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Frank C. Passero, M.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Setting



As a physician I aim to provide patients with an understanding of their medical condition and guidance as they navigate complex medical decisions. I consider honesty, compassion and my medical knowledge as foundational principles upon which I seek to build a trusting patient-physician relationship. Getting to know my patients, their unique circumstances and goals is a key aspect of my practice, in order to provide patients with a personalized plan of care.

I obtained my medical degree from Jefferson Medical College in Philadelphia, Pennsylvania and went on to complete internship, residency, and a chief medical residency in Internal Medicine at Scripps Mercy Hospital in San Diego. I pursued my Hematology and Oncology fellowship training at Tufts Medical Center in Boston, Massachusetts where I carried out laboratory research studying the effects of proteasome and HDAC inhibitors in lymphoma.

I have a special interest in plasma cell disorders including myeloma and amyloidosis, and would like to provide patients with the opportunity to participate in well-designed clinical trials for these and other related diseases.



MD | Thomas Jefferson University Hospital

Post-doctoral Training & Residency

07/01/2014 - 06/30/2017
Fellowship in Hematology & Oncology at Tufts Medical Center

07/01/2011 - 06/30/2014
Residency in Internal Medicine at Mercy Hospital & Medical Center-San Diego (GME)

06/24/2010 - 06/23/2011
Internship in Internal Medicine at Mercy Hospital & Medical Center-San Diego (GME)

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Clinical Trials

A Phase II Study of Steroid Sparing Treatment With Daratumumab and Lenalidomide in Newly Diagnosed Transplant Ineligible Patients With Multiple Myeloma

Lead Researcher: Frank C Passero

The purpose of this study is to determine the effects of daratumumab and lenalidomide without steroids for treating patients with multiple myeloma.

View Study Details


Journal Articles

Komisarof J, Forman J, Goldman B, Syposs C, Passero F, Garbade E. "A Rare Case of Renal Thrombotic Microangiopathy and Focal Segmental Glomerulosclerosis Secondary to Plasma Cell Leukemia." Case reports in hematology.. 2023 2023:7803704. Epub 2023 Feb 18.

Alom MS, Grewal R, Passero FC, Goldman B, Choung HYG. "Light chain deposition disease masquerading as smoking-associated nodular glomerulosclerosis with deposits identified by electron microscopy only." CEN case reports.. 2022 Mar 22; Epub 2022 Mar 22.

Komisarof J, Lipof J, DiTursi J, Chowdhry A, Grace Choung HY, Burack WR, Constine L, Passero F. "An Unusual Case of Multiple Myeloma with Light-Chain Cast Nephropathy Secondary to a Very Large Plasmacytoma without Bone Marrow Involvement." Case reports in hematology.. 2022 2022:7531142. Epub 2022 Feb 21.