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Research Hints at the Potential of Pain Relief with CBD

Friday, November 7, 2025

Reaching for CBD-infused lotion or oil may seem like a low-risk way to find pain relief, but little is actually known about the impact that CBD has on the nervous system.

Over the past decade, the use of cannabis products for pain management has increased, in part because in 2018 Congress signed a law removing hemp from the federal Controlled Substances Act, thereby legalizing hemp-derived CBD. Today, it is most commonly found in oil form, as well as in lotions and cosmetics, and it is widely understood that CBD does not cause a ‘high’. However, what CBD does in the human body and brain is not well understood. Currently, the Food and Drug Administration has only approved CBD as an adjunctive treatment for certain forms of epilepsy, and it is not recommended for use during pregnancy.

“We need to understand more about this compound, what mechanisms it interacts with in the brain, its impact on the body, and whether it is a potentially safer solution for treating the chronic pain epidemic,” said Kuan Hong Wang, PhD, professor of Neuroscience and member of the Del Monte Institute for Neuroscience at the University of Rochester, whose lab in collaboration with researchers at Harvard Medical School and Boston Children’s Hospital, recently discovered that in mice, they could effectively deliver CBD to the brain for neuropathic pain relief with no adverse side effects. This research was published today in the journal Cell Chemical Biology.

Sex and Age Shape Progression of Batten Disease, Brainwave Study Finds

Thursday, November 6, 2025

Batten disease is a rare inherited condition that affects brain development and function. CLN3 disease is the most common type of this disease. The symptoms are life changing. They usually begin between the ages of four and seven. Children will experience vision loss, problems with cognition, movement, seizures, and difficulties with speech. The symptoms make it a difficult disease to study, and how the disease progresses in males versus females is not well understood; however, it is common for female patients with CLN3 to experience a later onset of symptoms compared to males and have a more rapid disease progression.

Researchers from the Del Monte Institute for Neuroscience at the University of Rochester have found that male and female brains show different responses as the disease progresses and have found a model of the disease that could transform future treatments, as explained in a paper published today in the Journal of Neurodevelopmental Disorders.

“Because vision and cognition decline early, it is hard for scientists to track how the disease progresses and develop reliable treatments using standard tests,” said Yanya Ding, PhD, an alumna of the Neuroscience Graduate program in the Wang Lab and first author of the study. “Being able to successfully track brain functions in mice gives us a model that could transform how we study possible treatments and therapeutics for this devastating disease.”

Using a non-invasive measure of brain electrical activity known as electroencephalography or EEG, and an audio test, researchers were able to detect how the brain responds to sound pattern changes in male and female mouse models of CLN3. They surprisingly discovered that male mice showed early auditory problems that improved with age, while female mice had persistent difficulties, evidence that both age and sex play important roles in the progression of Batten disease.

Previous research led by the co-senior author of this study, John Foxe, PhD, principal investigator of the Fredrick J. and Marion A. Schindler Cognitive Neurophysiology Lab at the University of Rochester, identified the easy-to-measure brain process or biomarker in human CLN3 patients that was used in this mouse study.

“These findings highlight the importance of tracking brain function over time and support the use of this EEG-based method as a valuable tool for monitoring disease progression and testing new treatments,” said Kuan Hong Wang, PhD, professor of Neuroscience and co-senior author of the new study. “By showing how Batten disease progresses differently in males and females, this research could help guide more personalized therapies and improve the timing of interventions for better outcomes.”

University of Rochester Neurobiologist Suzanne Haber Elected to National Academy of Medicine

Saturday, October 18, 2025

Suzanne N. Haber, PhD

Suzanne N. Haber, PhD, an internationally recognized scientist whose work has transformed our understanding of the brain networks that play a central role in many mental health disorders, including obsessive compulsive disorder (OCD) and depression, has been elected to the National Academy of Medicine (NAM). Recognized as one of the highest accolades in health and medicine, the distinction acknowledges Haber’s significant contributions to the fields of neuroscience and psychiatry over the past 40 years.   

Dean’s professor in the Department of Pharmacology and Physiology at the University of Rochester School of Medicine & Dentistry, Haber is a biological map maker, charting the brain regions and circuits that regulate motivation, cognition, and motor control. Through anatomical studies and the use of advanced imaging techniques she’s identified abnormalities in brain circuitry that contribute to neurological and mental health disorders ranging from schizophrenia and OCD to post-traumatic stress disorder, addiction, and depression.

Leader of the National Institutes of Health-funded Silvio O. Conte Center for Basic and Translational Mental Health Research at the University of Rochester, Haber partners with scientists and physicians from institutions across the country to turn her findings on circuit dysfunction into treatments that can improve people’s lives. She’s currently using circuitry models to determine which circuits physicians should target for deep brain stimulation and transcranial magnetic stimulation therapy to be most effective for individuals with OCD, depression, and addiction. 

“Suzanne’s research is highly translational,” said Steve Dewhurst, PhD, vice president for Research at the University of Rochester. “Her broad knowledge of brain networks, including the so-called ‘OCD network’, combined with the expertise of state-of-the-art imaging specialists and physicians attuned to patient needs, creates an ideal foundation for understanding how the OCD network regulates brain function in both health and disease. It also sets the stage for the development of innovative treatment strategies. This recognition is a testament to her remarkable insight and collaborative nature.”

BGG Student Marco Zocchi Defends Thesis!

Wednesday, October 15, 2025

"A Weekend in Los Angeles: Leveraging Data Science to Improve Reproducibility in Neurorehabilitation Research"

Thursday, October 9, 2025

Aaron Huynh, B.S., a PhD Student in the Neuroscience Graduate Program, recently attended the 3rd annual Reproducible Rehabilitation (ReproRehab) Research Summit as a Learning Fellow. He set goals to share his research, connect with fellow scientists studying neural recovery and rehabilitation, and gather insights to strengthen his experimental design and professional growth. Because of this experience, he gained a deeper understanding of emerging methods in motor neuroscience, valuable feedback that refined his research approach, and new professional connections that will help shape the next stages of his work.

Seven current and former NGP students received 2025 GEPA awards

Wednesday, October 1, 2025

Jiwon Choi, Jessica Ogu, Jessica Fiser, Catrin Zharry, Jonathan Williams, Michael Giannetto all were recipients of the Graduate Student Achievement/Fellowship Award.

Kathryn Toffolo, Phd was a recipient of a Postdoc Award.

If you see any of these outstanding people, let them know you heard of the award and give them a heartfelt congratulations.

Wonderful job to all.  Outstanding showing for NGP for another year.

Graduate Alumni Fellowship - Jessica Fiser

Wednesday, October 1, 2025

This fellowship annually recognizes an incoming first-year student with promise for exceptional accomplishment in graduate study.

J. Newell Stannard Scholarship - Jiwon Choi

Wednesday, October 1, 2025

To recognize one deserving incoming graduate student for their commendable academic achievements. Dr. Stannard developed the world’s first doctoral program in radiation biology at the School of Medicine and was a faculty member for almost 40 years before retiring in 1975.

Merritt and Marjorie Cleveland Fellowship - Jessica Ogu

Wednesday, October 1, 2025

Fellowship was established in 1991 from Mr. and Mrs. Merritt Cleveland and is awarded to a PhD student entering graduate study through the Biomedical Sciences Program with interest in developing a neuroscience-related research career.

Outstanding Student Mentor - Michael Giannetto

Wednesday, October 1, 2025

This award, established in 2015, recognizes a student mentor who guides, supports, and promotes the training and career development of others.

Provosts Fellowship - Jonathan Williams

Wednesday, October 1, 2025

First awarded in 1990, the Provost's Fellowship is one of the most prestigious graduate fellowships awarded by the University of Rochester, awarded to PhD applicants who possess an exemplary record of academic achievement and scholarly accomplishment from backgrounds which are underrepresented in higher education

Sarah C. Mangelsdorf and Karl S. Rosengren Presidential Award Recipients - Lia Calcines-Rodriguez & Abigail Alpers

Wednesday, October 1, 2025

The Presidential Award celebrates students who demonstrate both scholarly excellence and leadership potential, particularly through mentoring, interdisciplinary collaboration, and public or science communication.

Team Science Showcase: Cracking the Code of Chronic Pain

Friday, September 26, 2025

The path to discovery knows no walls. Labs must be nimble, intuitive, and creative to make advancements that will lead to a better understanding of the human body and treatments for disease.

When tackling a complex problem like chronic pain, which the Centers for Disease Control and Prevention estimates affects more than 50 million adults in the United States, researchers from a myriad of specialties need to join forces to ask questions and piece together answers. At the University of Rochester, dentists, neuroscientists, surgeons, psychiatrists, anesthesiologists, nurse practitioners, and others are partnering to gain knowledge and insights that could transform treatment, care, and outcomes.

“I’ve never had any collaborative environment like here. Not everyone can work with you, but everybody will listen and try to find connections,” said Eli Eliav, DMD, PhD, MBA, director of the Eastman Institute for Oral Health at the University of Rochester. “To conduct pain research, a multidisciplinary approach is key. There will never be one molecule or one drug that will solve all the pain problems in the world."

The Team(s)

At the Neuromedicine Pain Center at the University of Rochester Medical Center, neurosurgeons, neurologists, and anesthesiologists partner to create the best care and treatment plans for patients. They also work with neuroscientists like Paul Geha, MD, associate professor of Psychiatry and Neuroscience and a member of the Del Monte Institute for Neuroscience.

He and Jennifer Gewandter, PhD, MPH, associate professor of Anesthesiology and Perioperative Medicine, along with neurosurgeon Steven Soler, MD, recruit people living with pain who are undergoing spinal cord stimulation—a surgery with an average success rate of 50 percent. Prior to implantation of a spinal cord stimulator, patients must undergo psychological testing to make sure important diagnoses, like PTSD or substance abuse, aren’t missed. Their research aims to add outcome prediction to the psychological clearance step with a more comprehensive test.

“Being able to work with Jennifer, who is an expert in clinical trials, helps us maintain that connection between the more mechanistic work we do on the research side with the actual applications in treatment,” Geha said.

Millisecond Windows of Time May Be Key to How We Hear, Study Finds

Thursday, September 18, 2025

What happens when you listen to speech at a different speed? Neuroscientists thought that your brain may turn up its processing speed as well. But it turns out that at least the auditory part of the brain keeps “listening” or clocking in at a fixed time. That is the key finding of new research out today in Nature Neuroscience. The research was led by Sam Norman-Haignere, PhD, assistant professor of Biostatistics and Computational Biology, Biomedical Engineering, and Neuroscience at the Del Monte Institute for Neuroscience at the University of Rochester, in collaboration with researchers at Columbia University, including Principal Investigator Nima Mesgarani, PhD, of the Zuckerman Institute, and Menoua Keshishian, who completed his PhD in Electrical Engineering in his lab.

“This was surprising. It turns out that when you slow down a word, the auditory cortex doesn't change the time window it is processing. It's like the auditory cortex is integrating across this fixed time scale,” said Norman-Haignere, the study's first author, who started the study as a postdoctoral researcher at Columbia. “One of the key goals of this kind of research is to build better computational models of how the brain processes information in speech, which will increase our set of scientific tools and ultimately help us understand what goes awry when someone has difficulty understanding speech and language processing.”

Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student - Sara Yablonski

Monday, September 1, 2025

The Edward Peck Curtis Awards for graduate student teaching are given to a small number of full-time graduate students who have a role in undergraduate education. Recipients have assisted in undergraduate instruction, and have had significant face-to-face interaction with undergraduates in the classroom or laboratory.

Brain’s Immune Cells Key to Wiring the Adolescent Brain

Tuesday, August 26, 2025

Making a smoothie, going for an evening walk, or having empathy for a loved one are all examples of executive functions that are controlled by the brain’s frontal cortex. This area of the brain goes through profound change throughout adolescence, and it is during this time that abnormalities in maturing circuits can set the stage for neurodevelopmental disorders, such as schizophrenia and ADHD. Researchers at the Del Monte Institute for Neuroscience at the University of Rochester have discovered that microglia, the brain’s immune cells, play a key role in how the brain adapts to the changes in this area during adolescence, which may transform how neurodevelopmental disorders are treated during this window and, possibly, into adulthood.

“A better understanding of the ways we can drive changes in these circuits offers new targets for disease treatment,” said Rianne Stowell, PhD, research assistant professor of Neuroscience at the University of Rochester Medical Center, and first author of the study out today in Nature Communications. “This area is also susceptible to change, both good and bad, during adolescence. Previous work in our lab has found that both direct activation of frontal dopamine circuits and rewarding behavior drive plasticity of dopaminergic connections to the frontal cortex during adolescence, but not adulthood.”

Scientists Reveal How Senses Work Together in the Brain

Friday, August 15, 2025

It has long been understood that experiencing two senses simultaneously, like seeing and hearing, can lead to improved responses relative to those seen when only one sensory input is experienced by itself. For example, a potential prey that gets visual and auditory clues that it is about to be attacked by a snake in the grass has a better chance of survival. Precisely how multiple senses are integrated or work together in the brain has been an area of fascination for neuroscientists for decades. New research by an international collaboration of scientists at the University of Rochester and a research team in Dublin, Ireland, has revealed some new key insights.

“Just like sensory integration, sometimes you need human integration,” said John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester and co-author of the study that shows how multisensory integration happens in the brain. These findings were published in Nature Human Behaviour today. “This research was built on decades of study and friendship. Sometimes ideas need time to percolate. There is a pace to science, and this research is the perfect example of that.”

Simon Kelly, PhD, professor at University College Dublin, led the study. In 2012, his lab discovered a way to measure information for a decision being gathered over time in the brain using an electroencephalographic (EEG) signal. This step followed years of research that set the stage for this work. “We were uniquely positioned to tackle this,” Kelly said. “The more we know about the fundamental brain architecture underlying such elementary behaviors, the better we can interpret differences in the behaviors and signals associated with such tasks in clinical groups and design mechanistically informed diagnostics and treatments.”

Research participants were asked to watch a simple dot animation while listening to a series of tones and press a button when they noticed a change in the dots, the tones, or both. Using EEG, the scientists were able to infer that when changes happened in both the dots and tones, auditory and visual decision processes unfolded in parallel but came together in the motor system. This allowed participants to speed up their reaction times. “We found that the EEG accumulation signal reached very different amplitudes when auditory versus visual targets were detected, indicating that there are distinct auditory and visual accumulators,” Kelly said.

Using computational models, the researchers then tried to explain the decision signal patterns as well as reaction times. In one model, the auditory and visual accumulators race against each other to trigger a motor reaction, while the other model integrates the auditory and visual accumulators and then sends the information to the motor system. Both models worked until researchers added a slight delay to either the audio or visual signals. Then the integration model did a much better job at explaining all the data, suggesting that during a multisensory (audiovisual) experience, the decision signals may start on their own sensory-specific tracks but then integrate when sending the information to areas of the brain that generate movement.

“The research provides a concrete model of the neural architecture through which multisensory decisions are made,” Kelly said. “It clarifies that distinct decision processes gather information from different modalities, but their outputs converge onto a single motor process where they combine to meet a single criterion for action.”

A Slice of Mentorship…and Cheesecake

Tuesday, July 22, 2025

Mentorship is more than guidance—it’s about creating space for growth, shared learning, and the occasional slice of cheesecake. In this new Learners on Location video, Elizabeth Plunk, PhD, and Ania Majewska, PhD, reflect on their dynamic as mentor and trainee, the collaborative culture of their neuroscience lab, and the small traditions that make a big difference, like celebrating achievements with treats from Cheesy Eddie’s.

Joan Goodman Dissertation Fellowship - Thomas Delgado

Monday, July 21, 2025

This fellowship was endowed by Joan Wright Goodman, PhD class of 1952, to support doctoral students across disciplines in the sciences. It is one of the University’s most competitive dissertation fellowships and is given to students who display exceptional ability and promise.

Vincent du Vigneaud Award Recipients - Luke Shaw & Bryan Redmond

Monday, July 21, 2025

Vincent du Vigneaud Award and Leadership Award for Excellence in Equity and Inclusion.

Irving L. Spar Fellowship - Catrin Zharyy

Monday, July 21, 2025

Honors the memory of Dr. Spar, a former Senior Associate Dean for Graduate Studies in the School of Medicine and Dentistry.

URSMD Meliora Scholarship - Jessica Ogu

Monday, July 21, 2025

Established in 2021, the University of Rochester School of Medicine and Dentistry Meliora Scholarship recognizes incoming PhD graduate students that demonstrate strength of character and exceptional promise for success.

University of Rochester Awarded Prestigious Aging Research Center Grant

Tuesday, July 15, 2025

The National Institutes of Health has awarded University of Rochester aging researcher Vera Gorbunova, PhD, a prestigious Nathan Shock Center grant. The grant will provide nearly $1 million per year over the next five years to establish the Upstate NY Comparative Biology of Aging Nathan Shock Center.

Lifespans vary widely—more than 100-fold—across the animal kingdom. The new center will compare the biology of various long- and short-lived animal species to identify biological mechanisms that promote longevity.

“It is about making people healthier overall,” says Gorbunova, the Doris Johns Cherry Professor of Biology, co-director of the Rochester Aging Research Center, and professor of Geriatrics/Aging at the University of Rochester Medical Center. “It really is about preventing all diseases.”

Gorbunova will lead a transdisciplinary team of faculty spanning the University and Medical Center, with expertise in veterinary biology, molecular biology, biochemistry, genetics, mass spectrometry, and bioinformatics.

“There are only eight centers like this in the country, so receiving this grant really puts us on the map in a more prominent way,” says Gorbunova.

Researchers Find “Forever Chemicals” Impact the Developing Male Brain

Wednesday, July 2, 2025

“Forever chemicals” or per- and polyfluoroalkyl substances (PFAS) have been widely used in consumer and industrial products for the better part of a century, but do not break down in the natural environment. One PFAS, perfluorohexanoic acid or PFHxA, is made up of a shorter chain of molecules and is thought to have less of an impact on human health. New research from the Del Monte Institute for Neuroscience at the University of Rochester suggests otherwise, finding that early life exposure to PFHxA may increase anxiety-related behaviors and memory deficits in male mice.

Hopefully, this is the first of many studies evaluating the neurotoxicity of PFHxA.”

“Although these effects were mild, finding behavioral effects only in males was reminiscent of the many neurodevelopmental disorders that are male-biased,” said Ania Majewska, PhD, professor of Neuroscience and senior author of the study out today in the European Journal of Neuroscience. Research has shown, males are more often diagnosed with neurodevelopmental disorders such as autism and ADHD. “This finding suggests that the male brain might be more vulnerable to environmental insults during neurodevelopment.”

Researchers exposed mice to PFHxA through a mealworm treat given to the mother during gestation and lactation. They found that the male mice exposed to higher doses of PFHxA in utero and through the mother’s breastmilk showed mild developmental changes, including a decrease in activity levels, increased anxiety-like behaviors, and memory deficits. They did not find any behavioral effects in females that were exposed to PFHxA in the same way.

Laurel Carney receives national mentorship award

Friday, June 27, 2025

Laurel Carney, the Marylou Ingram Professor in Biomedical Engineering and a professor of neuroscience, received the 2025 David T. Blackstock Mentorship Award from the Acoustical Society of America. Presented by the ASA Student Association, the Blackstock Award recognizes exceptional mentorship in the field of acoustics and is based on nominations submitted by ASA members.

The award was established in 2004 by the ASA Student Council to honor individuals who demonstrate outstanding dedication and excellence in mentoring students across a wide range of areas. It was named in honor of David T. Blackstock, a pioneer in nonlinear acoustics and a former professor at both the University of Rochester and the University of Texas at Austin.

Glial Replacement Therapy Slows Huntington’s Disease in Adult Mice

Monday, June 16, 2025

Huntington’s disease has long defied attempts to rescue suffering neurons. A new study in Cell Reports shows that transplanting healthy human glial progenitor cells into the brains of adult animal models of the disease not only slowed motor and cognitive decline but also extended lifespan. These findings shift our understanding of Huntington’s pathology and open a potential path to cell-based therapies in adults already showing symptoms.

“Glia are essential caretakers of neurons,” said Steve Goldman, MD, PhD, co-director of the University of Rochester Center for Translational Neuromedicine and lead author of the study. “The restoration of healthy glial support—even after symptoms begin—could reset neuronal gene expression, stabilize synaptic function, and meaningfully delay disease progression. This study shifts the perspective on Huntington’s from a neuron-centric view to one that shows a critical role for glial pathology in driving synaptic dysfunction. It also tells us that the adult brain still has the capacity for repair when you target the right cells.”

20th Annual Steven Schwid Research Symposium Award - Leah Sheppard

Wednesday, June 11, 2025

Best Oral Pesentation June 11, 2025 "Mix23 Role in the Mitochondria and Development of Motor and Cognitive Impairment”

Why Don’t Bats Get Cancer? Researchers Discover Protection from Genes and Strong Immune Systems

Monday, June 9, 2025

UR scientists studying longevity are seeking to apply their findings to humans.

A study to look at why long-lived bats do not get cancer has broken new ground about the biological defenses that resist the disease.

Reported in the journal Nature Communications, a University of Rochester research team found that four common species of bats have superpowers allowing them to live up to 35 years, which is equal to about 180 human years, without cancer.

Vera Gorbunova, PhD, and Andrei Seluanov, PhD, members of the UR Department of Biology and Wilmot Cancer Institute, led the work. Their key discoveries on how bats prevent cancer:

• Bats and humans have a gene called p53, a tumor-suppressor that can shut down cancer. (Mutations in p53, limiting its ability act properly, occur in about half of all human cancers.) A species known as the “little brown” bat—found in Rochester and upstate New York—contain two copies of p53 and have elevated p53 activity compared to humans. High levels of p53 in the body can kill cancer cells before they become harmful in a process known as apoptosis. If levels of p53 are too high, however, this is bad because it eliminates too many cells. But bats have an enhanced system that balances apoptosis effectively.
• An enzyme, telomerase, is inherently active in bats, which allows their cells to proliferate indefinitely. This is an advantage in aging because it supports tissue regeneration during aging and injury. If cells divide uncontrollably, though, the higher p53 activity in bats compensates and can remove cancerous cells that may arise.
• Bats have an extremely efficient immune system, knocking out multiple deadly pathogens. This also contributes to bats’ anti-cancer abilities by recognizing and wiping out cancer cells, Gorbunova said. As humans age, the immune system slows, and people tend to get more inflammation (in joints and other organs), but bats are good at controlling inflammation, too. This intricate system allows them to stave off viruses and age-related diseases.

University Research Award Winners 2025

Tuesday, May 27, 2025

Congratulations to Mitchell Jude and Wang Kuan Hong who recieved a 2025 research award for Optogenetic Inactivation Of Cortico-Cortical Projection Pathways In Non-Human Primate.

Announcement of PhD Commencement Awards - 2025

Wednesday, May 7, 2025

Congratulations to our very own Luke Shaw and Bryan Redmond who are the 2025 recipients of the Vincent du Vigneaud Award and Leadership Award for Excellence in Equity and Inclusion, respectively.

Super proud of these accomplishments and for continuing to shine the light on the NGP.

- Chris Holt, Director Neuroscience Graduate Program

This kind of sleep is essential for a healthy brain

Friday, April 25, 2025

Exercising can keep you mentally engaged and increase blood flow to the brain, which is helpful in glymphatic clearance, says Maiken Nedergaard, codirector of the Center for Translational Neuromedicine. Minimizing stress also boosts the process, she added.

Researchers Find Temporary Anxiety Impacts Learning

Monday, April 21, 2025

A brief episode of anxiety may have a bigger influence on a person’s ability to learn what is safe and what is not. The research recently published in Nature Science of Learning used a virtual reality game that involved picking flowers with bees in some of the blossoms that would sting the participant—simulated by a mild electrical stimulation on the hand.

Researchers worked with 70 neurotypical participants between the ages of 20 and 30. Claire Marino, a research assistant in the ZVR Lab, and Pavel Rjabtsenkov, a Neuroscience graduate student at the University of Rochester School of Medicine and Dentistry, were co-first authors of the study that found that the people who learned to distinguish between the safe and dangerous areas—where the bees were and were not—showed better spatial memory and had lower anxiety, while participants who did not learn the different areas had higher anxiety and heightened fear even in safe areas. Surprisingly, they discovered that temporary feelings of anxiety had the biggest impact on learning and not a person’s general tendency to feel anxious.

“These results help explain why some people struggle with anxiety-related disorders, such as PTSD, where they may have difficulty distinguishing safe situations from dangerous ones,” said the senior author of this study, Benjamin Suarez-Jimenez, PhD, associate professor of Neuroscience and Center for Visual Science at the Del Monte Institute of Neuroscience at the University of Rochester. “The findings suggest that excessive anxiety disrupts spatial learning and threat recognition, which could contribute to chronic fear responses. Understanding these mechanisms may help improve treatments for anxiety and stress-related disorders by targeting how people process environmental threats.”

Suarez-Jimenez explains that it is now important to understand if individuals with psychopathologies of anxiety and stress have similar variations in spatial memory. Adding an attention-tracking measure, like eye-tracking, to future studies could help determine whether a focus on potential threats impacts broader environmental awareness.

Additional authors include Caitlin Sharp, Zonia Ali, Evelyn Pineda, Shreya Bavdekar, Tanya Garg, Kendal Jordan, Mary Halvorsen, Carlos Aponte, and Julie Blue of the University of Rochester Medical Center, and Xi Zhu, PhD, of Columbia University Irving Medical Center. The research was supported by the National Institute of Mental Health, Wellcome Trust Fellowship, and the European Research Council Grant.

Modulating the Brain’s Immune System May Curb Damage in Alzheimer’s

Thursday, April 17, 2025

New research suggests that calming the brain’s immune cells might prevent or lessen the damaging inflammation seen in Alzheimer’s disease. The study points to the key role of the hormone and neurotransmitter norepinephrine, and this new understanding could pave the way for more focused treatments that start earlier and are tailored to the needs of each person.

“Norepinephrine is a major signaling factor in the brain and affects almost every cell type. In the context of neurodegenerative diseases such as Alzheimer’s disease, it has been shown to be anti-inflammatory,” said Ania Majewska, PhD, with the Del Monte Institute for Neuroscience at the University of Rochester, and senior author of the study, which appears in the journal Brain, Behavior, and Immunity. “In this study, we describe how enhancing norepinephrine’s action on microglia can mitigate early inflammatory changes and neuronal injury in Alzheimer’s models.”

Brain Chemicals & Immune Cells

The research, which was conducted in mice, included teams from two labs, combining research programs studying the complex role of the brain’s immune system and the role of inflammation in Alzheimer's. Led by Linh Le, PhD, a graduate student in both labs, the researchers focused on norepinephrine, a chemical in the brain that helps control inflammation. In our brains, immune cells called microglia usually help keep things in balance. Microglia have a receptor called β2AR, which acts like a “switch” and directs the cells to respond to norepinephrine and calm down inflammation.

In Alzheimer’s disease and as we age, this calming switch becomes less active, especially in areas of the brain where harmful protein clumps called amyloid plaques build up. As these plaques form, the nearby microglia lose more of their β2AR receptors, making it harder for them to fight inflammation.

When scientists removed or blocked the receptor, the brain’s damage worsened: more plaques, increased inflammation, and more harm to brain cells. On the other hand, when they stimulated or "turned up" the receptor, the harmful effects were reduced. Interestingly, the results appeared to depend on factors like the animal’s sex and how early the treatment started.

Do neurons transmit light?

Monday, April 14, 2025

Optics and brain and cognitive science researchers aim to see if neurons can transport light like fiber-optic communications channels

Neurons, the cells in brains and spinal cords that make up the central nervous system, communicate by firing electrical pulses. But scientists have found hints that neurons may transmit light as well, which would profoundly change current models of how the nervous system works.

Researchers from the University of Rochester have begun an ambitious project to study if living neurons can transmit light through their axons—the long, tail-like nerve fibers of neurons that resemble optical fibers. The John Templeton Foundation provided a three-year, $1.5 million grant to support the research.

“There are scientific papers offering indications that light transport could happen in neuron axons, but there’s still not clear experimental evidence,” says the principal investigator, Pablo Postigo, a professor at Rochester’s Institute of Optics. “Scientists have shown that there is ultra-weak photon emission in the brain, but no one understands why the light is there.”

If light is at play and scientists can understand why, it could have major implications for medically treating brain diseases and drastically change the way physicians heal the brain. But measuring optical transport between neurons would be no easy task.

“A neuron’s axon is less than two microns wide, so if you want to measure the optical properties, you need to use nanophotonic techniques,” says Postigo. “If there is light transmission, it may happen with very tiny amounts of light, even a single photon at a time.”

Postigo, an expert in nanophotonics, will design probes that are able to interact optically with living neurons. He is partnering with Michel Telias, an assistant professor of ophthalmology and of neuroscience and a member of the Center for Visual Science, who specializes in measuring the electrical properties of neurons and their action potentials.

Using the photonic nanoprobes, the researchers will inject light into the neuron axon and detect the outcoming photons. If the neuron’s axon can transmit light, they will measure the light’s wavelengths and intensities.

written by Luke Auburn Director of Communications, Hajim School of Engineering & Applied Sciences

Joan Wright Goodman Dissertation Fellowship Recipient

Friday, April 11, 2025

Thomas Delgado has been awarded a Joan Wright Goodman Dissertation Fellowship for 2025-2026!  This fellowship was endowed by Joan Wright Goodman, PhD class of 1952, to support doctoral students across disciplines in the sciences.  It is one of the University’s most competitive dissertation fellowships and is given to students who display exceptional ability and promise.

Congratulations to Thomas. We are very proud of this achievement. Keep up the good work.