URMC / Labs / Anolik Lab / Publications Publications Kenney HMRangel-Moreno JPeng YChen KLBruno JEmbong APritchett EFox JIBecerril-Villanueva EGamboa-Domínguez AQuataert SMuthukrishnan GWood RWKorman BDAnolik JHXing LRitchlin CTSchwarz EMWu CL Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.; Frontiers in immunology; Vol 14, pp. 1237498. 2023 Aug 25. Inamo JKeegan JGriffith AGhosh THorisberger AHoward KPulford JMurzin EHancock BJonsson AHSeifert JFeser MLNorris JMCao YApruzzese WLouis Bridges SBykerk VGoodman SDonlin LFirestein GSPerlman HBathon JMHughes LBTabechian DFiler APitzalis CAnolik JHMoreland LGuthridge JMJames JABrenner MBRaychaudhuri SSparks JAMichael Holers VDeane KDLederer JARao DAZhang F Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis.; bioRxiv : the preprint server for biology. 2023 Jul 04. Weinand KSakaue SNathan AJonsson AHZhang FWatts GFMZhu ZRao DAAnolik JHBrenner MBDonlin LTWei KRaychaudhuri S The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis.; bioRxiv : the preprint server for biology. 2023 Apr 08. Dunlap GWagner AMeednu NZhang FJonsson AHWei KSakaue SNathan ABykerk VPDonlin LTGoodman SMFirestein GSBoyle DLHolers VMMoreland LWTabechian DPitzalis CFiler ARaychaudhuri SBrenner MBMcDavid ARao DAAnolik JH Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium.; bioRxiv : the preprint server for biology. 2023 Mar 21. Kang JBShen AZSakaue SLuo YGurajala SNathan ARumker LAguiar VRCValencia CLagattuta KZhang FJonsson AHYazar SAlquicira-Hernandez JKhalili HAnanthakrishnan ANJagadeesh KDey KDaly MJXavier RJDonlin LTAnolik JHPowell JERao DABrenner MBGutierrez-Arcelus MRaychaudhuri S Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.; medRxiv : the preprint server for health sciences. 2023 Mar 20. Jonsson AHZhang FDunlap GGomez-Rivas EWatts GFMFaust HJRupani KVMears JRMeednu NWang RKeras GCoblyn JSMassarotti EMTodd DJAnolik JHMcDavid AWei KRao DARaychaudhuri SBrenner MB Granzyme K+ CD8 T cells form a core population in inflamed human tissue.; Science translational medicine; Vol 14(649). 2022 Jun 15. Lerman IBawany FWhitt WEsaa FYon JBabkowski NRapp MBScott GAAnolik JHRichardson CT Prominent B cell signature differentiates discoid from subacute cutaneous lupus erythematosus.; The Journal of investigative dermatology. 2022 May 17. Meednu NRangel-Moreno JZhang FEscalera-Rivera KCorsiero EPrediletto EDiCarlo EGoodman SDonlin LTRaychauduri SBombardieri MPitzalis COrange DEMcDavid AAnolik JH Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression.; Cell reports; Vol 39(5). 2022 May 03. Rangel-Moreno JGarcia-Hernandez MLOwen TBarnard JBecerril-Villanueva EKashyap TArgueta CGamboa-Dominguez ATamir SLandesman YGoldman BIRitchlin CTAnolik JH Small molecule inhibitors of nuclear export ameliorate lupus by modulating plasma cell generation and survival.; Arthritis & rheumatology (Hoboken, N.J.). 2022 Mar 25. Fava ARao DAMohan CZhang TRosenberg AFenaroli PBelmont HMIzmirly PClancy RMonroy Trujillo JFine DArazi ABerthier CCDavidson AJames JADiamond BHacohen NWofsy DRaychaudhuri SApruzzese WBuyon JPetri M Urine Proteomics and Renal Single Cell Transcriptomics Implicate IL-16 in Lupus Nephritis.; Arthritis & rheumatology (Hoboken, N.J.). 2021 Nov 16. Barnas JLAlbrecht JMeednu NAlzamareh DFBaker CMcDavid ALooney RJAnolik JH B Cell Activation and Plasma Cell Differentiation Are Promoted by IFN-λ in Systemic Lupus Erythematosus.; Journal of immunology (Baltimore, Md. : 1950). 2021 Oct 27. Meednu NBarnard JCallahan KCoca AMarston BThiele RTabechian DBolster MCurtis JMackay MGraf JKeating RSmith EBoyle KKeyes-Elstein LWelch BGoldmuntz EAnolik JH Activated peripheral blood B cells in rheumatoid arthritis and relationship to anti-TNF treatment and response: randomized clinical trial for anti-TNF effects on B cells.; Arthritis & rheumatology (Hoboken, N.J.). 2021 Aug 04. Zhang FMears JRShakib LBeynor JIShanaj SKorsunsky INathan ADonlin LTRaychaudhuri S IFN- γ and TNF- α drive a CXCL10 + CCL2 + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation.; bioRxiv : the preprint server for biology. 2020 Aug 05. Chen JWRice TABannock JMBielecka AAStrauss JDCatanzaro JRWang HMenard LCAnolik JHPalm NWMeffre E Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition.; Science (New York, N.Y.); Vol 369(6501). 2020 Jul 17. Wei KKorsunsky IMarshall JLGao AWatts GFMMajor TCroft APWatts JBlazar PELange JKThornhill TSFiler ARaza KDonlin LTSiebel CWBuckley CDRaychaudhuri SBrenner MB Notch signalling drives synovial fibroblast identity and arthritis pathology.; Nature. 2020 Apr 22. Jenks SACashman KSZumaquero EMarigorta UMPatel AVWang XTomar DWoodruff MCSimon ZBugrovsky RBlalock ELScharer CDTipton CMWei CLim SSPetri MNiewold TBAnolik JHGibson GEun-Hyung Lee FBoss JMLund FESanz I Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.; Immunity; Vol 52(1). 2020 Jan 14. Barnas JLLooney RJAnolik JH B cell targeted therapies in autoimmune disease.; Current opinion in immunology; Vol 61. 2019 Dec. Mensah KAChen JWSchickel JNIsnardi IYamakawa NVega-Loza AAnolik JHGatti RAGelfand EWMontgomery RRHorowitz MCCraft JEMeffre E Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis.; Science translational medicine; Vol 11(519). 2019 Nov 20. Bocharnikov AVKeegan JWacleche VSCao YFonseka CYWang GMuise ESZhang KXArazi AKeras GLi ZJQu YGurish MFPetri MBuyon JPPutterman CWofsy DJames JAGuthridge JMDiamond BAnolik JHMackey MFAlves SENigrovic PACostenbader KHBrenner MBLederer JARao DA PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21.; JCI insight; Vol 4(20). 2019 Oct 17. Arazi ARao DABerthier CCDavidson ALiu YHoover PJChicoine AEisenhaure TMJonsson AHLi SLieb DJZhang FSlowikowski KBrowne EPNoma ASutherby DSteelman SSmilek DETosta PApruzzese WMassarotti EDall'Era MPark MKamen DLFurie RAPayan-Schober FPendergraft WFMcInnis EABuyon JPPetri MAPutterman CKalunian KCWoodle ESLederer JAHildeman DANusbaum CRaychaudhuri SKretzler MAnolik JHBrenner MBWofsy DHacohen NDiamond B Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis.; Nature immunology; Vol 20(10). 2019 Oct. Dieudonné YGies VGuffroy AKeime CBird AKLiesveld JBarnas JLPoindron VDouiri NSoulas-Sprauel PMartin TMeffre EAnolik JHKorganow AS Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN.; Journal of autoimmunity; Vol 102. 2019 Aug. Arazi ARao DABerthier CCDavidson ALiu YHoover PJChicoine AEisenhaure TMJonsson AHLi SLieb DJZhang FSlowikowski KBrowne EPNoma ASutherby DSteelman SSmilek DETosta PApruzzese WMassarotti EDall'Era MPark MKamen DLFurie RAPayan-Schober FPendergraft WFMcInnis EABuyon JPPetri MAPutterman CKalunian KCWoodle ESLederer JAHildeman DANusbaum CRaychaudhuri SKretzler MAnolik JHBrenner MBWofsy DHacohen NDiamond B The immune cell landscape in kidneys of patients with lupus nephritis.; Nature immunology; Vol 20(7). 2019 Jul. Gao LOConnell MAllen MLiesveld JMcDavid AAnolik JHLooney RJ Bone marrow mesenchymal stem cells from patients with SLE maintain an interferon signature during in vitro culture.; Cytokine. 2019 May 29. Zhang FWei KSlowikowski KFonseka CYRao DAKelly SGoodman SMTabechian DHughes LBSalomon-Escoto KWatts GFMJonsson AHRangel-Moreno JMeednu NRozo CApruzzese WEisenhaure TMLieb DJBoyle DLMandelin AMBoyce BFDiCarlo EGravallese EMGregersen PKMoreland LFirestein GSHacohen NNusbaum CLederer JAPerlman HPitzalis CFiler AHolers VMBykerk VPDonlin LTAnolik JHBrenner MBRaychaudhuri S Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.; Nature immunology. 2019 May 06. Richardson CTSlack MADhillon GMarcus CZBarnard JPalanichamy ASanz ILooney RJAnolik JH Failure of B Cell Tolerance in CVID.; Frontiers in immunology; Vol 10. 2019. Sun WMeednu NRosenberg ARangel-Moreno JWang VGlanzman JOwen TZhou XZhang HBoyce BFAnolik JHXing L B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation.; Nature communications; Vol 9(1). 2018 Dec 03. Donlin LTRao DAWei KSlowikowski KMcGeachy MJTurner JDMeednu NMizoguchi FGutierrez-Arcelus MLieb DJKeegan JMuskat KHillman JRozo CRicker EEisenhaure TMLi SBrowne EPChicoine ASutherby DNoma ANusbaum CKelly SPernis ABIvashkiv LBGoodman SMRobinson WHUtz PJLederer JAGravallese EMBoyce BFHacohen NPitzalis CGregersen PKFirestein GSRaychaudhuri SMoreland LWHolers VMBykerk VPFiler ABoyle DLBrenner MBAnolik JH Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue; Arthritis research & therapy; Vol 20(1). 2018 Jul 11. Gies VSchickel JNJung SJoublin AGlauzy SKnapp AMSoley APoindron VGuffroy AChoi JYGottenberg JEAnolik JHMartin TSoulas-Sprauel PMeffre EKorganow AS Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus.; JCI insight; Vol 3(5). 2018 Mar 08. Jenks SACashman KSZumaquero EMarigorta UMPatel AVWang XTomar DWoodruff MCSimon ZBugrovsky RBlalock ELScharer CDTipton CMWei CLim SSPetri MNiewold TBAnolik JHGibson GLee FEBoss JMLund FESanz I Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.; Immunity; Vol 49(4). 2018 Jan 16. Bird AKChang MBarnard JGoldman BIMeednu NRangel-Moreno JAnolik JH Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers.; Journal of immunology (Baltimore, Md. : 1950). 2017 Jun 05. Meednu NZhang HOwen TSun WWang VCistrone CRangel-Moreno JXing LAnolik JH Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis.; Arthritis & rheumatology (Hoboken, N.J.); Vol 68(4). 2016 Apr. Rangel-Moreno JTo JYOwen TGoldman BISmrcka AVAnolik JH Inhibition of G protein βγ subunit signaling abrogates nephritis in lupus prone mice.; Arthritis & rheumatology (Hoboken, N.J.). 2016 Mar 18. Bird AKMeednu NAnolik JH New insights into B cell biology in systemic lupus erythematosus and Sjögren's syndrome.; Current opinion in rheumatology; Vol 27(5). 2015 Sep. Adlowitz DGBarnard JBiear JNCistrone COwen TWang WPalanichamy AEzealah ECampbell DWei CLooney RJSanz IAnolik JH Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response.; PloS one; Vol 10(6). 2015. Zhang HHilton MJAnolik JHWelle SLZhao CYao ZLi XWang ZBoyce BFXing L NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.; The Journal of clinical investigation; Vol 124(7). 2014 Jul. Wang WRangel-Moreno JOwen TBarnard JNevarez SIchikawa HTAnolik JH Long-term B cell depletion in murine lupus eliminates autoantibody-secreting cells and is associated with alterations in the kidney plasma cell niche.; Journal of immunology (Baltimore, Md. : 1950); Vol 192(7). 2014 Apr 1. Palanichamy ABauer JWYalavarthi SMeednu NBarnard JOwen TCistrone CBird ARabinovich ANevarez SKnight JSDedrick RRosenberg AWei CRangel-Moreno JLiesveld JSanz IBaechler EKaplan MJAnolik JH Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus.; Journal of immunology (Baltimore, Md. : 1950); Vol 192(3). 2014 Feb 1. Ambatipudi KSSwatkoski SMoresco JJTu PGCoca AAnolik JHGucek MSanz IYates JRMelvin JE Quantitative proteomics of parotid saliva in primary Sjögren's syndrome.; Proteomics; Vol 12(19-20). 2012 Oct. Ichikawa HTConley TMuchamuel TJiang JLee SOwen TBarnard JNevarez SGoldman BIKirk CJLooney RJAnolik JH Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells.; Arthritis and rheumatism; Vol 64(2). 2012 Feb. Marian VAnolik JH Treatment targets in systemic lupus erythematosus: biology and clinical perspective.; Arthritis research & therapy; Vol 14 Suppl 4. 2012. Marcus CDhillon GAnolik JH B cell immunology for the clinician.; The Pediatric infectious disease journal; Vol 30(2). 2011 Feb. Kobie JJZheng BBryk PBarnes MRitchlin CTTabechian DAAnandarajah APLooney RJThiele RGAnolik JHCoca AWei CRosenberg AFFeng CTreanor JJLee FESanz I Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor.; Arthritis research & therapy; Vol 13(6). 2011. Bekar KWOwen TDunn RIchikawa TWang WWang RBarnard JBrady SNevarez SGoldman BIKehry MAnolik JH Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus.; Arthritis and rheumatism; Vol 62(8). 2010 Aug. Marston BPalanichamy AAnolik JH B cells in the pathogenesis and treatment of rheumatoid arthritis.; Current opinion in rheumatology; Vol 22(3). 2010 May. Ahmed SAnolik JH B-cell biology and related therapies in systemic lupus erythematosus.; Rheumatic diseases clinics of North America; Vol 36(1). 2010 Feb. Anolik JHLooney RJLund FERandall TDSanz I Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets.; Immunologic research; Vol 45(2-3). 2009 Dec. Palanichamy ABarnard JZheng BOwen TQuach TWei CLooney RJSanz IAnolik JH Novel human transitional B cell populations revealed by B cell depletion therapy.; Journal of immunology (Baltimore, Md. : 1950); Vol 182(10). 2009 May 15. Coca AAnolik JH Two negative randomized controlled trials in lupus: now what?; F1000 medicine reports; Vol 1. 2009. Palanichamy ABarnard JZheng BOwen TQuach TWei CLooney RJSanz IAnolik JH Novel populations of human transitional B cells revealed by B cell depletion therapy; Journal of Immunology. 2009 Jan 01. Coca AAnolik J Two negative randomized controlled trials in lupus: now what? Faculty of 1000 invited commentary; . 2009 Jan 01. View All Publications