URMC / Labs / Butler Lab / Publications Recent Publications Walling LRButler JS (2017 Nov 06). Homologous VapC toxins inhibit translation and cell growth by sequence specific cleavage of tRNA(fMet). Journal of bacteriology. Walling LRButler JS (2016 Sep 26). Structural determinants for antitoxin identity and insulation of cross talk between homologous toxin-antitoxin systems. Journal of bacteriology. Seward CHManzella AAlam AButler JSDziejman M (2015 Oct). Using S. cerevisiae as a Model System to Investigate V. cholerae VopX-Host Cell Protein Interactions and Phenotypes. Toxins. Jin GPavelka MSButler JS (2015 Apr). Structure-function analysis of VapB4 antitoxin identifies critical features of a minimal VapC4 toxin-binding module. Journal of bacteriology. Hamilton BManzella ASchmidt KDiMarco VButler JS (2014). Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. PloS one. Schmidt KButler JS (2013 Mar). Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity. Wiley interdisciplinary reviews. RNA. Schmidt KXu ZMathews DHButler JS (2012 Oct). Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillance. RNA (New York, N.Y.). Alam AMiller KAChaand MButler JSDziejman M (2011 Apr). Identification of Vibrio cholerae type III secretion system effector proteins. Infection and immunity. Butler JSMitchell P (2011). Rrp6, rrp47 and cofactors of the nuclear exosome. Advances in experimental medicine and biology. Callahan KPButler JS (2010 Feb 5). TRAMP complex enhances RNA degradation by the nuclear exosome component Rrp6. The Journal of biological chemistry. Butler JSMitchell P (2010). Rrp6, Rrp47 and cofactors of the nuclear exosome. Advances in experimental medicine and biology. Roth KMByam JFang FButler JS (2009 Jun). Regulation of NAB2 mRNA 3'-end formation requires the core exosome and the Trf4p component of the TRAMP complex. RNA (New York, N.Y.). Callahan KPButler JS (2008 Dec). Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p. Nucleic acids research. Hoskins JButler JS (2008 May). RNA-based 5-fluorouracil toxicity requires the pseudouridylation activity of Cbf5p. Genetics. Callahan KPButler JS (2008). Lifting the veil on the transcriptome. Genome biology. Fang FPhillips SButler JS (2005 Oct). Rat1p and Rai1p function with the nuclear exosome in the processing and degradation of rRNA precursors. RNA (New York, N.Y.). Roth KMWolf MKRossi MButler JS (2005 Mar). The nuclear exosome contributes to autogenous control of NAB2 mRNA levels. Molecular and cellular biology. Fang FHoskins JButler JS (2004 Dec). 5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs. Molecular and cellular biology. Kuai LFang FButler JSSherman F (2004 Jun 8). Polyadenylation of rRNA in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. Lum PYArmour CDStepaniants SBCavet GWolf MKButler JSHinshaw JCGarnier PPrestwich GDLeonardson AGarrett-Engele PRush CMBard MSchimmack GPhillips JWRoberts CJShoemaker DD (2004 Jan 9). Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell. Phillips SButler JS (2003 Sep). Contribution of domain structure to the RNA 3' end processing and degradation functions of the nuclear exosome subunit Rrp6p. RNA (New York, N.Y.). Das BButler JSSherman F (2003 Aug). Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae. Molecular and cellular biology. Butler JS (2002 Feb). The yin and yang of the exosome. Trends in cell biology. Burkard KTButler JS (2000 Jan). A nuclear 3'-5' exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p. Molecular and cellular biology. Briggs MWBurkard KTButler JS (1998 May 22). Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3' end formation. The Journal of biological chemistry. Liang SBriggs MWButler JS (1997 Jun). Regulation of tRNA suppressor activity by an intron-encoded polyadenylation signal. RNA (New York, N.Y.). Proweller AButler JS (1997 Feb 28). Ribosome concentration contributes to discrimination against poly(A)- mRNA during translation initiation in Saccharomyces cerevisiae. The Journal of biological chemistry. Briggs MWButler JS (1996 Jul). RNA polymerase III defects suppress a conditional-lethal poly(A) polymerase mutation in Saccharomyces cerevisiae. Genetics. Proweller AButler JS (1996 May 3). Ribosomal association of poly(A)-binding protein in poly(A)-deficient Saccharomyces cerevisiae. The Journal of biological chemistry. Guo ZRusso PYun DFButler JSSherman F (1995 May 9). Redundant 3' end-forming signals for the yeast CYC1 mRNA. Proceedings of the National Academy of Sciences of the United States of America. Proweller AButler S (1994 Nov 1). Efficient translation of poly(A)-deficient mRNAs in Saccharomyces cerevisiae. Genes & development. Patel DButler JS (1992 Jul). Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase. Molecular and cellular biology. Sadhale PPSapolsky RDavis RWButler JSPlatt T (1991 Jul 11). Polymerase chain reaction mapping of yeast GAL7 mRNA polyadenylation sites demonstrates that 3' end processing in vitro faithfully reproduces the 3' ends observed in vivo. Nucleic acids research. Butler JSSadhale PPPlatt T (1990 Jun). RNA processing in vitro produces mature 3' ends of a variety of Saccharomyces cerevisiae mRNAs. Molecular and cellular biology. Butler JSPlatt T (1988 Dec 2). RNA processing generates the mature 3' end of yeast CYC1 messenger RNA in vitro. Science (New York, N.Y.). Butler JSSpringer MGrunberg-Manago M (1987 Jun). AUU-to-AUG mutation in the initiator codon of the translation initiation factor IF3 abolishes translational autocontrol of its own gene (infC) in vivo. Proceedings of the National Academy of Sciences of the United States of America. Butler JSSpringer MDondon JGraffe MGrunberg-Manago M (1986 Dec 20). Escherichia coli protein synthesis initiation factor IF3 controls its own gene expression at the translational level in vivo. Journal of molecular biology. Springer MGraffe MButler JSGrunberg-Manago M (1986 Jun). Genetic definition of the translational operator of the threonine-tRNA ligase gene in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. Butler JSSpringer MDondon JGrunberg-Manago M (1986 Jan). Posttranscriptional autoregulation of Escherichia coli threonyl tRNA synthetase expression in vivo. Journal of bacteriology. Springer MPlumbridge JAButler JSGraffe MDondon JMayaux JFFayat GLestienne PBlanquet SGrunberg-Manago M (1985 Sep 5). Autogenous control of Escherichia coli threonyl-tRNA synthetase expression in vivo. Journal of molecular biology. Butler JSClark JM (1984 Feb 28). Eucaryotic initiation factor 4B of wheat germ binds to the translation initiation region of a messenger ribonucleic acid. Biochemistry.