Lab Members

Research in the Miller group centers on (1) photonic sensors, particularly with regard to continuous monitoring of microphysiological systems and biomanufacturing; (2) medical diagnostics, including paper-based point-of-care and self-tests for RNA viruses.

Measuring circulating antibodies in human serum using arrayed imaging reflectometry (AIR), a label free multiplex optical biosensor.

Development and synthesis of sorbent polymers for the detection of analytes of interest in the fields of medicine, agriculture, environment, and biological and chemical warfare agent detection. Incorporating sorbent polymers into our current sensing platforms will enable the improvement in the specificity and selectivity compared to current photonic sensing platforms.

My research interests revolve around developing diagnostic technologies that are portable, rapid, cost-effective and capable of providing accurate results at the point of care, enabling timely disease detection, and improving healthcare accessibility. I am currently developing enzyme free methods for HIV detection at the point of care.

My research is focused on using integrated photonic circuits for the detection of biomedically relevant molecules. More specifically, advancing Waveguide Enhanced Raman Spectroscopy for small molecule detection and Ring Resonators for larger molecule detection.

Photonic sensor-integrated organ-on-a-chip systems for monitoring drug efficacy in disease models.

I am interested in the detection of bloodborne viruses, specifically HIV and HCV. I am using paper microfluidics to isolate viral RNA from a whole blood sample and detecting the presence of that viral RNA by capturing loop-mediated isothermal amplification (LAMP) product on photonic ring resonators. The goal is to be able to test for and detect these viruses at the point of care, reducing the time from diagnosis to treatment, improving patient outcomes.

My research is centered on optical and photonic measurement techniques. I develop and use integrated photonic sensors, and optical systems for use with those sensors, for use in various biomedical applications including waveguide-enhanced Raman spectroscopy, organ-on-a-chip systems, and disposable medical diagnostics.

I aim to integrate multiple tissue-chip systems and obtain real-time data on their excretion profiles, enabling a deeper understanding of their interactions in health and disease states to inform new prevention and treatment strategies. Presently, I look at the effects of lung infections on a blood-brain barrier model.

My research interests focus on the development of portable, point-of-care diagnostics and at-home testing platforms to make healthcare more accessible and user-friendly. I am particularly interested in designing diagnostic take-home kits that enable routine health monitoring and disease detection in a convenient, reliable way. Currently, I am working on tissue chip models for drug testing, creating physiologically relevant systems to accelerate safe drug development while reducing reliance on animal testing.

Observing the effects of poly/perfluoroalkyl substances and other environmentally ubiquitous toxicants on the human blood-brain barrier, especially concerning chronic neuroinflammation and barrier disruption, using organ-on-a-chip systems.

I am interested in cell biology and optics. My research involves developing an optical biosensor-based continuous monitoring system for a human tendon-on-a-chip (hToC) model to study tendon fibrovascular injury. This system will be used to screen drugs that could potentially inhibit tendon fibrosis.

 I am researching methods to develop a point of care test for HIV.

Generating large scale data for analysis of photonic wafer fabrication to better understand the process variation in the fabrication of our ring resonator multiple sensors.

Integration of photonic sensors in microphysiological “tissue chip” systems to better understand the breakdown of tissues in the context of disease.