. Sparks RPGuida WCSowden MPJenkins JLStarr MLFratti RASparks CESparks JD (2016 Aug 2). Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells. Biochemical and biophysical research communications. Fang HWei SLee THHayes JJ (2016 Jun 30). Chromatin structure-dependent conformations of the H1 CTD. Nucleic acids research. Gamble CEBrule CEDean KMFields SGrayhack EJ (2016 Jun 29). Adjacent Codons Act in Concert to Modulate Translation Efficiency in Yeast. Cell. Black PJMiller ASHayes JJ (2016 Jun 27). Radioresistance of GGG sequences to prompt strand break formation from direct-type radiation damage. Radiation and environmental biophysics. Wu GRadwan MKXiao MAdachi HFan JYu YT (2016 Jun 7). The TOR signaling pathway regulates starvation-induced pseudouridylation of yeast U2 snRNA. RNA (New York, N.Y.). Popp MWMaquat LE (2016 Jun 2). Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine. Cell. Coudray NLasala RZhang ZClark KMDumont MEStokes DL (2016 May 30). Deducing the Symmetry of Helical Assemblies: Applications to Membrane Proteins. Journal of structural biology. Salsi EFarah EErmolenko DN (2016 May 22). EF-G Activation by Phosphate Analogs. Journal of molecular biology. Kennedy RBSimon WLGibson MJGoergen KMGrill DEOberg ALPoland GA (2016 May 17). The composition of immune cells serves as a predictor of adaptive immunity in a cohort of 50- to 74-year-old adults. Immunology. Miralem TLerner-Marmarosh NGibbs PEJenkins JLHeimiller CMaines MD (2016 May 10). Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Xu SSchafer XMunger J (2016 May 1). Expression of Oncogenic Alleles Induces Multiple Blocks to Human Cytomegalovirus Infection. Journal of virology. Monaghan MWakabayashi HGriffiths AEFay PJ (2016 May). Stabilizing interactions between D666-S1787 and T657-Y1792 at the A2-A3 interface support factor VIIIa stability in the blood clotting pathway. Journal of thrombosis and haemostasis : JTH. Ling CErmolenko DN (2016 Apr 27). Structural insights into ribosome translocation. Wiley interdisciplinary reviews. RNA. Piekna-Przybylska DBambara RABalakrishnan L (2016 Apr 22). Acetylation regulates DNA repair mechanisms in human cells. Cell cycle (Georgetown, Tex.). Yue HFang HWei SHayes JJLee TH (2016 Apr 12). Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome. Biochemistry. Shaheen RHan LFaqeih EEwida NAlobeid EPhizicky EMAlkuraya FS (2016 Apr 7). A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition. Human genetics. Maquat LE (2016 Apr). Eukaryotic antisense ahead of its time. Nature reviews. Molecular cell biology. DiChiacchio LSloma MFMathews DH (2016 Apr 1). AccessFold: predicting RNA-RNA interactions with consideration for competing self-structure. Bioinformatics (Oxford, England). Hollenbaugh JAMontero CSchinazi RFMunger JKim B (2016 Apr). Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages. Virology. Carter JATriplett EStriemer CCMiller BL (2016 Mar 15). A label-free, multiplex competitive assay for small molecule pollutants. Biosensors & bioelectronics. Wu GAdachi HGe JStephenson DQuery CCYu YT (2016 Mar 15). Pseudouridines in U2 snRNA stimulate the ATPase activity of Prp5 during spliceosome assembly. The EMBO journal. Polevoda BMcDougall WMBennett RPSalter JDSmith HC (2016 Mar 14). Structural and functional assessment of APOBEC3G macromolecular complexes. Methods (San Diego, Calif.). Bertozzi CZimmermann IEngeler SHilf RJDutzler R (2016 Mar). Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels. PLoS biology. Elbarbary RAMaquat LE (2016 Mar 1). Coupling pre-mRNA splicing and 3' end formation to mRNA export: alternative ways to punch the nuclear export clock. Genes & development. Nganou CKennedy SDMcCamant DW (2016 Feb 25). Disagreement Between the Structure of the dTpT Thymine Pair Determined by NMR and Molecular Dynamics Simulations Using Amber 14 Force Fields. The journal of physical chemistry. B. McAnany JDReichert JPMiller BL (2016 Feb 24). Probing the geometric constraints of RNA binding via dynamic covalent chemistry. Bioorganic & medicinal chemistry. Elbarbary RALucas BAMaquat LE (2016 Feb 12). Retrotransposons as regulators of gene expression. Science (New York, N.Y.). Huang CKarijolich JYu YT (2016 Feb 4). Detection and quantification of RNA 2'-O-methylation and pseudouridylation. Methods (San Diego, Calif.). Kurosaki TMaquat LE (2016 Feb 1). Nonsense-mediated mRNA decay in humans at a glance. Journal of cell science. Hilimire TABennett RPStewart RAGarcia-Miranda PBlume ABecker JSherer NHelms EDButcher SESmith HCMiller BL (2016 Jan 15). N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA. ACS chemical biology. Uppal NFoxe JJButler JSAcluche FMolholm S (2016 Jan 13). The neural dynamics of somatosensory processing and adaptation across childhood: A high-density electrical mapping study. Journal of neurophysiology. Agrawal AASalsi EChatrikhi RHenderson SJenkins JLGreen MRErmolenko DNKielkopf CL (2016). An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal. Nature communications. Brule CEDean KMGrayhack EJ (2016). RNA-ID, a Powerful Tool for Identifying and Characterizing Regulatory Sequences. Methods in enzymology. Huang CWu GYu YT (2016). Purification and Functional Reconstitution of Box H/ACA Ribonucleoprotein Particles. Methods in molecular biology (Clifton, N.J.). Gibbs PEMiralem TLerner-Marmarosh NMaines MD (2016). Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice. Journal of diabetes research. DiChiacchio LMathews DH (2016). Predicting RNA-RNA Interactions Using RNAstructure. Methods in molecular biology (Clifton, N.J.). Xu ZZMathews DH (2016). Experiment-Assisted Secondary Structure Prediction with RNAstructure. Methods in molecular biology (Clifton, N.J.). Xu ZZMathews DH (2016). Prediction of Secondary Structures Conserved in Multiple RNA Sequences. Methods in molecular biology (Clifton, N.J.). Xu ZZMathews DH (2016). Secondary Structure Prediction of Single Sequences Using RNAstructure. Methods in molecular biology (Clifton, N.J.). Jenkins JLWedekind JE (2016). The Quick and the Dead: A Guide to Fast Phasing of Small Ribozyme and Riboswitch Crystal Structures. Methods in molecular biology (Clifton, N.J.). Kennedy SD (2016). NMR Methods for Characterization of RNA Secondary Structure. Methods in molecular biology (Clifton, N.J.). Leamy KAAssmann SMMathews DHBevilacqua PC (2016 Jan). Bridging the gap between in vitro and in vivo RNA folding. Quarterly reviews of biophysics. Xiao JMoon YLi LRustchenko EWakabayashi HZhao XFeng CGill SRMcLaren SMalmstrom HRen YQuivey RKoo HKopycka-Kedzierawski DT (2016). Candida albicans Carriage in Children with Severe Early Childhood Caries (S-ECC) and Maternal Relatedness. PloS one. Ling CErmolenko DN (2015 Dec 29). Initiation factor 2 stabilizes the ribosome in a semirotated conformation. Proceedings of the National Academy of Sciences of the United States of America. Zhu GKoszelak-Rosenblum MConnelly SMDumont MEMalkowski MG (2015 Dec 11). The Crystal Structure of an Integral Membrane Fatty Acid α-Hydroxylase. The Journal of biological chemistry. Quivey RGGrayhack EJFaustoferri RCHubbard CJBaldeck JDWolf ASMacGilvray MERosalen PLScott-Anne KSantiago BGopal SPayne JMarquis RE (2015 Dec). Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants. Molecular oral microbiology. Balliano AJHayes JJ (2015 Dec). Base excision repair in chromatin: Insights from reconstituted systems. DNA repair. Goodwin CMXu SMunger J (2015 Dec). Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network. Trends in microbiology. Guy MPShaw MWeiner CLHobson LStark ZRose KKalscheuer VMGecz JPhizicky EM (2015 Dec). Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1. Human mutation. Chen JLBellaousov STubbs JDKennedy SDLopez MJMathews DHTurner DH (2015 Nov 17). Nuclear Magnetic Resonance-Assisted Prediction of Secondary Structure for RNA: Incorporation of Direction-Dependent Chemical Shift Constraints. Biochemistry. Dutta DWedekind JE (2015 Nov 6). Gene Regulation Gets in Tune: How Riboswitch Tertiary-Structure Networks Adapt to Meet the Needs of Their Transcription Units. Journal of molecular biology. Huang HSantoso NPower DSimpson SDieringer MMiao HGurova KGiam CZElledge SJZhu J (2015 Nov 6). FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency. The Journal of biological chemistry. Nadtochiy SMUrciuoli WZhang JSchafer XMunger JBrookes PS (2015 Nov). Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation. Journal of molecular and cellular cardiology. Aytenfisu AHLiberman JAWedekind JEMathews DH (2015 Nov). Molecular mechanism for preQ1-II riboswitch function revealed by molecular dynamics. RNA (New York, N.Y.). Polevoda BMcDougall WMTun BNCheung MSalter JDFriedman AESmith HC (2015 Oct 30). RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates. Nucleic acids research. Campbell ABushman JMunger JNoble MPröschel CMayer-Pröschel M (2015 Oct 15). Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia. Glia. Cutter ARHayes JJ (2015 Oct 7). A brief review of nucleosome structure. FEBS letters. Seward CHManzella AAlam AButler JSDziejman M (2015 Oct). Using S. cerevisiae as a Model System to Investigate V. cholerae VopX-Host Cell Protein Interactions and Phenotypes. Toxins. Yada KNogami KTakeyama MOgiwara KWakabayashi HShima M (2015 Oct). Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity. Journal of thrombosis and haemostasis : JTH. Karijolich JYi CYu YT (2015 Oct). Transcriptome-wide dynamics of RNA pseudouridylation. Nature reviews. Molecular cell biology. Loerch SKielkopf CL (2015 Sep 25). Dividing and Conquering the Family of RNA Recognition Motifs: A Representative Case Based on hnRNP L. Journal of molecular biology. Wu YShi BDing XLiu THu XYip KYYang ZRMathews DHLu ZJ (2015 Sep 3). Improved prediction of RNA secondary structure by integrating the free energy model with restraints derived from experimental probing data. Nucleic acids research. Cozen AEQuartley EHolmes ADHrabeta-Robinson EPhizicky EMLowe TM (2015 Sep). ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments. Nature methods. Lin DGrossfield A (2015 Aug 18). Thermodynamics of Micelle Formation and Membrane Fusion Modulate Antimicrobial Lipopeptide Activity. Biophysical journal. Leioatts NRomo TDDanial SAGrossfield A (2015 Aug 4). Retinal Conformation Changes Rhodopsin's Dynamic Ensemble. Biophysical journal. Buescher JMAntoniewicz MRBoros LGBurgess SCBrunengraber HClish CBDeBerardinis RJFeron OFrezza CGhesquiere BGottlieb EHiller KJones RGKamphorst JJKibbey RGKimmelman ACLocasale JWLunt SYMaddocks ODMalloy CMetallo CMMeuillet EJMunger JNöh KRabinowitz JDRalser MSauer UStephanopoulos GSt-Pierre JTennant DAWittmann CVander Heiden MGVazquez AVousden KYoung JDZamboni NFendt SM (2015 Aug). A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current opinion in biotechnology. Liberman JASuddala KCAytenfisu AChan DBelashov IASalim MMathews DHSpitale RCWalter NGWedekind JE (2015 Jul 7). Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics. Proceedings of the National Academy of Sciences of the United States of America. Miller BL (2015 Jul). mRNA regulation: A patch for a splice. Nature chemical biology. Power DSantoso NDieringer MYu JHuang HSimpson SSeth IMiao HZhu J (2015 Jul). IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. Virology. Condon DEKennedy SDMort BCKierzek RYildirim ITurner DH (2015 Jun 9). Stacking in RNA: NMR of Four Tetramers Benchmark Molecular Dynamics. Journal of chemical theory and computation. Ling CErmolenko DN (2015 Jun 2). Ribosome subunit joining frozen in time. Structure (London, England : 1993). Chen JLKennedy SDTurner DH (2015 Jun 2). Structural features of a 3' splice site in influenza a. Biochemistry. Xu SSpencer CMMunger J (2015 Jun). Transformation with oncogenic Ras and the simian virus 40 T antigens induces caspase-dependent sensitivity to fatty acid biosynthetic inhibition. Journal of virology. Wolf ASGrayhack EJ (2015 May). Asc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats. RNA (New York, N.Y.). Xu FHuang YLi LGannon PLinster EHuber MKapos PBienvenut WPolevoda BMeinnel THell RGiglione CZhang YWirtz MChen SLi X (2015 May). Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. The Plant cell. Jin GPavelka MSButler JS (2015 Apr). Structure-function analysis of VapB4 antitoxin identifies critical features of a minimal VapC4 toxin-binding module. Journal of bacteriology. Elbarbary RAMaquat LE (2015 Apr 1). CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention. Genes & development. Okeyo-Owuor TWhite BSChatrikhi RMohan DRKim SGriffith MDing LKetkar-Kulkarni SHundal JLaird KMKielkopf CLLey TJWalter MJGraubert TA (2015 Apr). U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing. Leukemia. Maquat LE (2015 Apr). The amazing web of post-transcriptional gene control: the sum of small changes can make for significant consequences. RNA (New York, N.Y.). Phizicky EMHopper AK (2015 Apr). tRNA processing, modification, and subcellular dynamics: past, present, and future. RNA (New York, N.Y.). Karijolich JYu YT (2015 Apr). The new era of RNA modification. RNA (New York, N.Y.). Aroda VRChristophi CAEdelstein SLZhang PHerman WHBarrett-Connor EDelahanty LMMontez MGAckermann RTZhuo XKnowler WCRatner RE (2015 Apr). The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up. The Journal of clinical endocrinology and metabolism. Popp MWMaquat LE (2015 Mar 20). RNA. A TRICK'n way to see the pioneer round of translation. Science (New York, N.Y.). Zuber JDanial SAConnelly SMNaider FDumont ME (2015 Mar 10). Identification of destabilizing and stabilizing mutations of Ste2p, a G protein-coupled receptor in Saccharomyces cerevisiae. Biochemistry. Baker JESriram RMiller BL (2015 Feb 21). Two-dimensional photonic crystals for sensitive microscale chemical and biochemical sensing. Lab on a chip. Han LKon YPhizicky EM (2015 Feb). Functional importance of Ψ38 and Ψ39 in distinct tRNAs, amplified for tRNAGln(UUG) by unexpected temperature sensitivity of the s2U modification in yeast. RNA (New York, N.Y.). Bulger MPalis J (2015 Feb). Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages. Trends in immunology. Kapogiannis DBoxer ASchwartz JBAbner ELBiragyn AMasharani UFrassetto LPetersen RCMiller BLGoetzl EJ (2015 Feb). Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Salsi EFarah ENetter ZDann JErmolenko DN (2015 Jan 30). Movement of elongation factor G between compact and extended conformations. Journal of molecular biology. Leong LSim DPatel CTran KLiu PHo EThompson TKretschmer PJWakabayashi HFay PJMurphy JE (2015 Jan 8). Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models. Blood. Fu YXu ZZLu ZJZhao SMathews DH (2015). Discovery of Novel ncRNA Sequences in Multiple Genome Alignments on the Basis of Conserved and Stable Secondary Structures. PloS one. Payea MJGuy MPPhizicky EM (2015). Methodology for the High-Throughput Identification and Characterization of tRNA Variants That Are Substrates for a tRNA Decay Pathway. Methods in enzymology. Gibbs PEMiralem TMaines MD (2015). Biliverdin reductase: a target for cancer therapy? Frontiers in pharmacology. Aytenfisu AHSpasic AGrossfield AStern HMathews DH (2015). 99 Improving the amber RNA force field. Journal of biomolecular structure & dynamics. Mathew EDumont ME (2015). A Novel Screening Approach for Optimal and Functional Fusion of T4 Lysozyme in GPCRs. Methods in enzymology. Gong CMaquat LE (2015). Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells. Methods in molecular biology (Clifton, N.J.). Jackson KLDayton RDOrchard EAJu SRinge DPetsko GAMaquat LEKlein RL (2015 Jan). Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis. Gene therapy. Popp MWMaquat LE (2015). Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics. Nature communications. Sloma MFMathews DH (2015). Improving RNA secondary structure prediction with structure mapping data. Methods in enzymology. Bucukovski JLatorre-Margalef NStallknecht DEMiller BL (2015). A Multiplex Label-Free Approach to Avian Influenza Surveillance and Serology. PloS one. Guy MPPhizicky EM (2015 Jan). Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes. RNA (New York, N.Y.). Shaheen RAbdel-Salam GMGuy MPAlomar RAbdel-Hamid MSAfifi HHIsmail SIEmam BAPhizicky EMAlkuraya FS (2015). Mutation in WDR4 impairs tRNA m(7)G46 methylation and causes a distinct form of microcephalic primordial dwarfism. Genome biology. Enwerem IIWu GYu YTHebert MD (2015). Cajal body proteins differentially affect the processing of box C/D scaRNPs. PloS one. Wu GHuang CYu YT (2015). Pseudouridine in mRNA: Incorporation, Detection, and Recoding. Methods in enzymology. Fu YSharma GMathews DH (2014 Dec 16). Dynalign II: common secondary structure prediction for RNA homologs with domain insertions. Nucleic acids research. DeVito SROrtiz-Riaño EMartínez-Sobrido LMunger J (2014 Dec 16). Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation. Proceedings of the National Academy of Sciences of the United States of America. Romo TDLeioatts NGrossfield A (2014 Dec 15). Lightweight object oriented structure analysis: tools for building tools to analyze molecular dynamics simulations. Journal of computational chemistry. Agrawal AAMcLaughlin KJJenkins JLKielkopf CL (2014 Dec 9). Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. Proceedings of the National Academy of Sciences of the United States of America. Mathers CSchafer XMartínez-Sobrido LMunger J (2014 Dec). The human cytomegalovirus UL26 protein antagonizes NF-κB activation. Journal of virology. Adachi HYu YT (2014 Nov 26). Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation. World journal of biological chemistry. Zhu JDavoli TPerriera JMChin CRGaiha GDJohn SPSigiollot FDGao GXu QQu HPertel TSims JSSmith JABaker REMaranda LNg AElledge SJBrass AL (2014 Oct 23). Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents. Cell reports. Lin DGrossfield A (2014 Oct 21). Thermodynamics of antimicrobial lipopeptide binding to membranes: origins of affinity and selectivity. Biophysical journal. Salsi EFarah EDann JErmolenko DN (2014 Oct 21). Following movement of domain IV of elongation factor G during ribosomal translocation. Proceedings of the National Academy of Sciences of the United States of America. Leioatts NSuresh PRomo TDGrossfield A (2014 Oct). Structure-based simulations reveal concerted dynamics of GPCR activation. Proteins. De CLiu DZheng BSingh USChavre SWhite CArnold RDHagen FKChu CKMoffat JF (2014 Oct). β-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism. Antiviral research. Le NTTakei YIzawa-Ishizawa YHeo KSLee HSmrcka AVMiller BLKo KATure SMorrell CFujiwara KAkaike MAbe J (2014 Oct 1). Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents. Journal of immunology (Baltimore, Md. : 1950). Pepenella SMurphy KJHayes JJ (2014 Sep 26). A distinct switch in interactions of the histone H4 tail domain upon salt-dependent folding of nucleosome arrays. The Journal of biological chemistry. Tian LWang CHagen FKGormley MAddya SSoccio RCasimiro MCZhou JPowell MJXu PDeng HSauve AAPestell RG (2014 Sep 15). Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells. Oncotarget. Monaghan MWakabayashi HGriffiths AWintermute JFay PJ (2014 Sep 2). Enhanced factor VIIIa stability of A2 domain interface variants results from an increased apparent affinity for the A2 subunit. Results from an increased apparent affinity for the A2 subunit. Thrombosis and haemostasis. Kurosaki TLi WHoque MPopp MWErmolenko DNTian BMaquat LE (2014 Sep 1). A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. Genes & development. Salter JDMorales GASmith HC (2014 Sep). Structural insights for HIV-1 therapeutic strategies targeting Vif. Trends in biochemical sciences. Kosloski MPShetty KAWakabayashi HFay PJBalu-Iyer SV (2014 Sep). Effects of replacement of factor VIII amino acids Asp519 and Glu665 with Val on plasma survival and efficacy in vivo. The AAPS journal. Jiang TKennedy SDMoss WNKierzek ETurner DH (2014 Aug 19). Secondary structure of a conserved domain in an intron of influenza A M1 mRNA. Biochemistry. Fiandaca MSKapogiannis DMapstone MBoxer AEitan ESchwartz JBAbner ELPetersen RCFederoff HJMiller BLGoetzl EJ (2014 Aug 14). Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimer's & dementia : the journal of the Alzheimer's Association. Zhang XWalker RCPhizicky EMMathews DH (2014 Aug 12). Influence of Sequence and Covalent Modifications on Yeast tRNA Dynamics. Journal of chemical theory and computation. Guy MPYoung DLPayea MJZhang XKon YDean KMGrayhack EJMathews DHFields SPhizicky EM (2014 Aug 1). Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis. Genes & development. Beckham CJOlsen JYin PNWu CHTing HJHagen FKScosyrev EMessing EMLee YF (2014 Aug). Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression. The Journal of urology. Avilés-Reyes AMiller JHSimpson-Haidaris PJHagen FKAbranches JLemos JA (2014 Aug). Modification of Streptococcus mutans Cnm by PgfS contributes to adhesion, endothelial cell invasion, and virulence. Journal of bacteriology. Kravets AYang FBethlendy GCao YSherman FRustchenko E (2014 Aug). Adaptation of Candida albicans to growth on sorbose via monosomy of chromosome 5 accompanied by duplication of another chromosome carrying a gene responsible for sorbose utilization. FEMS yeast research. Karijolich JYu YT (2014 Aug). Therapeutic suppression of premature termination codons: mechanisms and clinical considerations (review). International journal of molecular medicine. Mnpotra JSQiao ZCai JLynch DLGrossfield ALeioatts NHurst DPPitman MCSong ZHReggio PH (2014 Jul 18). Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complex. The Journal of biological chemistry. Wakabayashi HWintermute JMFay PJ (2014 Jul 3). Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa. Thrombosis and haemostasis. Takahashi MElbarbary RAWatanabe NGoto AKamiya DWatabe YUchiyama TNarita MTakahashi MTakahashi YIshihara NMiyazawa TYoshida TKawano MTamura MNashimoto M (2014 Jul). Screening of a heptamer-type sgRNA library for potential therapeutic agents against hematological malignancies. Leukemia research. Gleghorn MLMaquat LE (2014 Jul). 'Black sheep' that don't leave the double-stranded RNA-binding domain fold. Trends in biochemical sciences. Prohaska KMBennett RPSalter JDSmith HC (2014 Jul). The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions. Wiley interdisciplinary reviews. RNA. Loerch SMaucuer AManceau VGreen MRKielkopf CL (2014 Jun 20). Cancer-relevant splicing factor CAPERα engages the essential splicing factor SF3b155 in a specific ternary complex. The Journal of biological chemistry. Romo TDGrossfield A (2014 Jun 17). How fast is your camera? Timescales for molecular motion and their role in restraining molecular dynamics. Biophysical journal. Heldenbrand HJanowski PAGiambaşu GGiese TJWedekind JEYork DM (2014 Jun 4). Evidence for the role of active site residues in the hairpin ribozyme from molecular simulations along the reaction path. Journal of the American Chemical Society. Hoskins JWOfori LOChen CZKumar ASobczak KNakamori MSouthall NPatnaik SMarugan JJZheng WAustin CPDisney MDMiller BLThornton CA (2014 Jun 1). Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects. Nucleic acids research. Gibbs PELerner-Marmarosh NPoulin AFarah EMaines MD (2014 Jun). Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Kinsey CBalakrishnan VO'Dell MRHuang JLNewman LWhitney-Miller CLHezel AFLand H (2014 May 22). Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression. Cell reports. Wakabayashi HMonaghan MFay PJ (2014 May 16). Cofactor activity in factor VIIIa of the blood clotting pathway is stabilized by an interdomain bond between His281 and Ser524 formed in factor VIII. The Journal of biological chemistry. Piekna-Przybylska DSullivan MASharma GBambara RA (2014 Apr 29). U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence. Biochemistry. Romo TDGrossfield A (2014 Apr 15). Unknown unknowns: the challenge of systematic and statistical error in molecular dynamics simulations. Biophysical journal. Proschel CStripay JLShih CHMunger JCNoble MD (2014 Apr). Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons. EMBO molecular medicine. Nadtochiy SMMadukwe JHagen FBrookes PS (2014 Apr). Mitochondrially targeted nitro-linoleate: a new tool for the study of cardioprotection. British journal of pharmacology. Sripakdeevong PCevec MChang ATErat MCZiegeler MZhao QFox GEGao XKennedy SDKierzek RNikonowicz EPSchwalbe HSigel RKTurner DHDas R (2014 Apr). Structure determination of noncanonical RNA motifs guided by ¹H NMR chemical shifts. Nature methods. Moran YFredman DPraher DLi XZWee LMRentzsch FZamore PDTechnau USeitz H (2014 Apr). Cnidarian microRNAs frequently regulate targets by cleavage. Genome research. Popp MWMaquat LE (2014 Apr). Defective secretory-protein mRNAs take the RAPP. Trends in biochemical sciences. Ishiguro KKim JShibuya HHernández-Hernández ASuzuki AFukagawa TShioi GKiyonari HLi XCSchimenti JHöög CWatanabe Y (2014 Mar 15). Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes & development. Aytenfisu AHSpasic ASeetin MGSerafini JMathews DH (2014 Mar 11). Modified Amber Force Field Correctly Models the Conformational Preference for Tandem GA pairs in RNA. Journal of chemical theory and computation. Kimura TVukoti KLynch DLHurst DPGrossfield APitman MCReggio PHYeliseev AAGawrisch K (2014 Mar). Global fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations. Proteins. Pepenella SMurphy KJHayes JJ (2014 Mar). Intra- and inter-nucleosome interactions of the core histone tail domains in higher-order chromatin structure. Chromosoma. Tanui PKennedy SDLunstad BDHaas ALeake DRozners E (2014 Feb 28). Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages. Organic & biomolecular chemistry. Ofori LOHilimire TABennett RPBrown NWSmith HCMiller BL (2014 Feb 13). High-affinity recognition of HIV-1 frameshift-stimulating RNA alters frameshifting in vitro and interferes with HIV-1 infectivity. Journal of medicinal chemistry. Condon DEYildirim IKennedy SDMort BCKierzek RTurner DH (2014 Feb 6). Optimization of an AMBER force field for the artificial nucleic acid, LNA, and benchmarking with NMR of L(CAAU). The journal of physical chemistry. B. Yadav ARSriram RCarter JAMiller BL (2014 Feb 1). Comparative study of solution-phase and vapor-phase deposition of aminosilanes on silicon dioxide surfaces. Materials science & engineering. C, Materials for biological applications. Marrero DPan QBarrett-Connor Ede Groot MZhang PPercy CFlorez HAckermann RMontez MRubin RR (2014 Feb). Impact of diagnosis of diabetes on health-related quality of life among high risk individuals: the Diabetes Prevention Program outcomes study. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. Leioatts NMertz BMartínez-Mayorga KRomo TDPitman MCFeller SEGrossfield ABrown MF (2014 Jan 21). Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures. Biochemistry. Lifson MABasu Roy DMiller BL (2014 Jan 21). Enhancing the detection limit of nanoscale biosensors via topographically selective functionalization. Analytical chemistry. Yadav ARMace CRMiller BL (2014 Jan 21). Examining the interactions of the splicing factor MBNL1 with target RNA sequences via a label-free, multiplex method. Analytical chemistry. Pop CRouskin SIngolia NTHan LPhizicky EMWeissman JSKoller D (2014). Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation. Molecular systems biology. Cadiz-Rivera BFromm Gde Vries CFields JMcGrath KEFiering SBulger M (2014). The chromatin "landscape" of a murine adult β-globin gene is unaffected by deletion of either the gene promoter or a downstream enhancer. PloS one. Hamilton BManzella ASchmidt KDiMarco VButler JS (2014). Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. PloS one. Sridharan RZuber JConnelly SMMathew EDumont ME (2014 Jan). Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors. Biochimica et biophysica acta. Elbarbary RAMaquat LE (2014). Dodging two bullets with one dsRNA-binding protein. Cell cycle (Georgetown, Tex.). Horn JNKao TCGrossfield A (2014). Coarse-grained molecular dynamics provides insight into the interactions of lipids and cholesterol with rhodopsin. Advances in experimental medicine and biology. Cohen LSArshava BKauffman SMathew EFracchiolla KEDing FXDumont MEBecker JMNaider F (2014 Jan). Guided reconstitution of membrane protein fragments. Biopolymers. Popp MWMaquat LE (2014 Jan). The dharma of nonsense-mediated mRNA decay in mammalian cells. Molecules and cells. Belfort MMarraffini LMacfarlan TBoeke JSlotkin KMalik HMaquat L (2014). Mobile DNA: an evolving field. Mobile DNA. Ortiz-Riaño ENgo NDevito SEggink DMunger JShaw MLde la Torre JCMartínez-Sobrido L (2014 Jan). Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor. Journal of virology. Mathews DH (2014). Using the RNAstructure Software Package to Predict Conserved RNA Structures. Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.]. Mathews DH (2014). RNA Secondary Structure Analysis Using RNAstructure. Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.]. Mathers CSpencer CMMunger J (2014). Distinct domains within the human cytomegalovirus U(L)26 protein are important for wildtype viral replication and virion stability. PloS one. Guy MPPhizicky EM (2014). Two-subunit enzymes involved in eukaryotic post-transcriptional tRNA modification. RNA biology. Liberman JABogue JTJenkins JLSalim MWedekind JE (2014). ITC analysis of ligand binding to preQ₁ riboswitches. Methods in enzymology. Adachi HYu YT (2014). Purification of radiolabeled RNA products using denaturing gel electrophoresis. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]. Lim SJScott AXiong XPVahidpour SKarijolich JGuo DPei SYu YTZhou RLi WX (2014). Requirement for CRIF1 in RNA interference and Dicer-2 stability. RNA biology. Yu YTMeier UT (2014). RNA-guided isomerization of uridine to pseudouridine--pseudouridylation. RNA biology. Larman HBLiang ACElledge SJZhu J (2014 Jan). Discovery of protein interactions using parallel analysis of translated ORFs (PLATO). Nature protocols. Bera APerkins EMZhu JZhu HDesai P (2014). DNA binding and condensation properties of the herpes simplex virus type 1 triplex protein VP19C. PloS one. Liu ZPWu HZhu JMiao H (2014). Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection. BMC bioinformatics. Brilot AFKorostelev AAErmolenko DNGrigorieff N (2013 Dec 24). Structure of the ribosome with elongation factor G trapped in the pretranslocation state. Proceedings of the National Academy of Sciences of the United States of America. Sutton KABlack PJMercer KRGarman EFOwen RLSnell EHBernhard WA (2013 Dec). Insights into the mechanism of X-ray-induced disulfide-bond cleavage in lysozyme crystals based on EPR, optical absorption and X-ray diffraction studies. Acta crystallographica. Section D, Biological crystallography. Suddala KCRinaldi AJFeng JMustoe AMEichhorn CDLiberman JAWedekind JEAl-Hashimi HMBrooks CLWalter NG (2013 Dec). Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure. Nucleic acids research. Pei SMinhajuddin MCallahan KPBalys MAshton JMNeering SJLagadinou EDCorbett CYe HLiesveld JLO'Dwyer KMLi ZShi LGreninger PSettleman JBenes CHagen FKMunger JCrooks PABecker MWJordan CT (2013 Nov 22). Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells. The Journal of biological chemistry. Wakabayashi HFay PJ (2013 Oct 25). Replacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXa. The Journal of biological chemistry. Azpurua JKe ZChen IXZhang QErmolenko DNZhang ZDGorbunova VSeluanov A (2013 Oct 22). Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage. Proceedings of the National Academy of Sciences of the United States of America. Raghuram NStrickfaden HMcDonald DWilliams KFang HMizzen CHayes JJTh'ng JHendzel MJ (2013 Oct 14). Pin1 promotes histone H1 dephosphorylation and stabilizes its binding to chromatin. The Journal of cell biology. Wang JLi DBambara RADykes C (2013 Oct). Reverse transcriptase backbone can alter the polymerization and RNase activities of non-nucleoside reverse transcriptase mutants K101E+G190S. The Journal of general virology. Seckler JMLeioatts NMiao HGrossfield A (2013 Oct). The interplay of structure and dynamics: insights from a survey of HIV-1 reverse transcriptase crystal structures. Proteins. Horn JNCravens AGrossfield A (2013 Oct 1). Interactions between fengycin and model bilayers quantified by coarse-grained molecular dynamics. Biophysical journal.