Cole Lab
Research in the Cole lab focuses on investigating toxicities associated with Pancreatic cancer and Rheumatoid arthritis. In particular, we utilize novel, longitudinal imaging techniques such as bioluminescence imaging (BLI) and dual energy x-ray absorptiometry (DEXA), along with combined techniques such as CRISPR gene editing, transcriptomics, proteomics, tissue culture, and histology to investigate the molecular mechanisms of disease-related skeletal muscle wasting.
Calvin Cole, Ph.D.
Principal Investigator
Learners on Location: Zach Sechrist and Calvin Cole
How does mentorship shape you as a scientist and as a person? In this episode of Learners on Location, Assistant Professor Calvin Cole, PhD, and fifth-year PhD student Zach Sechrist share how mentorship at the University of Rochester goes beyond the lab. From studying cancer cachexia (muscle wasting in cancer patients) to building habits around fitness, mental health, and personal growth, their relationship highlights how taking care of yourself can lead to stronger research and greater impact.
- Ovarian Insulin Signaling Is Intact Despite Systemic Insulin Resistance in a Mouse Model of Polycystic Ovary Syndrome.; Endocrinology. 2026 Mar 09.
- Synovial lymphatic system structure and function in rheumatoid arthritis: lymphatic phases, telocytes, and therapeutic modulation through Eexercise.; Current opinion in rheumatology. 2026 Mar 04.
- Ablation of Tumor-Derived IGFBP-3 Attenuates Cancer-Associated Skeletal Muscle Wasting in Murine Pancreatic Cancer.; American journal of physiology. Cell physiology. 2026 Jan 12.
- Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression.; Nature communications; Vol 15(1), pp. 6152. 2024 Jul 21.
Contact Us
Cole Lab
601 Elmwood Ave
Room 1.7534
Rochester, NY 14642