URMC / Biochemistry & Biophysics / Research / Recent Publications Recent Publications Jiang MLi HZhang YYang YLu RLiu KLin SLan XWang HWu HZhu JZhou ZXu JLee DKZhang LLee YCYuan JAbrams JAWang TCSepulveda ARWu QChen HSun XShe JChen XQue J (2017 Oct 11). Transitional basal cells at the squamous-columnar junction generate Barrett's oesophagus. Nature. Tencer AHCox KLDi LBridgers JBLyu JWang XSims JKWeaver TMAllen HFZhang YGatchalian JDarcy MAGibson MDIkebe JLi WWade PAHayes JJStrahl BDKono HPoirier MGMusselman CAKutateladze TG (2017 Oct 10). Covalent Modifications of Histone H3K9 Promote Binding of CHD3. Cell reports. Murphy KJCutter ARFang HPostnikov YVBustin MHayes JJ (2017 Sep 29). HMGN1 and 2 remodel core and linker histone tail domains within chromatin. Nucleic acids research. Glasser EAgrawal AAJenkins JLKielkopf CL (2017 Sep 01). Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs. Biochemistry. Novosjolova IKennedy SDRozners E (2017 Aug 31). 2-Methoxypyridine as Thymidine Mimic in Watson-Crick Base Pairs of DNA and PNA: Synthesis, Thermal Stability and NMR Structural Studies. Chembiochem : a European journal of chemical biology. Hayashi TJean MHuang HSimpson SSantoso NGZhu J (2017 Aug 22). Screening of an FDA-approved compound library identifies levosimendan as a novel anti-HIV-1 agent that inhibits viral transcription. Antiviral research. Mutisya DHardcastle TCheruiyot SKPallan PSKennedy SDEgli MKelley MLSmith AVBRozners E (2017 Aug 21). Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs. Nucleic acids research. Poole ARVicino IAdachi HYu YTHebert MD (2017 Aug 14). Regulatory RNPs: a novel class of ribonucleoproteins that potentially contribute to ribosome heterogeneity. Biology open. Tan ZSharma GMathews DH (2017 Jul 20). Modeling RNA Secondary Structure with Sequence Comparison and Experimental Mapping Data. Biophysical journal. Kauffmann ADKennedy SDZhao JTurner DH (2017 Jul 12). Nuclear Magnetic Resonance Structure of an 8 × 8 Nucleotide RNA Internal Loop Flanked on Each Side by Three Watson-Crick Pairs and Comparison to Three-Dimensional Predictions. Biochemistry. Romo TDLewis AKBraun ARGrossfield ASachs JN (2017 Jul 05). Minimal nucleation state of alpha-Synuclein is stabilized by dynamic threonine-water networks. ACS chemical neuroscience. Nadtochiy SMWang YTZhang JNehrke KSchafer XWelle KGhaemmaghami SMunger JBrookes PS (2017 Jul 03). Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation. The Biochemical journal. Ward MDatta AWise MMathews DH (2017 Jun 06). Advanced multi-loop algorithms for RNA secondary structure prediction reveal that the simplest model is best. Nucleic acids research. Elbarbary RAMaquat LE (2017 Jun 06). Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism. Nature structural & molecular biology. Bednar JGarcia-Saez IBoopathi RCutter ARPapai GReymer ASyed SHLone INTonchev OCrucifix CMenoni HPapin CSkoufias DAKurumizaka HLavery RHamiche AHayes JJSchultz PAngelov DPetosa CDimitrov S (2017 Jun 01). Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1. Molecular cell. Elbarbary RAMiyoshi KMyers JRDu PAshton JMTian BMaquat LE (2017 May 26). Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition. Science (New York, N.Y.). Polevoda BJoseph RFriedman AEBennett RPGreiner RDe Zoysa TStewart RASmith HC (2017 May 26). DNA mutagenic activity and capacity for HIV-1 restriction of the cytidine deaminase APOBEC3G depend on whether DNA or RNA binds to tyrosine 315. The Journal of biological chemistry. Hilimire TAChamberlain JMAnokhina VBennett RPSwart OMyers JRAshton JMStewart RAFeatherston ALGates KHelms EDSmith HCDewhurst SMiller BL (2017 May 05). HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells. ACS chemical biology. Bednar JGarcia-Saez IBoopathi RCutter ARPapai GReymer ASyed SHLone INTonchev OCrucifix CMenoni HPapin CSkoufias DAKurumizaka HLavery RHamiche AHayes JJSchultz PAngelov DPetosa CDimitrov S (2017 May 04). Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1. Molecular cell. East-Seletsky AO'Connell MRBurstein DKnott GJDoudna JA (2017 May 04). RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes. Molecular cell. Wedekind JEDutta DBelashov IAJenkins JL (2017 Apr 28). Metalloriboswitches: RNA-Based Inorganic Ion Sensors that Regulate Genes. The Journal of biological chemistry. 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Yang FZhang LWakabayashi HMyers JJiang YCao YJimenez-Ortigosa CPerlin DSRustchenko E (2017 Feb 21). Tolerance to caspofungin in Candida albicans is associated with at least three distinctive mechanisms that govern expression of FKS genes and cell wall remodeling. Antimicrobial agents and chemotherapy. Aytenfisu AHSpasic AGrossfield AStern HAMathews DH (2017 Feb 14). Revised RNA Dihedral Parameters for the Amber Force Field Improve RNA Molecular Dynamics. Journal of chemical theory and computation. Clark KMJenkins JLFedoriw NDumont ME (2017 Feb). Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors. Protein science : a publication of the Protein Society. Balliano AHao FNjeri CBalakrishnan LHayes JJ (2017 Jan 18). HMGB1 Stimulates Activity of Polymerase β on Nucleosome Substrates. Biochemistry. 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