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ENT Opens Dedicated Pediatric Center

Pediatric patients in need of otolaryngology services now have a dedicated team and location designed to meet their specific needs. UR Medicine Pediatric Otolaryngology and Audiology opened in February in a spacious child-friendly suite at 125 Lattimore Road to provide a full array of diagnostic and therapeutic services.

The area’s only dedicated pediatric-centered ENT program, it expands upon the department’s Clinton Woods location, which will continue to offer pediatric services.

“Having space dedicated to caring for children and working with their families supports our goal of providing comprehensive care for children with ear, nose and throat problems,” said program director Margo McKenna Benoit, M.D., associate professor of Otolaryngology.peds providers

The area’s only fellowship-trained pediatric otolaryngologists, Margo Benoit, M.D. and John Faria, M.D., assistant professor of            Otolaryngology, are teamed with advanced practice providers Laine DiNoto, NP, and Amanda Didas, PA, to care for patients at the new location.

Designed to be spacious and welcoming for families, the site offers nine fully equipped exam rooms, comprehensive audiology services including two pediatric sound booths, and an environment conducive to coordinating care across pediatric specialties.



HPV May Lurk In Your Throat

Wednesday, January 31, 2018

By Susanne Pallo

Human papilloma virus (HPV), the culprit behind cervical cancer and some forms of head and neck cancer may hide in small pockets on the surface of tonsils in people not known to carry the virus. The finding, reported by University of Rochester Medical Center researchers in the Journal of the American Medical Association, could be pivotal for the prevention of oropharyngeal cancers that form on the tonsils and tongue.

By mid-adulthood, most people have been exposed to HPV. The same strains that cause cervical cancer (mainly HPV 16 and 18) cause head and neck cancers. While verified tests exist to detect HPV in people before they develop cervical cancer, the same is not true for HPV-related head and neck cancers, which are expected to outnumber cervical cancer cases by 2020.

Only about five percent of HPV-infected people will develop cancer of the mouth or throat, suggesting most people’s immune systems can easily hold back HPV infections. Which begs the question, why doesn’t the immune system protect the five percent who develop cancer?

Our findings could have far-reaching implications for identifying people at risk of developing HPV-related head and neck cancers and ultimately preventing them.

Matthew Miller, M.D., associate professor of Otolaryngology and Neurosurgery at URMC believes the answer lies is biofilms - thin, slimy sheets of bacteria. He and his colleagues found HPV encased in biofilms inside pockets on the tonsil surface, called tonsil crypts, which is where HPV-related head and neck cancers often originate.

Miller and study co-author, Katherine Reith, M.D., an Otolaryngology resident at URMC, studied tissue samples from 102 patients who had elective tonsillectomies. Five of those samples contained HPV and four contained high risk strains, HPV 16 and 18. In every case, HPV was found in tonsil crypts biofilms.

The group believes HPV is shed from the tonsil during an active infection and gets trapped in the biofilm, where it may be protected from immune attack. In the crypts, the virus likely lays in wait for an opportunity to reinstate infection or invade the tonsil tissue to develop cancer.

“Given the lack of universal HPV immunization and the potential for the virus to evade the immune system even in individuals with detectable HPV in their blood, our findings could have far-reaching implications for identifying people at risk of developing HPV-related head and neck cancers and ultimately preventing them,” Miller said.

Now, the team plans to investigate potential screening tools, such as an oral rinse, to detect HPV in the mouth and throat. The next step would be to develop topical antimicrobials that would disrupt the biofilm and allow the immune system to clear the virus.

While scientists still do not know if HPV vaccines reduce head and neck cancer, Miller recommends all young boys and girls receive a full course of the vaccinations. He hopes that better oral HPV screening tools will help determine the impact of the vaccine on these cancers.

Read the full study in JAMA.