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Bohmann Lab

Welcome to the Bohmann Lab

Expression of activated alleles of ras and JNKK (rasVal12 and Hepact) causes the appearance of maliganant, invasive tumors in the Drosophila brain (lower panel).  Differentiated Neurons are labeled in red, Tumor cells in green, and the actin cytoskeleton in blue

Expression of activated alleles of ras and JNKK
(rasVal12 and Hepact) causes the appearance of
malignant, invasive tumors in the Drosophila brain
(lower panel). Differentiated Neurons are labeled in
red, Tumor cells in green, and the actin
cytoskeleton in blue

The Bohmann lab uses Drosophila genetics, tissue culture approaches and biochemistry to model aging, cancer and metabolic regulation. Genetic, genomic, molecular and cell biological techniques are combined to achieve a systems level understanding of these complex processes.

Specific current projects include studies on JNK, Fos, Foxo and Nrf2 dependent signaling and gene regulation in oxidative stress response and aging. We are also working on signaling pathways that control malignancy in an in vivo cancer model. A recent focus of interest concerns the role of matrix metallo proteases in developmentally controlled as well as pathological cell movements and tissue invasiveness.

Dirk P. Bohmann, Ph.D.

Dirk P. Bohmann, Ph.D.
Principal Investigator

Selected Publications

Mello S Bohmann D. Counting the Minutes.; eLife; Vol 9. 2020 Jan 07.

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.; Cell; Vol 177(3). 2019 Apr 18.

Chatterjee N, Bohmann D. BET-ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors.; BioEssays : news and reviews in molecular, cellular and developmental biology. 2018 Mar 30.

Chatterjee N, Tian M, Spirohn K, Boutros M, Bohmann D. Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.; PLoS genetics; Vol 12(5). 2016 May.

 

More papers:PubMed

 

Contact Us

  Bohmann Lab
KMRB 2-9639
601 Elmwood Ave
Rochester, NY 14642

 (585) 273-2904

  (585) 273-1450