Anolik Lab

B Cells and Immune Diseases

Defining the role of B cells in systemic autoimmunity has been instrumental in characterizing the impact of B cell depletion (BCD) on the human immune system and establishing B cell targeted therapies. This has been a major advance in the field of immunologic disease with broad implications in rheumatoid arthritis, lupus, diabetes, malignancy, and immune deficiency.

Findings demonstrating a link between the clinical response and the immunologic reconstitution with transitional B cells was the first delineation of a B regulatory cell population in humans, greatly advancing our understanding of BCD therapy and human B cell development pathways. A prominent publication defining new populations of human transitional B cells provided further fundamental insights into the developmental process followed by human B cells, identifying a new population of human transitional B cells. Recent work has elucidated a previously unrecognized cross-talk between the B cell compartment and neutrophil driven α interferon production in the bone marrow in systemic lupus erythematosus (SLE) that alters B cell development and selection, as well as a critical role for B cells in regulation of bone homeostasis in RA.

Jennifer H. Anolik, M.D., Ph.D.
Principal Investigator

Projects

B Cell Roles in Rheumatoid Arthritis

Phenotypic profiles of Primary Sjogren’s (pSS) and normal control characterized by multi-parameter flow cytometry. Cluster analysis reveals two distinct cluster of pSS patients based on T and B cells.

Immunologic and Ultrasound Biomarkers in Primary Sjögren’s Syndrome

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Publications

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1. Horisberger A
2. Griffith A
3. Keegan J
4. Arazi A
5. Pulford J
6. Murzin E
7. Howard K
8. Hancock B
9. Fava A
10. Sasaki T
11. Ghosh T
12. Inamo J
13. Beuschel R
14. Cao Y
15. Preisinger K
16. Gutierrez-Arcelus M
17. Eisenhaure TM
18. Guthridge J
19. Hoover PJ
20. Dall'Era M
21. Wofsy D
22. Kamen DL
23. Kalunian KC
24. Furie R
25. Belmont M
26. Izmirly P
27. Clancy R
28. Hildeman D
29. Woodle ES
30. Apruzzese W
31. McMahon MA
32. Grossman J
33. Barnas JL
34. Payan-Schober F
35. Ishimori M
36. Weisman M
37. Kretzler M
38. Berthier CC
39. Hodgin JB
40. Demeke DS
41. Putterman C
42. Brenner MB
43. Anolik JH
44. Raychaudhuri S
45. Hacohen N
46. James JA
47. Davidson A
48. Petri MA
49. Buyon JP
50. Diamond B
51. Zhang F
52. Lederer JA
53. Rao DA
Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis.; The Journal of clinical investigation. 2025 Jun 19.
1. Inamo J
2. Keegan J
3. Griffith A
4. Ghosh T
5. Horisberger A
6. Howard K
7. Pulford JF
8. Murzin E
9. Hancock B
10. Dominguez ST
11. Gurra MG
12. Gurajala S
13. Jonsson AH
14. Seifert JA
15. Feser ML
16. Norris JM
17. Cao Y
18. Apruzzese W
19. Bridges SL
20. Bykerk VP
21. Goodman S
22. Donlin LT
23. Firestein GS
24. Bathon JM
25. Hughes LB
26. Filer A
27. Pitzalis C
28. Anolik JH
29. Moreland L
30. Hacohen N
31. Guthridge JM
32. James JA
33. Cuda CM
34. Perlman H
35. Brenner MB
36. Raychaudhuri S
37. Sparks JA
38. Holers VM
39. Deane KD
40. Lederer J
41. Rao DA
42. Zhang F
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis.; The Journal of clinical investigation; Vol 135(6). 2025 Mar 17.
1. Donado CA
2. Theisen E
3. Zhang F
4. Nathan A
5. Fairfield ML
6. Rupani KV
7. Jones D
8. Johannes KP
9. Raychaudhuri S
10. Dwyer DF
11. Jonsson AH
12. Brenner MB
Granzyme K activates the entire complement cascade.; Nature. 2025 Feb 06.
1. Alzamareh DF
2. Meednu N
3. Nandedkar-Kulkarni N
4. Krenitsky D
5. Barnard J
6. Yasaka K
7. Durrett W
8. Thakar J
9. Rangel-Moreno J
10. Anolik JH
11. Barnas JL
Interferon activation in bone marrow long-lived plasma cells in systemic lupus erythematosus.; Frontiers in immunology; Vol 15, pp. 1499551. 2025 Jan 10.

Affiliations

In the News

October 22, 2025
Jennifer Anolik Presents at Upstate Medical Center Symposium

October 20, 2025
National Scleroderma Foundation Rochester Education Forum Held at URMC

September 29, 2025
Jessica Stern, MD Awarded a Mentored Patient-Oriented Research Career Development Award (K23)

May 23, 2025
AIR Research Presented at the 2025 AAI Meeting

May 23, 2025
Dr. Javier Rangel-Moreno Lecturer at the 2025 Course of Biomedicine and Immunology

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Contact Us

Anolik Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642

Jennifer_Anolik@urmc.rochester.edu

(585) 275-2891